Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

PNAS 97 (11): 6155-6160

Copyright © 2000 by the National Academy of Sciences.


Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances

Sun Wook Hwang*, Hawon Cho*, Jiyeon Kwak*, Soon-Youl Lee*, Chang-Joong Kang*, Jooyoung Jung*, Soohyun Cho*, Kyung Hoon Min{dagger}, Young-Ger Suh{dagger}, Donghee Kim{ddagger}, and Uhtaek Oh*,§

*Sensory Research Group, National Creative Research Initiatives, {dagger}Division of Medicinal Chemistry, College of Pharmacy, Seoul National University, San 56-1, Shinlim, Kwanak-Gu, Seoul 151-742, Korea; and {ddagger}Department of Physiology and Biophysics, Finch University of Health Sciences/The Chicago Medical School, North Chicago, IL 60064

Received for publication July 16, 1999.

Abstract: Capsaicin, a pungent ingredient of hot peppers, causes excitation of small sensory neurons, and thereby produces severe pain. A nonselective cation channel activated by capsaicin has been identified in sensory neurons and a cDNA encoding the channel has been cloned recently. However, an endogenous activator of the receptor has not yet been found. In this study, we show that several products of lipoxygenases directly activate the capsaicin-activated channel in isolated membrane patches of sensory neurons. Among them, 12- and 15-(S)-hydroperoxyeicosatetraenoic acids, 5- and 15-(S)-hydroxyeicosatetraenoic acids, and leukotriene B4 possessed the highest potency. The eicosanoids also activated the cloned capsaicin receptor (VR1) expressed in HEK cells. Prostaglandins and unsaturated fatty acids failed to activate the channel. These results suggest a novel signaling mechanism underlying the pain sensory transduction.

§ To whom reprint requests should be addressed. E-mail: utoh{at}

Edited by Julius Axelrod, National Institutes of Health, Bethesda, MD, and approved March 17, 2000

This paper was submitted directly (Track II) to the PNAS office.

Ethanol contributes to neurogenic pancreatitis by activation of TRPV1.
S. R. Vigna, R. A. Shahid, and R. A. Liddle (2014)
FASEB J 28, 891-896
   Abstract »    Full Text »    PDF »
Long-term potentiation in hippocampal oriens interneurons: postsynaptic induction, presynaptic expression and evaluation of candidate retrograde factors.
E. Nicholson and D. M. Kullmann (2013)
Phil Trans R Soc B 369, 20130133
   Abstract »    Full Text »    PDF »
Activation of Neuronal Transient Receptor Potential Vanilloid 1 Channel Underlies 20-Hydroxyeicosatetraenoic Acid-Induced Vasoactivity: Role for Protein Kinase A.
K. J. Bubb, H. Wen, C. M. Panayiotou, M. Finsterbusch, F. J. Khan, M. V. Chan, J. V. Priestley, M. D. Baker, and A. Ahluwalia (2013)
Hypertension 62, 426-433
   Abstract »    Full Text »    PDF »
The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1).
S. L. Morales-Lazaro, S. A. Simon, and T. Rosenbaum (2013)
J. Physiol. 591, 3109-3121
   Abstract »    Full Text »    PDF »
Pulmonary chemoreflex responses are potentiated by tumor necrosis factor-alpha in mice.
R.-L. Lin, Y.-J. Lin, M. J. Geer, R. Kryscio, and L.-Y. Lee (2013)
J Appl Physiol 114, 1536-1543
   Abstract »    Full Text »    PDF »
Sensory Nerve Terminal Mitochondrial Dysfunction Activates Airway Sensory Nerves via Transient Receptor Potential (TRP) Channels.
L. Nesuashvili, S. H. Hadley, P. K. Bahia, and T. E. Taylor-Clark (2013)
Mol. Pharmacol. 83, 1007-1019
   Abstract »    Full Text »    PDF »
Protease-activated Receptor 2 (PAR2) Protein and Transient Receptor Potential Vanilloid 4 (TRPV4) Protein Coupling Is Required for Sustained Inflammatory Signaling.
D. P. Poole, S. Amadesi, N. A. Veldhuis, F. C. Abogadie, T. Lieu, W. Darby, W. Liedtke, M. J. Lew, P. McIntyre, and N. W. Bunnett (2013)
J. Biol. Chem. 288, 5790-5802
   Abstract »    Full Text »    PDF »
Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system.
