Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Logo for

PNAS 96 (26): 14955-14960

Copyright © 1999 by the National Academy of Sciences.

BIOLOGICAL SCIENCES / CELL BIOLOGY

Modulation of Ca2+ entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): Evidence for roles of TRP and IP3R in store depletion-activated Ca2+ entry

Guylain Boulay*,{dagger}, Darren M. Brown*,{dagger}, Ning Qin*,{dagger}, Meisheng Jiang*, Alexander Dietrich*, Michael Xi Zhu{ddagger}, Zhangguo Chen{ddagger}, Mariel Birnbaumer*,§,¶, Katsuhiko Mikoshiba||, and Lutz Birnbaumer*,¶,**,{ddagger}{ddagger}

Departments of *Anesthesiology, §Physiology, and **Biological Chemistry, and Molecular, Cell, and Developmental Biology, and Molecular Biology and Brain Research Institutes, University of California, Los Angeles, CA 90095; {ddagger}Department of Pharmacology and Neurobiotechnology Center, Ohio State University, Columbus, OH 43210; and ||Department of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane dai, Minato-ku, Tokyo 108-8639, Japan

Contributed by Lutz Birnbaumer

Accepted for publication October 20, 1999.

Abstract: Homologues of Drosophilia transient receptor potential (TRP) have been proposed to be unitary subunits of plasma membrane ion channels that are activated as a consequence of active or passive depletion of Ca2+ stores. In agreement with this hypothesis, cells expressing TRPs display novel Ca2+-permeable cation channels that can be activated by the inositol 1,4,5-trisphosphate receptor (IP3R) protein. Expression of TRPs alters cells in many ways, including up-regulation of IP3Rs not coded for by TRP genes, and proof that TRP forms channels of these and other cells is still missing. Here, we document physical interaction of TRP and IP3R by coimmunoprecipitation and glutathione S-transferase-pulldown experiments and identify two regions of IP3R, F2q and F2g, that interact with one region of TRP, C7. These interacting regions were expressed in cells with an unmodified complement of TRPs and IP3Rs to study their effect on agonist- as well as store depletion-induced Ca2+ entry and to test for a role of their respective binding partners in Ca2+ entry. C7 and an F2q-containing fragment of IP3R decreased both forms of Ca2+ entry. In contrast, F2g enhanced the two forms of Ca2+ entry. We conclude that store depletion-activated Ca2+ entry occurs through channels that have TRPs as one of their normal structural components, and that these channels are directly activated by IP3Rs. IP3Rs, therefore, have the dual role of releasing Ca2+ from stores and activating Ca2+ influx in response to either increasing IP3 or decreasing luminal Ca2+.

{dagger} G.B., D.M.B., and N.Q. contributed equally to this work.

{ddagger}{ddagger} To whom reprint requests should be sent at the * address. E-mail: lutzb{at}ucla.edu.

See commentary on page 14669.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transient receptor potential canonical type 3 channels facilitate endothelium-derived hyperpolarization-mediated resistance artery vasodilator activity.
S. Senadheera, Y. Kim, T. H. Grayson, S. Toemoe, M. Y. Kochukov, J. Abramowitz, G. D. Housley, R. L. Bertrand, P. S. Chadha, P. P. Bertrand, et al. (2012)
Cardiovasc Res 95, 439-447
   Abstract »    Full Text »    PDF »
Heterologous expression of pneumococcal virulence factor PspC on the surface of Lactococcus lactis confers adhesive properties.
T. M. Asmat, K. Klingbeil, I. Jensch, G. Burchhardt, and S. Hammerschmidt (2012)
Microbiology 158, 771-780
   Abstract »    Full Text »    PDF »
Streptococcus pneumoniae Infection of Host Epithelial Cells via Polymeric Immunoglobulin Receptor Transiently Induces Calcium Release from Intracellular Stores.
T. M. Asmat, V. Agarwal, S. Rath, J.-P. Hildebrandt, and S. Hammerschmidt (2011)
J. Biol. Chem. 286, 17861-17869
   Abstract »    Full Text »    PDF »
Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord.
Y. H. Belgacem and L. N. Borodinsky (2011)
PNAS 108, 4482-4487
   Abstract »    Full Text »    PDF »
Isoform-Selective Physical Coupling of TRPC3 Channels to IP3 Receptors in Smooth Muscle Cells Regulates Arterial Contractility.
