Fumihiko Urano, XiaoZhong Wang, Anne Bertolotti, Yuhong Zhang, Peter Chung, Heather P. Harding, David Ron ^*

Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-Jun amino-terminal kinases (JNKs or SAPKs). Mammalian homologs of yeast IRE1, which activate chaperone genes in response to ER stress, also activated JNK, and IRE1^/ fibroblasts were impaired in JNK activation by ER stress. The cytoplasmic part of IRE1 bound TRAF2, an adaptor protein that couples plasma membrane receptors to JNK activation. Dominant-negative TRAF2 inhibited activation of JNK by IRE1. Activation of JNK by endogenous signals initiated in the ER proceeds by a pathway similar to that initiated by cell surface receptors in response to extracellular signals.

Skirball Institute of Biomolecular Medicine, Departments of Medicine, Cell Biology and the Kaplan Cancer Center, New York University Medical School, New York, NY 10016, USA.
^*   To whom correspondence should be addressed: E-mail: ron{at}saturn.med.nyu.edu

Gender differences control the susceptibility to ER stress-induced acute kidney injury.

R. Hodeify, J. Megyesi, A. Tarcsafalvi, H. I. Mustafa, N. S. Hti Lar Seng, and P. M. Price (2013)
Am J Physiol Renal Physiol 304, F875-F882
 |  Abstract »  |  Full Text »  |  PDF »

RNF13, a RING Finger Protein, Mediates Endoplasmic Reticulum Stress-induced Apoptosis through the Inositol-requiring Enzyme (IRE1{alpha})/c-Jun NH2-terminal Kinase Pathway.

M. Arshad, Z. Ye, X. Gu, C. K. Wong, Y. Liu, D. Li, L. Zhou, Y. Zhang, W. P. Bay, V. C. Yu, et al. (2013)
J. Biol. Chem. 288, 8726-8736
 |  Abstract »  |  Full Text »  |  PDF »

Differential responses of pancreatic {beta}-cells to ROS and RNS.

G. P. Meares, D. Fontanilla, K. A. Broniowska, T. Andreone, J. R. Lancaster Jr., and J. A. Corbett (2013)
Am J Physiol Endocrinol Metab 304, E614-E622
 |  Abstract »  |  Full Text »  |  PDF »

Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver.

T. Otoda, T. Takamura, H. Misu, T. Ota, S. Murata, H. Hayashi, H. Takayama, A. Kikuchi, T. Kanamori, K. R. Shima, et al. (2013)
Diabetes 62, 811-824
 |  Abstract »  |  Full Text »  |  PDF »

Rab1b overexpression modifies Golgi size and gene expression in HeLa cells and modulates the thyrotrophin response in thyroid cells in culture.

N. Romero, C. I. Dumur, H. Martinez, I. A. Garcia, P. Monetta, I. Slavin, L. Sampieri, N. Koritschoner, A. A. Mironov, M. A. De Matteis, et al. (2013)
Mol. Biol. Cell 24, 617-632
 |  Abstract »  |  Full Text »  |  PDF »

Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response.

B. M. Gardner, D. Pincus, K. Gotthardt, C. M. Gallagher, and P. Walter (2013)
Cold Spring Harb Perspect Biol 5, a013169
 |  Abstract »  |  Full Text »  |  PDF »

Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies.

Z. Song, D. Zhao, and L. Yang (2013)
Acta Biochim Biophys Sin
 |  Abstract »  |  Full Text »  |  PDF »

hCG-induced endoplasmic reticulum stress triggers apoptosis and reduces steroidogenic enzyme expression through activating transcription factor 6 in Leydig cells of the testis.

S.-J. Park, T.-S. Kim, C.-K. Park, S.-H. Lee, J.-M. Kim, K.-S. Lee, I.-k. Lee, J.-W. Park, M. A. Lawson, and D.-S. Lee (2013)
J. Mol. Endocrinol. 50, 151-166
 |  Abstract »  |  Full Text »  |  PDF »

Ataxin-2 interacts with FUS and intermediate-length polyglutamine expansions enhance FUS-related pathology in amyotrophic lateral sclerosis.

