Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

PNAS 99 (5): 3129-3134

Copyright © 2002 by the National Academy of Sciences.


Quorum-sensing regulators control virulence gene expression in Vibrio cholerae

Jun Zhu*, Melissa B. Miller{dagger}, Russell E. Vance*, Michelle Dziejman*, Bonnie L. Bassler{dagger}, and John J. Mekalanos*,{ddagger}

*Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115; and {dagger}Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014

Contributed by John J. Mekalanos

Accepted for publication December 21, 2001.

Abstract: The production of virulence factors including cholera toxin and the toxin-coregulated pilus in the human pathogen Vibrio cholerae is strongly influenced by environmental conditions. The well-characterized ToxR signal transduction cascade is responsible for sensing and integrating the environmental information and controlling the virulence regulon. We show here that, in addition to the known components of the ToxR signaling circuit, quorum-sensing regulators are involved in regulation of V. cholerae virulence. We focused on the regulators LuxO and HapR because homologues of these two proteins control quorum sensing in the closely related luminous marine bacterium Vibrio harveyi. Using an infant mouse model, we found that a luxO mutant is severely defective in colonization of the small intestine. Gene arrays were used to profile transcription in the V. cholerae wild type and the luxO mutant. These studies revealed that the ToxR regulon is repressed in the luxO mutant, and that this effect is mediated by another negative regulator, HapR. We show that LuxO represses hapR expression early in log-phase growth, and constitutive expression of hapR blocks ToxR-regulon expression. Additionally, LuxO and HapR regulate a variety of other cellular processes including motility, protease production, and biofilm formation. Together these data suggest a role for quorum sensing in modulating expression of blocks of virulence genes in a reciprocal fashion in vivo.

{ddagger} To whom reprint requests should be addressed. E-mail: john_mekalanos{at}

A quantitative comparison of sRNA-based and protein-based gene regulation.
P. Mehta, S. Goyal, and N. S. Wingreen (2014)
Mol Syst Biol 4, 221
   Abstract »    Full Text »    PDF »
A stochastic model of Escherichia coli AI-2 quorum signal circuit reveals alternative synthesis pathways.
J. Li, L. Wang, Y. Hashimoto, C.-Y. Tsao, T. K. Wood, J. J. Valdes, E. Zafiriou, and W. E. Bentley (2014)
Mol Syst Biol 2, 67
   Abstract »    Full Text »    PDF »
Enhanced Interaction of Vibrio cholerae Virulence Regulators TcpP and ToxR under Oxygen-Limiting Conditions.
F. Fan, Z. Liu, N. Jabeen, L. D. Birdwell, J. Zhu, and B. Kan (2014)
Infect. Immun. 82, 1676-1682
   Abstract »    Full Text »    PDF »
RNase E Affects the Expression of the Acyl-Homoserine Lactone Synthase Gene sinI in Sinorhizobium meliloti.
K. Baumgardt, P. Charoenpanich, M. McIntosh, A. Schikora, E. Stein, S. Thalmann, K.-H. Kogel, G. Klug, A. Becker, and E. Evguenieva-Hackenberg (2014)
J. Bacteriol. 196, 1435-1447
   Abstract »    Full Text »    PDF »
Identification of a Membrane-Bound Transcriptional Regulator That Links Chitin and Natural Competence in Vibrio cholerae.
A. B. Dalia, D. W. Lazinski, and A. Camilli (2014)
mBio 5, e01028-13
   Abstract »    Full Text »    PDF »
Indole inhibits bacterial quorum sensing signal transmission by interfering with quorum sensing regulator folding.
J. Kim and W. Park (2013)
Microbiology 159, 2616-2625
   Abstract »    Full Text »    PDF »
Promotion of Colonization and Virulence by Cholera Toxin Is Dependent on Neutrophils.