A. Adebiyi, G. Zhao, D. Narayanan, C. M. Thomas-Gatewood, J. P. Bannister, and J. H. Jaggar (2010)
Circ. Res. 106, 1603-1612
   Abstract »    Full Text »    PDF »
TRPC3 Regulates Agonist-stimulated Ca2+ Mobilization by Mediating the Interaction between Type I Inositol 1,4,5-Trisphosphate Receptor, RACK1, and Orai1.
G. E. Woodard, J. J. Lopez, I. Jardin, G. M. Salido, and J. A. Rosado (2010)
J. Biol. Chem. 285, 8045-8053
   Abstract »    Full Text »    PDF »
Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.
S. Kiyonaka, K. Kato, M. Nishida, K. Mio, T. Numaga, Y. Sawaguchi, T. Yoshida, M. Wakamori, E. Mori, T. Numata, et al. (2009)
PNAS 106, 5400-5405
   Abstract »    Full Text »    PDF »
A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry.
Y. Liao, N. W. Plummer, M. D. George, J. Abramowitz, M. X. Zhu, and L. Birnbaumer (2009)
PNAS 106, 3202-3206
   Abstract »    Full Text »    PDF »
Physiology and pathophysiology of canonical transient receptor potential channels.
J. Abramowitz and L. Birnbaumer (2009)
FASEB J 23, 297-328
   Abstract »    Full Text »    PDF »
TRPC3 Controls Agonist-stimulated Intracellular Ca2+ Release by Mediating the Interaction between Inositol 1,4,5-Trisphosphate Receptor and RACK1.
B. C. Bandyopadhyay, H. L. Ong, T. P. Lockwich, X. Liu, B. C. Paria, B. B. Singh, and I. S. Ambudkar (2008)
J. Biol. Chem. 283, 32821-32830
   Abstract »    Full Text »    PDF »
Stim1 and Orai1 Mediate CRAC Currents and Store-Operated Calcium Entry Important for Endothelial Cell Proliferation.
I. F. Abdullaev, J. M. Bisaillon, M. Potier, J. C. Gonzalez, R. K. Motiani, and M. Trebak (2008)
Circ. Res. 103, 1289-1299
   Abstract »    Full Text »    PDF »
Orai1 Mediates the Interaction between STIM1 and hTRPC1 and Regulates the Mode of Activation of hTRPC1-forming Ca2+ Channels.
I. Jardin, J. J. Lopez, G. M. Salido, and J. A. Rosado (2008)
J. Biol. Chem. 283, 25296-25304
   Abstract »    Full Text »    PDF »
Orai, STIM1 and iPLA2{beta}: a view from a different perspective.
V. M. Bolotina (2008)
J. Physiol. 586, 3035-3042
   Abstract »    Full Text »    PDF »
Differential effects of intravenous anesthetics on capacitative calcium entry in human pulmonary artery smooth muscle cells.
M. Yang, X. Ding, and P. A. Murray (2008)
Am J Physiol Lung Cell Mol Physiol 294, L1007-L1012
   Abstract »    Full Text »    PDF »
TRPC3 Is the Erythropoietin-regulated Calcium Channel in Human Erythroid Cells.
Q. Tong, I. Hirschler-Laszkiewicz, W. Zhang, K. Conrad, D. W. Neagley, D. L. Barber, J. Y. Cheung, and B. A. Miller (2008)
J. Biol. Chem. 283, 10385-10395
   Abstract »    Full Text »    PDF »
IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid.
J. Fernandes, I. M. Lorenzo, Y. N. Andrade, A. Garcia-Elias, S. A. Serra, J. M. Fernandez-Fernandez, and M. A. Valverde (2008)
J. Cell Biol. 181, 143-155
   Abstract »    Full Text »    PDF »
Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells.
V. Hinkovska-Galcheva, A. Clark, S. VanWay, J.-B. Huang, M. Hiraoka, A. Abe, M. Borofsky, R. G. Kunkel, T. Shanley, J. A. Shayman, et al. (2008)
J. Lipid Res. 49, 531-542
   Abstract »    Full Text »    PDF »
Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels.
