Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Annu. Rev. Biophys. Biomol. Struct. 29 (1): 49-79

Copyright © 2000 by Annual Reviews.

Integration of Protein Abundance and Structure Data Reveals Competition in the ErbB Signaling Network.
C. Kiel, E. Verschueren, J.-S. Yang, and L. Serrano (2013)
Science Signaling 6, ra109
   Abstract »    Full Text »    PDF »
Chimeras of sperm PLC{zeta} reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization.
M. Theodoridou, M. Nomikos, D. Parthimos, J. R. Gonzalez-Garcia, K. Elgmati, B. L. Calver, Z. Sideratou, G. Nounesis, K. Swann, and F. A. Lai (2013)
Mol. Hum. Reprod. 19, 852-864
   Abstract »    Full Text »    PDF »
Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage.
A. Cohnen, S. C. Chiang, A. Stojanovic, H. Schmidt, M. Claus, P. Saftig, O. Janssen, A. Cerwenka, Y. T. Bryceson, and C. Watzl (2013)
Blood 122, 1411-1418
   Abstract »    Full Text »    PDF »
Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice.
H. Oishi, S. Itoh, K. Matsumoto, H. Ishitobi, R. Suzuki, M. Ema, T. Kojima, K. Uchida, M. Kato, T. Miyata, et al. (2012)
J. Biochem. 152, 549-555
   Abstract »    Full Text »    PDF »
A structure-based protocol for learning the family-specific mechanisms of membrane-binding domains.
M. Kallberg, N. Bhardwaj, R. Langlois, and H. Lu (2012)
Bioinformatics 28, i431-i437
   Abstract »    Full Text »    PDF »
Protein Kinase C: The "Masters" of Calcium and Lipid.
P. Lipp and G. Reither (2011)
Cold Spring Harb Perspect Biol 3, a004556
   Abstract »    Full Text »    PDF »
Arabidopsis thaliana calcium-dependent lipid-binding protein (AtCLB): a novel repressor of abiotic stress response.
K. de Silva, B. Laska, C. Brown, H. W. Sederoff, and M. Khodakovskaya (2011)
J. Exp. Bot. 62, 2679-2689
   Abstract »    Full Text »    PDF »
Ca2+ induces clustering of membrane proteins in the plasma membrane via electrostatic interactions.
F. E. Zilly, N. D. Halemani, D. Walrafen, L. Spitta, A. Schreiber, R. Jahn, and T. Lang (2011)
EMBO J. 30, 1209-1220
   Abstract »    Full Text »    PDF »
A Vibrio Effector Protein Is an Inositol Phosphatase and Disrupts Host Cell Membrane Integrity.
C. A. Broberg, L. Zhang, H. Gonzalez, M. A. Laskowski-Arce, and K. Orth (2010)
Science 329, 1660-1662
   Abstract »    Full Text »    PDF »
Phospholipid-Binding Protein EhC2A Mediates Calcium-Dependent Translocation of Transcription Factor URE3-BP to the Plasma Membrane of Entamoeba histolytica.
H. Moreno, A. S. Linford, C. A. Gilchrist, and W. A. Petri Jr. (2010)
Eukaryot. Cell 9, 695-704
   Abstract »    Full Text »    PDF »
Structural Basis of Membrane Targeting by the Dock180 Family of Rho Family Guanine Exchange Factors (Rho-GEFs).
L. Premkumar, A. A. Bobkov, M. Patel, L. Jaroszewski, L. A. Bankston, B. Stec, K. Vuori, J.-F. Cote, and R. C. Liddington (2010)
J. Biol. Chem. 285, 13211-13222
   Abstract »    Full Text »    PDF »
Structural Basis of Protein Kinase C Isoform Function.
S. F. Steinberg (2008)
Physiol Rev 88, 1341-1378
   Abstract »    Full Text »    PDF »
Large-scale quantitative LC-MS/MS analysis of detergent-resistant membrane proteins from rat renal collecting duct.
