Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

J. Cell Biol. 155 (4): 661-674

Copyright © 2001 by the Rockefeller University Press.


Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins

Sabine Mechtersheimer1, Paul Gutwein1, Nancy Agmon-Levin1, Alexander Stoeck1, Matthias Oleszewski1, Svenja Riedle1, Rolf Postina4, Falk Fahrenholz4, Mina Fogel2, Vance Lemmon3, and Peter Altevogt1

1 Tumor Immunology Program, G0100, German Cancer Research Center, D-69120 Heidelberg, Germany
2 Department of Pathology, Kaplan Hospital, Rehovot 76100, Israel
3 Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106
4 Institute of Biochemistry, University of Mainz, D-55128 Mainz, Germany

Address correspondence to Peter Altevogt, Tumor Immunology Program, G0100, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. Tel.: 49-6221-423-714. Fax: 49-6221-423-702. E-mail: p.altevogt{at}

Abstract: The L1 adhesion molecule plays an important role in axon guidance and cell migration in the nervous system. L1 is also expressed by many human carcinomas. In addition to cell surface expression, the L1 ectodomain can be released by a metalloproteinase, but the biological function of this process is unknown. Here we demonstrate that membrane-proximal cleavage of L1 can be detected in tumors and in the developing mouse brain. The shedding of L1 involved a disintegrin and metalloproteinase (ADAM)10, as transfection with dominant-negative ADAM10 completely abolishes L1 release. L1-transfected CHO cells (L1-CHO) showed enhanced haptotactic migration on fibronectin and laminin, which was blocked by antibodies to {alpha}vß5 and L1. Migration of L1-CHO cells, but not the basal migration of CHO cells, was blocked by a metalloproteinase inhibitor, indicating a role for L1 shedding in the migration process. CHO and metalloproteinase-inhibited L1-CHO cells were stimulated to migrate by soluble L1-Fc protein. The induction of migration was blocked by {alpha}vß5-specific antibodies and required Arg-Gly-Asp sites in L1. A 150-kD L1 fragment released by plasmin could also stimulate CHO cell migration. We propose that ectodomain-released L1 promotes migration by autocrine/paracrine stimulation via {alpha}vß5. This regulatory loop could be relevant for migratory processes under physiological and pathophysiological conditions.

Key Words: L1; shedding; ADAM10; cell migration; integrins

EMT-associated up-regulation of L1CAM provides insights into L1CAM-mediated integrin signalling and NF-{kappa}B activation.
H. Kiefel, S. Bondong, M. Pfeifer, U. Schirmer, N. Erbe-Hoffmann, H. Schafer, S. Sebens, and P. Altevogt (2012)
Carcinogenesis 33, 1919-1929
   Abstract »    Full Text »    PDF »
TAG1 Regulates the Endocytic Trafficking and Signaling of the Semaphorin3A Receptor Complex.
P. Dang, E. Smythe, and A. J. W. Furley (2012)
J. Neurosci. 32, 10370-10382
   Abstract »    Full Text »    PDF »
Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-{kappa}B activation.
S. Bondong, H. Kiefel, T. Hielscher, A. G. Zeimet, R. Zeillinger, D. Pils, E. Schuster, D. C. Castillo-Tong, I. Cadron, I. Vergote, et al. (2012)
Ann. Onc. 23, 1795-1802
   Abstract »    Full Text »    PDF »
ADAM10 promotes pituitary adenoma cell migration by regulating cleavage of CD44 and L1.
Y. Pan, C. Han, C. Wang, G. Hu, C. Luo, X. Gan, F. Zhang, Y. Lu, and X. Ding (2012)
J. Mol. Endocrinol. 49, 21-33
   Abstract »    Full Text »    PDF »
Aberrant L1 Cell Adhesion Molecule Affects Tumor Behavior and Chemosensitivity in Anaplastic Thyroid Carcinoma.