J. Queen and K. J. F. Satchell (2013)
Infect. Immun. 81, 3338-3345
   Abstract »    Full Text »    PDF »
Exploring Environmental Control of Cyclic di-GMP Signaling in Vibrio cholerae by Using the Ex Vivo Lysate Cyclic di-GMP Assay (TELCA).
B. J. Koestler and C. M. Waters (2013)
Appl. Envir. Microbiol. 79, 5233-5241
   Abstract »    Full Text »    PDF »
Vibrio cholerae ToxR Downregulates Virulence Factor Production in Response to Cyclo(Phe-Pro).
X. R. Bina, D. L. Taylor, A. Vikram, V. M. Ante, and J. E. Bina (2013)
mBio 4, e00366-13
   Abstract »    Full Text »    PDF »
Quorum Sensing Regulatory Cascades Control Vibrio fluvialis Pathogenesis.
Y. Wang, H. Wang, W. Liang, A. J. Hay, Z. Zhong, B. Kan, and J. Zhu (2013)
J. Bacteriol. 195, 3583-3589
   Abstract »    Full Text »    PDF »
Type VI secretion system regulation as a consequence of evolutionary pressure.
S. T. Miyata, V. Bachmann, and S. Pukatzki (2013)
J. Med. Microbiol. 62, 663-676
   Abstract »    Full Text »    PDF »
Antagonistic self-sensing and mate-sensing signaling controls antibiotic-resistance transfer.
A. Chatterjee, L. C. C. Cook, C.-C. Shu, Y. Chen, D. A. Manias, D. Ramkrishna, G. M. Dunny, and W.-S. Hu (2013)
PNAS 110, 7086-7090
   Abstract »    Full Text »    PDF »
A transcriptional regulator linking quorum sensing and chitin induction to render Vibrio cholerae naturally transformable.
M. Lo Scrudato and M. Blokesch (2013)
Nucleic Acids Res. 41, 3644-3658
   Abstract »    Full Text »    PDF »
The Iron-Dependent Regulator Fur Controls Pheromone Signaling Systems and Luminescence in the Squid Symbiont Vibrio fischeri ES114.
A. N. Septer, N. L. Lyell, and E. V. Stabb (2013)
Appl. Envir. Microbiol. 79, 1826-1834
   Abstract »    Full Text »    PDF »
Exploiting Quorum Sensing To Confuse Bacterial Pathogens.
B. LaSarre and M. J. Federle (2013)
Microbiol. Mol. Biol. Rev. 77, 73-111
   Abstract »    Full Text »    PDF »
Bile salt-induced intermolecular disulfide bond formation activates Vibrio cholerae virulence.
M. Yang, Z. Liu, C. Hughes, A. M. Stern, H. Wang, Z. Zhong, B. Kan, W. Fenical, and J. Zhu (2013)
PNAS 110, 2348-2353
   Abstract »    Full Text »    PDF »
Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control.
S. T. Rutherford and B. L. Bassler (2012)
Cold Spring Harb Perspect Med 2, a012427
   Abstract »    Full Text »    PDF »
Functional Characterization of the Stringent Response Regulatory Gene dksA of Vibrio cholerae and Its Role in Modulation of Virulence Phenotypes.
R. R. Pal, S. Bag, S. Dasgupta, B. Das, and R. K. Bhadra (2012)
J. Bacteriol. 194, 5638-5648
   Abstract »    Full Text »    PDF »
The low-resolution solution structure of Vibrio cholerae Hfq in complex with Qrr1 sRNA.
H. A. Vincent, C. A. Henderson, C. M. Stone, P. D. Cary, D. M. Gowers, F. Sobott, J. E. Taylor, and A. J. Callaghan (2012)
Nucleic Acids Res. 40, 8698-8710
   Abstract »    Full Text »    PDF »
Iron and Quorum Sensing Coordinately Regulate the Expression of Vulnibactin Biosynthesis in Vibrio vulnificus.
