Mitsutoshi Setou, Terunaga Nakagawa, Dae-Hyun Seog, Nobutaka Hirokawa ^*

Experiments with vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B (NR2B subunit) show that they are transported along microtubules by KIF17, a neuron-specific molecular motor in neuronal dendrites. Selective transport is accomplished by direct interaction of the KIF17 tail with a PDZ domain of mLin-10 (Mint1/X11), which is a constituent of a large protein complex including mLin-2 (CASK), mLin-7 (MALS/Velis), and the NR2B subunit. This interaction, specific for a neurotransmitter receptor critically important for plasticity in the postsynaptic terminal, may be a regulatory point for synaptic plasticity and neuronal morphogenesis.

Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
^*   To whom correspondence should be addressed. E-mail: hirokawa{at}m.u-tokyo.ac.jp

Coupling Mechanical Forces to Electrical Signaling: Molecular Motors and the Intracellular Transport of Ion Channels.

J. Barry and C. Gu (2013)
Neuroscientist 19, 145-159
 |  Abstract »  |  Full Text »  |  PDF »

The kinesin-3 family motor KLP-4 regulates anterograde trafficking of GLR-1 glutamate receptors in the ventral nerve cord of Caenorhabditis elegans.

M. I. Monteiro, S. Ahlawat, J. R. Kowalski, E. Malkin, S. P. Koushika, and P. Juo (2012)
Mol. Biol. Cell 23, 3647-3662
 |  Abstract »  |  Full Text »  |  PDF »

A novel split kinesin assay identifies motor proteins that interact with distinct vesicle populations.

B. Jenkins, H. Decker, M. Bentley, J. Luisi, and G. Banker (2012)
J. Cell Biol. 198, 749-761
 |  Abstract »  |  Full Text »  |  PDF »

Specific Sets of Intrinsic and Extrinsic Factors Drive Excitatory and Inhibitory Circuit Formation.

A. Terauchi and H. Umemori (2012)
Neuroscientist 18, 271-286
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of NMDA Receptor Transport: A KIF17-Cargo Binding/Releasing Underlies Synaptic Plasticity and Memory In Vivo.

X. Yin, X. Feng, Y. Takei, and N. Hirokawa (2012)
J. Neurosci. 32, 5486-5499
 |  Abstract »  |  Full Text »  |  PDF »

Small GTPase Rab17 Regulates Dendritic Morphogenesis and Postsynaptic Development of Hippocampal Neurons.

Y. Mori, T. Matsui, Y. Furutani, Y. Yoshihara, and M. Fukuda (2012)
J. Biol. Chem. 287, 8963-8973
 |  Abstract »  |  Full Text »  |  PDF »

Kinesin-2 family in vertebrate ciliogenesis.

C. Zhao, Y. Omori, K. Brodowska, P. Kovach, and J. Malicki (2012)
PNAS 109, 2388-2393
 |  Abstract »  |  Full Text »  |  PDF »

Gonadotropin-Releasing Hormone Neurons Extend Complex Highly Branched Dendritic Trees Outside the Blood-Brain Barrier.

M. K. Herde, K. Geist, R. E. Campbell, and A. E. Herbison (2011)
Endocrinology 152, 3832-3841
 |  Abstract »  |  Full Text »  |  PDF »

Impaired {alpha}-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Trafficking and Function by Mutant Huntingtin.

M. Mandal, J. Wei, P. Zhong, J. Cheng, L. J. Duffney, W. Liu, E. Y. Yuen, A. E. Twelvetrees, S. Li, X.-J. Li, et al. (2011)
J. Biol. Chem. 286, 33719-33728
 |  Abstract »  |  Full Text »  |  PDF »

Functional NMDA Receptors at Axonal Growth Cones of Young Hippocampal Neurons.

P. Y. Wang, R. S. Petralia, Y.-X. Wang, R. J. Wenthold, and S. D. Brenowitz (2011)
J. Neurosci. 31, 9289-9297
 |  Abstract »  |  Full Text »  |  PDF »

Kinesin I Transports Tetramerized Kv3 Channels through the Axon Initial Segment via Direct Binding.

M. Xu, Y. Gu, J. Barry, and C. Gu (2010)
J. Neurosci. 30, 15987-16001
 |  Abstract »  |  Full Text »  |  PDF »

Neuroligin 1 Is Dynamically Exchanged at Postsynaptic Sites.

