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Genes & Dev. 16 (3): 388-398

Copyright © 2002 by Cold Spring Harbor Laboratory Press.

Vol. 16, No. 3, pp. 388-398, February 1, 2002

mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family

Hua-Wei Chen,1,3 Xiu Chen,1,3 Su-Wan Oh,1 Maria J. Marinissen,2 J. Silvio Gutkind,2 and Steven X. Hou1,4

1 The Laboratory of Immunobiology, National Institutes of Health, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA; 2 Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA

The JAK/STAT signal transduction pathway controls numerous events in Drosophila melanogaster development. Receptors for the pathway have yet to be identified. Here we have identified a Drosophila gene that shows embryonic mutant phenotypes identical to those in the hopscotch (hop)/JAK kinase and marelle (mrl)/Stat92e mutations. We named this gene master of marelle (mom). Genetic analyses place mom's function between upd (the ligand) and hop. We further show that cultured cells transfected with the mom gene bind UPD and activate the HOP/STAT92E signal transduction pathway. mom encodes a protein distantly related to the mammalian cytokine receptor family. These data show that mom functions as a receptor of the Drosophila JAK/STAT signal transduction pathway.

[Key Words: Drosophila; JAK/STAT; signal transduction; cytokine receptor]

3 These authors contributed equally to this work.

4 Corresponding author.

GENES & DEVELOPMENT 16:388-398 © 2002 by Cold Spring Harbor Laboratory Press  ISSN 0890-9369/02 $5.00

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