Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 24 April 2007
Vol. 2007, Issue 383, p. pe16
[DOI: 10.1126/stke.3832007pe16]

PERSPECTIVES

What Is Left Behind—Quality Control in Germ Cell Migration

Bijan Boldajipour and Erez Raz*

Germ Cell Development, Max-Planck-Institute for Biophysical Chemistry, 37077 Göttingen, Germany and Institute of Cell Biology, Center for Molecular Biology of Inflammation (ZMBE), University of Münster, 48149 Münster, Germany.

Abstract: Cell differentiation, cell proliferation, cell death, and cell migration are tightly controlled during animal development and adult homeostasis. Failure to regulate these processes can result in tumor formation and metastasis. Aberrant cells are therefore often cleared by induction of cell death. Recent work has elucidated the mechanism of elimination of mouse primordial germ cells that fail to migrate properly and highlights the similarity of this mechanism to those governing the same phenomenon in Drosophila. In addition, these studies underscore the different functions a single signaling pathway can have in controlling cell survival, cell proliferation, and cell migration during different phases of development.

*Corresponding author. E-mail, eraz{at}gwdg.de

Citation: B. Boldajipour, E. Raz, What Is Left Behind—Quality Control in Germ Cell Migration. Sci. STKE 2007, pe16 (2007).

Read the Full Text



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882