Y. Liao, C. Erxleben, J. Abramowitz, V. Flockerzi, M. X. Zhu, D. L. Armstrong, and L. Birnbaumer (2008)
PNAS 105, 2895-2900
   Abstract »    Full Text »    PDF »
Calcium Release from Presynaptic Internal Stores Is Required for Ethanol to Increase Spontaneous {gamma}-Aminobutyric Acid Release onto Cerebellum Purkinje Neurons.
M. K. Kelm, H. E. Criswell, and G. R. Breese (2007)
J. Pharmacol. Exp. Ther. 323, 356-364
   Abstract »    Full Text »    PDF »
Suppression of TRPC3 Leads to Disappearance of Store-operated Channels and Formation of a New Type of Store-independent Channels in A431 Cells.
E. Kaznacheyeva, L. Glushankova, V. Bugaj, O. Zimina, A. Skopin, V. Alexeenko, L. Tsiokas, I. Bezprozvanny, and G. N. Mozhayeva (2007)
J. Biol. Chem. 282, 23655-23662
   Abstract »    Full Text »    PDF »
Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2.
G. I. Anyatonwu, M. Estrada, X. Tian, S. Somlo, and B. E. Ehrlich (2007)
PNAS 104, 6454-6459
   Abstract »    Full Text »    PDF »
Inositol Trisphosphate Receptor Ca2+ Release Channels.
J. K. Foskett, C. White, K.-H. Cheung, and D.-O. D. Mak (2007)
Physiol Rev 87, 593-658
   Abstract »    Full Text »    PDF »
Orai proteins interact with TRPC channels and confer responsiveness to store depletion.
Y. Liao, C. Erxleben, E. Yildirim, J. Abramowitz, D. L. Armstrong, and L. Birnbaumer (2007)
PNAS 104, 4682-4687
   Abstract »    Full Text »    PDF »
Thiol oxidation causes pulmonary vasodilation by activating K+ channels and inhibiting store-operated Ca2+ channels.
C. Schach, M. Xu, O. Platoshyn, S. H. Keller, and J. X.-J. Yuan (2007)
Am J Physiol Lung Cell Mol Physiol 292, L685-L698
   Abstract »    Full Text »    PDF »
The Inositol 1,4,5-Trisphosphate Receptor (IP3R) and Its Regulators: Sometimes Good and Sometimes Bad Teamwork.
C.-u. Choe and B. E. Ehrlich (2006)
Sci. STKE 2006, re15
   Abstract »    Full Text »    PDF »
Homer 1 Mediates Store- and Inositol 1,4,5-Trisphosphate Receptor-dependent Translocation and Retrieval of TRPC3 to the Plasma Membrane.
J. Y. Kim, W. Zeng, K. Kiselyov, J. P. Yuan, M. H. Dehoff, K. Mikoshiba, P. F. Worley, and S. Muallem (2006)
J. Biol. Chem. 281, 32540-32549
   Abstract »    Full Text »    PDF »
Caveolin-1 Regulates Store-Operated Ca2+ Influx by Binding of Its Scaffolding Domain to Transient Receptor Potential Channel-1 in Endothelial Cells.
A. M. Kwiatek, R. D. Minshall, D. R. Cool, R. A. Skidgel, A. B. Malik, and C. Tiruppathi (2006)
Mol. Pharmacol. 70, 1174-1183
   Abstract »    Full Text »    PDF »
Interaction of STIM1 with Endogenously Expressed Human Canonical TRP1 upon Depletion of Intracellular Ca2+ Stores.
JoseJ. Lopez, G. M. Salido, J. A. Pariente, and J. A. Rosado (2006)
J. Biol. Chem. 281, 28254-28264
   Abstract »    Full Text »    PDF »
Native TRPC7 Channel Activation by an Inositol Trisphosphate Receptor-dependent Mechanism.
G. Vazquez, G. St. J. Bird, Y. Mori, and J. W. Putney Jr. (2006)
J. Biol. Chem. 281, 25250-25258
   Abstract »    Full Text »    PDF »
Pregnancy-enhanced store-operated Ca2+ channel function in uterine artery endothelial cells is associated with enhanced agonist-specific transient receptor potential channel 3-inositol 1,4,5-trisphosphate receptor 2 interaction.
