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Sci. Signal., 19 March 2013
Vol. 6, Issue 267, p. ec69
[DOI: 10.1126/scisignal.2004147]


Cell Biology Coordinating Metabolism

L. Bryan Ray

Science, Science Signaling, AAAS, Washington, DC 20005, USA

Growth factors help to coordinate metabolism with growth in part by stimulating the activity of the protein kinase mTORC1 (mechanistic target of rapamycin complex 1). Ben-Sahra et al. and Robitaille et al. independently identified a key target of mTORC1—carbamolyl-phosphate synthase 2, or CAD, the rate-limiting enzyme for de novo synthesis of pyrimidines. Metabolomic profiling and phosphoproteomic analyses of normal cells and cells lacking signaling by mTORC1 converged on CAD as a key point at which growth-promoting signals also ramp up production of nucleic acids.

I. Ben-Sahra, J. J. Howell, J. M. Asara, B. D. Manning, Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science 339, 1323–1328 (2013). [Abstract] [Full Text]

A. M. Robitaille, S. Christen, M. Shimobayashi, M. Cornu, L. L. Fava, S. Moes, C. Prescianotto-Baschong, U. Sauer, P. Jenoe, M. N. Hall, Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339, 1320–1323 (2013). [Abstract] [Full Text]

Citation: L. B. Ray, Coordinating Metabolism. Sci. Signal. 6, ec69 (2013).

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