Y. Wen, I. H. Kim, J.-S. Son, B.-H. Lee, and K.-S. Kim (2012)
J. Biol. Chem. 287, 26727-26739
   Abstract »    Full Text »    PDF »
Evidence that the Vibrio vulnificus flagellar regulator FlhF is regulated by a quorum sensing master regulator SmcR.
S. M. Kim, D. H. Lee, and S. H. Choi (2012)
Microbiology 158, 2017-2025
   Abstract »    Full Text »    PDF »
Stringent Response Regulation of Biofilm Formation in Vibrio cholerae.
H. He, J. N. Cooper, A. Mishra, and D. M. Raskin (2012)
J. Bacteriol. 194, 2962-2972
   Abstract »    Full Text »    PDF »
LitR of Vibrio salmonicida Is a Salinity-Sensitive Quorum-Sensing Regulator of Phenotypes Involved in Host Interactions and Virulence.
A. M. Bjelland, H. Sorum, D. A. Tegegne, H. C. Winther-Larsen, N. P. Willassen, and H. Hansen (2012)
Infect. Immun. 80, 1681-1689
   Abstract »    Full Text »    PDF »
Connecting Environment and Genome Plasticity in the Characterization of Transformation-Induced SOS Regulation and Carbon Catabolite Control of the Vibrio cholerae Integron Integrase.
Z. Baharoglu, E. Krin, and D. Mazel (2012)
J. Bacteriol. 194, 1659-1667
   Abstract »    Full Text »    PDF »
Interaction of the Histone-Like Nucleoid Structuring Protein and the General Stress Response Regulator RpoS at Vibrio cholerae Promoters That Regulate Motility and Hemagglutinin/Protease Expression.
H. Wang, J. C. Ayala, J. A. Benitez, and A. J. Silva (2012)
J. Bacteriol. 194, 1205-1215
   Abstract »    Full Text »    PDF »
Quorum Sensing Contributes to Natural Transformation of Vibrio cholerae in a Species-Specific Manner.
G. Suckow, P. Seitz, and M. Blokesch (2011)
J. Bacteriol. 193, 4914-4924
   Abstract »    Full Text »    PDF »
A High-Throughput Screening Assay for Inhibitors of Bacterial Motility Identifies a Novel Inhibitor of the Na+-Driven Flagellar Motor and Virulence Gene Expression in Vibrio cholerae.
L. Rasmussen, E. L. White, A. Pathak, J. C. Ayala, H. Wang, J.-H. Wu, J. A. Benitez, and A. J. Silva (2011)
Antimicrob. Agents Chemother. 55, 4134-4143
   Abstract »    Full Text »    PDF »
Quorum Sensing and Silencing in Vibrio parahaemolyticus.
C. J. Gode-Potratz and L. L. McCarter (2011)
J. Bacteriol. 193, 4224-4237
   Abstract »    Full Text »    PDF »
The VarS/VarA two-component system modulates the activity of the Vibrio cholerae quorum-sensing transcriptional regulator HapR.
A. M. Tsou, Z. Liu, T. Cai, and J. Zhu (2011)
Microbiology 157, 1620-1628
   Abstract »    Full Text »    PDF »
Regulation of Cytotoxicity by Quorum-Sensing Signaling in Vibrio vulnificus Is Mediated by SmcR, a Repressor of hlyU.
C.-P. Shao, H.-R. Lo, J.-H. Lin, and L.-I. Hor (2011)
J. Bacteriol. 193, 2557-2565
   Abstract »    Full Text »    PDF »
Proteomic Analysis of the Vibrio cholerae Type II Secretome Reveals New Proteins, Including Three Related Serine Proteases.
A. E. Sikora, R. A. Zielke, D. A. Lawrence, P. C. Andrews, and M. Sandkvist (2011)
J. Biol. Chem. 286, 16555-16566
   Abstract »    Full Text »    PDF »
The Vibrio cholerae VarS/VarA two-component system controls the expression of virulence proteins through ToxT regulation.
