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Science 288 (5466): 675-678

Copyright © 2000 by the American Association for the Advancement of Science

Control of Homeostasis of CD8+ Memory T Cells by Opposing Cytokines

Chia Chi Ku, 12* Masaaki Murakami, 1* Akemi Sakamoto, 1 John Kappler, 1245 Philippa Marrack 1235dagger

Memory T cells maintain their numbers for long periods after antigen exposure. Here we show that CD8+ T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2). Therefore, the numbers of CD8+ memory T cells in animals are controlled by a balance between IL-15 and IL-2.

1 Howard Hughes Medical Institute, Department of Medicine, National Jewish Medical and Research Center and Departments of
2 Immunology,
3 Biochemistry and Molecular Biology,
4 Pharmacology, and
5 Medicine, University of Colorado Health Sciences Center, Denver, CO 80206, USA.
*   These authors contributed equally to the work.

dagger    To whom correspondence should be addressed. E-mail: marrackp{at}

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CD11chigh Dendritic Cell Ablation Impairs Lymphopenia-Driven Proliferation of Naive and Memory CD8+ T Cells.
T. Zaft, A. Sapoznikov, R. Krauthgamer, D. R. Littman, and S. Jung (2005)
J. Immunol. 175, 6428-6435
   Abstract »    Full Text »    PDF »
{gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells.
J. D. French, C. L. Roark, W. K. Born, and R. L. O'Brien (2005)
PNAS 102, 14741-14746
   Abstract »    Full Text »    PDF »
The Death Receptor Fas (CD95/APO-1) Mediates the Deletion of T Lymphocytes Undergoing Homeostatic Proliferation.
K. A. Fortner and R. C. Budd (2005)
J. Immunol. 175, 4374-4382
   Abstract »    Full Text »    PDF »
IL-7 Receptor Expression Levels Do Not Identify CD8+ Memory T Lymphocyte Precursors following Peptide Immunization.
M.-H. Lacombe, M.-P. Hardy, J. Rooney, and N. Labrecque (2005)
J. Immunol. 175, 4400-4407
   Abstract »    Full Text »    PDF »
Homeostatic T cell proliferation as a barrier to T cell tolerance.
S. P. Hickman and L. A. Turka (2005)
Phil Trans R Soc B 360, 1713-1721
   Abstract »    Full Text »    PDF »
Human T Cells Constitutively Express IL-15 That Promotes Ex Vivo T Cell Homeostatic Proliferation through Autocrine/Juxtacrine Loops.
M.-E. Miranda-Carus, M. Benito-Miguel, M. A. Llamas, A. Balsa, and E. Martin-Mola (2005)
J. Immunol. 175, 3656-3662
   Abstract »    Full Text »    PDF »
CD8+ T cells produce IL-2, which is required for CD4+CD25+ T cell regulation of effector CD8+ T cell development for contact hypersensitivity responses.
D. D. Kish, A. V. Gorbachev, and R. L. Fairchild (2005)
J. Leukoc. Biol. 78, 725-735
   Abstract »    Full Text »    PDF »
IL-2 Responsiveness of CD4 and CD8 lymphocytes: further investigations with human IL-2R{beta} transgenic mice.
F. Gesbert, J.-L. Moreau, and J. Theze (2005)
Int. Immunol. 17, 1093-1102
   Abstract »    Full Text »    PDF »

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