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Science 288 (5475): 2357-2360

Copyright © 2000 by the American Association for the Advancement of Science

Cross Talk Between Interferon-gamma and -alpha /beta Signaling Components in Caveolar Membrane Domains

Akinori Takaoka, 1 Yukiko Mitani, 1 Hirofumi Suemori, 2 Mitsuharu Sato, 1 Taeko Yokochi, 1 Shigeru Noguchi, 2 Nobuyuki Tanaka, 1 Tadatsugu Taniguchi 1*

Definition of cellular responses to cytokines often involves cross-communication through their respective receptors. Here, signaling by interferon-gamma (IFN-gamma ) is shown to depend on the IFN-alpha /beta receptor components. Although these IFNs transmit signals through distinct receptor complexes, the IFN-alpha /beta receptor component, IFNAR1, facilitates efficient assembly of IFN-gamma -activated transcription factors. This cross talk is contingent on a constitutive subthreshold IFN-alpha /beta signaling and the association between the two nonligand-binding receptor components, IFNAR1 and IFNGR2, in the caveolar membrane domains. This aspect of signaling cross talk by IFNs may apply to other cytokines.

1 Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
2 Meiji Institute of Health Science, Meiji Milk Products, Naruda 540, Odawara-shi, Kanagawa 250-0862, Japan.
*   To whom correspondence should be addressed. E-mail: tada{at}m.u-tokyo.ac.jp


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
Differential localization of IL-2- and -15 receptor chains in membrane rafts of human T cells.
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J. Leukoc. Biol. 72, 199-206
   Abstract »    Full Text »    PDF »
Cytokine Signaling: STATS IN PLASMA MEMBRANE RAFTS.
P. B. Sehgal, G. G. Guo, M. Shah, V. Kumar, and K. Patel (2002)
J. Biol. Chem. 277, 12067-12074
   Abstract »    Full Text »    PDF »
Down-modulation of Type 1 Interferon Responses by Receptor Cross-competition for a Shared Jak Kinase.
E. Dondi, E. Pattyn, G. Lutfalla, X. Van Ostade, G. Uze, S. Pellegrini, and J. Tavernier (2001)
J. Biol. Chem. 276, 47004-47012
   Abstract »    Full Text »    PDF »
A completely foreign receptor can mediate an interferon-{gamma}-like response.
B. Strobl, V. Arulampalam, H. Is'harc, S. J. Newman, J. F. Schlaak, D. Watling, A. P. Costa-Pereira, F. Schaper, I. Behrmann, K. C. F. Sheehan, et al. (2001)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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T. Falguieres, F. Mallard, C. Baron, D. Hanau, C. Lingwood, B. Goud, J. Salamero, and L. Johannes (2001)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
Interferon resistance of cutaneous T-cell lymphoma-derived clonal T-helper 2 cells allows selective viral replication.
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
The Receptor Interaction Region of Tyk2 Contains a Motif Required for Its Nuclear Localization.
J. Ragimbeau, E. Dondi, A. Vasserot, P. Romero, G. Uze, and S. Pellegrini (2001)
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M. Matsumoto, K. Hisatake, Y. Nogi, and M. Tsujimoto (2001)
J. Biol. Chem. 276, 33086-33092
   Abstract »    Full Text »    PDF »
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T. C. Wagner, S. Velichko, D. Vogel, M. R. S. Rani, S. Leung, R. M. Ransohoff, G. R. Stark, H. D. Perez, and E. Croze (2002)
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   Abstract »    Full Text »    PDF »

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