Sci. Signal., 19 March 2013
Cell Biology Coordinating Metabolism
L. Bryan Ray
Science, Science Signaling, AAAS, Washington, DC 20005, USA
Growth factors help to coordinate metabolism with growth in part by stimulating the activity of the protein kinase mTORC1 (mechanistic target of rapamycin complex 1). Ben-Sahra et al. and Robitaille et al. independently identified a key target of mTORC1—carbamolyl-phosphate synthase 2, or CAD, the rate-limiting enzyme for de novo synthesis of pyrimidines. Metabolomic profiling and phosphoproteomic analyses of normal cells and cells lacking signaling by mTORC1 converged on CAD as a key point at which growth-promoting signals also ramp up production of nucleic acids.
A. M. Robitaille, S. Christen, M. Shimobayashi, M. Cornu, L. L. Fava, S. Moes, C. Prescianotto-Baschong, U. Sauer, P. Jenoe, M. N. Hall, Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339, 1320–1323 (2013). [Abstract] [Full Text]
Citation: L. B. Ray, Coordinating Metabolism. Sci. Signal. 6, ec69 (2013).
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