I. U. Schapitz, B. Behrend, Y. Pechmann, C. Lappe-Siefke, S. J. Kneussel, K. E. Wallace, A. V. Stempel, F. Buck, S. G. N. Grant, M. Schweizer, et al. (2010)
J. Neurosci. 30, 12733-12744
 |  Abstract »  |  Full Text »  |  PDF »

KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC.

F. Jaulin and G. Kreitzer (2010)
J. Cell Biol. 190, 443-460
 |  Abstract »  |  Full Text »  |  PDF »

Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms.

J. W. Hammond, T. L. Blasius, V. Soppina, D. Cai, and K. J. Verhey (2010)
J. Cell Biol. 189, 1013-1025
 |  Abstract »  |  Full Text »  |  PDF »

Intraflagellar transport molecules in ciliary and nonciliary cells of the retina.

T. Sedmak and U. Wolfrum (2010)
J. Cell Biol. 189, 171-186
 |  Abstract »  |  Full Text »  |  PDF »

Novel Mediators of Amyloid Precursor Protein Signaling.

A. Swistowski, Q. Zhang, M. E. Orcholski, D. Crippen, C. Vitelli, A. Kurakin, and D. E. Bredesen (2009)
J. Neurosci. 29, 15703-15712
 |  Abstract »  |  Full Text »  |  PDF »

X11{beta} rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.

J. C. Mitchell, B. B. Ariff, D. M. Yates, K.-F. Lau, M. S. Perkinton, B. Rogelj, J. D. Stephenson, C. C.J. Miller, and D. M. McLoughlin (2009)
Hum. Mol. Genet. 18, 4492-4500
 |  Abstract »  |  Full Text »  |  PDF »

Kif5b is an essential forward trafficking motor for the Kv1.5 cardiac potassium channel.

A. D. Zadeh, Y. Cheng, H. Xu, N. Wong, Z. Wang, C. Goonasekara, D. F. Steele, and D. Fedida (2009)
J. Physiol. 587, 4565-4574
 |  Abstract »  |  Full Text »  |  PDF »

Actin and Microtubule-Based Cytoskeletal Cues Direct Polarized Targeting of Proteins in Neurons.

D. B. Arnold (2009)
Science Signaling 2, pe49
 |  Abstract »  |  Full Text »  |  PDF »

The Cleavage Products of Amyloid-{beta} Precursor Protein Are Sorted to Distinct Carrier Vesicles That Are Independently Transported within Neurites.

V. Muresan, N. H. Varvel, B. T. Lamb, and Z. Muresan (2009)
J. Neurosci. 29, 3565-3578
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Motors and Synaptic Assembly.

Qian Cai and Z.-H. Sheng (2009)
Neuroscientist 15, 78-89
 |  Abstract »  |  PDF »

Polarized Targeting of Neurexins to Synapses Is Regulated by their C-Terminal Sequences.

R. Fairless, H. Masius, A. Rohlmann, K. Heupel, M. Ahmad, C. Reissner, T. Dresbach, and M. Missler (2008)
J. Neurosci. 28, 12969-12981
 |  Abstract »  |  Full Text »  |  PDF »

SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis.

H.-W. Chao, C.-J. Hong, T.-N. Huang, Y.-L. Lin, and Y.-P. Hsueh (2008)
J. Cell Biol. 182, 141-155
 |  Abstract »  |  Full Text »  |  PDF »

Microtubules Have Opposite Orientation in Axons and Dendrites of Drosophila Neurons.

M. C. Stone, F. Roegiers, and M. M. Rolls (2008)
Mol. Biol. Cell 19, 4122-4129
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular Transport and Kinesin Superfamily Proteins, KIFs: Structure, Function, and Dynamics.

N. Hirokawa and Y. Noda (2008)
Physiol Rev 88, 1089-1118
 |  Abstract »  |  Full Text »  |  PDF »

Activation of 5-HT2A/C Receptors Counteracts 5-HT1A Regulation of N-Methyl-D-aspartate Receptor Channels in Pyramidal Neurons of Prefrontal Cortex.

E. Y. Yuen, Q. Jiang, P. Chen, J. Feng, and Z. Yan (2008)
J. Biol. Chem. 283, 17194-17204
 |  Abstract »  |  Full Text »  |  PDF »

Potassium Channels: Newly Found Players in Synaptic Plasticity.