K. Starowicz and B. Przewlocka (2012)
Phil Trans R Soc B 367, 3286-3299
   Abstract »    Full Text »    PDF »
Unravelling the Mystery of Capsaicin: A Tool to Understand and Treat Pain.
J. O'Neill, C. Brock, A. E. Olesen, T. Andresen, M. Nilsson, and A. H. Dickenson (2012)
Pharmacol. Rev. 64, 939-971
   Abstract »    Full Text »    PDF »
Sensory and Signaling Mechanisms of Bradykinin, Eicosanoids, Platelet-Activating Factor, and Nitric Oxide in Peripheral Nociceptors.
G. Petho and P. W. Reeh (2012)
Physiol Rev 92, 1699-1775
   Abstract »    Full Text »    PDF »
Pharmacological Characterization of (3S)-3-(Hydroxymethyl)-4-(5-Methylpyridin-2-yl)-N-[6-(2,2,2-Trifluoroethoxy)pyridin-3-yl]-3,4-Dihydro-2H-Benzo[b][1,4]Oxazine-8-Carboxamide (JTS-653), a Novel Transient Receptor Potential Vanilloid 1 Antagonist.
Y. Kitagawa, A. Miyai, K. Usui, Y. Hamada, K. Deai, M. Wada, Y. Koga, M. Sakata, M. Hayashi, M. Tominaga, et al. (2012)
J. Pharmacol. Exp. Ther. 342, 520-528
   Abstract »    Full Text »    PDF »
7-tert-Butyl-6-(4-Chloro-Phenyl)-2-Thioxo-2,3-Dihydro-1H-Pyrido[2,3-d]Pyrimidin-4-One, a Classic Polymodal Inhibitor of Transient Receptor Potential Vanilloid Type 1 with a Reduced Liability for Hyperthermia, Is Analgesic and Ameliorates Visceral Hypersensitivity.
M. S. Nash, P. McIntyre, A. Groarke, E. Lilley, A. Culshaw, A. Hallett, M. Panesar, A. Fox, and S. Bevan (2012)
J. Pharmacol. Exp. Ther. 342, 389-398
   Abstract »    Full Text »    PDF »
Heat shock factor 1 regulates the expression of the TRPV1 gene in the rat preoptic-anterior hypothalamus area during lipopolysaccharide-induced fever.
M. Fan-xin, S. Li-mei, S. Bei, Q. Xin, Y. Yu, and C. Yu (2012)
Exp Physiol 97, 730-740
   Abstract »    Full Text »    PDF »
Agonist-Dependent Potentiation of Vanilloid Receptor Transient Receptor Potential Vanilloid Type 1 Function by Stilbene Derivatives.
X. Zhang, X.-N. Du, G.-H. Zhang, Z.-F. Jia, X.-J. Chen, D.-Y. Huang, B.-Y. Liu, and H.-L. Zhang (2012)
Mol. Pharmacol. 81, 689-700
   Abstract »    Full Text »    PDF »
Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors.
A. M. Gregus, S. Doolen, D. S. Dumlao, M. W. Buczynski, T. Takasusuki, B. L. Fitzsimmons, X.-Y. Hua, B. K. Taylor, E. A. Dennis, and T. L. Yaksh (2012)
PNAS 109, 6721-6726
   Abstract »    Full Text »    PDF »
20-Hydroxyeicosatetraenoic Acid (20-HETE) Is a Novel Activator of Transient Receptor Potential Vanilloid 1 (TRPV1) Channel.
H. Wen, J. Ostman, K. J. Bubb, C. Panayiotou, J. V. Priestley, M. D. Baker, and A. Ahluwalia (2012)
J. Biol. Chem. 287, 13868-13876
   Abstract »    Full Text »    PDF »
Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury.
K. C. Thomas, J. K. Roberts, C. E. Deering-Rice, E. G. Romero, R. O. Dull, J. Lee, G. S. Yost, and C. A. Reilly (2012)
Am J Physiol Lung Cell Mol Physiol 302, L111-L119
   Abstract »    Full Text »    PDF »
Antagonism of the TRPv1 receptor partially corrects muscle metaboreflex overactivity in spontaneously hypertensive rats.
