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J. Cell Biol. 149 (1): 223-236

Copyright © 2000 by the Rockefeller University Press.

Original Article

Extracellular-Regulated Kinase Activation and Cas/Crk Coupling Regulate Cell Migration and Suppress Apoptosis during Invasion of the Extracellular Matrix

Samuel Y. Choa, and Richard L. Klemkea

a Department of Immunology, The Scripps Research Institute, La Jolla, California 92037
Department of Immunology, CAL-9, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037.(858) 784-7785(858) 784-7750


Abstract: Regulation of cell migration/invasion is important for embryonic development, immune function, and angiogenesis. However, migratory cells must also coordinately activate survival mechanisms to invade the extracellular matrix and colonize foreign sites in the body. Although invasive cells activate protective programs to survive under diverse and sometimes hostile conditions, the molecular signals that regulate these processes are poorly understood. Evidence is provided that signals that induce cell invasion also promote cell survival by suppressing apoptosis of migratory cells. Extracellular-regulated kinase (ERK) activation and molecular coupling of the adaptor proteins p130 Crk-associated substrate (CAS) and c-CrkII (Crk) represent two distinct pathways that induce cell invasion and protect cells from apoptosis in a three-dimensional collagen matrix. CAS/Crk-mediated cell invasion and survival requires activation of the small GTPase Rac, whereas ERK-induced cell invasion, but not survival requires myosin light chain kinase activation and myosin light chain phosphorylation. Uncoupling CAS from Crk or inhibition of ERK activity prevents migration and induces apoptosis of invasive cells. These findings provide molecular evidence that during invasion of the extracellular matrix, cells coordinately regulate migration and survival mechanisms through ERK activation and CAS/Crk coupling.

Key Words: cell survival • mitogen-activated protein kinases • signal transduction • three-dimensional collagen • integrins

Abbreviations used in this paper: β-gal, β-galactosidase; BrdU, bromodeoxyuridine; CAS, p130 Crk-associated substrate; Crk, c-CrkII; ECM, extracellular matrix; ERK, extracellular-regulated kinase; FAK, focal adhesion kinase; GFP, green fluorescent protein; HA, hemagglutinin; MEK, ERK kinase; MLC, myosin light chain; MLCK, MLC kinase; PI, propidium iodide; PI3K, phosphatidylinositol 3-kinase; SH, Src-homology; 3-D, three-dimensional.