M.-J. Yu, T. Pisitkun, G. Wang, J. F. Aranda, P. A. Gonzales, D. Tchapyjnikov, R.-F. Shen, M. A. Alonso, and M. A. Knepper (2008)
Am J Physiol Cell Physiol 295, C661-C678
   Abstract »    Full Text »    PDF »
Kinetic Analysis of the Interaction of the C1 Domain of Protein Kinase C with Lipid Membranes by Stopped-flow Spectroscopy.
D. R. Dries and A. C. Newton (2008)
J. Biol. Chem. 283, 7885-7893
   Abstract »    Full Text »    PDF »
Role of the Diacylglycerol Kinase {alpha}-Conserved Domains in Membrane Targeting in Intact T Cells.
E. Merino, M. A. Sanjuan, I. Moraga, A. Cipres, and I. Merida (2007)
J. Biol. Chem. 282, 35396-35404
   Abstract »    Full Text »    PDF »
H. Feng, M. Ren, L. Chen, and C. S. Rubin (2007)
J. Biol. Chem. 282, 31273-31288
   Abstract »    Full Text »    PDF »
Prediction of protein orientation upon immobilization on biological and nonbiological surfaces.
A. H. Talasaz, M. Nemat-Gorgani, Y. Liu, P. Stahl, R. W. Dutton, M. Ronaghi, and R. W. Davis (2006)
PNAS 103, 14773-14778
   Abstract »    Full Text »    PDF »
Conserved Domains Subserve Novel Mechanisms and Functions in DKF-1, a Caenorhabditis elegans Protein Kinase D.
H. Feng, M. Ren, and C. S. Rubin (2006)
J. Biol. Chem. 281, 17815-17826
   Abstract »    Full Text »    PDF »
Protein Kinase C (PKC){alpha} and PKC{theta} Are the Major PKC Isotypes Involved in TCR Down-Regulation.
M. von Essen, M. W. Nielsen, C. M. Bonefeld, L. Boding, J. M. Larsen, M. Leitges, G. Baier, N. Odum, and C. Geisler (2006)
J. Immunol. 176, 7502-7510
   Abstract »    Full Text »    PDF »
Crystal Structure of the C2 Domain of Class II Phosphatidylinositide 3-Kinase C2{alpha}.
L. Liu, X. Song, D. He, C. Komma, A. Kita, J. V. Virbasius, G. Huang, H. D. Bellamy, K. Miki, M. P. Czech, et al. (2006)
J. Biol. Chem. 281, 4254-4260
   Abstract »    Full Text »    PDF »
Specific Translocation of Protein Kinase C{alpha} to the Plasma Membrane Requires Both Ca2+ and PIP2 Recognition by Its C2 Domain.
J. H. Evans, D. Murray, C. C. Leslie, and J. J. Falke (2006)
Mol. Biol. Cell 17, 56-66
   Abstract »    Full Text »    PDF »
Assigning Functional Domains within the p101 Regulatory Subunit of Phosphoinositide 3-Kinase {gamma}.
P. Voigt, C. Brock, B. Nurnberg, and M. Schaefer (2005)
J. Biol. Chem. 280, 5121-5127
   Abstract »    Full Text »    PDF »
Inhibition of Gap Junction Activity through the Release of the C1B Domain of Protein Kinase C{gamma} (PKC{gamma}) from 14-3-3: IDENTIFICATION OF PKC{gamma}-BINDING SITES.
T. A. Nguyen, L. J. Takemoto, and D. J. Takemoto (2004)
J. Biol. Chem. 279, 52714-52725
   Abstract »    Full Text »    PDF »
Pore Formation by Equinatoxin, a Eukaryotic Pore-forming Toxin, Requires a Flexible N-terminal Region and a Stable {beta}-Sandwich.
K. Kristan, Z. Podlesek, V. Hojnik, I. Gutierrez-Aguirre, G. Guncar, D. Turk, J. M. Gonzalez-Manas, J. H. Lakey, P. Macek, and G. Anderluh (2004)
J. Biol. Chem. 279, 46509-46517
   Abstract »    Full Text »    PDF »
The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo.