M. A. Farg, K. Y. Soo, S. T. Warraich, V. Sundaramoorthy, I. P. Blair, and J. D. Atkin (2013)
Hum. Mol. Genet. 22, 717-728
 |  Abstract »  |  Full Text »  |  PDF »

Xenobiotic Perturbation of ER Stress and the Unfolded Protein Response.

M. A. Lafleur, J. L. Stevens, and J. W. Lawrence (2013)
Toxicol Pathol 41, 235-262
 |  Abstract »  |  Full Text »  |  PDF »

CARD3 Deficiency Exacerbates Diet-Induced Obesity, Hepatosteatosis, and Insulin Resistance in Male Mice.

X.-A. Wang, S. Deng, D. Jiang, R. Zhang, S. Zhang, J. Zhong, L. Yang, T. Wang, S. Hong, S. Guo, et al. (2013)
Endocrinology 154, 685-697
 |  Abstract »  |  Full Text »  |  PDF »

Endothelial Acyl-CoA Synthetase 1 Is Not Required for Inflammatory and Apoptotic Effects of a Saturated Fatty Acid-Rich Environment.

X. Li, O. Gonzalez, X. Shen, S. Barnhart, F. Kramer, J. E. Kanter, A. Vivekanandan-Giri, K. Tsuchiya, P. Handa, S. Pennathur, et al. (2013)
Arterioscler Thromb Vasc Biol 33, 232-240
 |  Abstract »  |  Full Text »  |  PDF »

c-Jun NH2-Terminal Kinase 1/2 and Endoplasmic Reticulum Stress as Interdependent and Reciprocal Causation in Diabetic Embryopathy.

X. Li, C. Xu, and P. Yang (2013)
Diabetes 62, 599-608
 |  Abstract »  |  Full Text »  |  PDF »

The IRE1{alpha}-XBP1 Pathway Positively Regulates Parathyroid Hormone (PTH)/PTH-related Peptide Receptor Expression and Is Involved in PTH-induced Osteoclastogenesis.

T. Tohmonda, M. Yoda, H. Mizuochi, H. Morioka, M. Matsumoto, F. Urano, Y. Toyama, and K. Horiuchi (2013)
J. Biol. Chem. 288, 1691-1695
 |  Abstract »  |  Full Text »  |  PDF »

Novel Role of HAX-1 in Ischemic Injury Protection Involvement of Heat Shock Protein 90.

C. K. Lam, W. Zhao, W. Cai, E. Vafiadaki, S. M. Florea, X. Ren, Y. Liu, N. Robbins, Z. Zhang, X. Zhou, et al. (2013)
Circ. Res. 112, 79-89
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-Inducible Gene 6 Triggers Apoptosis and Exacerbates ER Stress-Induced {beta}-Cell Death.

Y.-C. Chen, E. S. Colvin, B. F. Maier, R. G. Mirmira, and P. T. Fueger (2013)
Mol. Endocrinol. 27, 162-171
 |  Abstract »  |  Full Text »  |  PDF »

Protein-Folding Homeostasis in the Endoplasmic Reticulum and Nutritional Regulation.

D. Ron and H. P. Harding (2012)
Cold Spring Harb Perspect Biol 4, a013177
 |  Abstract »  |  Full Text »  |  PDF »

Degradation of the Endoplasmic Reticulum by Autophagy during Endoplasmic Reticulum Stress in Arabidopsis.

Y. Liu, J. S. Burgos, Y. Deng, R. Srivastava, S. H. Howell, and D. C. Bassham (2012)
PLANT CELL 24, 4635-4651
 |  Abstract »  |  Full Text »  |  PDF »

Endoplasmic Reticulum Stress, Pancreatic {beta}-Cell Degeneration, and Diabetes.

