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Science 288 (5469): 1254-1256

Copyright © 2000 by the American Association for the Advancement of Science

Role for Rapid Dendritic Protein Synthesis in Hippocampal mGluR-Dependent Long-Term Depression

Kimberly M. Huber, Matthew S. Kayser, Mark F. Bear *

A hippocampal pyramidal neuron receives more than 104 excitatory glutamatergic synapses. Many of these synapses contain the molecular machinery for messenger RNA translation, suggesting that the protein complement (and thus function) of each synapse can be regulated on the basis of activity. Here, local postsynaptic protein synthesis, triggered by synaptic activation of metabotropic glutamate receptors, was found to modify synaptic transmission within minutes.

Howard Hughes Medical Institute and Department of Neuroscience, Brown University, Providence, RI 02912, USA.
*   To whom correspondence should be addressed. E-mail: mbear{at}brown.edu

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K. J. O'Riordan, I-C. Huang, M. Pizzi, P. Spano, F. Boroni, R. Egli, P. Desai, O. Fitch, L. Malone, H. Jin Ahn, et al. (2006)
J. Neurosci. 26, 4870-4879
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Metabotropic Receptor-Dependent Long-Term Depression Persists in the Absence of Protein Synthesis in the Mouse Model of Fragile X Syndrome.
E. D. Nosyreva and K. M. Huber (2006)
J Neurophysiol 95, 3291-3295
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Age-related enhancement of a protein synthesis-dependent late phase of LTP induced by low frequency paired-pulse stimulation in hippocampus..
Y.-Y. Huang and E. R. Kandel (2006)
Learn. Mem. 13, 298-306
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NF-{kappa}B Regulates Spatial Memory Formation and Synaptic Plasticity through Protein Kinase A/CREB Signaling.
B. Kaltschmidt, D. Ndiaye, M. Korte, S. Pothion, L. Arbibe, M. Prullage, J. Pfeiffer, A. Lindecke, V. Staiger, A. Israel, et al. (2006)
Mol. Cell. Biol. 26, 2936-2946
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Differential Roles for Group 1 mGluR Subtypes in Induction and Expression of Chemically Induced Hippocampal Long-Term Depression.
L. J. Volk, C. A. Daly, and K. M. Huber (2006)
J Neurophysiol 95, 2427-2438
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Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration..
B. A. Grueter, H. B. Gosnell, C. M. Olsen, N. L. Schramm-Sapyta, T. Nekrasova, G. E. Landreth, and D. G. Winder (2006)
J. Neurosci. 26, 3210-3219
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Tyrosine Phosphatases Regulate AMPA Receptor Trafficking during Metabotropic Glutamate Receptor-Mediated Long-Term Depression.
P. R. Moult, C. M. Gladding, T. M. Sanderson, S. M. Fitzjohn, Z. I. Bashir, E. Molnar, and G. L. Collingridge (2006)
J. Neurosci. 26, 2544-2554
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Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression..
J. L. Banko, L. Hou, F. Poulin, N. Sonenberg, and E. Klann (2006)
J. Neurosci. 26, 2167-2173
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Matrix Metalloproteinase-9 Is Required for Hippocampal Late-Phase Long-Term Potentiation and Memory.
V. Nagy, O. Bozdagi, A. Matynia, M. Balcerzyk, P. Okulski, J. Dzwonek, R. M. Costa, A. J. Silva, L. Kaczmarek, and G. W. Huntley (2006)
J. Neurosci. 26, 1923-1934
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