Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 11 December 2012
Vol. 5, Issue 254, p. ec319
[DOI: 10.1126/scisignal.2003850]

EDITORS' CHOICE

Cell Biology Dissecting Wnt Signaling

L. Bryan Ray

Science, Science Signaling, AAAS, Washington, DC 20005, USA

The Wnt signaling pathway plays a key role in regulating a broad range of functions from development to cancer. But a precise understanding of how Wnt proteins act through their receptors (Frizzled proteins) has been elusive. By paring the system down to its core reactions and performing kinetic analysis in cultured cells, Hernández et al. deduced the mechanism of Wnt action without invoking any previous assumptions. Such quantitative analysis of mass balance may offer a way to identify essential control points in other complicated signaling systems and thus help define targets for therapeutic intervention.

A. R. Hernández, A. M. Klein, M. W. Kirschner, Kinetic responses of β-catenin specify the sites of Wnt control. Science 338, 1337–1340 (2012). [Abstract] [Full Text]

Citation: L. B. Ray, Dissecting Wnt Signaling. Sci. Signal. 5, ec319 (2012).



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882