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Sci. Signal., 5 March 2013
Vol. 6, Issue 265, p. ec60
[DOI: 10.1126/scisignal.2004116]


Cancer Genetic Clues to Meningioma

Paula A. Kiberstis

Science, AAAS, Washington, DC 20005, USA

Meningiomas are the most common primary brain tumors in adults. Located within the layer of tissue covering the brain, these tumors are usually slow-growing and benign but can cause serious neurological complications. About half of these tumors have mutations in the neurofibromin 2 gene (NF2). To identify other genes that contribute to meningioma pathogenesis, Clark et al. performed genome sequence analysis on 300 tumors. Meningiomas fell into two general classes: benign tumors located at the skull base—which tend to harbor mutations in the TRAF7, KLF4, AKT1, and SMO genes—and higher-grade tumors located in the cerebral and cerebellar hemispheres that harbor mutations in NF2.

V. E. Clark, E. Z. Erson-Omay, A. Serin, J. Yin, J. Cotney, K. Özduman, T. Avsar, J. Li, P. B. Murray, O. Henegariu, S. Yilmaz, J. M. Günel, G. Carrión-Grant, B. Yilmaz, C. Grady, B. Tanrikulu, M. Bakircioglu, H. Kaymakçalan, A. O. Caglayan, L. Sencar, E. Ceyhun, A. F. Atik, Y. Bayri, H. Bai, L. E. Kolb, R. M. Hebert, S. B. Omay, K. Mishra-Gorur, M. Choi, J. D. Overton, E. C. Holland, S. Mane, M. W. State, K. Bilgüvar, J. M. Baehring, P. H. Gutin, J. M. Piepmeier, A. Vortmeyer, C. W. Brennan, M. N. Pamir, T. Kiliç, R. P. Lifton, J. P. Noonan, K. Yasuno, M. Günel, Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Science 339, 1077–1080 (2013). [Abstract] [Full Text]

Citation: P. A. Kiberstis, Genetic Clues to Meningioma. Sci. Signal. 6, ec60 (2013).

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