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Cell surface proteins Nasrat and Polehole stabilize the Torso-like extracellular determinant in Drosophila oogenesis
1 Instituto de Biología Molecular de Barcelona
(CSIC), 08034 Barcelona, Spain; 2 Instituto de
Parasitología y Biomedicina (CSIC), 18001 Granada, Spain
Structural cell-surface and extracellular-matrix proteins modulate
intercellular signaling events during development, buthow this is
achieved remains largely unknown. Here we identifya novel family of
Drosophila proteins, Nasrat and Polehole, thatcoat the
oocyte surface and play two roles: They mediate assemblyof the
eggshell, and act in the Torso RTK signaling pathway thatspecifies the
terminal regions of the embryo. Nasrat and Poleholeare essential for
extracellular accumulation of Torso-like, afactor secreted during
oogenesis that initiates Torso receptoractivation. Stabilization of
secreted factors by specialized pericellularproteins may be a general
mechanism during signaling and developmentalpatterning.