F. R. Papa (2012)
Cold Spring Harb Perspect Med 2, a007666
 |  Abstract »  |  Full Text »  |  PDF »

ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.

E. Mahoney, D. M. Lucas, S. V. Gupta, A. J. Wagner, S. E. M. Herman, L. L. Smith, Y.-Y. Yeh, L. Andritsos, J. A. Jones, J. M. Flynn, et al. (2012)
Blood 120, 1262-1273
 |  Abstract »  |  Full Text »  |  PDF »

DangER: protein ovERload. Targeting protein degradation to treat myeloma.

L. I. Aronson and F. E. Davies (2012)
Haematologica 97, 1119-1130
 |  Abstract »  |  Full Text »  |  PDF »

Stearic Acid Accumulation in Macrophages Induces Toll-Like Receptor 4/2-Independent Inflammation Leading to Endoplasmic Reticulum Stress-Mediated Apoptosis.

E. K. Anderson, A. A. Hill, and A. H. Hasty (2012)
Arterioscler Thromb Vasc Biol 32, 1687-1695
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of XBP1 splicing by inhibition of IRE1{alpha} is a promising therapeutic option in multiple myeloma.

N. Mimura, M. Fulciniti, G. Gorgun, Y.-T. Tai, D. Cirstea, L. Santo, Y. Hu, C. Fabre, J. Minami, H. Ohguchi, et al. (2012)
Blood 119, 5772-5781
 |  Abstract »  |  Full Text »  |  PDF »

Chikungunya virus-induced autophagy delays caspase-dependent cell death.

P.-E. Joubert, S. W. Werneke, C. de la Calle, F. Guivel-Benhassine, A. Giodini, L. Peduto, B. Levine, O. Schwartz, D. J. Lenschow, and M. L. Albert (2012)
J. Exp. Med. 209, 1029-1047
 |  Abstract »  |  Full Text »  |  PDF »

Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism.

T. D. Baird and R. C. Wek (2012)
Adv Nutr 3, 307-321
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Subtilase Cytotoxin-Induced Cell Death by an RNA-Dependent Protein Kinase-Like Endoplasmic Reticulum Kinase-Dependent Proteasome Pathway in HeLa Cells.

K. Yahiro, H. Tsutsuki, K. Ogura, S. Nagasawa, J. Moss, and M. Noda (2012)
Infect. Immun. 80, 1803-1814
 |  Abstract »  |  Full Text »  |  PDF »

Lipid-Induced Endoplasmic Reticulum Stress in Liver Cells Results in Two Distinct Outcomes: Adaptation with Enhanced Insulin Signaling or Insulin Resistance.

C. S. Achard and D. R. Laybutt (2012)
Endocrinology 153, 2164-2177
 |  Abstract »  |  Full Text »  |  PDF »

Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis.

H. Tanjore, T. S. Blackwell, and W. E. Lawson (2012)
Am J Physiol Lung Cell Mol Physiol 302, L721-L729
 |  Abstract »  |  Full Text »  |  PDF »

Pancreatic {beta}-cells depend on basal expression of active ATF6{alpha}-p50 for cell survival even under nonstress conditions.

T. Teodoro, T. Odisho, E. Sidorova, and A. Volchuk (2012)
Am J Physiol Cell Physiol 302, C992-C1003
 |  Abstract »  |  Full Text »  |  PDF »

Lipin-2 Reduces Proinflammatory Signaling Induced by Saturated Fatty Acids in Macrophages.

M. Valdearcos, E. Esquinas, C. Meana, L. Pena, L. Gil-de-Gomez, J. Balsinde, and M. A. Balboa (2012)
J. Biol. Chem. 287, 10894-10904
 |  Abstract »  |  Full Text »  |  PDF »

The Endoplasmic Reticulum Stress Transducer OASIS Is involved in the Terminal Differentiation of Goblet Cells in the Large Intestine.

