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PNAS 98 (20): 11032-11038

Copyright © 2001 by the National Academy of Sciences.

Colloquium Paper


COLLOQUIUM PAPER

Sensory experience and sensory activity regulate chemosensory receptor gene expression in Caenorhabditis elegans

Erin L. Peckol*, Emily R. Troemel{dagger}, and Cornelia I. Bargmann{ddagger}

Howard Hughes Medical Institute, Programs in Developmental Biology, Neuroscience, and Genetics, Departments of Anatomy and Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0452

Abstract: Changes in the environment cause both short-term and long-term changes in an animal's behavior. Here we show that specific sensory experiences cause changes in chemosensory receptor gene expression that may alter sensory perception in the nematode Caenorhabditis elegans. Three predicted chemosensory receptor genes expressed in the ASI chemosensory neurons, srd-1, str-2, and str-3, are repressed by exposure to the dauer pheromone, a signal of crowding. Repression occurs at pheromone concentrations below those that induce formation of the alternative dauer larva stage, suggesting that exposure to pheromones can alter the chemosensory behaviors of non-dauer animals. In addition, ASI expression of srd-1, but not str-2 and str-3, is induced by sensory activity of the ASI neurons. Expression of two receptor genes is regulated by developmental entry into the dauer larva stage. srd-1 expression in ASI neurons is repressed in dauer larvae. str-2 expression in dauer animals is induced in the ASI neurons, but repressed in the AWC neurons. The ASI and AWC neurons remodel in the dauer stage, and these results suggest that their sensory specificity changes as well. We suggest that experience-dependent changes in chemosensory receptor gene expression may modify olfactory behaviors.


* Present address: Project Biotech, The University of Arizona, Tucson, AZ 85721.

{dagger} Present address: Renovis Pharmaceuticals, South San Francisco, CA 94080.

{ddagger} To whom reprint requests should be addressed. E-mail: cori{at}itsa.ucsf.edu.

This paper was presented at the Inaugural Arthur M. Sackler Colloquium of the National Academy of Sciences, "Neural Signaling," held February 15–17, 2001, at the National Academy of Sciences in Washington, DC.

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