S. M Gifford, F.-X. Yi, and I. M Bird (2006)
J. Endocrinol. 190, 385-395
   Abstract »    Full Text »    PDF »
TRPC3 and TRPC4 Associate to Form a Redox-sensitive Cation Channel: EVIDENCE FOR EXPRESSION OF NATIVE TRPC3-TRPC4 HETEROMERIC CHANNELS IN ENDOTHELIAL CELLS.
M. Poteser, A. Graziani, C. Rosker, P. Eder, I. Derler, H. Kahr, M. X. Zhu, C. Romanin, and K. Groschner (2006)
J. Biol. Chem. 281, 13588-13595
   Abstract »    Full Text »    PDF »
Unexpected Role of TRPC6 Channel in Familial Nephrotic Syndrome: Does It Have Clinical Implications?.
M. P. Winn, N. Daskalakis, R. F. Spurney, and J. P. Middleton (2006)
J. Am. Soc. Nephrol. 17, 378-387
   Full Text »    PDF »
Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels.
B. T. Kawasaki, Y. Liao, and L. Birnbaumer (2006)
PNAS 103, 335-340
   Abstract »    Full Text »    PDF »
ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice.
G. Huang, J. Yao, W. Zeng, Y. Mizuno, K. E. Kamm, J. T. Stull, H. P. Harding, D. Ron, and S. Muallem (2006)
J. Cell Sci. 119, 153-161
   Abstract »    Full Text »    PDF »
Novel Compartment Implicated in Calcium Signaling--Is It an "Induced Coupling Domain"?.
C. Hisatsune and K. Mikoshiba (2005)
Sci. STKE 2005, pe53
   Abstract »    Full Text »    PDF »
Endogenous TRPC1, TRPC3, and TRPC7 Proteins Combine to Form Native Store-operated Channels in HEK-293 Cells.
T. K. Zagranichnaya, X. Wu, and M. L. Villereal (2005)
J. Biol. Chem. 280, 29559-29569
   Abstract »    Full Text »    PDF »
Increased Vascular Smooth Muscle Contractility in TRPC6-/- Mice.
A. Dietrich, M. Mederos y Schnitzler, M. Gollasch, V. Gross, U. Storch, G. Dubrovska, M. Obst, E. Yildirim, B. Salanova, H. Kalwa, et al. (2005)
Mol. Cell. Biol. 25, 6980-6989
   Abstract »    Full Text »    PDF »
The Foot Structure from the Type 1 Ryanodine Receptor Is Required for Functional Coupling to Store-operated Channels.
A. Sampieri, M. Diaz-Munoz, A. Antaramian, and L. Vaca (2005)
J. Biol. Chem. 280, 24804-24815
   Abstract »    Full Text »    PDF »
MxA, a Member of the Dynamin Superfamily, Interacts with the Ankyrin-like Repeat Domain of TRPC.
M. P. Lussier, S. Cayouette, P. K. Lepage, C. L. Bernier, N. Francoeur, M. St-Hilaire, M. Pinard, and G. Boulay (2005)
J. Biol. Chem. 280, 19393-19400
   Abstract »    Full Text »    PDF »
Visualization of localized store-operated calcium entry in mouse astrocytes. Close proximity to the endoplasmic reticulum.
V. A. Golovina (2005)
J. Physiol. 564, 737-749
   Abstract »    Full Text »    PDF »
Store-Operated Calcium Channels.
A. B. Parekh and J. W. Putney Jr. (2005)
Physiol Rev 85, 757-810
   Abstract »    Full Text »    PDF »
Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel.
E. Yildirim, B. T. Kawasaki, and L. Birnbaumer (2005)
PNAS 102, 3307-3311
   Abstract »    Full Text »    PDF »
The TRP Superfamily of Cation Channels.
C. Montell (2005)
Sci. STKE 2005, re3
   Abstract »    Full Text »    PDF »
Role of Na+/Ca2+ exchange in regulating cytosolic Ca2+ in cultured human pulmonary artery smooth muscle cells.
S. Zhang, J. X.-J. Yuan, K. E. Barrett, and H. Dong (2005)
Am J Physiol Cell Physiol 288, C245-C252
   Abstract »    Full Text »    PDF »
Cleavage of SNAP-25 and VAMP-2 impairs store-operated Ca2+ entry in mouse pancreatic acinar cells.