R. Dunn, D. A. Klos, A. S. Adler, and L. Hicke (2004)
J. Cell Biol. 165, 135-144
   Abstract »    Full Text »    PDF »
Conservation and covariance in PH domain sequences: physicochemical profile and information theoretical analysis of XLA-causing mutations in the Btk PH domain.
B. Shen and M. Vihinen (2004)
Protein Eng. Des. Sel. 17, 267-276
   Abstract »    Full Text »    PDF »
Membrane Recognition and Targeting by Lipid-Binding Domains.
J. P. DiNitto, T. C. Cronin, and D. G. Lambright (2003)
Sci. STKE 2003, re16
   Abstract »    Full Text »    PDF »
Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module.
P. Berger, C. Schaffitzel, I. Berger, N. Ban, and U. Suter (2003)
PNAS 100, 12177-12182
   Abstract »    Full Text »    PDF »
Unique targeting of cytosolic phospholipase A2 to plasma membranes mediated by the NADPH oxidase in phagocytes.
Z. Shmelzer, N. Haddad, E. Admon, I. Pessach, T. L. Leto, Z. Eitan-Hazan, M. Hershfinkel, and R. Levy (2003)
J. Cell Biol. 162, 683-692
   Abstract »    Full Text »    PDF »
Critical Role of the Pleckstrin Homology Domain in Dbs Signaling and Growth Regulation.
E. J. Fuentes, A. E. Karnoub, M. A. Booden, C. J. Der, and S. L. Campbell (2003)
J. Biol. Chem. 278, 21188-21196
   Abstract »    Full Text »    PDF »
The Molecular Basis of Differential Subcellular Localization of C2 Domains of Protein Kinase C-{alpha} and Group IVa Cytosolic Phospholipase A2.
R. V. Stahelin, J. D. Rafter, S. Das, and W. Cho (2003)
J. Biol. Chem. 278, 12452-12460
   Abstract »    Full Text »    PDF »
The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels.
D. C. Ko, J. Binkley, A. Sidow, and M. P. Scott (2003)
PNAS 100, 2518-2525
   Abstract »    Full Text »    PDF »
Discovery and Prospect of Protein Kinase C Research: Epilogue.
Y. Nishizuka (2003)
J. Biochem. 133, 155-158
   Full Text »    PDF »
Roles of G{beta}{gamma} in membrane recruitment and activation of p110{gamma}/p101 phosphoinositide 3-kinase {gamma}.
C. Brock, M. Schaefer, H. P. Reusch, C. Czupalla, M. Michalke, K. Spicher, G. Schultz, and B. Nurnberg (2003)
J. Cell Biol. 160, 89-99
   Abstract »    Full Text »    PDF »
Regulation of Inositol Phospholipid Binding and Signaling through Syndecan-4.
J. R. Couchman, S. Vogt, S.-T. Lim, Y. Lim, E.-S. Oh, G. D. Prestwich, A. Theibert, W. Lee, and A. Woods (2002)
J. Biol. Chem. 277, 49296-49303
   Abstract »    Full Text »    PDF »
Two-step Membrane Binding by Equinatoxin II, a Pore-forming Toxin from the Sea Anemone, Involves an Exposed Aromatic Cluster and a Flexible Helix.
Q. Hong, I. Gutierrez-Aguirre, A. Barlic, P. Malovrh, K. Kristan, Z. Podlesek, P. Macek, D. Turk, J. M. Gonzalez-Manas, J. H. Lakey, et al. (2002)
J. Biol. Chem. 277, 41916-41924
   Abstract »    Full Text »    PDF »
Critical Role of the Pleckstrin Homology and Cysteine-rich Domains in Vav Signaling and Transforming Activity.
T. R. Palmby, K. Abe, and C. J. Der (2002)
J. Biol. Chem. 277, 39350-39359
   Abstract »    Full Text »    PDF »
The C2 Domain of Phosphatidylserine Decarboxylase 2 Is Not Required for Catalysis but Is Essential for in Vivo Function.