J. Jang, K.-T. Jung, J. Park, C.-K. Yoo, and G.-E. Rhie (2011)
Microbiology 157, 1466-1473
   Abstract »    Full Text »    PDF »
Evidence on How a Conserved Glycine in the Hinge Region of HapR Regulates Its DNA Binding Ability: LESSONS FROM A NATURAL VARIANT.
M. Dongre, N. S. Singh, C. Dureja, N. Peddada, A. K. Solanki, Ashish, and S. Raychaudhuri (2011)
J. Biol. Chem. 286, 15043-15049
   Abstract »    Full Text »    PDF »
NOD-Like Receptor Activation by Outer Membrane Vesicles from Vibrio cholerae Non-O1 Non-O139 Strains Is Modulated by the Quorum-Sensing Regulator HapR.
H. Bielig, P. K. Rompikuntal, M. Dongre, B. Zurek, B. Lindmark, M. Ramstedt, S. N. Wai, and T. A. Kufer (2011)
Infect. Immun. 79, 1418-1427
   Abstract »    Full Text »    PDF »
Involvement of Quorum Sensing and Heat-Stable Enterotoxin a in Cell Damage Caused by a Porcine Enterotoxigenic Escherichia coli Strain.
J. Zhu, X. Yin, H. Yu, L. Zhao, P. Sabour, and J. Gong (2011)
Infect. Immun. 79, 1688-1695
   Abstract »    Full Text »    PDF »
TagA is a secreted protease of Vibrio cholerae that specifically cleaves mucin glycoproteins.
R. L. Szabady, J. H. Yanta, D. K. Halladin, M. J. Schofield, and R. A. Welch (2011)
Microbiology 157, 516-525
   Abstract »    Full Text »    PDF »
Quorum sensing and a global regulator TsrA control expression of type VI secretion and virulence in Vibrio cholerae.
J. Zheng, O. S. Shin, D. E. Cameron, and J. J. Mekalanos (2010)
PNAS 107, 21128-21133
   Abstract »    Full Text »    PDF »
The LysR-Type Virulence Activator AphB Regulates the Expression of Genes in Vibrio cholerae in Response to Low pH and Anaerobiosis.
G. Kovacikova, W. Lin, and K. Skorupski (2010)
J. Bacteriol. 192, 4181-4191
   Abstract »    Full Text »    PDF »
Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model.
F. Duan and J. C. March (2010)
PNAS 107, 11260-11264
   Abstract »    Full Text »    PDF »
Direct Interaction between Quorum-sensing Regulator SmcR and RNA Polymerase Is Mediated by Integration Host Factor to Activate vvpE Encoding Elastase in Vibrio vulnificus.
H. S. Jeong, S. M. Kim, M. S. Lim, K. S. Kim, and S. H. Choi (2010)
J. Biol. Chem. 285, 9357-9366
   Abstract »    Full Text »    PDF »
Probing bacterial transmembrane histidine kinase receptor-ligand interactions with natural and synthetic molecules.
W.-L. Ng, Y. Wei, L. J. Perez, J. Cong, T. Long, M. Koch, M. F. Semmelhack, N. S. Wingreen, and B. L. Bassler (2010)
PNAS 107, 5575-5580
   Abstract »    Full Text »    PDF »
In vivo actin cross-linking induced by Vibrio cholerae type VI secretion system is associated with intestinal inflammation.
A. T. Ma and J. J. Mekalanos (2010)
PNAS 107, 4365-4370
   Abstract »    Full Text »    PDF »
The Virulence Transcriptional Activator AphA Enhances Biofilm Formation by Vibrio cholerae by Activating Expression of the Biofilm Regulator VpsT.
M. Yang, E. M. Frey, Z. Liu, R. Bishar, and J. Zhu (2010)
Infect. Immun. 78, 697-703
   Abstract »    Full Text »    PDF »
Quorum-regulated biofilms enhance the development of conditionally viable, environmental Vibrio cholerae.
