Sci. Signal., 5 February 2013
Science Signaling Podcast: 5 February 2013
Felix Randow1 and Annalisa M. VanHook2
1 MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Hills Road, Cambridge CB2 0QH, UK.
Abstract: This Podcast features an interview with Felix Randow, senior author of a Research Article that appears in the 5 February 2013 issue of Science Signaling. Intracellular pathogens such as Salmonella damage vesicular membranes in infected cells. The cargo receptor NDP52 drives selective autophagy of Salmonella and the damaged vesicles with which it is associated. NDP52 detects Salmonella infection by binding to galectin-8, a host protein that is recruited to membranes damaged by the pathogen. By solving the crystal structure of NDP52 in complex with galectin-8, Li et al. revealed how NDP52 stimulates selective autophagy in response to infection by Salmonella.
Citation: F. Randow, A. M. VanHook, Science Signaling Podcast: 5 February 2013. Sci. Signal. 6, pc4 (2013).
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