J. Kim and D. A. Hoffman (2008)
Neuroscientist 14, 276-286
 |  Abstract »  |  PDF »

Lin-7 targets the Kir 2.3 channel on the basolateral membrane via a L27 domain interaction with CASK.

C. Alewine, B.-y. Kim, V. Hegde, and P. A. Welling (2007)
Am J Physiol Cell Physiol 293, C1733-C1741
 |  Abstract »  |  Full Text »  |  PDF »

CDK-5 Regulates the Abundance of GLR-1 Glutamate Receptors in the Ventral Cord of Caenorhabditis elegans.

P. Juo, T. Harbaugh, G. Garriga, and J. M. Kaplan (2007)
Mol. Biol. Cell 18, 3883-3893
 |  Abstract »  |  Full Text »  |  PDF »

MARCH-XI, a Novel Transmembrane Ubiquitin Ligase Implicated in Ubiquitin-dependent Protein Sorting in Developing Spermatids.

Y. Morokuma, N. Nakamura, A. Kato, M. Notoya, Y. Yamamoto, Y. Sakai, H. Fukuda, S. Yamashina, Y. Hirata, and S. Hirose (2007)
J. Biol. Chem. 282, 24806-24815
 |  Abstract »  |  Full Text »  |  PDF »

Synaptic Anchorage of AMPA Receptors by Cadherins through Neural Plakophilin-Related Arm Protein AMPA Receptor-Binding Protein Complexes.

J. B. Silverman, S. Restituito, W. Lu, L. Lee-Edwards, L. Khatri, and E. B. Ziff (2007)
J. Neurosci. 27, 8505-8516
 |  Abstract »  |  Full Text »  |  PDF »

Chronic Intermittent Ethanol Treatment Selectively Alters N-Methyl-D-aspartate Receptor Subunit Surface Expression in Cultured Cortical Neurons.

M. Qiang, A. D. Denny, and M. K. Ticku (2007)
Mol. Pharmacol. 72, 95-102
 |  Abstract »  |  Full Text »  |  PDF »

Glycogen Synthase Kinase 3 Regulates N-Methyl-D-aspartate Receptor Channel Trafficking and Function in Cortical Neurons.

P. Chen, Z. Gu, W. Liu, and Z. Yan (2007)
Mol. Pharmacol. 72, 40-51
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of cardiac potassium channel trafficking.

D. F. Steele, J. Eldstrom, and D. Fedida (2007)
J. Physiol. 582, 17-26
 |  Abstract »  |  Full Text »  |  PDF »

NXF2 is involved in cytoplasmic mRNA dynamics through interactions with motor proteins.

K. Takano, T. Miki, J. Katahira, and Y. Yoneda (2007)
Nucleic Acids Res. 35, 2513-2521
 |  Abstract »  |  Full Text »  |  PDF »

Missorting of Tau in Neurons Causes Degeneration of Synapses That Can Be Rescued by the Kinase MARK2/Par-1.

E. Thies and E.-M. Mandelkow (2007)
J. Neurosci. 27, 2896-2907
 |  Abstract »  |  Full Text »  |  PDF »

Loss of {alpha}-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function.

K. Ikegami, R. L. Heier, M. Taruishi, H. Takagi, M. Mukai, S. Shimma, S. Taira, K. Hatanaka, N. Morone, I. Yao, et al. (2007)
PNAS 104, 3213-3218
 |  Abstract »  |  Full Text »  |  PDF »

Deletion of CASK in mice is lethal and impairs synaptic function.

D. Atasoy, S. Schoch, A. Ho, K. A. Nadasy, X. Liu, W. Zhang, K. Mukherjee, E. D. Nosyreva, R. Fernandez-Chacon, M. Missler, et al. (2007)
PNAS 104, 2525-2530
 |  Abstract »  |  Full Text »  |  PDF »

Neuronal Polarity and the Kinesin Superfamily Proteins.

T. Nakata and N. Hirokawa (2007)
Sci. STKE 2007, pe6
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Analysis of Mint/X11 Proteins: Essential Presynaptic Functions of a Neuronal Adaptor Protein Family.