K. S. Kim, J.-K. Min, Z. L. Liang, K. Lee, J. U. Lee, K.-H. Bae, M. H. Lee, S. E. Lee, M. J. Ryu, S. J. Kim, et al. (2012)
Clin. Cancer Res. 18, 3071-3078
   Abstract »    Full Text »    PDF »
Alterations in Protein Regulators of Neurodevelopment in the Cerebrospinal Fluid of Infants with Posthemorrhagic Hydrocephalus of Prematurity.
D. M. Morales, R. R. Townsend, J. P. Malone, C. A. Ewersmann, E. M. Macy, T. E. Inder, and D. D. Limbrick Jr. (2012)
Mol. Cell. Proteomics 11, M111.011973
   Abstract »    Full Text »    PDF »
L1 Cell Adhesion Molecule Promotes Tumorigenicity and Metastatic Potential in Non-Small Cell Lung Cancer.
J. Hai, C.-Q. Zhu, B. Bandarchi, Y.-H. Wang, R. Navab, F. A. Shepherd, I. Jurisica, and M.-S. Tsao (2012)
Clin. Cancer Res. 18, 1914-1924
   Abstract »    Full Text »    PDF »
Myofibroblast-induced tumorigenicity of pancreatic ductal epithelial cells is L1CAM dependent.
H. Schafer, C. Geismann, C. Heneweer, J.-H. Egberts, O. Korniienko, H. Kiefel, G. Moldenhauer, M. G. Bachem, H. Kalthoff, P. Altevogt, et al. (2012)
Carcinogenesis 33, 84-93
   Abstract »    Full Text »    PDF »
The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.
K. Doberstein, J. Pfeilschifter, and P. Gutwein (2011)
Carcinogenesis 32, 1713-1723
   Abstract »    Full Text »    PDF »
Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis.
K. Zen, Y.-L. Guo, L.-M. Li, Z. Bian, C.-Y. Zhang, and Y. Liu (2011)
Blood 117, 4885-4894
   Abstract »    Full Text »    PDF »
L1-CAM expression in ccRCC correlates with shorter patients survival times and confers chemoresistance in renal cell carcinoma cells.
K. Doberstein, A. Wieland, S. B. B. Lee, R. A. A. Blaheta, S. Wedel, H. Moch, P. Schraml, J. Pfeilschifter, G. Kristiansen, and P. Gutwein (2011)
Carcinogenesis 32, 262-270
   Abstract »    Full Text »    PDF »
Low Cholesterol Triggers Membrane Microdomain-dependent CD44 Shedding and Suppresses Tumor Cell Migration.
T. Murai, Y. Maruyama, K. Mio, H. Nishiyama, M. Suga, and C. Sato (2011)
J. Biol. Chem. 286, 1999-2007
   Abstract »    Full Text »    PDF »
Cancer Cells Cut Homophilic Cell Adhesion Molecules and Run.
S. E. L. Craig and S. M. Brady-Kalnay (2011)
Cancer Res. 71, 303-309
   Abstract »    Full Text »    PDF »
Imatinib Upregulates Compensatory Integrin Signaling in a Mouse Model of Gastrointestinal Stromal Tumor and Is More Effective When Combined with Dasatinib.
F. Rossi, Y. Yozgat, E. de Stanchina, D. Veach, B. Clarkson, K. Manova, F. G. Giancotti, C. R. Antonescu, and P. Besmer (2010)
Mol. Cancer Res. 8, 1271-1283
   Abstract »    Full Text »    PDF »
CRASH Syndrome: Does It Teach Us about Neurotrophic Functions of Cell Adhesion Molecules?.
L. Zhang (2010)
Neuroscientist 16, 470-474
   Abstract »    PDF »
L1 Cell Adhesion Molecule Is a Novel Therapeutic Target in Intrahepatic Cholangiocarcinoma.
