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Sci. STKE, 6 December 2005
Vol. 2005, Issue 313, p. pe53
[DOI: 10.1126/stke.3132005pe53]


Novel Compartment Implicated in Calcium Signaling—Is It an "Induced Coupling Domain"?

Chihiro Hisatsune1 and Katsuhiko Mikoshiba1,2,3*

1Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute (BSI), 2-1 Hirosawa, Wako City, Saitama 351-0198, Japan.
2Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 3-4-1, Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan.
3Calcium Oscillation Project, ICORP, Japan Science and Technology Agency, 3 Nibancho, Chiyoda-ku, Tokyo 102-0084, Japan.

Abstract: The endoplasmic reticulum (ER) is not simply a uniform continuous organelle, but is spatially and functionally heterogeneous with nonuniform distribution of endoplasmic Ca2+-handling proteins, such as Ca2+-binding proteins, Ca2+ pumps, and Ca2+-release channels. Such nonuniform distribution of Ca2+-handling proteins is thought to create a spatially divided calcium store and to contribute to the generation of complex intracellular Ca2+ dynamics. In addition to the particular distribution of these Ca2+-handling proteins within ER, extracellular stimuli may also stimulate the formation of dynamic new ER compartments containing Ca2+-handling proteins. These compartments containing Ca2+-handling proteins have potential roles in Ca2+ signaling; specifically, they may function as "induced coupling domains" between the ER and plasma membrane, thereby allowing Ca2+ entry into the ER.

*Corresponding author. E-mail, mikosiba{at}

Citation: C. Hisatsune, K. Mikoshiba, Novel Compartment Implicated in Calcium Signaling—Is It an "Induced Coupling Domain"? Sci. STKE 2005, pe53 (2005).

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