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Science 288 (5472): 1796-1802

Copyright © 2000 by the American Association for the Advancement of Science

Kinesin Superfamily Motor Protein KIF17 and mLin-10 in NMDA Receptor-Containing Vesicle Transport

Mitsutoshi Setou, Terunaga Nakagawa, Dae-Hyun Seog, Nobutaka Hirokawa *

Experiments with vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B (NR2B subunit) show that they are transported along microtubules by KIF17, a neuron-specific molecular motor in neuronal dendrites. Selective transport is accomplished by direct interaction of the KIF17 tail with a PDZ domain of mLin-10 (Mint1/X11), which is a constituent of a large protein complex including mLin-2 (CASK), mLin-7 (MALS/Velis), and the NR2B subunit. This interaction, specific for a neurotransmitter receptor critically important for plasticity in the postsynaptic terminal, may be a regulatory point for synaptic plasticity and neuronal morphogenesis.

Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
*   To whom correspondence should be addressed. E-mail: hirokawa{at}m.u-tokyo.ac.jp


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K. Hill, Y. Li, M. Bennett, M. McKay, X. Zhu, J. Shern, E. Torre, J. J. Lah, A. I. Levey, and R. A. Kahn (2003)
J. Biol. Chem. 278, 36032-36040
   Abstract »    Full Text »    PDF »
Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head.
T. Nakata and N. Hirokawa (2003)
J. Cell Biol. 162, 1045-1055
   Abstract »    Full Text »    PDF »
IFT20 Links Kinesin II with a Mammalian Intraflagellar Transport Complex That Is Conserved in Motile Flagella and Sensory Cilia.
S. A. Baker, K. Freeman, K. Luby-Phelps, G. J. Pazour, and J. C. Besharse (2003)
J. Biol. Chem. 278, 34211-34218
   Abstract »    Full Text »    PDF »
Kinectin Anchors the Translation Elongation Factor-1{delta} to the Endoplasmic Reticulum.
L.-L. Ong, C. P. N. Er, A. Ho, M. T. Aung, and H. Yu (2003)
J. Biol. Chem. 278, 32115-32123
   Abstract »    Full Text »    PDF »
Regulation of early endocytic vesicle motility and fission in a reconstituted system.
E. Bananis, J. W. Murray, R. J. Stockert, P. Satir, and A. W. Wolkoff (2003)
J. Cell Sci. 116, 2749-2761
   Abstract »    Full Text »    PDF »
A Scaffold Protein JIP-1b Enhances Amyloid Precursor Protein Phosphorylation by JNK and Its Association with Kinesin Light Chain 1.
H. Inomata, Y. Nakamura, A. Hayakawa, H. Takata, T. Suzuki, K. Miyazawa, and N. Kitamura (2003)
J. Biol. Chem. 278, 22946-22955
   Abstract »    Full Text »    PDF »
Kinesin Superfamily Proteins (KIFs) in the Mouse Transcriptome.
H. Miki, M. Setou, RIKEN GER Group, GSL Members, and N. Hirokawa (2003)
Genome Res. 13, 1455-1465
   Abstract »    Full Text »    PDF »
Trafficking of signaling modules by kinesin motors.
B. J. Schnapp (2003)
J. Cell Sci. 116, 2125-2135
   Abstract »    Full Text »    PDF »

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