A. Ho, W. Morishita, D. Atasoy, X. Liu, K. Tabuchi, R. E. Hammer, R. C. Malenka, and T. C. Sudhof (2006)
J. Neurosci. 26, 13089-13101
 |  Abstract »  |  Full Text »  |  PDF »

TTLL7 Is a Mammalian beta-Tubulin Polyglutamylase Required for Growth of MAP2-positive Neurites.

K. Ikegami, M. Mukai, J.-i. Tsuchida, R. L. Heier, G. R. MacGregor, and M. Setou (2006)
J. Biol. Chem. 281, 30707-30716
 |  Abstract »  |  Full Text »  |  PDF »

TIP-1 Has PDZ Scaffold Antagonist Activity.

C. Alewine, O. Olsen, J. B. Wade, and P. A. Welling (2006)
Mol. Biol. Cell 17, 4200-4211
 |  Abstract »  |  Full Text »  |  PDF »

Autoinhibition regulates the motility of the C. elegans intraflagellar transport motor OSM-3.

M. Imanishi, N. F. Endres, A. Gennerich, and R. D. Vale (2006)
J. Cell Biol. 174, 931-937
 |  Abstract »  |  Full Text »  |  PDF »

Mapping the GRIF-1 Binding Domain of the Kinesin, KIF5C, Substantiates a Role for GRIF-1 as an Adaptor Protein in the Anterograde Trafficking of Cargoes.

M. J. Smith, K. Pozo, K. Brickley, and F. A. Stephenson (2006)
J. Biol. Chem. 281, 27216-27228
 |  Abstract »  |  Full Text »  |  PDF »

Myosin motor Myo1c and its receptor NEMO/IKK-{gamma} promote TNF-{alpha}-induced serine307 phosphorylation of IRS-1.

Y. Nakamori, M. Emoto, N. Fukuda, A. Taguchi, S. Okuya, M. Tajiri, M. Miyagishi, K. Taira, Y. Wada, and Y. Tanizawa (2006)
J. Cell Biol. 173, 665-671
 |  Abstract »  |  Full Text »  |  PDF »

Dopamine D1 activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit trafficking..

P. J. Hallett, R. Spoelgen, B. T. Hyman, D. G. Standaert, and A. W. Dunah (2006)
J. Neurosci. 26, 4690-4700
 |  Abstract »  |  Full Text »  |  PDF »

G{gamma}13 Interacts with PDZ Domain-containing Proteins.

Z. Li, O. Benard, and R. F. Margolskee (2006)
J. Biol. Chem. 281, 11066-11073
 |  Abstract »  |  Full Text »  |  PDF »

Brain Corticosteroid Receptor Dynamics and Trafficking: Implications from Live Cell Imaging.

M. Nishi and M. Kawata (2006)
Neuroscientist 12, 119-133
 |  Abstract »  |  PDF »

Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy..

K. Boekhoorn, D. Terwel, B. Biemans, P. Borghgraef, O. Wiegert, G. J. A. Ramakers, K. de Vos, H. Krugers, T. Tomiyama, H. Mori, et al. (2006)
J. Neurosci. 26, 3514-3523
 |  Abstract »  |  Full Text »  |  PDF »

A role for Sec8 in oligodendrocyte morphological differentiation.

M. Anitei, M. Ifrim, M.-A. Ewart, A. E. Cowan, J. H. Carson, R. Bansal, and S. E. Pfeiffer (2006)
J. Cell Sci. 119, 807-818
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Myosin Vb in Glutamate Receptor Trafficking.

M.-F. Lise, T. P. Wong, A. Trinh, R. M. Hines, L. Liu, R. Kang, D. J. Hines, J. Lu, J. R. Goldenring, Y. T. Wang, et al. (2006)
J. Biol. Chem. 281, 3669-3678
 |  Abstract »  |  Full Text »  |  PDF »

MKLP1 requires specific domains for its dendritic targeting.

X. Xu, C. He, Z. Zhang, and Y. Chen (2006)
J. Cell Sci. 119, 452-458
 |  Abstract »  |  Full Text »  |  PDF »

Neuronal cotransport of glycine receptor and the scaffold protein gephyrin.

C. Maas, N. Tagnaouti, S. Loebrich, B. Behrend, C. Lappe-Siefke, and M. Kneussel (2006)
J. Cell Biol. 172, 441-451
 |  Abstract »  |  Full Text »  |  PDF »

A Role for Kif17 in Transport of Kv4.2.

