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Sci. Signal., 11 December 2012
Vol. 5, Issue 254, p. mr2
Celebrating 30 Years of Wnt Signaling
Ken M. Cadigan2, and
Renée van Amerongen3*
1 Division of Medicinal Chemistry, VU University, De Boelelaan 1083, 1081 HV Amsterdam, Netherlands. 2 Department of Molecular, Cellular and Developmental Biology, Natural Science Building, University of Michigan, Ann Arbor, MI 48109, USA. 3 Division of Molecular Oncology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.
Meeting Information: EMBO Conference—30 Years of Wnt Signalling, 27 June to 1 July 2012, Egmond aan Zee, Netherlands
Wnt signal transduction is crucial for embryonic development and tissue homeostasis in multicellular animals. Hyperactivation of the Wnt pathway drives tumor formation, yet activation of the Wnt pathway in stem cells holds great promise for injury repair and regeneration. Between 27 June and 1 July 2012, scientists from all over the globe gathered in the beachfront town of Egmond aan Zee in the Netherlands to celebrate the 30th anniversary of this blossoming and exciting field. The latest advances and breakthroughs were discussed at the aptly named European Molecular Biology Organization conference 30 Years of Wnt Signalling. Many presenters discussed unpublished data, a hallmark of past and hopefully future Wnt meetings. This Meeting Report summarizes some of the highlights of this conference, including the presentation of the long-awaited crystal structure of a Wnt protein bound to its receptor and the identification of exciting new possibilities for targeting the pathway in treating disease.
Nam Hee Kim, Hyun Sil Kim, Nam-Gyun Kim, Inhan Lee, Hyung-Seok Choi, Xiao-Yan Li, Shi Eun Kang, So Young Cha, Joo Kyung Ryu, Jung Min Na, Changbum Park, Kunhong Kim, Sanghyuk Lee, Barry M. Gumbiner, Jong In Yook, and Stephen J. Weiss (1 November 2011) Sci. Signal.4 (197), ra71.
[DOI: 10.1126/scisignal.2001744] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
Kristin K. Jernigan, Christopher S. Cselenyi, Curtis A. Thorne, Alison J. Hanson, Emilios Tahinci, Nicole Hajicek, William M. Oldham, Laura A. Lee, Heidi E. Hamm, John R. Hepler, Tohru Kozasa, Maurine E. Linder, and Ethan Lee (11 May 2010) Sci. Signal.3 (121), ra37.
[DOI: 10.1126/scisignal.2000647] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
Richard G. James, Travis L. Biechele, William H. Conrad, Nathan D. Camp, Daniel M. Fass, Michael B. Major, Karen Sommer, XianHua Yi, Brian S. Roberts, Michele A. Cleary, William T. Arthur, Michael MacCoss, David J. Rawlings, Stephen J. Haggarty, and Randall T. Moon (26 May 2009) Sci. Signal.2 (72), ra25.
[DOI: 10.1126/scisignal.2000230] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
Michael B. Major, Brian S. Roberts, Jason D. Berndt, Shane Marine, Jamie Anastas, Namjin Chung, Marc Ferrer, XianHua Yi, Cristi L. Stoick-Cooper, Priska D. von Haller, Lorna Kategaya, Andy Chien, Stephane Angers, Michael MacCoss, Michele A. Cleary, William T. Arthur, and Randall T. Moon (11 November 2008) Sci. Signal.1 (45), ra12.
[DOI: 10.1126/scisignal.2000037] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »