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Science 288 (5469): 1254-1256

Copyright © 2000 by the American Association for the Advancement of Science

Role for Rapid Dendritic Protein Synthesis in Hippocampal mGluR-Dependent Long-Term Depression

Kimberly M. Huber, Matthew S. Kayser, Mark F. Bear *

A hippocampal pyramidal neuron receives more than 104 excitatory glutamatergic synapses. Many of these synapses contain the molecular machinery for messenger RNA translation, suggesting that the protein complement (and thus function) of each synapse can be regulated on the basis of activity. Here, local postsynaptic protein synthesis, triggered by synaptic activation of metabotropic glutamate receptors, was found to modify synaptic transmission within minutes.

Howard Hughes Medical Institute and Department of Neuroscience, Brown University, Providence, RI 02912, USA.
*   To whom correspondence should be addressed. E-mail: mbear{at}

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Cytoplasmic Polyadenylation Element Binding Protein 1-Mediated mRNA Translation in Purkinje Neurons Is Required for Cerebellar Long-Term Depression and Motor Coordination.
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J. Neurosci. 27, 6400-6411
   Abstract »    Full Text »    PDF »
Dysregulated Metabotropic Glutamate Receptor-Dependent Translation of AMPA Receptor and Postsynaptic Density-95 mRNAs at Synapses in a Mouse Model of Fragile X Syndrome.
R. S. Muddashetty, S. Kelic, C. Gross, M. Xu, and G. J. Bassell (2007)
J. Neurosci. 27, 5338-5348
   Abstract »    Full Text »    PDF »
The Role of Protein Synthesis in Striatal Long-Term Depression..
H. H. Yin, M. I. Davis, J. A. Ronesi, and D. M. Lovinger (2006)
J. Neurosci. 26, 11811-11820
   Abstract »    Full Text »    PDF »
Serotonin Increases Phosphorylation of Synaptic 4EBP through TOR, but Eukaryotic Initiation Factor 4E Levels Do Not Limit Somatic Cap-Dependent Translation in Aplysia Neurons.
M. Carroll, J. Dyer, and W. S. Sossin (2006)
Mol. Cell. Biol. 26, 8586-8598
   Abstract »    Full Text »    PDF »
NMDA-Dependent, But Not Group I Metabotropic Glutamate Receptor-Dependent, Long-Term Depression at Schaffer Collateral-CA1 Synapses Is Associated with Long-Term Reduction of Release from the Rapidly Recycling Presynaptic Vesicle Pool.
X.-l. Zhang, Z.-y. Zhou, J. Winterer, W. Muller, and P. K. Stanton (2006)
J. Neurosci. 26, 10270-10280
   Abstract »    Full Text »    PDF »
Early Postnatal Plasticity in Neocortex of Fmr1 Knockout Mice.
N. S. Desai, T. M. Casimiro, S. M. Gruber, and P. W. Vanderklish (2006)
J Neurophysiol 96, 1734-1745
   Abstract »    Full Text »    PDF »
Roles of Glutamate Receptors and the Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Activity-dependent Dendritic Protein Synthesis in Hippocampal Neurons.
R. Gong, C. S. Park, N. R. Abbassi, and S.-J. Tang (2006)
J. Biol. Chem. 281, 18802-18815
   Abstract »    Full Text »    PDF »
mRNA transport in dendrites: RNA granules, motors, and tracks..
N. Hirokawa (2006)
J. Neurosci. 26, 7139-7142
   Abstract »    Full Text »    PDF »
Current advances in local protein synthesis and synaptic plasticity..
B. E. Pfeiffer and K. M. Huber (2006)
J. Neurosci. 26, 7147-7150
   Abstract »    Full Text »    PDF »

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