Sci. Signal., 30 April 2013
Mitophagy Where Parkin Parks
L. Bryan Ray
Science, Science Signaling, AAAS, Washington, DC 20005, USA
Damaged mitochondria are removed from cells in a process known as mitophagy. Failure of this quality-control mechanism contributes to Parkinsons disease. When damaged mitochondria lose membrane depolarization, the protein kinase, PINK1, accumulates on the mitochondrial surface, recruits Parkin, and promotes mitophagy. Chen and Dorn describe another component of this process, mitofusin 2, which appears to function as the receptor for Parkin on the surface of damaged mitochondria.
Citation: L. B. Ray, Where Parkin Parks. Sci. Signal. 6, ec96 (2013).
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