M. Kamruzzaman, S. M. N. Udden, D. E. Cameron, S. B. Calderwood, G. B. Nair, J. J. Mekalanos, and S. M. Faruque (2010)
PNAS 107, 1588-1593
   Abstract »    Full Text »    PDF »
Quorum Sensing Negatively Regulates Hemolysin Transcriptionally and Posttranslationally in Vibrio cholerae.
A. M. Tsou and J. Zhu (2010)
Infect. Immun. 78, 461-467
   Abstract »    Full Text »    PDF »
TetR-Type Transcriptional Regulator VtpR Functions as a Global Regulator in Vibrio tubiashii.
H. Hasegawa and C. C. Hase (2009)
Appl. Envir. Microbiol. 75, 7602-7609
   Abstract »    Full Text »    PDF »
AI-2 quorum-sensing inhibitors affect the starvation response and reduce virulence in several Vibrio species, most likely by interfering with LuxPQ.
G. Brackman, S. Celen, K. Baruah, P. Bossier, S. Van Calenbergh, H. J. Nelis, and T. Coenye (2009)
Microbiology 155, 4114-4122
   Abstract »    Full Text »    PDF »
Levels of the Secreted Vibrio cholerae Attachment Factor GbpA Are Modulated by Quorum-Sensing-Induced Proteolysis.
B. A. Jude, R. M. Martinez, K. Skorupski, and R. K. Taylor (2009)
J. Bacteriol. 191, 6911-6917
   Abstract »    Full Text »    PDF »
Overexpression of VpsS, a Hybrid Sensor Kinase, Enhances Biofilm Formation in Vibrio cholerae.
N. J. Shikuma, J. C. N. Fong, L. S. Odell, B. S. Perchuk, M. T. Laub, and F. H. Yildiz (2009)
J. Bacteriol. 191, 5147-5158
   Abstract »    Full Text »    PDF »
Attenuation of Edwardsiella tarda Virulence by Small Peptides That Interfere with LuxS/Autoinducer Type 2 Quorum Sensing.
M. Zhang, X.-d. Jiao, Y.-h. Hu, and L. Sun (2009)
Appl. Envir. Microbiol. 75, 3882-3890
   Abstract »    Full Text »    PDF »
Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms.
E. Karatan and P. Watnick (2009)
Microbiol. Mol. Biol. Rev. 73, 310-347
   Abstract »    Full Text »    PDF »
Molecular Diversification in the Quorum-Sensing System of Vibrio cholerae: Role of Natural Selection in the Emergence of Pandemic Strains.
N. M. Talyzina, P. K. Ingvarsson, J. Zhu, S. N. Wai, and A. Andersson (2009)
Appl. Envir. Microbiol. 75, 3808-3812
   Abstract »    Full Text »    PDF »
Indole Acts as an Extracellular Cue Regulating Gene Expression in Vibrio cholerae.
R. S. Mueller, S. Beyhan, S. G. Saini, F. H. Yildiz, and D. H. Bartlett (2009)
J. Bacteriol. 191, 3504-3516
   Abstract »    Full Text »    PDF »
Regulatory targets of quorum sensing in Vibrio cholerae: evidence for two distinct HapR-binding motifs.
A. M. Tsou, T. Cai, Z. Liu, J. Zhu, and R. V. Kulkarni (2009)
Nucleic Acids Res. 37, 2747-2756
   Abstract »    Full Text »    PDF »
Moderation of pathogen-induced mortality: the role of density in Bacillus thuringiensis virulence.
B. Raymond, R. J Ellis, and M. B Bonsall (2009)
Biol Lett 5, 218-220
   Abstract »    Full Text »    PDF »
Role of Melanin Pigment in Expression of Vibrio cholerae Virulence Factors.