J. A. Rosado, P. C. Redondo, G. M. Salido, S. O. Sage, and J. A. Pariente (2005)
Am J Physiol Cell Physiol 288, C214-C221
   Abstract »    Full Text »    PDF »
Pharmacological Modulation of Sarcoplasmic Reticulum Function in Smooth Muscle.
R. Laporte, A. Hui, and I. Laher (2004)
Pharmacol. Rev. 56, 439-513
   Abstract »    Full Text »    PDF »
Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells.
J. Shi, E. Mori, Y. Mori, M. Mori, J. Li, Y. Ito, and R. Inoue (2004)
J. Physiol. 561, 415-432
   Abstract »    Full Text »    PDF »
Erythropoietin-modulated calcium influx through TRPC2 is mediated by phospholipase C{gamma} and IP3R.
Q. Tong, X. Chu, J. Y. Cheung, K. Conrad, R. Stahl, D. L. Barber, G. Mignery, and B. A. Miller (2004)
Am J Physiol Cell Physiol 287, C1667-C1678
   Abstract »    Full Text »    PDF »
Overexpression of TRPC1 enhances pulmonary vasoconstriction induced by capacitative Ca2+ entry.
N. Kunichika, Y. Yu, C. V. Remillard, O. Platoshyn, S. Zhang, and J. X.-J. Yuan (2004)
Am J Physiol Lung Cell Mol Physiol 287, L962-L969
   Abstract »    Full Text »    PDF »
Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion.
S. Treves, C. Franzini-Armstrong, L. Moccagatta, C. Arnoult, C. Grasso, A. Schrum, S. Ducreux, M. X. Zhu, K. Mikoshiba, T. Girard, et al. (2004)
J. Cell Biol. 166, 537-548
   Abstract »    Full Text »    PDF »
Store-Operated Channels: Diversity and Activation Mechanisms.
V. M. Bolotina (2004)
Sci. STKE 2004, pe34
   Abstract »    Full Text »    PDF »
A role for SNAP-25 but not VAMPs in store-mediated Ca2+ entry in human platelets.
P. C. Redondo, A. G. S. Harper, G. M. Salido, J. A. Pariente, S. O. Sage, and J. A. Rosado (2004)
J. Physiol. 558, 99-109
   Abstract »    Full Text »    PDF »
Regulation of TRPC6 Channel Activity by Tyrosine Phosphorylation.
C. Hisatsune, Y. Kuroda, K. Nakamura, T. Inoue, T. Nakamura, T. Michikawa, A. Mizutani, and K. Mikoshiba (2004)
J. Biol. Chem. 279, 18887-18894
   Abstract »    Full Text »    PDF »
Control of Aldosterone Secretion: A Model for Convergence in Cellular Signaling Pathways.
A. SPAT and L. HUNYADY (2004)
Physiol Rev 84, 489-539
   Abstract »    Full Text »    PDF »
Capacitative calcium entry and TRPC channel proteins are expressed in rat distal pulmonary arterial smooth muscle.
J. Wang, L. A. Shimoda, and J. T. Sylvester (2004)
Am J Physiol Lung Cell Mol Physiol 286, L848-L858
   Abstract »    Full Text »    PDF »
Role of Calcium in Neurotensin-Evoked Enhancement in Firing in Mesencephalic Dopamine Neurons.
F. St-Gelais, M. Legault, M.-J. Bourque, P.-P. Rompre, and L.-E. Trudeau (2004)
J. Neurosci. 24, 2566-2574
   Abstract »    Full Text »    PDF »
Expression and relative abundance of short transient receptor potential channels in the rat renal microcirculation.
C. S. Facemire, P. J. Mohler, and W. J. Arendshorst (2004)
Am J Physiol Renal Physiol 286, F546-F551
   Abstract »    Full Text »
Agonist-induced Ca2+ entry determined by inositol 1,4,5-trisphosphate recognition.
D. B. van Rossum, R. L. Patterson, K. Kiselyov, D. Boehning, R. K. Barrow, D. L. Gill, and S. H. Snyder (2004)
PNAS 101, 2323-2327
   Abstract »    Full Text »    PDF »
Regulation of canonical transient receptor potential isoform 3 (TRPC3) channel by protein kinase G.
H.-Y. Kwan, Y. Huang, and X. Yao (2004)
PNAS 101, 2625-2630
   Abstract »    Full Text »    PDF »
Exocytotic Insertion of TRPC6 Channel into the Plasma Membrane upon Gq Protein-coupled Receptor Activation.
