Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. Signal., 29 April 2008
Vol. 1, Issue 17, p. pe17
[DOI: 10.1126/stke.117pe17]

PERSPECTIVES

Notch Signaling in Osteoblasts

Ernesto Canalis*

Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, CT 06105, USA, and University of Connecticut School of Medicine, Farmington, CT 06030, USA.

Abstract: Bone remodeling is the result of the coordinated activity of osteoblasts, which form new matrix, and osteoclasts, which resorb bone. Notch proteins are single-pass transmembrane receptors that determine cell fate. Recent gain-of-function and loss-of-function experiments reveal a suppressive effect of Notch in osteoblast and osteoclast differentiation in development and in the postnatal bone, which establishes a role for Notch signaling in bone remodeling.

*Corresponding author. E-mail, ecanalis{at}stfranciscare.org

Citation: E. Canalis, Notch Signaling in Osteoblasts. Sci. Signal. 1, pe17 (2008).

Read the Full Text

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882