S. P. Valeru, P. K. Rompikuntal, T. Ishikawa, K. Vaitkevicius, A. Sjoling, N. Dolganov, J. Zhu, G. Schoolnik, and S. N. Wai (2009)
Infect. Immun. 77, 935-942
   Abstract »    Full Text »    PDF »
Gene dosage compensation calibrates four regulatory RNAs to control Vibrio cholerae quorum sensing.
S. L. Svenningsen, K. C. Tu, and B. L. Bassler (2009)
EMBO J. 28, 429-439
   Abstract »    Full Text »    PDF »
Diversity and Seasonality of Bioluminescent Vibrio cholerae Populations in Chesapeake Bay.
Y.-G. Zo, N. Chokesajjawatee, C. Grim, E. Arakawa, H. Watanabe, and R. R. Colwell (2009)
Appl. Envir. Microbiol. 75, 135-146
   Abstract »    Full Text »    PDF »
Distinct Sensory Pathways in Vibrio cholerae El Tor and Classical Biotypes Modulate Cyclic Dimeric GMP Levels To Control Biofilm Formation.
B. K. Hammer and B. L. Bassler (2009)
J. Bacteriol. 191, 169-177
   Abstract »    Full Text »    PDF »
The Extracellular Nuclease Dns and Its Role in Natural Transformation of Vibrio cholerae.
M. Blokesch and G. K. Schoolnik (2008)
J. Bacteriol. 190, 7232-7240
   Abstract »    Full Text »    PDF »
A Consensus Sequence for Binding of SmcR, a Vibrio vulnificus LuxR Homologue, and Genome-wide Identification of the SmcR Regulon.
D. H. Lee, H. S. Jeong, H. G. Jeong, K. M. Kim, H. Kim, and S. H. Choi (2008)
J. Biol. Chem. 283, 23610-23618
   Abstract »    Full Text »    PDF »
Functional independence of a variant LuxOPL91 from a non-O1 non-O139 Vibrio cholerae over the activity of CsrA and Fis.
M. Dongre, R. Tripathi, V. Jain, and S. Raychaudhuri (2008)
J. Med. Microbiol. 57, 1041-1045
   Full Text »    PDF »
Mucosal penetration primes Vibrio cholerae for host colonization by repressing quorum sensing.
Z. Liu, T. Miyashiro, A. Tsou, A. Hsiao, M. Goulian, and J. Zhu (2008)
PNAS 105, 9769-9774
   Abstract »    Full Text »    PDF »
Regulation of autoinducer 2 production and luxS expression in a pathogenic Edwardsiella tarda strain.
M. Zhang, K. Sun, and L. Sun (2008)
Microbiology 154, 2060-2069
   Abstract »    Full Text »    PDF »
Cell-Cell Communication in Bacteria: United We Stand.
S. B. von Bodman, J. M. Willey, and S. P. Diggle (2008)
J. Bacteriol. 190, 4377-4391
   Full Text »    PDF »
A defined transposon mutant library and its use in identifying motility genes in Vibrio cholerae.
D. E. Cameron, J. M. Urbach, and J. J. Mekalanos (2008)
PNAS 105, 8736-8741
   Abstract »    Full Text »    PDF »
Putative Quorum-Sensing Regulator BlxR of Brucella melitensis Regulates Virulence Factors Including the Type IV Secretion System and Flagella.
A. A. Rambow-Larsen, G. Rajashekara, E. Petersen, and G. Splitter (2008)
J. Bacteriol. 190, 3274-3282
   Abstract »    Full Text »    PDF »
Quorum Sensing Controls Biofilm Formation in Vibrio cholerae through Modulation of Cyclic Di-GMP Levels and Repression of vpsT.
C. M. Waters, W. Lu, J. D. Rabinowitz, and B. L. Bassler (2008)
J. Bacteriol. 190, 2527-2536
   Abstract »    Full Text »    PDF »
Red bayberry extract inhibits growth and virulence gene expression of the human pathogen Vibrio cholerae.