R. Asada, A. Saito, N. Kawasaki, S. Kanemoto, H. Iwamoto, M. Oki, H. Miyagi, S. Izumi, and K. Imaizumi (2012)
J. Biol. Chem. 287, 8144-8153
 |  Abstract »  |  Full Text »  |  PDF »

Hepatic TRAF2 Regulates Glucose Metabolism Through Enhancing Glucagon Responses.

Z. Chen, L. Sheng, H. Shen, Y. Zhao, S. Wang, R. Brink, and L. Rui (2012)
Diabetes 61, 566-573
 |  Abstract »  |  Full Text »  |  PDF »

IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin.

W.-C. Chiang, C. Messah, and J. H. Lin (2012)
Mol. Biol. Cell 23, 758-770
 |  Abstract »  |  Full Text »  |  PDF »

Cdc37/Hsp90 Protein-mediated Regulation of IRE1{alpha} Protein Activity in Endoplasmic Reticulum Stress Response and Insulin Synthesis in INS-1 Cells.

A. Ota and Y. Wang (2012)
J. Biol. Chem. 287, 6266-6274
 |  Abstract »  |  Full Text »  |  PDF »

IRE1{alpha} activation protects mice against acetaminophen-induced hepatotoxicity.

K. Y. Hur, J.-S. So, V. Ruda, M. Frank-Kamenetsky, K. Fitzgerald, V. Koteliansky, T. Iwawaki, L. H. Glimcher, and A.-H. Lee (2012)
J. Exp. Med. 209, 307-318
 |  Abstract »  |  Full Text »  |  PDF »

New insights on stress-induced epithelial phenotypic changes.

N. Pallet (2012)
Nephrol. Dial. Transplant. 27, 483-485
 |  Full Text »  |  PDF »

Activation of Endoplasmic Reticulum Stress by Hyperglycemia Is Essential for Muller Cell-Derived Inflammatory Cytokine Production in Diabetes.

Y. Zhong, J. Li, Y. Chen, J. J. Wang, R. Ratan, and S. X. Zhang (2012)
Diabetes 61, 492-504
 |  Abstract »  |  Full Text »  |  PDF »

Dissociation of Inositol-requiring Enzyme (IRE1{alpha})-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice.

M. J. Jurczak, A.-H. Lee, F. R. Jornayvaz, H.-Y. Lee, A. L. Birkenfeld, B. A. Guigni, M. Kahn, V. T. Samuel, L. H. Glimcher, and G. I. Shulman (2012)
J. Biol. Chem. 287, 2558-2567
 |  Abstract »  |  Full Text »  |  PDF »

Inflammation, Endoplasmic Reticulum Stress, Autophagy, and the Monocyte Chemoattractant Protein-1/CCR2 Pathway.

P. E. Kolattukudy and J. Niu (2012)
Circ. Res. 110, 174-189
 |  Abstract »  |  Full Text »  |  PDF »

IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux.

H. Lee, J.-Y. Noh, Y. Oh, Y. Kim, J.-W. Chang, C.-W. Chung, S.-T. Lee, M. Kim, H. Ryu, and Y.-K. Jung (2012)
Hum. Mol. Genet. 21, 101-114
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis.

K. Kakisaka, S. C. Cazanave, C. D. Fingas, M. E. Guicciardi, S. F. Bronk, N. W. Werneburg, J. L. Mott, and G. J. Gores (2012)
Am J Physiol Gastrointest Liver Physiol 302, G77-G84
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of ER Stress-Induced Apoptosis in Atherosclerosis.

C. M. Scull and I. Tabas (2011)
Arterioscler Thromb Vasc Biol 31, 2792-2797
 |  Abstract »  |  Full Text »  |  PDF »

The Binding Protein BiP Attenuates Stress-Induced Cell Death in Soybean via Modulation of the N-Rich Protein-Mediated Signaling Pathway.