H. Kitamura, W.-I Wu, and D. R. Voelker (2002)
J. Biol. Chem. 277, 33720-33726
   Abstract »    Full Text »    PDF »
TAPAS-1, a Novel Microdomain within the Unique N-terminal Region of the PDE4A1 cAMP-specific Phosphodiesterase That Allows Rapid, Ca2+-triggered Membrane Association with Selectivity for Interaction with Phosphatidic Acid.
G. S. Baillie, E. Huston, G. Scotland, M. Hodgkin, I. Gall, A. H. Peden, C. MacKenzie, E. S. Houslay, R. Currie, T. R. Pettitt, et al. (2002)
J. Biol. Chem. 277, 28298-28309
   Abstract »    Full Text »    PDF »
The N-terminal Domain of the Reticulocyte-type 15-Lipoxygenase Is Not Essential for Enzymatic Activity but Contains Determinants for Membrane Binding.
M. Walther, M. Anton, M. Wiedmann, R. Fletterick, and H. Kuhn (2002)
J. Biol. Chem. 277, 27360-27366
   Abstract »    Full Text »    PDF »
Associations of B- and C-Raf with Cholesterol, Phosphatidylserine, and Lipid Second Messengers. PREFERENTIAL BINDING OF Raf TO ARTIFICIAL LIPID RAFTS.
M. Hekman, H. Hamm, A. V. Villar, B. Bader, J. Kuhlmann, J. Nickel, and U. R. Rapp (2002)
J. Biol. Chem. 277, 24090-24102
   Abstract »    Full Text »    PDF »
Role of paired basic residues of protein C-termini in phospholipid binding.
D. Scheglmann, K. Werner, G. Eiselt, and R. Klinger (2002)
Protein Eng. Des. Sel. 15, 521-527
   Abstract »    Full Text »    PDF »
Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain.
M. J. Romanowski, R. E. Soccio, J. L. Breslow, and S. K. Burley (2002)
PNAS 99, 6949-6954
   Abstract »    Full Text »    PDF »
Critical but Distinct Roles for the Pleckstrin Homology and Cysteine-Rich Domains as Positive Modulators of Vav2 Signaling and Transformation.
M. A. Booden, S. L. Campbell, and C. J. Der (2002)
Mol. Cell. Biol. 22, 2487-2497
   Abstract »    Full Text »    PDF »
Molecular Basis of the Specific Subcellular Localization of the C2-like Domain of 5-Lipoxygenase.
S. Kulkarni, S. Das, C. D. Funk, D. Murray, and W. Cho (2002)
J. Biol. Chem. 277, 13167-13174
   Abstract »    Full Text »    PDF »
Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins.
J. T. Snyder, K. L. Rossman, M. A. Baumeister, W. M. Pruitt, D. P. Siderovski, C. J. Der, M. A. Lemmon, and J. Sondek (2001)
J. Biol. Chem. 276, 45868-45875
   Abstract »    Full Text »    PDF »
All Phox Homology (PX) Domains from Saccharomyces cerevisiae Specifically Recognize Phosphatidylinositol 3-Phosphate.
J. W. Yu and M. A. Lemmon (2001)
J. Biol. Chem. 276, 44179-44184
   Abstract »    Full Text »    PDF »
Direct targeting of cis-Golgi matrix proteins to the Golgi apparatus.
S.-i. Yoshimura, N. Nakamura, F. A. Barr, Y. Misumi, Y. Ikehara, H. Ohno, M. Sakaguchi, and K. Mihara (2001)
J. Cell Sci. 114, 4105-4115
   Abstract »    Full Text »    PDF »
Membrane Targeting by C1 and C2 Domains.
W. Cho (2001)
J. Biol. Chem. 276, 32407-32410
   Full Text »    PDF »
How Membranes Shape Protein Structure.
S. H. White, A. S. Ladokhin, S. Jayasinghe, and K. Hristova (2001)
J. Biol. Chem. 276, 32395-32398
   Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882