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Science 287 (5461): 2262-2267

Copyright © 2000 by the American Association for the Advancement of Science

Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction

Yasunori Hayashi, * Song-Hai Shi, * José A. Esteban, Antonella Piccini, Jean-Christophe Poncer, dagger Roberto Malinow ddagger

To elucidate mechanisms that control and execute activity-dependent synaptic plasticity, alpha -amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors (AMPA-Rs) with an electrophysiological tag were expressed in rat hippocampal neurons. Long-term potentiation (LTP) or increased activity of the calcium/calmodulin-dependent protein kinase II (CaMKII) induced delivery of tagged AMPA-Rs into synapses. This effect was not diminished by mutating the CaMKII phosphorylation site on the GluR1 AMPA-R subunit, but was blocked by mutating a predicted PDZ domain interaction site. These results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
*   These authors contributed equally to this work.

dagger    Present address: INSERM U261, Institut Pasteur, 25 rue du Dr. Roux, 75015 Paris, France.

ddagger    To whom correspondence should be addressed. E-mail: malinow{at}cshl.org

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. Neurosci. 29, 1017-1033
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. Neurosci. 28, 10220-10233
   Abstract »    Full Text »    PDF »
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Y.-P. Zhang, N. Holbro, and T. G. Oertner (2008)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
Homeostatic regulation of AMPA receptor expression at single hippocampal synapses.
Q. Hou, D. Zhang, L. Jarzylo, R. L. Huganir, and H.-Y. Man (2008)
PNAS 105, 775-780
   Abstract »    Full Text »    PDF »
The Role of Hippocampal GluR1 and GluR2 Receptors in Manic-Like Behavior.
J. Du, T. K. Creson, L.-J. Wu, M. Ren, N. A. Gray, C. Falke, Y. Wei, Y. Wang, R. Blumenthal, R. Machado-Vieira, et al. (2008)
J. Neurosci. 28, 68-79
   Abstract »    Full Text »    PDF »
Differential Trafficking of AMPA and NMDA Receptors during Long-Term Potentiation in Awake Adult Animals.
J. M. Williams, D. Guevremont, S. E. Mason-Parker, C. Luxmanan, W. P. Tate, and W. C. Abraham (2007)
J. Neurosci. 27, 14171-14178
   Abstract »    Full Text »    PDF »
Vigorous Motor Activity in Caenorhabditis elegans Requires Efficient Clearance of Dopamine Mediated by Synaptic Localization of the Dopamine Transporter DAT-1.
P. W. McDonald, S. L. Hardie, T. N. Jessen, L. Carvelli, D. S. Matthies, and R. D. Blakely (2007)
J. Neurosci. 27, 14216-14227
   Abstract »    Full Text »    PDF »
GluR1 Links Structural and Functional Plasticity at Excitatory Synapses.
C. D. Kopec, E. Real, H. W. Kessels, and R. Malinow (2007)
J. Neurosci. 27, 13706-13718
   Abstract »    Full Text »    PDF »
Functional Compartmentalization of Endosomal Trafficking for the Synaptic Delivery of AMPA Receptors during Long-Term Potentiation.
T. C. Brown, S. S. Correia, C. N. Petrok, and J. A. Esteban (2007)
J. Neurosci. 27, 13311-13315
   Abstract »    Full Text »    PDF »
Activity-dependent Regulation of h Channel Distribution in Hippocampal CA1 Pyramidal Neurons.
M. Shin and D. M. Chetkovich (2007)
J. Biol. Chem. 282, 33168-33180
   Abstract »    Full Text »    PDF »
Neuron type-specific effects of brain-derived neurotrophic factor in rat superficial dorsal horn and their relevance to 'central sensitization'.
V. B. Lu, K. Ballanyi, W. F. Colmers, and P. A. Smith (2007)
J. Physiol. 584, 543-563
   Abstract »    Full Text »    PDF »

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