M. Mizuno, M. N. Murphy, J. H. Mitchell, and S. A. Smith (2011)
J. Physiol. 589, 6191-6204
   Abstract »    Full Text »    PDF »
Resolvin D2 Is a Potent Endogenous Inhibitor for Transient Receptor Potential Subtype V1/A1, Inflammatory Pain, and Spinal Cord Synaptic Plasticity in Mice: Distinct Roles of Resolvin D1, D2, and E1.
C.-K. Park, Z.-Z. Xu, T. Liu, N. Lu, C. N. Serhan, and R.-R. Ji (2011)
J. Neurosci. 31, 18433-18438
   Abstract »    Full Text »    PDF »
Resolving TRPV1- and TNF-{alpha}-Mediated Spinal Cord Synaptic Plasticity and Inflammatory Pain with Neuroprotectin D1.
C.-K. Park, N. Lu, Z.-Z. Xu, T. Liu, C. N. Serhan, and R.-R. Ji (2011)
J. Neurosci. 31, 15072-15085
   Abstract »    Full Text »    PDF »
Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease.
C. A. Hillery, P. C. Kerstein, D. Vilceanu, M. E. Barabas, D. Retherford, A. M. Brandow, N. J. Wandersee, and C. L. Stucky (2011)
Blood 118, 3376-3383
   Abstract »    Full Text »    PDF »
International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions.
M. Back, S.-E. Dahlen, J. M. Drazen, J. F. Evans, C. N. Serhan, T. Shimizu, T. Yokomizo, and G. E. Rovati (2011)
Pharmacol. Rev. 63, 539-584
   Abstract »    Full Text »    PDF »
Supplemental arachidonic acid-enriched oil improves the taste of thigh meat of Hinai-jidori chickens.
R. Kiyohara, S. Yamaguchi, K. Rikimaru, and H. Takahashi (2011)
Poultry Science 90, 1817-1822
   Abstract »    Full Text »    PDF »
Acetylcholine and norepinephrine mediate GABAergic but not glycinergic transmission enhancement by melittin in adult rat substantia gelatinosa neurons.
T. Liu, T. Fujita, and E. Kumamoto (2011)
J Neurophysiol 106, 233-246
   Abstract »    Full Text »    PDF »
Amelioration of Neuropathic Pain by Novel Transient Receptor Potential Vanilloid 1 Antagonist AS1928370 in Rats without Hyperthermic Effect.
T. Watabiki, T. Kiso, T. Kuramochi, K. Yonezawa, N. Tsuji, A. Kohara, S. Kakimoto, T. Aoki, and N. Matsuoka (2011)
J. Pharmacol. Exp. Ther. 336, 743-750
   Abstract »    Full Text »    PDF »
International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family.
L.-J. Wu, T.-B. Sweet, and D. E. Clapham (2010)
Pharmacol. Rev. 62, 381-404
   Abstract »    Full Text »    PDF »
Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice.
E. Ceppa, F. Cattaruzza, V. Lyo, S. Amadesi, J.-C. Pelayo, D. P. Poole, N. Vaksman, W. Liedtke, D. M. Cohen, E. F. Grady, et al. (2010)
Am J Physiol Gastrointest Liver Physiol 299, G556-G571
   Abstract »    Full Text »    PDF »
Distinct Modulations of Human Capsaicin Receptor by Protons and Magnesium through Different Domains.
S. Wang, K. Poon, R. E. Oswald, and H. h. Chuang (2010)
J. Biol. Chem. 285, 11547-11556
   Abstract »    Full Text »    PDF »
17{beta}-Estradiol Mediates the Sex Difference in Capsaicin-Induced Nociception in Rats.
Y.-C. Lu, C.-W. Chen, S.-Y. Wang, and F.-S. Wu (2009)
J. Pharmacol. Exp. Ther. 331, 1104-1110
   Abstract »    Full Text »    PDF »
Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia.
A. M. Patwardhan, P. E. Scotland, A. N. Akopian, and K. M. Hargreaves (2009)
PNAS 106, 18820-18824
   Abstract »    Full Text »    PDF »
Fat location defines sensation.
U. Oh and J. N. Wood (2009)
PNAS 106, 18435-18436
   Full Text »    PDF »
Selective Expression of a Sodium Pump Isozyme by Cough Receptors and Evidence for Its Essential Role in Regulating Cough.