S. Cayouette, M. P. Lussier, E.-L. Mathieu, S. M. Bousquet, and G. Boulay (2004)
J. Biol. Chem. 279, 7241-7246
   Abstract »    Full Text »    PDF »
N-Linked Protein Glycosylation Is a Major Determinant for Basal TRPC3 and TRPC6 Channel Activity.
A. Dietrich, M. Mederos y Schnitzler, J. Emmel, H. Kalwa, T. Hofmann, and T. Gudermann (2003)
J. Biol. Chem. 278, 47842-47852
   Abstract »    Full Text »    PDF »
Analysis of the Polycystins in Aortic Vascular Smooth Muscle Cells.
Q. Qian, M. Li, Y. Cai, C. J. Ward, S. Somlo, P. C. Harris, and V. E. Torres (2003)
J. Am. Soc. Nephrol. 14, 2280-2287
   Abstract »    Full Text »    PDF »
RhoA Interaction with Inositol 1,4,5-Trisphosphate Receptor and Transient Receptor Potential Channel-1 Regulates Ca2+ Entry: ROLE IN SIGNALING INCREASED ENDOTHELIAL PERMEABILITY.
D. Mehta, G. U. Ahmmed, B. C. Paria, M. Holinstat, T. Voyno-Yasenetskaya, C. Tiruppathi, R. D. Minshall, and A. B. Malik (2003)
J. Biol. Chem. 278, 33492-33500
   Abstract »    Full Text »    PDF »
Activation of Store-operated Calcium Channels: ASSESSMENT OF THE ROLE OF SNARE-MEDIATED VESICULAR TRANSPORT.
C. C. Scott, W. Furuya, W. S. Trimble, and S. Grinstein (2003)
J. Biol. Chem. 278, 30534-30539
   Abstract »    Full Text »    PDF »
Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells.
Q. Qian, L. W. Hunter, M. Li, M. Marin-Padilla, Y. S. Prakash, S. Somlo, P. C. Harris, V. E. Torres, and G. C. Sieck (2003)
Hum. Mol. Genet. 12, 1875-1880
   Abstract »    Full Text »    PDF »
Regulation of Canonical Transient Receptor Potential (TRPC) Channel Function by Diacylglycerol and Protein Kinase C.
K. Venkatachalam, F. Zheng, and D. L. Gill (2003)
J. Biol. Chem. 278, 29031-29040
   Abstract »    Full Text »    PDF »
TRPC3 Mediates T-cell Receptor-dependent Calcium Entry in Human T-lymphocytes.
S. Philipp, B. Strauss, D. Hirnet, U. Wissenbach, L. Mery, V. Flockerzi, and M. Hoth (2003)
J. Biol. Chem. 278, 26629-26638
   Abstract »    Full Text »    PDF »
A Calmodulin/Inositol 1,4,5-Trisphosphate (IP3) Receptor-binding Region Targets TRPC3 to the Plasma Membrane in a Calmodulin/IP3 Receptor-independent Process.
B. J. Wedel, G. Vazquez, R. R. McKay, G. St. J. Bird, and J. W. Putney Jr. (2003)
J. Biol. Chem. 278, 25758-25765
   Abstract »    Full Text »    PDF »
The Store-operated Calcium Entry Pathways in Human Carcinoma A431 Cells: Functional Properties and Activation Mechanisms.
K. Gusev, L. Glouchankova, A. Zubov, E. Kaznacheyeva, Z. Wang, I. Bezprozvanny, and G. N. Mozhayeva (2003)
J. Gen. Physiol. 122, 81-94
   Abstract »    Full Text »    PDF »
Signaling Mechanism for Receptor-activated Canonical Transient Receptor Potential 3 (TRPC3) Channels.
M. Trebak, G. St. J. Bird, R. R. McKay, L. Birnbaumer, and J. W. Putney Jr. (2003)
J. Biol. Chem. 278, 16244-16252
   Abstract »    Full Text »    PDF »
Phospholipase C{delta}4 is required for Ca2+ mobilization essential for acrosome reaction in sperm.
K. Fukami, M. Yoshida, T. Inoue, M. Kurokawa, R. A. Fissore, N. Yoshida, K. Mikoshiba, and T. Takenawa (2003)
J. Cell Biol. 161, 79-88
   Abstract »    Full Text »    PDF »
TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomach.