P. A. A. Reis, G. L. Rosado, L. A. C. Silva, L. C. Oliveira, L. B. Oliveira, M. D. L. Costa, F. C. Alvim, and E. P. B. Fontes (2011)
Plant Physiology 157, 1853-1865
 |  Abstract »  |  Full Text »  |  PDF »

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.

B. F. Teske, S. A. Wek, P. Bunpo, J. K. Cundiff, J. N. McClintick, T. G. Anthony, and R. C. Wek (2011)
Mol. Biol. Cell 22, 4390-4405
 |  Abstract »  |  Full Text »  |  PDF »

IRE1-Dependent Activation of AMPK in Response to Nitric Oxide.

G. P. Meares, K. J. Hughes, A. Naatz, F. R. Papa, F. Urano, P. A. Hansen, E. N. Benveniste, and J. A. Corbett (2011)
Mol. Cell. Biol. 31, 4286-4297
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Stress Inside Out: Cell-Extrinsic Effects of the Unfolded Protein Response in Tumor Cells Modulate the Immunological Landscape of the Tumor Microenvironment.

N. R. Mahadevan and M. Zanetti (2011)
J. Immunol. 187, 4403-4409
 |  Abstract »  |  Full Text »  |  PDF »

Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis.

E. Seyhun, A. Malo, C. Schafer, C. A. Moskaluk, R.-T. Hoffmann, B. Goke, and C. H. Kubisch (2011)
Am J Physiol Gastrointest Liver Physiol 301, G773-G782
 |  Abstract »  |  Full Text »  |  PDF »

Diacerhein Improves Glucose Tolerance and Insulin Sensitivity in Mice on a High-Fat Diet.

N. Tobar, A. G. Oliveira, D. Guadagnini, R. A. Bagarolli, G. Z. Rocha, T. G. Araujo, J. C. Santos-Silva, R. L. Zollner, L. H. B. Boechat, J. B. C. Carvalheira, et al. (2011)
Endocrinology 152, 4080-4093
 |  Abstract »  |  Full Text »  |  PDF »

Paraoxonase-2 Modulates Stress Response of Endothelial Cells to Oxidized Phospholipids and a Bacterial Quorum-Sensing Molecule.

J. B. Kim, Y.-R. Xia, C. E. Romanoski, S. Lee, Y. Meng, Y.-S. Shi, N. Bourquard, K. W. Gong, Z. Port, V. Grijalva, et al. (2011)
Arterioscler Thromb Vasc Biol 31, 2624-2633
 |  Abstract »  |  Full Text »  |  PDF »

Heightened Induction of Proapoptotic Signals in Response to Endoplasmic Reticulum Stress in Primary Fibroblasts from a Mouse Model of Longevity.

A. A. Sadighi Akha, J. M. Harper, A. B. Salmon, B. A. Schroeder, H. M. Tyra, D. T. Rutkowski, and R. A. Miller (2011)
J. Biol. Chem. 286, 30344-30351
 |  Abstract »  |  Full Text »  |  PDF »

Alveolar Epithelial Cells Undergo Epithelial-to-Mesenchymal Transition in Response to Endoplasmic Reticulum Stress.

H. Tanjore, D.-S. Cheng, A. L. Degryse, D. F. Zoz, R. Abdolrasulnia, W. E. Lawson, and T. S. Blackwell (2011)
J. Biol. Chem. 286, 30972-30980
 |  Abstract »  |  Full Text »  |  PDF »

Peptides derived from the bifunctional kinase/RNase enzyme IRE1{alpha} modulate IRE1{alpha} activity and protect cells from endoplasmic reticulum stress.

M. Bouchecareilh, A. Higa, S. Fribourg, M. Moenner, and E. Chevet (2011)
FASEB J 25, 3115-3129
 |  Abstract »  |  Full Text »  |  PDF »

Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides.

