Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 17 April 2007
Vol. 2007, Issue 382, p. pe15
[DOI: 10.1126/stke.3822007pe15]

PERSPECTIVES

Regulation of PC12 Cell Differentiation by cAMP Signaling to ERK Independent of PKA: Do All the Connections Add Up?

Matthew J. Gerdin* and Lee E. Eiden

Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institutes of Health, 9000 Rockville Pike, Building 49, Room 5A27, Bethesda, MD 20892, USA.

Abstract: Pituitary adenylate cyclase–activating polypeptide (PACAP) is a neuropeptide that elevates adenosine 3',5'-monophosphate (cyclic AMP, also abbreviated cAMP) to elicit neuritogenesis in PC12 cells. This effect appears to be independent of cAMP-dependent protein kinase (PKA) yet dependent on cAMP, leading to the conclusion that another cAMP-binding protein and subsequent signaling pathway must exist to mediate this PKA-independent signaling mechanism. Such a protein was identified as exchange protein directly activated by cAMP (EPAC). Although EPAC may play an indirect role in PACAP-mediated neuritogenesis, it does not serve as the only PKA-independent link from cAMP that leads to neuritogenesis. Thus, the challenge remains to construct a signaling network that incorporates the known mediators, working independently of PKA, that are ultimately responsible for PACAP-mediated neuritogenesis.

*Corresponding author. Telephone, 301-435-4105; e-mail, matthewgerdin{at}mail.nih.gov

Citation: M. J. Gerdin, L. E. Eiden, Regulation of PC12 Cell Differentiation by cAMP Signaling to ERK Independent of PKA: Do All the Connections Add Up? Sci. STKE 2007, pe15 (2007).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pituitary Adenylate Cyclase-Activating Polypeptide 38-Mediated Rin Activation Requires Src and Contributes to the Regulation of Hsp27 Signaling during Neuronal Differentiation.
G.-X. Shi, L. Jin, and D. A. Andres (2008)
Mol. Cell. Biol. 28, 4940-4951
   Abstract »    Full Text »    PDF »
pathFinder: A Static Network Analysis Tool for Pharmacological Analysis of Signal Transduction Pathways.
B. B. Samal and L. E. Eiden (2008)
Science Signaling 1, pt4
   Abstract »    Full Text »    PDF »
A cAMP-Dependent, Protein Kinase A-Independent Signaling Pathway Mediating Neuritogenesis through Egr1 in PC12 Cells.
A. Ravni, D. Vaudry, M. J. Gerdin, M. V. Eiden, A. Falluel-Morel, B. J. Gonzalez, H. Vaudry, and L. E. Eiden (2008)
Mol. Pharmacol. 73, 1688-1708
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882