Y. M. Lee, B. J. Kim, H. J. Kim, D. K. Yang, M. H. Zhu, K. P. Lee, I. So, and K. W. Kim (2003)
Am J Physiol Gastrointest Liver Physiol 284, G604-G616
   Abstract »    Full Text »    PDF »
Domain organization of the type 1 inositol 1,4,5-trisphosphate receptor as revealed by single-particle analysis.
P. C. A. da Fonseca, S. A. Morris, E. P. Nerou, C. W. Taylor, and E. P. Morris (2003)
PNAS 100, 3936-3941
   Abstract »    Full Text »    PDF »
IRBIT, a Novel Inositol 1,4,5-Trisphosphate (IP3) Receptor-binding Protein, Is Released from the IP3 Receptor upon IP3 Binding to the Receptor.
H. Ando, A. Mizutani, T. Matsu-ura, and K. Mikoshiba (2003)
J. Biol. Chem. 278, 10602-10612
   Abstract »    Full Text »    PDF »
The mouse C-type transient receptor potential 2 (TRPC2) channel: Alternative splicing and calmodulin binding to its N terminus.
E. Yildirim, A. Dietrich, and L. Birnbaumer (2003)
PNAS 100, 2220-2225
   Abstract »    Full Text »    PDF »
Epidermal Growth Factor-induced Depletion of the Intracellular Ca2+ Store Fails to Activate Capacitative Ca2+ Entry in a Human Salivary Cell Line.
B.-X. Zhang, X. Ma, C.-K. Yeh, M. D. Lifschitz, M. X. Zhu, and M. S. Katz (2002)
J. Biol. Chem. 277, 48165-48171
   Abstract »    Full Text »    PDF »
Endogenously Expressed Trp1 Is Involved in Store-mediated Ca2+ Entry by Conformational Coupling in Human Platelets.
J. A. Rosado, S. L. Brownlow, and S. O. Sage (2002)
J. Biol. Chem. 277, 42157-42163
   Abstract »    Full Text »    PDF »
Involvement of TRPC in the abnormal calcium influx observed in dystrophic (mdx) mouse skeletal muscle fibers.
C. Vandebrouck, D. Martin, M. C.-V. Schoor, H. Debaix, and P. Gailly (2002)
J. Cell Biol. 158, 1089-1096
   Abstract »    Full Text »    PDF »
Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation.
M. Sweeney, Y. Yu, O. Platoshyn, S. Zhang, S. S. McDaniel, and J. X.-J. Yuan (2002)
Am J Physiol Lung Cell Mol Physiol 283, L144-L155
   Abstract »    Full Text »    PDF »
Two-state Conformational Changes in Inositol 1,4,5-Trisphosphate Receptor Regulated by Calcium.
K. Hamada, T. Miyata, K. Mayanagi, J. Hirota, and K. Mikoshiba (2002)
J. Biol. Chem. 277, 21115-21118
   Abstract »    Full Text »    PDF »
Comparison of Human TRPC3 Channels in Receptor-activated and Store-operated Modes. DIFFERENTIAL SENSITIVITY TO CHANNEL BLOCKERS SUGGESTS FUNDAMENTAL DIFFERENCES IN CHANNEL COMPOSITION.
M. Trebak, G. St. J. Bird, R. R. McKay, and J. W. Putney Jr. (2002)
J. Biol. Chem. 277, 21617-21623
   Abstract »    Full Text »    PDF »
Calcium Influx Factor from Cytochrome P-450 Metabolism and Secretion-like Coupling Mechanisms for Capacitative Calcium Entry in Corneal Endothelial Cells.
Q. Xie, Y. Zhang, C. Zhai, and J. A. Bonanno (2002)
J. Biol. Chem. 277, 16559-16566
   Abstract »    Full Text »    PDF »
The Role of Endogenous Human Trp4 in Regulating Carbachol-induced Calcium Oscillations in HEK-293 Cells.
X. Wu, G. Babnigg, T. Zagranichnaya, and M. L. Villereal (2002)
J. Biol. Chem. 277, 13597-13608
   Abstract »    Full Text »    PDF »
TRP Channel Proteins and Signal Transduction.
