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Sci. Signal., 7 May 2013
Vol. 6, Issue 274, p. pc12
[DOI: 10.1126/scisignal.2004254]


Science Signaling Podcast: 7 May 2013

Hilmar Bading1 and Annalisa M. VanHook2

1 Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), University of Heidelberg, INF 364 69120 Heidelberg, Germany.
2 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005, USA.

Abstract: This Podcast features an interview with Hilmar Bading, senior author of a Research Article that appears in the 7 May 2013 issue of Science Signaling and addresses the requirement for calcium signaling in long-term memory formation in the fruit fly. Short-term memory depends on alterations in the function of existing neuronal connections and is accomplished through changes in the activity, abundance, or distribution of proteins. In contrast, long-term memory depends on structural changes in neuronal connections and requires gene transcription. In vertebrates, these transcriptional changes are mediated by nuclear calcium signaling. Using a Pavlovian conditioning protocol and genetically encoded calcium sensors, Bading's group found that nuclear calcium signaling is also required for long-term memory formation in fruit flies.

Citation: H. Bading, A. M. VanHook, Science Signaling Podcast: 7 May 2013. Sci. Signal. 6, pc12 (2013).

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