J.-K. Min, J.-M. Kim, S. Li, J. W. Lee, H. Yoon, C. J. Ryu, S. H. Jeon, J.-H. Lee, J. Y. Kim, H. K. Yoon, et al. (2010)
Clin. Cancer Res. 16, 3571-3580
   Abstract »    Full Text »    PDF »
Inside-Out Regulation of L1 Conformation, Integrin Binding, Proteolysis, and Concomitant Cell Migration.
M. M. Chen, C. Y. Lee, H. A. Leland, G. Y. Lin, A. M. Montgomery, and S. Silletti (2010)
Mol. Biol. Cell 21, 1671-1685
   Abstract »    Full Text »    PDF »
Therapeutic Antibodies to Human L1CAM: Functional Characterization and Application in a Mouse Model for Ovarian Carcinoma.
S. Wolterink, G. Moldenhauer, M. Fogel, H. Kiefel, M. Pfeifer, S. Luttgau, R. Gouveia, J. Costa, J. Endell, U. Moebius, et al. (2010)
Cancer Res. 70, 2504-2515
   Abstract »    Full Text »    PDF »
L1-CAM as a Target for Treatment of Cancer with Monoclonal Antibodies.
Anticancer Res 29, 4919-4931
   Abstract »    Full Text »    PDF »
L1 Cell Adhesion Molecule Is a Novel Independent Poor Prognostic Factor of Extrahepatic Cholangiocarcinoma.
S. Li, Y. S. Jo, J.-H. Lee, J.-K. Min, E. S. Lee, T. Park, J.-M. Kim, and H. J. Hong (2009)
Clin. Cancer Res. 15, 7345-7351
   Abstract »    Full Text »    PDF »
An Integrin-Contactin Complex Regulates CNS Myelination by Differential Fyn Phosphorylation.
L. S. Laursen, C. W. Chan, and C. ffrench-Constant (2009)
J. Neurosci. 29, 9174-9185
   Abstract »    Full Text »    PDF »
ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the {gamma}-Secretase.
T. Tousseyn, A. Thathiah, E. Jorissen, T. Raemaekers, U. Konietzko, K. Reiss, E. Maes, A. Snellinx, L. Serneels, O. Nyabi, et al. (2009)
J. Biol. Chem. 284, 11738-11747
   Abstract »    Full Text »    PDF »
The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells.
L. Maddaluno, S. E. Verbrugge, C. Martinoli, G. Matteoli, A. Chiavelli, Y. Zeng, E. D. Williams, M. Rescigno, and U. Cavallaro (2009)
J. Exp. Med. 206, 623-635
   Abstract »    Full Text »    PDF »
Extracellular Cleavage of Cadherin-11 by ADAM Metalloproteases Is Essential for Xenopus Cranial Neural Crest Cell Migration.
C. McCusker, H. Cousin, R. Neuner, and D. Alfandari (2009)
Mol. Biol. Cell 20, 78-89
   Abstract »    Full Text »    PDF »
R. M. Gouveia, C. M. Gomes, M. Sousa, P. M. Alves, and J. Costa (2008)
J. Biol. Chem. 283, 28038-28047
   Abstract »    Full Text »    PDF »
Role of ADAMs in Endothelial Cell Permeability: Cadherin Shedding and Leukocyte Rolling.
B. Ponnuchamy and R. A. Khalil (2008)
Circ. Res. 102, 1139-1142
   Full Text »    PDF »
L1 cell adhesion molecule (L1CAM) as a pathogenetic factor in endometriosis.
D. Finas, M. Huszar, A. Agic, S. Dogan, H. Kiefel, S. Riedle, D. Gast, R. Marcovich, F. Noack, P. Altevogt, et al. (2008)
Hum. Reprod. 23, 1053-1062
   Abstract »    Full Text »    PDF »
The Differential Role of L1 in Ovarian Carcinoma and Normal Ovarian Surface Epithelium.
S. Zecchini, M. Bianchi, N. Colombo, R. Fasani, G. Goisis, C. Casadio, G. Viale, J. Liu, M. Herlyn, A. K. Godwin, et al. (2008)
Cancer Res. 68, 1110-1118
   Abstract »    Full Text »    PDF »
L1 Interaction with Ankyrin Regulates Mediolateral Topography in the Retinocollicular Projection.
