Sci. STKE, 6 December 2005
Transduction Peptides Within Naturally Occurring Proteins
Homeoprotein Cell Biology, CNRS UMR 8542, Ecole Normale Supérieure, 46 rue dUlm, 75230 Paris cedex 05, France.
Abstract: First identified as peptides derived from the human immunodeficiency virus (HIV) transcriptional regulator Tat and the Drosophila transcription factor Antennapedia, transduction (or cell-penetrating) peptide sequences enable soluble proteins to cross biological membranes and interact with cytosolic and nuclear targets. Proteins containing such sequences have been found to function as transcription factors, to inhibit apoptosis, to play roles in axon guidance, or to transport viral mRNA between cells. The recent demonstration that dynorphins are able to act as transduction peptides suggests that these neuropeptides may have roles independent of opiate receptor activation.
Citation: A. Joliot, Transduction Peptides Within Naturally Occurring Proteins. Sci. STKE 2005, pe54 (2005).
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