S. B. Mazzone, S. M. Reynolds, N. Mori, M. Kollarik, D. G. Farmer, A. C. Myers, and B. J. Canning (2009)
J. Neurosci. 29, 13662-13671
   Abstract »    Full Text »    PDF »
Membrane-Delimited Coupling of TRPV1 and mGluR5 on Presynaptic Terminals of Nociceptive Neurons.
Y. H. Kim, C.-K. Park, S. K. Back, C. J. Lee, S. J. Hwang, Y. C. Bae, H. S. Na, J. S. Kim, S. J. Jung, and S. B. Oh (2009)
J. Neurosci. 29, 10000-10009
   Abstract »    Full Text »    PDF »
The Role of The TRPV1 Endogenous Agonist N-Oleoyldopamine in Modulation of Nociceptive Signaling at the Spinal Cord Level.
D. Spicarova and J. Palecek (2009)
J Neurophysiol 102, 234-243
   Abstract »    Full Text »    PDF »
Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology.
M. W. Buczynski, D. S. Dumlao, and E. A. Dennis (2009)
J. Lipid Res. 50, 1015-1038
   Abstract »    Full Text »    PDF »
Pharmacology of Vanilloid Transient Receptor Potential Cation Channels.
J. Vriens, G. Appendino, and B. Nilius (2009)
Mol. Pharmacol. 75, 1262-1279
   Abstract »    Full Text »    PDF »
TRPV1 channels control synaptic plasticity in the developing superior colliculus.
S. Maione, L. Cristino, A. L. Migliozzi, A. L. Georgiou, K. Starowicz, T. E. Salt, and V. Di Marzo (2009)
J. Physiol. 587, 2521-2535
   Abstract »    Full Text »    PDF »
Localization of the Endocannabinoid-Degrading Enzyme Fatty Acid Amide Hydrolase in Rat Dorsal Root Ganglion Cells and Its Regulation after Peripheral Nerve Injury.
I. J. Lever, M. Robinson, M. Cibelli, C. Paule, P. Santha, L. Yee, S. P. Hunt, B. F. Cravatt, M. R. Elphick, I. Nagy, et al. (2009)
J. Neurosci. 29, 3766-3780
   Abstract »    Full Text »    PDF »
Physiology of Cell Volume Regulation in Vertebrates.
E. K. Hoffmann, I. H. Lambert, and S. F. Pedersen (2009)
Physiol Rev 89, 193-277
   Abstract »    Full Text »    PDF »
Contributions of Central and Peripheral TRPV1 Receptors to Mechanically Evoked and Spontaneous Firing of Spinal Neurons in Inflamed Rats.
S. McGaraughty, K. L. Chu, B. S. Brown, C. Z. Zhu, C. Zhong, S. K. Joshi, P. Honore, C. R. Faltynek, and M. F. Jarvis (2008)
J Neurophysiol 100, 3158-3166
   Abstract »    Full Text »    PDF »
Constitutive Activity at the Cannabinoid CB1 Receptor Is Required for Behavioral Response to Noxious Chemical Stimulation of TRPV1: Antinociceptive Actions of CB1 Inverse Agonists.
B. Fioravanti, M. De Felice, C. L. Stucky, K. A. Medler, M.-C. Luo, L. R. Gardell, M. Ibrahim, T. P. Malan Jr, H. I. Yamamura, M. H. Ossipov, et al. (2008)
J. Neurosci. 28, 11593-11602
   Abstract »    Full Text »    PDF »
Properties of the Inner Pore Region of TRPV1 Channels Revealed by Block with Quaternary Ammoniums.
A. Jara-Oseguera, I. Llorente, T. Rosenbaum, and L. D. Islas (2008)
J. Gen. Physiol. 132, 547-562
   Abstract »    Full Text »    PDF »
General Anesthetics Sensitize the Capsaicin Receptor Transient Receptor Potential V1.
P. M. Cornett, J. A. Matta, and G. P. Ahern (2008)
Mol. Pharmacol. 74, 1261-1268
   Abstract »    Full Text »    PDF »
Differential effects of airway afferent nerve subtypes on cough and respiration in anesthetized guinea pigs.
Y.-L. Chou, M. D. Scarupa, N. Mori, and B. J. Canning (2008)
Am J Physiol Regulatory Integrative Comp Physiol 295, R1572-R1584
   Abstract »    Full Text »    PDF »
(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo.