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. Biol. Chem. 278, 13016-13025
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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S. Tanimura, K. Nomura, K.-i. Ozaki, M. Tsujimoto, T. Kondo, and M. Kohno (2002)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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L. A. Cary, R. A. Klinghoffer, C. Sachsenmaier, and J. A. Cooper (2002)
Mol. Cell. Biol. 22, 2427-2440
   Abstract »    Full Text »    PDF »
Apoptotic Regulation by the Crk Adapter Protein Mediated by Interactions with Wee1 and Crm1/Exportin.
J. J. Smith, D. A. Richardson, J. Kopf, M. Yoshida, R. E. Hollingsworth, and S. Kornbluth (2002)
Mol. Cell. Biol. 22, 1412-1423
   Abstract »    Full Text »    PDF »
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S. Y. Cho and R. L. Klemke (2002)
J. Cell Biol. 156, 725-736
   Abstract »    Full Text »    PDF »
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A. B. da Rocha, D.R.A. Mans, A. Regner, and G. Schwartsmann (2002)
Oncologist 7, 17-33
   Abstract »    Full Text »    PDF »
Dissection of HEF1-dependent functions in motility and transcriptional regulation.
S. J. Fashena, M. B. Einarson, G. M. O'Neill, C. Patriotis, and E. A. Golemis (2002)
J. Cell Sci. 115, 99-111
   Abstract »    Full Text »    PDF »
Mechanisms of CAS Substrate Domain Tyrosine Phosphorylation by FAK and Src.
P. J. Ruest, N.-Y. Shin, T. R. Polte, X. Zhang, and S. K. Hanks (2001)
Mol. Cell. Biol. 21, 7641-7652
   Abstract »    Full Text »    PDF »
Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins.
D. G. Stupack, X. S. Puente, S. Boutsaboualoy, C. M. Storgard, and D. A. Cheresh (2001)
J. Cell Biol. 155, 459-470
   Abstract »    Full Text »    PDF »
Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells.
Z. Ma, D. J. Webb, M. Jo, and S. L. Gonias (2001)
J. Cell Sci. 114, 3387-3396
   Abstract »    Full Text »    PDF »
Proteolysis of the Docking Protein HEF1 and Implications for Focal Adhesion Dynamics.
G. M. O'Neill and E. A. Golemis (2001)
Mol. Cell. Biol. 21, 5094-5108
   Abstract »    Full Text »    PDF »
Molecular Mechanisms Mediating Mammalian Mitogen-activated Protein Kinase (MAPK) Kinase (MEK)-MAPK Cell Survival Signals.
B. A. Ballif and J. Blenis (2001)
Cell Growth Differ. 12, 397-408
   Full Text »    PDF »
Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis.
Y. Ohba, K. Ikuta, A. Ogura, J. Matsuda, N. Mochizuki, K. Nagashima, K. Kurokawa, B. J. Mayer, K. Maki, J.-i. Miyazaki, et al. (2001)
EMBO J. 20, 3333-3341
   Abstract »    Full Text »    PDF »
Rac Mediates Cytoskeletal Rearrangements and Increased Cell Motility Induced by Urokinase-Type Plasminogen Activator Receptor Binding to Vitronectin.
L. Kjoller and A. Hall (2001)
J. Cell Biol. 152, 1145-1158
   Abstract »    Full Text »    PDF »
The Mechanism of Heat Shock Activation of ERK Mitogen-activated Protein Kinases in the Interleukin 3-dependent ProB Cell Line BaF3.
D. C. H. Ng and M. A. Bogoyevitch (2000)
J. Biol. Chem. 275, 40856-40866
   Abstract »    Full Text »    PDF »
c-Src Signaling Induced by the Adapters Sin and Cas Is Mediated by Rap1 GTPase.
L. Xing, C. Ge, R. Zeltser, G. Maskevitch, B. J. Mayer, and K. Alexandropoulos (2000)
Mol. Cell. Biol. 20, 7363-7377
   Abstract »    Full Text »    PDF »
Regulation of c-SRC Activity and Function by the Adapter Protein CAS.
M. R. Burnham, P. J. Bruce-Staskal, M. T. Harte, C. L. Weidow, A. Ma, S. A. Weed, and A. H. Bouton (2000)
Mol. Cell. Biol. 20, 5865-5878
   Abstract »    Full Text »    PDF »
The mechanism of heat shock activation of ERK Mitogen-Activated Protein Kinases (ERK MAPKs) in the Interleukin 3-dependent cell line BaF3.
D. C.H. Ng and M. A. Bogoyevitch (2000)
J. Biol. Chem.
   Abstract »
Gi-mediated Cas Tyrosine Phosphorylation in Vascular Endothelial Cells Stimulated with Sphingosine 1-Phosphate. POSSIBLE INVOLVEMENT IN CELL MOTILITY ENHANCEMENT IN COOPERATION WITH Rho-MEDIATED PATHWAYS.
T. Ohmori, Y. Yatomi, H. Okamoto, Y. Miura, G. Rile, K. Satoh, and Y. Ozaki (2001)
J. Biol. Chem. 276, 5274-5280
   Abstract »    Full Text »    PDF »
The v-Crk Oncogene Enhances Cell Survival and Induces Activation of Protein Kinase B/Akt.
J. C. Stam, W. J. C. Geerts, H. H. Versteeg, A. J. Verkleij, and P. M. P. v. B. en Henegouwen (2001)
J. Biol. Chem. 276, 25176-25183
   Abstract »    Full Text »    PDF »
Rac1 Mediates Type I Collagen-dependent MMP-2 Activation. ROLE IN CELL INVASION ACROSS COLLAGEN BARRIER.
Y. Zhuge and J. Xu (2001)
J. Biol. Chem. 276, 16248-16256
   Abstract »    Full Text »    PDF »
Inhibition of Cell Migration by Abl Family Tyrosine Kinases through Uncoupling of Crk-CAS Complexes.
K. H. Kain and R. L. Klemke (2001)
J. Biol. Chem. 276, 16185-16192
   Abstract »    Full Text »    PDF »
Suppression of Chemically Induced Apoptosis but Not Necrosis of Renal Proximal Tubular Epithelial (LLC-PK1) Cells by Focal Adhesion Kinase (FAK). ROLE OF FAK IN MAINTAINING FOCAL ADHESION ORGANIZATION AFTER ACUTE RENAL CELL INJURY.
B. van de Water, F. Houtepen, M. Huigsloot, and I. B. Tijdens (2001)
J. Biol. Chem. 276, 36183-36193
   Abstract »    Full Text »    PDF »
Dedicated Myosin Light Chain Kinases with Diverse Cellular Functions.
K. E. Kamm and J. T. Stull (2001)
J. Biol. Chem. 276, 4527-4530
   Full Text »    PDF »
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S. Y. Cho and R. L. Klemke (2002)
J. Cell Biol. 156, 725-736
   Abstract »    Full Text »    PDF »
Vasopressin-mediated mitogenic signaling in intestinal epithelial cells.
T. Chiu, S. S. Wu, C. Santiskulvong, P. Tangkijvanich, H. F. Yee Jr., and E. Rozengurt (2002)
Am J Physiol Cell Physiol 282, C434-C450
   Abstract »    Full Text »    PDF »

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