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Sci. Signal., 5 February 2013
Vol. 6, Issue 261, p. pe5
[DOI: 10.1126/scisignal.2003820]

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Therapeutic Hints from Analyzing the Attractor Landscape of the p53 Regulatory Circuit

Wei Wang*

Department of Chemistry and Biochemistry and Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093–0359, USA.

Abstract: Genes are interconnected in the cell to form a genetic network that regulates cell fate. Targeting multiple genes is expected to be more effective in developing therapeutics than targeting single genes. A recent study demonstrated the possibility of systematically searching for such combinatorial treatments by characterizing the attractor landscape of the p53 regulatory circuit.

* Corresponding author. E-mail: wei-wang{at}ucsd.edu

Citation: W. Wang, Therapeutic Hints from Analyzing the Attractor Landscape of the p53 Regulatory Circuit. Sci. Signal. 6, pe5 (2013).

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