M. Buhusi, M. C. Schlatter, G. P. Demyanenko, R. Thresher, and P. F. Maness (2008)
J. Neurosci. 28, 177-188
   Abstract »    Full Text »    PDF »
Semaphorin3D Regulates Axon Axon Interactions by Modulating Levels of L1 Cell Adhesion Molecule.
M. A. Wolman, A. M. Regnery, T. Becker, C. G. Becker, and M. C. Halloran (2007)
J. Neurosci. 27, 9653-9663
   Abstract »    Full Text »    PDF »
Expression of L1-CAM and ADAM10 in Human Colon Cancer Cells Induces Metastasis.
N. Gavert, M. Sheffer, S. Raveh, S. Spaderna, M. Shtutman, T. Brabletz, F. Barany, P. Paty, D. Notterman, E. Domany, et al. (2007)
Cancer Res. 67, 7703-7712
   Abstract »    Full Text »    PDF »
CNS Progenitor Cells Promote a Permissive Environment for Neurite Outgrowth via a Matrix Metalloproteinase-2-Dependent Mechanism.
Y. Zhang, H. J. Klassen, B. A. Tucker, M.-T. R. Perez, and M. J. Young (2007)
J. Neurosci. 27, 4499-4506
   Abstract »    Full Text »    PDF »
Copper-67 Radioimmunotherapy and Growth Inhibition by Anti-L1-Cell Adhesion Molecule Monoclonal Antibodies in a Therapy Model of Ovarian Cancer Metastasis.
K. Knogler, J. Grunberg, K. Zimmermann, S. Cohrs, M. Honer, S. Ametamey, P. Altevogt, M. Fogel, P. A. Schubiger, and I. Novak-Hofer (2007)
Clin. Cancer Res. 13, 603-611
   Abstract »    Full Text »    PDF »
Cell Adhesion Molecule L1 Disrupts E-Cadherin-Containing Adherens Junctions and Increases Scattering and Motility of MCF7 Breast Carcinoma Cells.
M. Shtutman, E. Levina, P. Ohouo, M. Baig, and I. B. Roninson (2006)
Cancer Res. 66, 11370-11380
   Abstract »    Full Text »    PDF »
Efficient Inhibition of Intra-Peritoneal Tumor Growth and Dissemination of Human Ovarian Carcinoma Cells in Nude Mice by Anti-L1-Cell Adhesion Molecule Monoclonal Antibody Treatment.
M. J.E. Arlt, I. Novak-Hofer, D. Gast, V. Gschwend, G. Moldenhauer, J. Grunberg, M. Honer, P. A. Schubiger, P. Altevogt, and A. Kruger (2006)
Cancer Res. 66, 936-943
   Abstract »    Full Text »    PDF »
The Shed Ectodomain of Nr-CAM Stimulates Cell Proliferation and Motility, and Confers Cell Transformation.
M. Conacci-Sorrell, A. Kaplan, S. Raveh, N. Gavert, T. Sakurai, and A. Ben-Ze'ev (2005)
Cancer Res. 65, 11605-11612
   Abstract »    Full Text »    PDF »
L1 Is Sequentially Processed by Two Differently Activated Metalloproteases and Presenilin/{gamma}-Secretase and Regulates Neural Cell Adhesion, Cell Migration, and Neurite Outgrowth.
T. Maretzky, M. Schulte, A. Ludwig, S. Rose-John, C. Blobel, D. Hartmann, P. Altevogt, P. Saftig, and K. Reiss (2005)
Mol. Cell. Biol. 25, 9040-9053
   Abstract »    Full Text »    PDF »
Selective Modulation of Integrin-mediated Cell Migration by Distinct ADAM Family Members.