P.-J. Chu, J. F. Rivera, and D. B. Arnold (2006)
J. Biol. Chem. 281, 365-373
 |  Abstract »  |  Full Text »  |  PDF »

Upregulation of Forebrain NMDA NR2B Receptors Contributes to Behavioral Sensitization after Inflammation.

L.-J. Wu, H. Toyoda, M.-G. Zhao, Y.-S. Lee, J. Tang, S. W. Ko, Y. H. Jia, F. W. F. Shum, C. V. Zerbinatti, G. Bu, et al. (2005)
J. Neurosci. 25, 11107-11116
 |  Abstract »  |  Full Text »  |  PDF »

Neurotransmitter release regulated by a MALS-liprin-{alpha} presynaptic complex.

O. Olsen, K. A. Moore, M. Fukata, T. Kazuta, J. C. Trinidad, F. W. Kauer, M. Streuli, H. Misawa, A. L. Burlingame, R. A. Nicoll, et al. (2005)
J. Cell Biol. 170, 1127-1134
 |  Abstract »  |  Full Text »  |  PDF »

Syntabulin-mediated anterograde transport of mitochondria along neuronal processes.

Q. Cai, C. Gerwin, and Z.-H. Sheng (2005)
J. Cell Biol. 170, 959-969
 |  Abstract »  |  Full Text »  |  PDF »

Microtubule Regulation of N-Methyl-D-aspartate Receptor Channels in Neurons.

E. Y. Yuen, Q. Jiang, J. Feng, and Z. Yan (2005)
J. Biol. Chem. 280, 29420-29427
 |  Abstract »  |  Full Text »  |  PDF »

Serotonin 5-HT1A Receptors Regulate NMDA Receptor Channels through a Microtubule-Dependent Mechanism.

E. Y. Yuen, Q. Jiang, P. Chen, Z. Gu, J. Feng, and Z. Yan (2005)
J. Neurosci. 25, 5488-5501
 |  Abstract »  |  Full Text »  |  PDF »

A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins.

W. Feng, J.-f. Long, and M. Zhang (2005)
PNAS 102, 6861-6866
 |  Abstract »  |  Full Text »  |  PDF »

GRIF-1 and OIP106, Members of a Novel Gene Family of Coiled-Coil Domain Proteins: ASSOCIATION IN VIVO AND IN VITRO WITH KINESIN.

K. Brickley, M. J. Smith, M. Beck, and F. A. Stephenson (2005)
J. Biol. Chem. 280, 14723-14732
 |  Abstract »  |  Full Text »  |  PDF »

RNA Interference-mediated Silencing of X11{alpha} and X11{beta} Attenuates Amyloid {beta}-Protein Levels via Differential Effects on {beta}-Amyloid Precursor Protein Processing.

Z. Xie, D. M. Romano, and R. E. Tanzi (2005)
J. Biol. Chem. 280, 15413-15421
 |  Abstract »  |  Full Text »  |  PDF »

Distinct LIN-10 Domains Are Required for Its Neuronal Function, Its Epithelial Function, and Its Synaptic Localization.

D. R. Glodowski, T. Wright, K. Martinowich, H. C.-H. Chang, D. Beach, and C. Rongo (2005)
Mol. Biol. Cell 16, 1417-1426
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Phenylalanine-Based Targeting Signal Directs Telencephalin to Neuronal Dendrites.

S. Mitsui, M. Saito, K. Hayashi, K. Mori, and Y. Yoshihara (2005)
J. Neurosci. 25, 1122-1131
 |  Abstract »  |  Full Text »  |  PDF »

Caenorhabditis elegans as a Model to Study Renal Development and Disease: Sexy Cilia.

M. M. Barr (2005)
J. Am. Soc. Nephrol. 16, 305-312
 |  Abstract »  |  Full Text »  |  PDF »

Differential localization of mammalian Lin-7 (MALS/Veli) PDZ proteins in the kidney.

O. Olsen, J. B. Wade, N. Morin, D. S. Bredt, and P. A. Welling (2005)
Am J Physiol Renal Physiol 288, F345-F352
 |  Abstract »  |  Full Text »  |  PDF »

Polarized sorting in epithelial cells: raft clustering and the biogenesis of the apical membrane.

S. Schuck and K. Simons (2004)
J. Cell Sci. 117, 5955-5964
 |  Abstract »  |  Full Text »  |  PDF »

Cycling of NMDA Receptors during Trafficking in Neurons before Synapse Formation.

