Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 18 February 2014
Vol. 7, Issue 313, p. pc6
[DOI: 10.1126/scisignal.2005151]

PODCASTS

Science Signaling Podcast: 18 February 2014

James W. Dennis1,2, Mohamed A. Soliman1,2,3, and Annalisa M. VanHook4

1 Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada.
2 Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Canada.
3 Department of Biochemistry, Faculty of Pharmacy, Cairo University, Egypt.
4 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This Podcast features an interview with Jim Dennis and Mohamed Soliman, authors of a Research Article that appears in the 18 February 2014 issue of Science Signaling, about an adaptor protein that limits glucose uptake metabolism. Adaptor proteins are key components of signal transduction networks because they mediate protein-protein interactions that can promote or block the formation of active signaling complexes. p66Shc is an adaptor protein that participates in signaling by receptor tyrosine kinases and plays a role in glucose metabolism. Mice that lack p66Shc have better glucose tolerance and insulin sensitivity than control mice, so they are resistant to developing diabetes and obesity. Soliman et al. found that at least some of p66Shc's effects on glucose metabolism required the mTOR pathway.

Citation: J. W. Dennis, M. A. Soliman, A. M. VanHook, Science Signaling Podcast: 18 February 2014. Sci. Signal. 7, pc6 (2014).

Read the Full Text



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882