B. Minke and B. Cook (2002)
Physiol Rev 82, 429-472
   Abstract »    Full Text »    PDF »
Cloning and Functional Expression of Human Short TRP7, a Candidate Protein for Store-operated Ca2+ Influx.
A. Riccio, C. Mattei, R. E. Kelsell, A. D. Medhurst, A. R. Calver, A. D. Randall, J. B. Davis, C. D. Benham, and M. N. Pangalos (2002)
J. Biol. Chem. 277, 12302-12309
   Abstract »    Full Text »    PDF »
Transient Receptor Potential 1 Regulates Capacitative Ca2+ Entry and Ca2+ Release from Endoplasmic Reticulum in B Lymphocytes.
Y. Mori, M. Wakamori, T. Miyakawa, M. Hermosura, Y. Hara, M. Nishida, K. Hirose, A. Mizushima, M. Kurosaki, E. Mori, et al. (2002)
J. Exp. Med. 195, 673-681
   Abstract »    Full Text »    PDF »
Calcium Transients in the Garter Snake Vomeronasal Organ.
A. R. Cinelli, D. Wang, P. Chen, W. Liu, and M. Halpern (2002)
J Neurophysiol 87, 1449-1472
   Abstract »    Full Text »    PDF »
Expression of Trp3 Determines Sensitivity of Capacitative Ca2+ Entry to Nitric Oxide and Mitochondrial Ca2+ Handling. EVIDENCE FOR A ROLE OF Trp3 AS A SUBUNIT OF CAPACITATIVE Ca2+ ENTRY CHANNELS.
B. Thyagarajan, M. Poteser, C. Romanin, H. Kahr, M. X. Zhu, and K. Groschner (2001)
J. Biol. Chem. 276, 48149-48158
   Abstract »    Full Text »    PDF »
Stabilization of Cortical Actin Induces Internalization of Transient Receptor Potential 3 (Trp3)-associated Caveolar Ca2+ Signaling Complex and Loss of Ca2+ Influx without Disruption of Trp3-Inositol Trisphosphate Receptor Association.
T. Lockwich, B. B. Singh, X. Liu, and I. S. Ambudkar (2001)
J. Biol. Chem. 276, 42401-42408
   Abstract »    Full Text »    PDF »
Activation of Inositol 1,4,5-Trisphosphate Receptor Is Essential for the Opening of Mouse TRP5 Channels.
H. Kanki, M. Kinoshita, A. Akaike, M. Satoh, Y. Mori, and S. Kaneko (2001)
Mol. Pharmacol. 60, 989-998
   Abstract »    Full Text »    PDF »
Potentiation and inhibition of Ca2+ release-activated Ca2+ channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP3 receptors.
M. Prakriya and R. S Lewis (2001)
J. Physiol. 536, 3-19
   Abstract »    Full Text »    PDF »
Ion Channels and Their Functional Role in Vascular Endothelium.
B. Nilius and G. Droogmans (2001)
Physiol Rev 81, 1415-1459
   Abstract »    Full Text »    PDF »
Human Trp3 forms both inositol trisphosphate receptor-dependent and receptor-independent store-operated cation channels in DT40 avian B lymphocytes.
G. Vazquez, J.-P. Lievremont, G. St. J. Bird, and J. W. Putney Jr. (2001)
PNAS 98, 11777-11782
   Abstract »    Full Text »    PDF »
Essential control of an endothelial cell ISOC by the spectrin membrane skeleton.
S. Wu, J. Sangerman, M. Li, G. H. Brough, S. R. Goodman, and T. Stevens (2001)
J. Cell Biol. 154, 1225-1234
   Abstract »    Full Text »    PDF »
2-Aminoethoxydiphenyl Borate Directly Inhibits Store-Operated Calcium Entry Channels in Human Platelets.
Y. Dobrydneva and P. Blackmore (2001)
Mol. Pharmacol. 60, 541-552
   Abstract »    Full Text »    PDF »
Physiology, Phylogeny, and Functions of the TRP Superfamily of Cation Channels.
C. Montell (2001)
Sci. STKE 2001, re1
   Abstract »    Full Text »    PDF »
Mechanisms of capacitative calcium entry.
J. W. Putney Jr, L. M. Broad, F.-J. Braun, J.-P. Lievremont, and G. S. J. Bird (2001)
J. Cell Sci. 114, 2223-2229
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882