J. Huang, L. C. Bridges, and J. M. White (2005)
Mol. Biol. Cell 16, 4982-4991
   Abstract »    Full Text »    PDF »
Matrix metalloproteinases are required for retinal ganglion cell axon guidance at select decision points.
C. L. Hehr, J. C. Hocking, and S. McFarlane (2005)
Development 132, 3371-3379
   Abstract »    Full Text »    PDF »
Cleavage of L1 in Exosomes and Apoptotic Membrane Vesicles Released from Ovarian Carcinoma Cells.
P. Gutwein, A. Stoeck, S. Riedle, D. Gast, S. Runz, T. P. Condon, A. Marme, M.-C. Phong, O. Linderkamp, A. Skorokhod, et al. (2005)
Clin. Cancer Res. 11, 2492-2501
   Abstract »    Full Text »    PDF »
L1, a novel target of {beta}-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers.
N. Gavert, M. Conacci-Sorrell, D. Gast, A. Schneider, P. Altevogt, T. Brabletz, and A. Ben-Ze'ev (2005)
J. Cell Biol. 168, 633-642
   Abstract »    Full Text »    PDF »
Clinicopathological study of cellular proliferation and invasion in gliomatosis cerebri: important role of neural cell adhesion molecule L1 in tumour invasion.
T Suzuki, S Izumoto, Y Fujimoto, M Maruno, Y Ito, and T Yoshimine (2005)
J. Clin. Pathol. 58, 166-171
   Abstract »    Full Text »    PDF »
The L1 Cell Adhesion Molecule Is Induced in Renal Cancer Cells and Correlates with Metastasis in Clear Cell Carcinomas.
Y. Allory, Y. Matsuoka, C. Bazille, E. I. Christensen, P. Ronco, and H. Debiec (2005)
Clin. Cancer Res. 11, 1190-1197
   Abstract »    Full Text »    PDF »
Zinc metalloproteinase-mediated cleavage of the human Nogo-66 receptor.
A. R. Walmsley, G. McCombie, U. Neumann, D. Marcellin, R. Hillenbrand, A. K. Mir, and S. Frentzel (2004)
J. Cell Sci. 117, 4591-4602
   Abstract »    Full Text »    PDF »
Hepatocyte Growth Factor-induced Ectodomain Shedding of Cell Adhesion Molecule L1: ROLE OF THE L1 CYTOPLASMIC DOMAIN.
M. Heiz, J. Grunberg, P. A. Schubiger, and I. Novak-Hofer (2004)
J. Biol. Chem. 279, 31149-31156
   Abstract »    Full Text »    PDF »
Extracellular Signal-regulated Kinase (ERK)-dependent Gene Expression Contributes to L1 Cell Adhesion Molecule-dependent Motility and Invasion.
S. Silletti, M. Yebra, B. Perez, V. Cirulli, M. McMahon, and A. M. P. Montgomery (2004)
J. Biol. Chem. 279, 28880-28888
   Abstract »    Full Text »    PDF »
Ectodomain Shedding of SHPS-1 and Its Role in Regulation of Cell Migration.
H. Ohnishi, H. Kobayashi, H. Okazawa, Y. Ohe, K. Tomizawa, R. Sato, and T. Matozaki (2004)
J. Biol. Chem. 279, 27878-27887
   Abstract »    Full Text »    PDF »
The Transmembrane CXC-Chemokine Ligand 16 Is Induced by IFN-{gamma} and TNF-{alpha} and Shed by the Activity of the Disintegrin-Like Metalloproteinase ADAM10.
S. Abel, C. Hundhausen, R. Mentlein, A. Schulte, T. A. Berkhout, N. Broadway, D. Hartmann, R. Sedlacek, S. Dietrich, B. Muetze, et al. (2004)
J. Immunol. 172, 6362-6372
   Abstract »    Full Text »    PDF »
Ectodomain Shedding of the Neural Recognition Molecule CHL1 by the Metalloprotease-disintegrin ADAM8 Promotes Neurite Outgrowth and Suppresses Neuronal Cell Death.