N. Gao, J. Shang, D. Huynh, V. L. Manthati, C. Arias, H. P. Harding, R. J. Kaufman, I. Mohr, D. Ron, J. R. Falck, et al. (2011)
Mol. Biol. Cell 22, 2994-3009
 |  Abstract »  |  Full Text »  |  PDF »

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus.

P. Westermark, A. Andersson, and G. T. Westermark (2011)
Physiol Rev 91, 795-826
 |  Abstract »  |  Full Text »  |  PDF »

Endoplasmic Reticulum Oxidoreductin-1-Like {beta} (ERO1l{beta}) Regulates Susceptibility to Endoplasmic Reticulum Stress and Is Induced by Insulin Flux in {beta}-Cells.

C. Khoo, J. Yang, G. Rajpal, Y. Wang, J. Liu, P. Arvan, and D. A. Stoffers (2011)
Endocrinology 152, 2599-2608
 |  Abstract »  |  Full Text »  |  PDF »

Role of p38 Protein Kinase in the Ligand-independent Ubiquitination and Down-regulation of the IFNAR1 Chain of Type I Interferon Receptor.

S. Bhattacharya, J. Qian, C. Tzimas, D. P. Baker, C. Koumenis, J. A. Diehl, and S. Y. Fuchs (2011)
J. Biol. Chem. 286, 22069-22076
 |  Abstract »  |  Full Text »  |  PDF »

Endoplasmic Reticulum Stress Enters a Nogo Zone.

J. P. Munoz and A. Zorzano (2011)
Science Translational Medicine 3, 88ps26
 |  Full Text »  |  PDF »

The Unfolded Protein Response Is Triggered by a Plant Viral Movement Protein.

C. Ye, M. B. Dickman, S. A. Whitham, M. Payton, and J. Verchot (2011)
Plant Physiology 156, 741-755
 |  Abstract »  |  Full Text »  |  PDF »

Fluoride's Effects on the Formation of Teeth and Bones, and the Influence of Genetics.

E. T. Everett (2011)
Journal of Dental Research 90, 552-560
 |  Abstract »  |  PDF »

The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology.

R. Asada, S. Kanemoto, S. Kondo, A. Saito, and K. Imaizumi (2011)
J. Biochem. 149, 507-518
 |  Abstract »  |  Full Text »  |  PDF »

The endoplasmic reticulum stress response and diabetic kidney disease.

R. Cunard and K. Sharma (2011)
Am J Physiol Renal Physiol 300, F1054-F1061
 |  Abstract »  |  Full Text »  |  PDF »

Dengue Virus Modulates the Unfolded Protein Response in a Time-dependent Manner.

J. Pena and E. Harris (2011)
J. Biol. Chem. 286, 14226-14236
 |  Abstract »  |  Full Text »  |  PDF »

Late Activation of Stress-activated Protein Kinases/c-Jun N-terminal Kinases Triggered by Cisplatin-induced DNA Damage in Repair-defective Cells.

L. Helbig, J. Damrot, J. Hulsenbeck, B. Koberle, A. Brozovic, M. Osmak, Z. Fiket, B. Kaina, and G. Fritz (2011)
J. Biol. Chem. 286, 12991-13001
 |  Abstract »  |  Full Text »  |  PDF »

Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease.

K. Volkmann, J. L. Lucas, D. Vuga, X. Wang, D. Brumm, C. Stiles, D. Kriebel, A. Der-Sarkissian, K. Krishnan, C. Schweitzer, et al. (2011)
J. Biol. Chem. 286, 12743-12755
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic {beta}-cells by stearoyl-CoA desaturase and Elovl6.

C. D. Green and L. K. Olson (2011)
Am J Physiol Endocrinol Metab 300, E640-E649
 |  Abstract »  |  Full Text »  |  PDF »

Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells.

E. Matsushita, N. Asai, A. Enomoto, Y. Kawamoto, T. Kato, S. Mii, K. Maeda, R. Shibata, S. Hattori, M. Hagikura, et al. (2011)
Mol. Biol. Cell 22, 736-747
 |  Abstract »  |  Full Text »  |  PDF »

Subtilase Cytotoxin Activates MAP Kinases through PERK and IRE1 Branches of the Unfolded Protein Response.