P. Washbourne, X.-B. Liu, E. G. Jones, and A. K. McAllister (2004)
J. Neurosci. 24, 8253-8264
 |  Abstract »  |  Full Text »  |  PDF »

Single nucleotide polymorphism (SNP) analysis of mouse quantitative trait loci for identification of candidate genes.

Y Yan, M Wang, W J Lemon, and M You (2004)
J. Med. Genet. 41, e111
 |  Full Text »  |  PDF »

Distribution and functions of kinectin isoforms.

N. Santama, C. P. N. Er, L.-L. Ong, and H. Yu (2004)
J. Cell Sci. 117, 4537-4549
 |  Abstract »  |  Full Text »  |  PDF »

Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating {gamma}-aminobutyric acid type A receptor membrane trafficking.

J. T. Kittler, P. Thomas, V. Tretter, Y. D. Bogdanov, V. Haucke, T. G. Smart, and S. J. Moss (2004)
PNAS 101, 12736-12741
 |  Abstract »  |  Full Text »  |  PDF »

NMDA Receptor GluR{epsilon}/NR2 Subunits Are Essential for Postsynaptic Localization and Protein Stability of GluR{zeta}1/NR1 Subunit.

M. Abe, M. Fukaya, T. Yagi, M. Mishina, M. Watanabe, and K. Sakimura (2004)
J. Neurosci. 24, 7292-7304
 |  Abstract »  |  Full Text »  |  PDF »

Protein Trafficking and Anchoring Complexes Revealed by Proteomic Analysis of Inward Rectifier Potassium Channel (Kir2.x)-associated Proteins.

D. Leonoudakis, L. R. Conti, S. Anderson, C. M. Radeke, L. M. M. McGuire, M. E. Adams, S. C. Froehner, J. R. Yates III, and C. A. Vandenberg (2004)
J. Biol. Chem. 279, 22331-22346
 |  Abstract »  |  Full Text »  |  PDF »

Facilitation of Stress-induced Phosphorylation of {beta}-Amyloid Precursor Protein Family Members by X11-like/Mint2 Protein.

H. Taru and T. Suzuki (2004)
J. Biol. Chem. 279, 21628-21636
 |  Abstract »  |  Full Text »  |  PDF »

A Multiprotein Trafficking Complex Composed of SAP97, CASK, Veli, and Mint1 Is Associated with Inward Rectifier Kir2 Potassium Channels.

D. Leonoudakis, L. R. Conti, C. M. Radeke, L. M. M. McGuire, and C. A. Vandenberg (2004)
J. Biol. Chem. 279, 19051-19063
 |  Abstract »  |  Full Text »  |  PDF »

Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97.

A. Bachmann, M. Timmer, J. Sierralta, G. Pietrini, E. D. Gundelfinger, E. Knust, and U. Thomas (2004)
J. Cell Sci. 117, 1899-1909
 |  Abstract »  |  Full Text »  |  PDF »

Functions of lipoprotein receptors in neurons.

U. Beffert, P. C. Stolt, and J. Herz (2004)
J. Lipid Res. 45, 403-409
 |  Abstract »  |  Full Text »  |  PDF »

Postsynaptic Density Assembly Is Fundamentally Different from Presynaptic Active Zone Assembly.

T. Bresler, M. Shapira, T. Boeckers, T. Dresbach, M. Futter, C. C. Garner, K. Rosenblum, E. D. Gundelfinger, and N. E. Ziv (2004)
J. Neurosci. 24, 1507-1520
 |  Abstract »  |  Full Text »  |  PDF »

Trans-Golgi network delivery of synaptic proteins in synaptogenesis.

V. Sytnyk, I. Leshchyns'ka, A. Dityatev, and M. Schachner (2004)
J. Cell Sci. 117, 381-388
 |  Abstract »  |  Full Text »  |  PDF »

Intraflagellar transport (IFT) cargo: IFT transports flagellar precursors to the tip and turnover products to the cell body.

H. Qin, D. R. Diener, S. Geimer, D. G. Cole, and J. L. Rosenbaum (2004)
J. Cell Biol. 164, 255-266
 |  Abstract »  |  Full Text »  |  PDF »

Dopamine D1-Dependent Trafficking of Striatal N-Methyl-D-aspartate Glutamate Receptors Requires Fyn Protein Tyrosine Kinase but Not DARPP-32.