S. Naus, M. Richter, D. Wildeboer, M. Moss, M. Schachner, and J. W. Bartsch (2004)
J. Biol. Chem. 279, 16083-16090
   Abstract »    Full Text »    PDF »
Brain development in mice lacking L1-L1 homophilic adhesion.
K. Itoh, L. Cheng, Y. Kamei, S. Fushiki, H. Kamiguchi, P. Gutwein, A. Stoeck, B. Arnold, P. Altevogt, and V. Lemmon (2004)
J. Cell Biol. 165, 145-154
   Abstract »    Full Text »    PDF »
Engagement of CD44 Promotes Rac Activation and CD44 Cleavage during Tumor Cell Migration.
T. Murai, Y. Miyazaki, H. Nishinakamura, K. N. Sugahara, T. Miyauchi, Y. Sako, T. Yanagida, and M. Miyasaka (2004)
J. Biol. Chem. 279, 4541-4550
   Abstract »    Full Text »    PDF »
Expression of the Disintegrin Metalloprotease, ADAM-10, in Prostate Cancer and Its Regulation by Dihydrotestosterone, Insulin-Like Growth Factor I, and Epidermal Growth Factor in the Prostate Cancer Cell Model LNCaP.
D. R. McCulloch, P. Akl, H. Samaratunga, A. C. Herington, and D. M. Odorico (2004)
Clin. Cancer Res. 10, 314-323
   Abstract »    Full Text »    PDF »
Cross Talk between Tetanus Neurotoxin-insensitive Vesicle-associated Membrane Protein-mediated Transport and L1-mediated Adhesion.
P. Alberts, R. Rudge, I. Hinners, A. Muzerelle, S. Martinez-Arca, T. Irinopoulou, V. Marthiens, S. Tooze, F. Rathjen, P. Gaspar, et al. (2003)
Mol. Biol. Cell 14, 4207-4220
   Abstract »    Full Text »    PDF »
Stimulated Shedding of Vascular Cell Adhesion Molecule 1 (VCAM-1) Is Mediated by Tumor Necrosis Factor-{alpha}-converting Enzyme (ADAM 17).
K. J. Garton, P. J. Gough, J. Philalay, P. T. Wille, C. P. Blobel, R. H. Whitehead, P. J. Dempsey, and E. W. Raines (2003)
J. Biol. Chem. 278, 37459-37464
   Abstract »    Full Text »    PDF »
ADAM-17-independent shedding of L-selectin.
B. Walcheck, S. R. Alexander, C. A. St. Hill, and E. Matala (2003)
J. Leukoc. Biol. 74, 389-394
   Abstract »    Full Text »    PDF »
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
C. Hundhausen, D. Misztela, T. A. Berkhout, N. Broadway, P. Saftig, K. Reiss, D. Hartmann, F. Fahrenholz, R. Postina, V. Matthews, et al. (2003)
Blood 102, 1186-1195
   Abstract »    Full Text »    PDF »
Close Homolog of L1 Is an Enhancer of Integrin-mediated Cell Migration.
M. Buhusi, B. R. Midkiff, A. M. Gates, M. Richter, M. Schachner, and P. F. Maness (2003)
J. Biol. Chem. 278, 25024-25031
   Abstract »    Full Text »    PDF »
A Synthetic Peptide Ligand of Neural Cell Adhesion Molecule (NCAM), C3d, Promotes Neuritogenesis and Synaptogenesis and Modulates Presynaptic Function in Primary Cultures of Rat Hippocampal Neurons.
D. Kiryushko, T. Kofoed, G. Skladchikova, A. Holm, V. Berezin, and E. Bock (2003)
J. Biol. Chem. 278, 12325-12334
   Abstract »    Full Text »    PDF »
The Proprotein Convertase PC5A and a Metalloprotease Are Involved in the Proteolytic Processing of the Neural Adhesion Molecule L1.