Y. Zhao, T. Tian, T. Huang, S. Nakajima, Y. Saito, S. Takahashi, J. Yao, A. W. Paton, J. C. Paton, and M. Kitamura (2011)
Toxicol. Sci. 120, 79-86
 |  Abstract »  |  Full Text »  |  PDF »

Endoplasmic Reticulum Stress Induced by Surfactant Protein C BRICHOS Mutants Promotes Proinflammatory Signaling by Epithelial Cells.

J. A. Maguire, S. Mulugeta, and M. F. Beers (2011)
44, 404-414
 |  Abstract »  |  Full Text »  |  PDF »

Deletion of Nck1 attenuates hepatic ER stress signaling and improves glucose tolerance and insulin signaling in liver of obese mice.

M. Latreille, M.-K. Laberge, G. Bourret, L. Yamani, and L. Larose (2011)
Am J Physiol Endocrinol Metab 300, E423-E434
 |  Abstract »  |  Full Text »  |  PDF »

Bifunctional Apoptosis Regulator (BAR), an Endoplasmic Reticulum (ER)-associated E3 Ubiquitin Ligase, Modulates BI-1 Protein Stability and Function in ER Stress.

J. Rong, L. Chen, J. I. Toth, M. Tcherpakov, M. D. Petroski, and J. C. Reed (2011)
J. Biol. Chem. 286, 1453-1463
 |  Abstract »  |  Full Text »  |  PDF »

Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4-CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA.

Z. Galehdar, P. Swan, B. Fuerth, S. M. Callaghan, D. S. Park, and S. P. Cregan (2010)
J. Neurosci. 30, 16938-16948
 |  Abstract »  |  Full Text »  |  PDF »

Biology of Endoplasmic Reticulum Stress in the Heart.

J. Groenendyk, P. K. Sreenivasaiah, D. H. Kim, L. B. Agellon, and M. Michalak (2010)
Circ. Res. 107, 1185-1197
 |  Abstract »  |  Full Text »  |  PDF »

The Unfolded Protein Response in Lung Disease.

S. J. Marcinak and D. Ron (2010)
7, 356-362
 |  Abstract »  |  Full Text »  |  PDF »

Protein Misfolding Induces Hypoxic Preconditioning via a Subset of the Unfolded Protein Response Machinery.

X. R. Mao and C. M. Crowder (2010)
Mol. Cell. Biol. 30, 5033-5042
 |  Abstract »  |  Full Text »  |  PDF »

Endoplasmic Reticulum Stress As a Therapeutic Target in Cardiovascular Disease.

T. Minamino, I. Komuro, and M. Kitakaze (2010)
Circ. Res. 107, 1071-1082
 |  Abstract »  |  Full Text »  |  PDF »

Novel targets for endoplasmic reticulum stress-induced apoptosis in B-CLL.

E. Rosati, R. Sabatini, G. Rampino, F. De Falco, M. Di Ianni, F. Falzetti, K. Fettucciari, A. Bartoli, I. Screpanti, and P. Marconi (2010)
Blood 116, 2713-2723
 |  Abstract »  |  Full Text »  |  PDF »

Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini.

A. Malo, B. Kruger, E. Seyhun, C. Schafer, R. T. Hoffmann, B. Goke, and C. H. Kubisch (2010)
Am J Physiol Gastrointest Liver Physiol 299, G877-G886
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Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues.

S. Laing, G. Wang, T. Briazova, C. Zhang, A. Wang, Z. Zheng, A. Gow, A. F. Chen, S. Rajagopalan, L. C. Chen, et al. (2010)
Am J Physiol Cell Physiol 299, C736-C749
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Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism.

R. Tomecki and A. Dziembowski (2010)
RNA 16, 1692-1724
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JNK1 and IKK{beta}: molecular links between obesity and metabolic dysfunction.

