Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 16 May 2006
Vol. 2006, Issue 335, p. re5
[DOI: 10.1126/stke.3352006re5]


Signaling During Pathogen Infection

Sylvia Münter1, Michael Way2*, and Freddy Frischknecht1*

1Department of Parasitology, Hygiene Institute, University of Heidelberg Medical School, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.
2Cell Motility Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

Abstract: Over the millennia, pathogens have coevolved with their hosts and acquired the ability to intercept, disrupt, mimic, and usurp numerous signaling pathways of those hosts. The study of host/pathogen interactions thus not only teaches us about the intricate biology of these parasitic invaders but also provides interesting insights into basic cellular processes both at the level of the individual cell and more globally throughout the organism. Host/pathogen relationships also provide insights into the evolutionary forces that shape biological diversity. Here we review a few recent examples of how viruses, bacteria, and parasites manipulate tyrosine kinase–mediated and Rho guanosine triphosphatase–mediated signaling pathways of their hosts to achieve efficient entry, replication, and exit during their infectious cycles.

*Corresponding authors. Telephone, 49-6221-566537; fax, 49-6221-564643; e-mail, freddy.frischknecht{at} (F.F.); telephone, 44-207-269 3733; fax, 44-207-269 3581; e-mail, Michael.Way{at} (M.W.)

Citation: S. Münter, M. Way, F. Frischknecht, Signaling During Pathogen Infection. Sci. STKE 2006, re5 (2006).

Read the Full Text

The Human Papillomavirus E7 Proteins Associate with p190RhoGAP and Alter Its Function.
B. Todorovic, A. C. Nichols, J. M. Chitilian, M. P. Myers, T. G. Shepherd, S. J. Parsons, J. W. Barrett, L. Banks, and J. S. Mymryk (2014)
J. Virol. 88, 3653-3663
   Abstract »    Full Text »    PDF »
Regulation of the Actin Cytoskeleton by Rho Kinase Controls Antigen Presentation by CD1d.
R. M. Gallo, M. A. Khan, J. Shi, R. Kapur, L. Wei, J. C. Bailey, J. Liu, and R. R. Brutkiewicz (2012)
J. Immunol. 189, 1689-1698
   Abstract »    Full Text »    PDF »
Role of Src Kinases in Mobilization of Glycosylphosphatidylinositol-Anchored Decay-Accelerating Factor by Dr Fimbria-Positive Adhering Bacteria.
C. J. Queval, V. Nicolas, and I. Beau (2011)
Infect. Immun. 79, 2519-2534
   Abstract »    Full Text »    PDF »
The BNIP-2 and Cdc42GAP Homology (BCH) Domain of p50RhoGAP/Cdc42GAP Sequesters RhoA from Inactivation by the Adjacent GTPase-activating Protein Domain.
Y. T. Zhou, L. L. Chew, S.-c. Lin, and B. C. Low (2010)
Mol. Biol. Cell 21, 3232-3246
   Abstract »    Full Text »    PDF »
Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks.
H. Sultana, G. Neelakanta, F. S. Kantor, S. E. Malawista, D. Fish, R. R. Montgomery, and E. Fikrig (2010)
J. Exp. Med. 207, 1727-1743
   Abstract »    Full Text »    PDF »
Visualizing cellular processes at the molecular level by cryo-electron tomography.
K. Ben-Harush, T. Maimon, I. Patla, E. Villa, and O. Medalia (2010)
J. Cell Sci. 123, 7-12
   Abstract »    Full Text »    PDF »
Herpes Simplex Virus Requires VP11/12 To Induce Phosphorylation of the Activation Loop Tyrosine (Y394) of the Src Family Kinase Lck in T Lymphocytes.
M. J. Wagner and J. R. Smiley (2009)
J. Virol. 83, 12452-12461
   Abstract »    Full Text »    PDF »
Activation of the PI3K/Akt Pathway Early during Vaccinia and Cowpox Virus Infections Is Required for both Host Survival and Viral Replication.
J. A. P. Soares, F. G. G. Leite, L. G. Andrade, A. A. Torres, L. P. De Sousa, L. S. Barcelos, M. M. Teixeira, P. C. P. Ferreira, E. G. Kroon, T. Souto-Padron, et al. (2009)
J. Virol. 83, 6883-6899
   Abstract »    Full Text »    PDF »
Silencing of Host Cell CYBB Gene Expression by the Nuclear Effector AnkA of the Intracellular Pathogen Anaplasma phagocytophilum.
J. C. Garcia-Garcia, K. E. Rennoll-Bankert, S. Pelly, A. M. Milstone, and J. S. Dumler (2009)
Infect. Immun. 77, 2385-2391
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 23 September 2008.
E. M. Adler, N. R. Gough, and A. M. VanHook (2008)
Science Signaling 1, pc8
   Abstract »    Full Text »
Native 3D intermediates of membrane fusion in herpes simplex virus 1 entry.
U. E. Maurer, B. Sodeik, and K. Grunewald (2008)
PNAS 105, 10559-10564
   Abstract »    Full Text »    PDF »
Geranylgeranylation but Not GTP-Loading of Rho GTPases Determines T Cell Function.
S. Waiczies, I. Bendix, and F. Zipp (2008)
Science Signaling 1, pt3
   Abstract »    Full Text »    PDF »
Neph1 Cooperates with Nephrin To Transduce a Signal That Induces Actin Polymerization.
P. Garg, R. Verma, D. Nihalani, D. B. Johnstone, and L. B. Holzman (2007)
Mol. Cell. Biol. 27, 8698-8712
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882