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Science 286 (5441): 961-964

Copyright © 1999 by the American Association for the Advancement of Science

Arabidopsis NPH3: A NPH1 Photoreceptor-Interacting Protein Essential for Phototropism

Andrei Motchoulski, Emmanuel Liscum *

Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in three loci [NPH2, root phototropism 2 (RPT2), and NPH3] disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene, now cloned, encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.

Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA.
*   To whom correspondence should be addressed. E-mail: liscumm{at}

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Y. Cheng, G. Qin, X. Dai, and Y. Zhao (2008)
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X. Gao, S. Nagawa, G. Wang, and Z. Yang (2008)
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Mol Plant 1, 15-26
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B. B. Stone, E. L. Stowe-Evans, R. M. Harper, R. B. Celaya, K. Ljung, G. Sandberg, and E. Liscum (2008)
Mol Plant 1, 129-144
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U. V. Pedmale and E. Liscum (2007)
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K. Dreher and J. Callis (2007)
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PNAS 103, 13549-13554
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M. L. Molas, J. Z. Kiss, and M. J. Correll (2006)
J. Exp. Bot. 57, 3217-3229
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PNAS 103, 10134-10139
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PLANT CELL 18, 1110-1119
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Plant Physiology 139, 448-457
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T. Emi, T. Kinoshita, K. Sakamoto, Y. Mineyuki, and K.-i. Shimazaki (2005)
Plant Physiology 138, 1615-1626
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PLANT CELL 17, 103-115
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Plant Physiology 136, 3639-3648
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J. Exp. Bot. 55, 2015-2027
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Blue Light Signaling through the Cryptochromes and Phototropins. So That's What the Blues Is All About.
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Plant Physiology 133, 1429-1436
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Plant Photobiology 2001: A Thousand Points of Enlightenment from Receptor Structures to Ecological Adaptation.
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The Enhancement of Phototropin-Induced Phototropic Curvature in Arabidopsis Occurs via a Photoreversible Phytochrome A-Dependent Modulation of Auxin Responsiveness.
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Plant Physiology 126, 826-834
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Structure of a flavin-binding plant photoreceptor domain: Insights into light-mediated signal transduction.
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Photoreceptors in Plant Photomorphogenesis to Date. Five Phytochromes, Two Cryptochromes, One Phototropin, and One Superchrome.
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Arabidopsis Research 2000.
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RPT2: A Signal Transducer of the Phototropic Response in Arabidopsis.
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PLANT CELL 12, 225-236
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J. Biol. Chem. 276, 11457-11460
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Structure of a flavin-binding plant photoreceptor domain: Insights into light-mediated signal transduction.
S. Crosson and K. Moffat (2001)
PNAS 98, 2995-3000
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