A. W. Dunah, A. C. Sirianni, A. A. Fienberg, E. Bastia, M. A. Schwarzschild, and David. G. Standaert (2004)
Mol. Pharmacol. 65, 121-129
 |  Abstract »  |  Full Text »  |  PDF »

The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells.

V. Chennathukuzhi, C. R. Morales, M. El-Alfy, and N. B. Hecht (2003)
PNAS 100, 15566-15571
 |  Abstract »  |  Full Text »  |  PDF »

Active surface transport of metabotropic glutamate receptors through binding to microtubules and actin flow.

A. Serge, L. Fourgeaud, A. Hemar, and D. Choquet (2003)
J. Cell Sci. 116, 5015-5022
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Dystrobrevin interacts directly with kinesin heavy chain in brain.

P. Macioce, G. Gambara, M. Bernassola, L. Gaddini, P. Torreri, G. Macchia, C. Ramoni, M. Ceccarini, and T. C. Petrucci (2003)
J. Cell Sci. 116, 4847-4856
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The Neuronal Adaptor Protein X11{alpha} Reduces A{beta} Levels in the Brains of Alzheimer's APPswe Tg2576 Transgenic Mice.

J.-H. Lee, K.-F. Lau, M. S. Perkinton, C. L. Standen, S. J. A. Shemilt, L. Mercken, J. D. Cooper, D. M. McLoughlin, and C. C. J. Miller (2003)
J. Biol. Chem. 278, 47025-47029
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PDZ Domain-mediated Interaction of Interleukin-16 Precursor Proteins with Myosin Phosphatase Targeting Subunits.

N. Bannert, K. Vollhardt, B. Asomuddinov, M. Haag, H. Konig, S. Norley, and R. Kurth (2003)
J. Biol. Chem. 278, 42190-42199
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Munc18 Interacting Proteins: ADP-RIBOSYLATION FACTOR-DEPENDENT COAT PROTEINS THAT REGULATE THE TRAFFIC OF {beta}-ALZHEIMER'S PRECURSOR PROTEIN.

K. Hill, Y. Li, M. Bennett, M. McKay, X. Zhu, J. Shern, E. Torre, J. J. Lah, A. I. Levey, and R. A. Kahn (2003)
J. Biol. Chem. 278, 36032-36040
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Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head.

T. Nakata and N. Hirokawa (2003)
J. Cell Biol. 162, 1045-1055
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IFT20 Links Kinesin II with a Mammalian Intraflagellar Transport Complex That Is Conserved in Motile Flagella and Sensory Cilia.

S. A. Baker, K. Freeman, K. Luby-Phelps, G. J. Pazour, and J. C. Besharse (2003)
J. Biol. Chem. 278, 34211-34218
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Kinectin Anchors the Translation Elongation Factor-1{delta} to the Endoplasmic Reticulum.

L.-L. Ong, C. P. N. Er, A. Ho, M. T. Aung, and H. Yu (2003)
J. Biol. Chem. 278, 32115-32123
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Regulation of early endocytic vesicle motility and fission in a reconstituted system.

E. Bananis, J. W. Murray, R. J. Stockert, P. Satir, and A. W. Wolkoff (2003)
J. Cell Sci. 116, 2749-2761
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A Scaffold Protein JIP-1b Enhances Amyloid Precursor Protein Phosphorylation by JNK and Its Association with Kinesin Light Chain 1.

H. Inomata, Y. Nakamura, A. Hayakawa, H. Takata, T. Suzuki, K. Miyazawa, and N. Kitamura (2003)
J. Biol. Chem. 278, 22946-22955
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Kinesin Superfamily Proteins (KIFs) in the Mouse Transcriptome.

H. Miki, M. Setou, RIKEN GER Group, GSL Members, and N. Hirokawa (2003)
Genome Res. 13, 1455-1465
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Trafficking of signaling modules by kinesin motors.

B. J. Schnapp (2003)
J. Cell Sci. 116, 2125-2135
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PDZ Domain Proteins: Plug and Play!.

C. Nourry, S. G. N. Grant, and J.-P. Borg (2003)
Sci. STKE 2003, re7
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Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice.

M. Fukaya, A. Kato, C. Lovett, S. Tonegawa, and M. Watanabe (2003)
PNAS 100, 4855-4860
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