Z. Zhong, X. Yu, and J. Zhu (2008)
J. Antimicrob. Chemother. 61, 753-754
   Full Text »    PDF »
Regulation of Motility by the ExpR/Sin Quorum-Sensing System in Sinorhizobium meliloti.
H. H. Hoang, N. Gurich, and J. E. Gonzalez (2008)
J. Bacteriol. 190, 861-871
   Abstract »    Full Text »    PDF »
Implications of Rewiring Bacterial Quorum Sensing.
E. L. Haseltine and F. H. Arnold (2008)
Appl. Envir. Microbiol. 74, 437-445
   Abstract »    Full Text »    PDF »
Regulatory Networks Controlling Vibrio cholerae Virulence Gene Expression.
J. S. Matson, J. H. Withey, and V. J. DiRita (2007)
Infect. Immun. 75, 5542-5549
   Full Text »    PDF »
The cyclic AMP receptor protein modulates quorum sensing, motility and multiple genes that affect intestinal colonization in Vibrio cholerae.
W. Liang, A. Pascual-Montano, A. J. Silva, and J. A. Benitez (2007)
Microbiology 153, 2964-2975
   Abstract »    Full Text »    PDF »
Mutations of the Quorum Sensing-Dependent Regulator VjbR Lead to Drastic Surface Modifications in Brucella melitensis.
S. Uzureau, M. Godefroid, C. Deschamps, J. Lemaire, X. De Bolle, and J.-J. Letesson (2007)
J. Bacteriol. 189, 6035-6047
   Abstract »    Full Text »    PDF »
Crystal Structure of the Vibrio cholerae Quorum-Sensing Regulatory Protein HapR.
R. S. De Silva, G. Kovacikova, W. Lin, R. K. Taylor, K. Skorupski, and F. J. Kull (2007)
J. Bacteriol. 189, 5683-5691
   Abstract »    Full Text »    PDF »
Vibrio cholerae Strains Possess Multiple Strategies for Abiotic and Biotic Surface Colonization.
R. S. Mueller, D. McDougald, D. Cusumano, N. Sodhi, S. Kjelleberg, F. Azam, and D. H. Bartlett (2007)
J. Bacteriol. 189, 5348-5360
   Abstract »    Full Text »    PDF »
Regulatory small RNAs circumvent the conventional quorum sensing pathway in pandemic Vibrio cholerae.
B. K. Hammer and B. L. Bassler (2007)
PNAS 104, 11145-11149
   Abstract »    Full Text »    PDF »
AI-2 quorum sensing affects antibiotic susceptibility in Streptococcus anginosus.
N. A. A. M. Ahmed, F. C. Petersen, and A. A. Scheie (2007)
J. Antimicrob. Chemother. 60, 49-53
   Abstract »    Full Text »    PDF »
Quorum Sensing Enhances the Stress Response in Vibrio cholerae.
A. Joelsson, B. Kan, and J. Zhu (2007)
Appl. Envir. Microbiol. 73, 3742-3746
   Abstract »    Full Text »    PDF »
Regulation of the stringent response is the essential function of the conserved bacterial G protein CgtA in Vibrio cholerae.
D. M. Raskin, N. Judson, and J. J. Mekalanos (2007)
PNAS 104, 4636-4641
   Abstract »    Full Text »    PDF »
Growth Phase Regulation of Vibrio cholerae RTX Toxin Export.
B. K. Boardman, B. M. Meehan, and K. J. Fullner Satchell (2007)
J. Bacteriol. 189, 1827-1835
   Abstract »    Full Text »    PDF »
Regulation of Rugosity and Biofilm Formation in Vibrio cholerae: Comparison of VpsT and VpsR Regulons and Epistasis Analysis of vpsT, vpsR, and hapR.
S. Beyhan, K. Bilecen, S. R. Salama, C. Casper-Lindley, and F. H. Yildiz (2007)
J. Bacteriol. 189, 388-402
   Abstract »    Full Text »    PDF »
Temporal Quorum-Sensing Induction Regulates Vibrio cholerae Biofilm Architecture.