C. S. Surowy, T. R. Neelands, B. R. Bianchi, S. McGaraughty, R. El Kouhen, P. Han, K. L. Chu, H. A. McDonald, M. Vos, W. Niforatos, et al. (2008)
J. Pharmacol. Exp. Ther. 326, 879-888
   Abstract »    Full Text »    PDF »
Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1.
S. Materazzi, R. Nassini, E. Andre, B. Campi, S. Amadesi, M. Trevisani, N. W. Bunnett, R. Patacchini, and P. Geppetti (2008)
PNAS 105, 12045-12050
   Abstract »    Full Text »    PDF »
Capsaicin Stimulates Uncoupled ATP Hydrolysis by the Sarcoplasmic Reticulum Calcium Pump.
Y. A. Mahmmoud (2008)
J. Biol. Chem. 283, 21418-21426
   Abstract »    Full Text »    PDF »
N-oleoyldopamine, a novel endogenous capsaicin-like lipid, protects the heart against ischemia-reperfusion injury via activation of TRPV1.
B. Zhong and D. H. Wang (2008)
Am J Physiol Heart Circ Physiol 295, H728-H735
   Abstract »    Full Text »    PDF »
T. Ohta, T. Imagawa, and S. Ito (2008)
J. Biol. Chem. 283, 9377-9387
   Abstract »    Full Text »    PDF »
Arachidonic Acid-Induced Ca2+ Entry Is Involved in Early Steps of Tumor Angiogenesis.
A. F. Pla, C. Grange, S. Antoniotti, C. Tomatis, A. Merlino, B. Bussolati, and L. Munaron (2008)
Mol. Cancer Res. 6, 535-545
   Abstract »    Full Text »    PDF »
Phospholipase A2 Activation Enhances Inhibitory Synaptic Transmission in Rat Substantia Gelatinosa Neurons.
T. Liu, T. Fujita, T. Nakatsuka, and E. Kumamoto (2008)
J Neurophysiol 99, 1274-1284
   Abstract »    Full Text »    PDF »
Ethanol Causes Neurogenic Vasodilation by TRPV1 Activation and CGRP Release in the Trigeminovascular System of The Guinea Pig.
P Nicoletti, M Trevisani, M Manconi, R Gatti, G D. Siena, G Zagli, S Benemei, J. Capone, P Geppetti, and L. Pini (2008)
Cephalalgia 28, 9-17
   Abstract »    Full Text »    PDF »
Tonic Endovanilloid Facilitation of Glutamate Release in Brainstem Descending Antinociceptive Pathways.
K. Starowicz, S. Maione, L. Cristino, E. Palazzo, I. Marabese, F. Rossi, V. de Novellis, and V. Di Marzo (2007)
J. Neurosci. 27, 13739-13749
   Abstract »    Full Text »    PDF »
Voltage is a partial activator of rat thermosensitive TRP channels.
J. A. Matta and G. P. Ahern (2007)
J. Physiol. 585, 469-482
   Abstract »    Full Text »    PDF »
Functional effects of nonsynonymous polymorphisms in the human TRPV1 gene.
H. Xu, W. Tian, Y. Fu, T. T. Oyama, S. Anderson, and D. M. Cohen (2007)
Am J Physiol Renal Physiol 293, F1865-F1876
   Abstract »    Full Text »    PDF »
The transient receptor potential vanilloid 1 (TRPV1) receptor protects against the onset of sepsis after endotoxin.
N. Clark, J. Keeble, E. S. Fernandes, A. Starr, L. Liang, D. Sugden, P. de Winter, and S. D. Brain (2007)
FASEB J 21, 3747-3755
   Abstract »    Full Text »    PDF »
12-Lipoxygenase-derived eicosanoids protect against myocardial ischemia/reperfusion injury via activation of neuronal TRPV1.
A. Sexton, M. McDonald, C. Cayla, C. Thiemermann, and A. Ahluwalia (2007)
FASEB J 21, 2695-2703
   Abstract »    Full Text »    PDF »
TRPV1 gene knockout impairs preconditioning protection against myocardial injury in isolated perfused hearts in mice.
B. Zhong and D. H. Wang (2007)
Am J Physiol Heart Circ Physiol 293, H1791-H1798
   Abstract »    Full Text »    PDF »
Sensitization and Activation of Intracranial Meningeal Nociceptors by Mast Cell Mediators.