G. Solinas and M. Karin (2010)
FASEB J 24, 2596-2611
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Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women.

M. Kars, L. Yang, M. F. Gregor, B. S. Mohammed, T. A. Pietka, B. N. Finck, B. W. Patterson, J. D. Horton, B. Mittendorfer, G. S. Hotamisligil, et al. (2010)
Diabetes 59, 1899-1905
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Ablation of C/EBP Homologous Protein Attenuates Endoplasmic Reticulum-Mediated Apoptosis and Cardiac Dysfunction Induced by Pressure Overload.

H. Y. Fu, K.-i. Okada, Y. Liao, O. Tsukamoto, T. Isomura, M. Asai, T. Sawada, K. Okuda, Y. Asano, S. Sanada, et al. (2010)
Circulation 122, 361-369
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In vivo cellular adaptation to ER stress: survival strategies with double-edged consequences.

K. Y. Tsang, D. Chan, J. F. Bateman, and K. S. E. Cheah (2010)
J. Cell Sci. 123, 2145-2154
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Hepatocyte Death: A Clear and Present Danger.

H. Malhi, M. E. Guicciardi, and G. J. Gores (2010)
Physiol Rev 90, 1165-1194
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Autophagy Induction by Capsaicin in Malignant Human Breast Cells Is Modulated by p38 and Extracellular Signal-Regulated Mitogen-Activated Protein Kinases and Retards Cell Death by Suppressing Endoplasmic Reticulum Stress-Mediated Apoptosis.

C.-H. Choi, Y.-K. Jung, and S.-H. Oh (2010)
Mol. Pharmacol. 78, 114-125
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The Activity of Yeast Hog1 MAPK Is Required during Endoplasmic Reticulum Stress Induced by Tunicamycin Exposure.

F. Torres-Quiroz, S. Garcia-Marques, R. Coria, F. Randez-Gil, and J. A. Prieto (2010)
J. Biol. Chem. 285, 20088-20096
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ER stress and the unfolded protein response in intestinal inflammation.

M. A. McGuckin, R. D. Eri, I. Das, R. Lourie, and T. H. Florin (2010)
Am J Physiol Gastrointest Liver Physiol 298, G820-G832
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Regulation of basal cellular physiology by the homeostatic unfolded protein response.

D. T. Rutkowski and R. S. Hegde (2010)
J. Cell Biol. 189, 783-794
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Matrix Metalloproteinase-3 Is Increased and Participates in Neuronal Apoptotic Signaling Downstream of Caspase-12 during Endoplasmic Reticulum Stress.

E. M. Kim, E. J. Shin, J. H. Choi, H. J. Son, I. S. Park, T. H. Joh, and O. Hwang (2010)
J. Biol. Chem. 285, 16444-16452
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eIF2{alpha} Phosphorylation Tips the Balance to Apoptosis during Osmotic Stress.

E. Bevilacqua, X. Wang, M. Majumder, F. Gaccioli, C. L. Yuan, C. Wang, X. Zhu, L. E. Jordan, D. Scheuner, R. J. Kaufman, et al. (2010)
J. Biol. Chem. 285, 17098-17111
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Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death.

K. T. Pfaffenbach, C. L. Gentile, A. M. Nivala, D. Wang, Y. Wei, and M. J. Pagliassotti (2010)
Am J Physiol Endocrinol Metab 298, E1027-E1035
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Evidence for Unfolded Protein Response Activation in Monocytes from Individuals with {alpha}-1 Antitrypsin Deficiency.

T. P. Carroll, C. M. Greene, C. A. O'Connor, A. M. Nolan, S. J. O'Neill, and N. G. McElvaney (2010)
J. Immunol. 184, 4538-4546
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The UPR and cell fate at a glance.

P. I. Merksamer and F. R. Papa (2010)
J. Cell Sci. 123, 1003-1006
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