Z. Liu, F. R. Stirling, and J. Zhu (2007)
Infect. Immun. 75, 122-126
   Abstract »    Full Text »    PDF »
Transcriptional Regulatory Cascade for Elastase Production in Vibrio vulnificus: LuxO ACTIVATES luxT EXPRESSION AND LuxT REPRESSES smcR EXPRESSION.
J.-B. Roh, M.-A. Lee, H.-J. Lee, S.-M. Kim, Y. Cho, Y.-J. Kim, Y.-J. Seok, S.-J. Park, and K.-H. Lee (2006)
J. Biol. Chem. 281, 34775-34784
   Abstract »    Full Text »    PDF »
Polyphosphate Stores Enhance the Ability of Vibrio cholerae To Overcome Environmental Stresses in a Low-Phosphate Environment.
I. K. Jahid, A. J. Silva, and J. A. Benitez (2006)
Appl. Envir. Microbiol. 72, 7043-7049
   Abstract »    Full Text »    PDF »
Vibrio cholerae virulence regulator-coordinated evasion of host immunity.
A. Hsiao, Z. Liu, A. Joelsson, and J. Zhu (2006)
PNAS 103, 14542-14547
   Abstract »    Full Text »    PDF »
N-Acyl-L-Homoserine Lactone Quorum Sensing Controls Butanediol Fermentation in Serratia plymuthica RVH1 and Serratia marcescens MG1.
R. Van Houdt, P. Moons, M. Hueso Buj, and C. W. Michiels (2006)
J. Bacteriol. 188, 4570-4572
   Abstract »    Full Text »    PDF »
A Vibrio cholerae protease needed for killing of Caenorhabditis elegans has a role in protection from natural predator grazing.
K. Vaitkevicius, B. Lindmark, G. Ou, T. Song, C. Toma, M. Iwanaga, J. Zhu, A. Andersson, M.-L. Hammarstrom, S. Tuck, et al. (2006)
PNAS 103, 9280-9285
   Abstract »    Full Text »    PDF »
Bundle-Forming Pili and EspA Are Involved in Biofilm Formation by Enteropathogenic Escherichia coli.
C. G. Moreira, K. Palmer, M. Whiteley, M. P. Sircili, L. R. Trabulsi, A. F. P. Castro, and V. Sperandio (2006)
J. Bacteriol. 188, 3952-3961
   Abstract »    Full Text »    PDF »
Contribution of Hemagglutinin/Protease and Motility to the Pathogenesis of El Tor Biotype Cholera.
A. J. Silva, G. J. Leitch, A. Camilli, and J. A. Benitez (2006)
Infect. Immun. 74, 2072-2079
   Abstract »    Full Text »    PDF »
The Transcriptional Regulator VqmA Increases Expression of the Quorum-Sensing Activator HapR in Vibrio cholerae.
Z. Liu, A. Hsiao, A. Joelsson, and J. Zhu (2006)
J. Bacteriol. 188, 2446-2453
   Abstract »    Full Text »    PDF »
Three New Regulators of Swarming in Vibrio parahaemolyticus.
S. Jaques and L. L. McCarter (2006)
J. Bacteriol. 188, 2625-2635
   Abstract »    Full Text »    PDF »
Increased Chatter: Cyclic Dipeptides as Molecules of Chemical Communication in Vibrio spp..
K. E. Klose (2006)
J. Bacteriol. 188, 2025-2026
   Full Text »    PDF »
Cyclo(Phe-Pro) Modulates the Expression of ompU in Vibrio spp..
D.-K. Park, K.-E. Lee, C.-H. Baek, I. H. Kim, J.-H. Kwon, W. K. Lee, K.-H. Lee, B.-S. Kim, S.-H. Choi, and K.-S. Kim (2006)
J. Bacteriol. 188, 2214-2221
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882