X.-C. Zhang, A. M. Strassman, R. Burstein, and D. Levy (2007)
J. Pharmacol. Exp. Ther. 322, 806-812
   Abstract »    Full Text »    PDF »
Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors.
C. E. Riera, H. Vogel, S. A. Simon, and J. l. Coutre (2007)
Am J Physiol Regulatory Integrative Comp Physiol 293, R626-R634
   Abstract »    Full Text »    PDF »
Role of TRPV1 and intracellular Ca2+ in excitation of cardiac sensory neurons by bradykinin.
Z.-Z. Wu and H.-L. Pan (2007)
Am J Physiol Regulatory Integrative Comp Physiol 293, R276-R283
   Abstract »    Full Text »    PDF »
Transient Receptor Potential Vanilloid 1 Agonists Cause Endoplasmic Reticulum Stress and Cell Death in Human Lung Cells.
K. C. Thomas, A. S. Sabnis, M. E. Johansen, D. L. Lanza, P. J. Moos, G. S. Yost, and C. A. Reilly (2007)
J. Pharmacol. Exp. Ther. 321, 830-838
   Abstract »    Full Text »    PDF »
Potentiation of glutamatergic synaptic transmission by protein kinase C-mediated sensitization of TRPV1 at the first sensory synapse.
P. Sikand and L. S. Premkumar (2007)
J. Physiol. 581, 631-647
   Abstract »    Full Text »    PDF »
Role of transient receptor potential vanilloid 1 receptors in endotoxin-induced airway inflammation in the mouse.
Z. Helyes, K. Elekes, J. Nemeth, G. Pozsgai, K. Sandor, L. Kereskai, R. Borzsei, E. Pinter, A. Szabo, and J. Szolcsanyi (2007)
Am J Physiol Lung Cell Mol Physiol 292, L1173-L1181
   Abstract »    Full Text »    PDF »
Heat Sensitization in Skin and Muscle Nociceptors Expressing Distinct Combinations of TRPV1 and TRPV2 Protein.
K. K. Rau, N. Jiang, R. D. Johnson, and B. Y. Cooper (2007)
J Neurophysiol 97, 2651-2662
   Abstract »    Full Text »    PDF »
Epinephrine enhances the sensitivity of rat vagal chemosensitive neurons: role of beta3-adrenoceptor.
Q. Gu, Y.-S. Lin, and L.-Y. Lee (2007)
J Appl Physiol 102, 1545-1555
   Abstract »    Full Text »    PDF »
Modulation of the Cold-Activated Channel TRPM8 by Lysophospholipids and Polyunsaturated Fatty Acids.
D. A. Andersson, M. Nash, and S. Bevan (2007)
J. Neurosci. 27, 3347-3355
   Abstract »    Full Text »    PDF »
TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A2 and 12-Lipoxygenase.
W.-S. Shim, M.-H. Tak, M.-H. Lee, M. Kim, M. Kim, J.-Y. Koo, C.-H. Lee, M. Kim, and U. Oh (2007)
J. Neurosci. 27, 2331-2337
   Abstract »    Full Text »    PDF »
Chemical Determinants Involved in Anandamide-induced Inhibition of T-type Calcium Channels.
J. Chemin, J. Nargeot, and P. Lory (2007)
J. Biol. Chem. 282, 2314-2323
   Abstract »    Full Text »    PDF »
TRPV1 is a novel target for omega-3 polyunsaturated fatty acids.
J. A. Matta, R. L. Miyares, and G. P. Ahern (2007)
J. Physiol. 578, 397-411
   Abstract »    Full Text »    PDF »
Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1.
T. K. Pareek, J. Keller, S. Kesavapany, N. Agarwal, R. Kuner, H. C. Pant, M. J. Iadarola, R. O. Brady, and A. B. Kulkarni (2007)
PNAS 104, 660-665
   Abstract »    Full Text »    PDF »
TRPV1 Receptor Mediates Glutamatergic Synaptic Input to Dorsolateral Periaqueductal Gray (dl-PAG) Neurons.
J. Xing and J. Li (2007)
J Neurophysiol 97, 503-511
   Abstract »    Full Text »    PDF »
Transient receptor potential ion channels as participants in thermosensation and thermoregulation.
M. J. Caterina (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R64-R76
   Abstract »    Full Text »    PDF »
Neuronal control of skin function: the skin as a neuroimmunoendocrine organ..
