Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 19 February 2013
Vol. 6, Issue 263, p. pc6
[DOI: 10.1126/scisignal.2004006]


Science Signaling Podcast: 19 February 2013

Jayne S. Danska1,2,3 and Annalisa M. VanHook4

1 Program in Genetics and Genome Biology, Hospital for Sick Children Research Institute, Toronto, Ontario M5G 1X8, Canada.
2 Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
3 Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada.
4 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005, USA.

Abstract: This Podcast features an interview with Jayne Danska, senior author of a paper that was released on Science Express on 17 January 2013. A group led by Danska has uncovered an interaction between the gut microbiota and sex hormones that influences the development of type 1 diabetes in mice. Although type 1 diabetes shows no sex bias in humans, females of the non-obese diabetic (NOD) mouse strain are about twice as likely to develop the disease as are NOD males. Markle et al. report that male-type gut microbiota were associated with an increase in testosterone that reduces an individual's chances of developing type 1 diabetes. This protection was prevented by interfering with testosterone signaling.

Citation: J. S. Danska, A. M. VanHook, Science Signaling Podcast: 19 February 2013. Sci. Signal. 6, pc6 (2013).

Read the Full Text

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882