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Sci. Signal., 26 March 2013
Vol. 6, Issue 268, p. eg3
[DOI: 10.1126/scisignal.2004149]


Focus Issue: From Genomic Mutations to Oncogenic Pathways

Nancy R. Gough1*

1 Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This two-issue series focuses on how understanding how signaling pathways are altered in cancer cells can enable researchers to develop more effective therapies. Cancer is a pleiotropic disease. Tumor cells change over time and, even within a specific tumor, cells may have different mutations and dependencies on different signaling pathways for survival or for metastatic potential. New tools and technologies for genomic- or systems-level analysis, as well as conventional biochemistry and cell biology approaches, are revealing how signaling pathways contribute to cancer development, cancer evolution, and drug resistance.

* Corresponding author. E-mail: ngough{at}

Citation: N. R. Gough, Focus Issue: From Genomic Mutations to Oncogenic Pathways. Sci. Signal. 6, eg3 (2013).

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