D. Roosterman, T. Goerge, S. W. Schneider, N. W. Bunnett, and M. Steinhoff (2006)
Physiol Rev 86, 1309-1379
   Abstract »    Full Text »    PDF »
Transient Receptor Potential Vanilloid Subtype 1 Mediates Microglial Cell Death In Vivo and In Vitro via Ca2+-Mediated Mitochondrial Damage and Cytochrome c Release.
S. R. Kim, S. U. Kim, U. Oh, and B. K. Jin (2006)
J. Immunol. 177, 4322-4329
   Abstract »    Full Text »    PDF »
Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus..
A. V. Derbenev, M. J. Monroe, N. R. Glatzer, and B. N. Smith (2006)
J. Neurosci. 26, 9666-9672
   Abstract »    Full Text »    PDF »
Reflex regulation of airway smooth muscle tone.
B. J. Canning (2006)
J Appl Physiol 101, 971-985
   Abstract »    Full Text »    PDF »
Transduction mechanisms in airway sensory nerves.
T. Taylor-Clark and B. J. Undem (2006)
J Appl Physiol 101, 950-959
   Abstract »    Full Text »    PDF »
Mediator mechanisms involved in TRPV1 and P2X receptor-mediated, ROS-evoked bradypneic reflex in anesthetized rats.
T. Ruan, Y. S. Lin, K.-S. Lin, and Y. R. Kou (2006)
J Appl Physiol 101, 644-654
   Abstract »    Full Text »    PDF »
Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs.
R. Gatti, E. Andre, S. Amadesi, T. Q. Dinh, A. Fischer, N. W. Bunnett, S. Harrison, P. Geppetti, and M. Trevisani (2006)
J Appl Physiol 101, 506-511
   Abstract »    Full Text »    PDF »
Mechanistic studies of acid-evoked coughing in anesthetized guinea pigs.
B. J. Canning, D. G. Farmer, and N. Mori (2006)
Am J Physiol Regulatory Integrative Comp Physiol 291, R454-R463
   Abstract »    Full Text »    PDF »
Transient Receptor Potential Channels in Cardiovascular Function and Disease.
R. Inoue, L. J. Jensen, J. Shi, H. Morita, M. Nishida, A. Honda, and Y. Ito (2006)
Circ. Res. 99, 119-131
   Abstract »    Full Text »    PDF »
Tactile Allodynia Initiated by Local Subcutaneous Endothelin-1 Is Prolonged by Activation of TRPV-1 Receptors.
K. Balonov, A. Khodorova, and G. R. Strichartz (2006)
Experimental Biology and Medicine 231, 1165-1170
   Abstract »    Full Text »    PDF »
Prostaglandin involvement in lung C-fiber activation by substance P in guinea pigs.
D. R. Bergren (2006)
J Appl Physiol 100, 1918-1927
   Abstract »    Full Text »    PDF »
Ethanol dilates coronary arteries and increases coronary flow via transient receptor potential vanilloid 1 and calcitonin gene-related peptide.
D. Gazzieri, M. Trevisani, F. Tarantini, P. Bechi, G. Masotti, G. F. Gensini, S. Castellani, N. Marchionni, P. Geppetti, and S. Harrison (2006)
Cardiovasc Res 70, 589-599
   Abstract »    Full Text »    PDF »
Kinetics of Penetration Influence the Apparent Potency of Vanilloids on TRPV1.
J. Lazar, D. C. Braun, A. Toth, Y. Wang, L. V. Pearce, V. A. Pavlyukovets, P. M. Blumberg, S. H. Garfield, S. Wincovitch, H.-K. Choi, et al. (2006)
Mol. Pharmacol. 69, 1166-1173
   Abstract »    Full Text »    PDF »
TRPV1 Recapitulates Native Capsaicin Receptor in Sensory Neurons in Association with Fas-Associated Factor 1.
S. Kim, C. Kang, C. Y. Shin, S. W. Hwang, Y. D. Yang, W. S. Shim, M.-Y. Park, E. Kim, M. Kim, B.-M. Kim, et al. (2006)
J. Neurosci. 26, 2403-2412
   Abstract »    Full Text »    PDF »
Multiple eicosanoid-activated nonselective cation channels regulate B-lymphocyte adhesion to integrin ligands.
