Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 12 February 2013
Vol. 6, Issue 262, p. pc5
[DOI: 10.1126/scisignal.2004007]

PODCASTS

Science Signaling Podcast: 12 February 2013

Gregg L. Semenza1,2,3,4,5, Maimon E. Hubbi1,2, and Annalisa M. VanHook6

1 Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
2 McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
3 Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
4 Departments of Medicine and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
5 Departments of Pediatrics and Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
6 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005, USA.

Abstract: This Podcast features an interview Gregg Semenza and Maimon Hubbi, authors of a paper that appears in the 12 February 2013 issue of Science Signaling. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein that mediates the transcriptional response to hypoxia, the decreased availability of oxygen. One of the outcomes of HIF-1–mediated gene regulation is activation of genes encoding proteins that inhibit cell proliferation. Hubbi et al. report that the α subunit of HIF-1 (HIF-1α) also inhibits cell proliferation in response to hypoxia by inhibiting the activity of a DNA helicase that is required for DNA replication.

Citation: G. L. Semenza, M. E. Hubbi, A. M. VanHook, Science Signaling Podcast: 12 February 2013. Sci. Signal. 6, pc5 (2013).

Read the Full Text



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882