I. Kalus, B. Schnegelsberg, N. G. Seidah, R. Kleene, and M. Schachner (2003)
J. Biol. Chem. 278, 10381-10388
   Abstract »    Full Text »    PDF »
Extracellular Cleavage of Bullous Pemphigoid Antigen 180/Type XVII Collagen and Its Involvement in Hemidesmosomal Disassembly.
Y. Hirako, K. Yoshino, D. Zillikens, and K. Owaribe (2003)
J. Biochem. 133, 197-206
   Abstract »    Full Text »    PDF »
Proteolytic Cleavage of the Ectodomain of the L1 CAM Family Member Tractin.
Y.-Z. Xu, Y. Ji, B. Zipser, J. Jellies, K. M. Johansen, and J. Johansen (2003)
J. Biol. Chem. 278, 4322-4330
   Abstract »    Full Text »    PDF »
The L1 Cell Adhesion Molecule Is Essential for Topographic Mapping of Retinal Axons.
G. P. Demyanenko and P. F. Maness (2003)
J. Neurosci. 23, 530-538
   Abstract »    Full Text »    PDF »
The ADAMs family of metalloproteases: multidomain proteins with multiple functions.
D. F. Seals and S. A. Courtneidge (2003)
Genes & Dev. 17, 7-30
   Full Text »    PDF »
Autolytic Processing at Glu586-Ser587within the Cysteine-rich Domain of Human Adamalysin 19/Disintegrin-Metalloproteinase 19 Is Necessary for Its Proteolytic Activity.
T. Kang, H. I. Park, Y. Suh, Y.-G. Zhao, H. Tschesche, and Q.-X. A. Sang (2002)
J. Biol. Chem. 277, 48514-48522
   Abstract »    Full Text »    PDF »
Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A.
V. Castellani, E. De Angelis, S. Kenwrick, and G. Rougon (2002)
EMBO J. 21, 6348-6357
   Abstract »    Full Text »    PDF »
The Extracellular N Terminus of the Endothelin B (ETB) Receptor Is Cleaved by a Metalloprotease in an Agonist-dependent Process.
E. Grantcharova, J. Furkert, H. P. Reusch, H.-W. Krell, G. Papsdorf, M. Beyermann, R. Schulein, W. Rosenthal, and A. Oksche (2002)
J. Biol. Chem. 277, 43933-43941
   Abstract »    Full Text »    PDF »
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for {alpha}-secretase activity in fibroblasts.
D. Hartmann, B. de Strooper, L. Serneels, K. Craessaerts, A. Herreman, W. Annaert, L. Umans, T. Lubke, A. Lena Illert, K. von Figura, et al. (2002)
Hum. Mol. Genet. 11, 2615-2624
   Abstract »    Full Text »    PDF »
Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163.
K. A. Hintz, A. J. Rassias, K. Wardwell, M. L. Moss, P. M. Morganelli, P. A. Pioli, A. L. Givan, P. K. Wallace, M. P. Yeager, and P. M. Guyre (2002)
J. Leukoc. Biol. 72, 711-717
   Abstract »    Full Text »    PDF »
Nr-CAM is a target gene of the beta -catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis.
M. E. Conacci-Sorrell, T. Ben-Yedidia, M. Shtutman, E. Feinstein, P. Einat, and A. Ben-Ze'ev (2002)
Genes & Dev. 16, 2058-2072
   Abstract »    Full Text »    PDF »
ADAM13 Disintegrin and Cysteine-rich Domains Bind to the Second Heparin-binding Domain of Fibronectin.
A. Gaultier, H. Cousin, T. Darribere, and D. Alfandari (2002)
J. Biol. Chem. 277, 23336-23344
   Abstract »    Full Text »    PDF »
The Neural Cell Adhesion Molecule L1 Potentiates Integrin-Dependent Cell Migration to Extracellular Matrix Proteins.
K. Thelen, V. Kedar, A. K. Panicker, R.-S. Schmid, B. R. Midkiff, and P. F. Maness (2002)
J. Neurosci. 22, 4918-4931
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882