X. Liu, P. Zhu, and B. D. Freedman (2006)
Am J Physiol Cell Physiol 290, C873-C882
   Abstract »    Full Text »    PDF »
Phosphorylation-Dependent Desensitization by Anandamide of Vanilloid Receptor-1 (TRPV1) Function in Rat Skeletal Muscle Arterioles and in Chinese Hamster Ovary Cells Expressing TRPV1.
E. Lizanecz, Z. Bagi, E. T. Pasztor, Z. Papp, I. Edes, N. Kedei, P. M. Blumberg, and A. Toth (2006)
Mol. Pharmacol. 69, 1015-1023
   Abstract »    Full Text »    PDF »
Novel Compounds That Interact with Both Leukotriene B4 Receptors and Vanilloid TRPV1 Receptors.
D. McHugh, R. S. McMaster, R. G. Pertwee, S. Roy, A. Mahadevan, R. K. Razdan, and R. A. Ross (2006)
J. Pharmacol. Exp. Ther. 316, 955-965
   Abstract »    Full Text »    PDF »
Systemic and Site-Specific Effects of A-425619, a Selective TRPV1 Receptor Antagonist, on Wide Dynamic Range Neurons in CFA-Treated and Uninjured Rats.
S. McGaraughty, K. L. Chu, C. R. Faltynek, and M. F. Jarvis (2006)
J Neurophysiol 95, 18-25
   Abstract »    Full Text »    PDF »
Attenuation of acid induced oesophagitis in VR-1 deficient mice.
K Fujino, S G de la Fuente, Y Takami, T Takahashi, and C R Mantyh (2006)
Gut 55, 34-40
   Abstract »    Full Text »    PDF »
TRPV1 Antagonists Elevate Cell Surface Populations of Receptor Protein and Exacerbate TRPV1-Mediated Toxicities in Human Lung Epithelial Cells.
M. E. Johansen, C. A. Reilly, and G. S. Yost (2006)
Toxicol. Sci. 89, 278-286
   Abstract »    Full Text »    PDF »
Downregulation of Transient Receptor Potential Melastatin 8 by Protein Kinase C-Mediated Dephosphorylation.
L. S. Premkumar, M. Raisinghani, S. C. Pingle, C. Long, and F. Pimentel (2005)
J. Neurosci. 25, 11322-11329
   Abstract »    Full Text »    PDF »
Leukotriene B4 signaling through NF-{kappa}B-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia.
M. Back, D.-x. Bu, R. Branstrom, Y. Sheikine, Z.-Q. Yan, and G. K. Hansson (2005)
PNAS 102, 17501-17506
   Abstract »    Full Text »    PDF »
Endogenous Unsaturated C18 N-Acylethanolamines Are Vanilloid Receptor (TRPV1) Agonists.
P. Movahed, B. A. G. Jonsson, B. Birnir, J. A. Wingstrand, T. D. Jorgensen, A. Ermund, O. Sterner, P. M. Zygmunt, and E. D. Hogestatt (2005)
J. Biol. Chem. 280, 38496-38504
   Abstract »    Full Text »    PDF »
Camphor Activates and Strongly Desensitizes the Transient Receptor Potential Vanilloid Subtype 1 Channel in a Vanilloid-Independent Mechanism.
H. Xu, N. T. Blair, and D. E. Clapham (2005)
J. Neurosci. 25, 8924-8937
   Abstract »    Full Text »    PDF »
Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin.
M. Raisinghani, R. M Pabbidi, and L. S Premkumar (2005)
J. Physiol. 567, 771-786
   Abstract »    Full Text »    PDF »
Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels.
M. van der Stelt, M. Trevisani, V. Vellani, L. De Petrocellis, A. Schiano Moriello, B. Campi, P. McNaughton, P. Geppetti, and V. Di Marzo (2005)
EMBO J. 24, 3026-3037
   Abstract »    Full Text »    PDF »
Role of Transient Receptor Potential Vanilloid 1 Receptors in Adjuvant-Induced Chronic Arthritis: In Vivo Study Using Gene-Deficient Mice.
A. Szabo, Z. Helyes, K. Sandor, A. Bite, E. Pinter, J. Nemeth, A. Banvolgyi, K. Bolcskei, K. Elekes, and J. Szolcsanyi (2005)
J. Pharmacol. Exp. Ther. 314, 111-119
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882