Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 29 May 2007
Vol. 2007, Issue 388, p. pe29
[DOI: 10.1126/stke.3882007pe29]

PERSPECTIVES

Microfluidic Devices for the Analysis of Single Cells: Leaving No Protein Uncounted

Marian Navratil, Christofer E. Whiting, and Edgar A. Arriaga*

207 Pleasant Street SE, Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.

Abstract: Microfluidic devices are revolutionizing bioanalysis, and designs capable of detecting single protein molecules are now available. Two recently described microfluidic devices provide information on the number of beta2-adrenergic receptors in individual cultured insect cells and measure the degradation of phycobilisomes in individual cyanobacteria, respectively. This latter experiment, which included the analysis of three single cells in parallel, heralds a bright future for high-throughput single-cell analyzers. These devices could greatly advance research in signal transduction and studies of the effects of environmental stimuli or xenobiotics on cellular responses.

*Corresponding author. E-mail: arriaga{at}chem.umn.edu

Citation: M. Navratil, C. E. Whiting, E. A. Arriaga, Microfluidic Devices for the Analysis of Single Cells: Leaving No Protein Uncounted. Sci. STKE 2007, pe29 (2007).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Science Signaling Podcast: 23 June 2009.
A. Levchenko and A. M. VanHook (2009)
Science Signaling 2, pc11
   Abstract »    Full Text »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882