Leslie van der Fits, Johan Memelink ^*

Biosynthesis of many classes of secondary metabolites in plants is induced by the stress hormone jasmonate. The gene for ORCA3, a jasmonate-responsive APETALA2 (AP2)-domain transcription factor from Catharanthus roseus, was isolated by transferred DNA activation tagging. Orca3 overexpression resulted in enhanced expression of several metabolite biosynthetic genes and, consequently, in increased accumulation of terpenoid indole alkaloids. Regulation of metabolite biosynthetic genes by jasmonate-responsive AP2-domain transcription factors may link plant stress responses to changes in metabolism.

Institute of Molecular Plant Sciences, Clusius Laboratory, Leiden University, Wassenaarseweg 64, 2333 AL, Leiden, Netherlands.
^*   To whom correspondence should be addressed. E-mail: Memelink{at}Rulbim.Leidenuniv.nl

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C. Wasternack and B. Hause (2013)
Ann. Bot. 111, 1021-1058
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Divergent DNA-Binding Specificities of a Group of ETHYLENE RESPONSE FACTOR Transcription Factors Involved in Plant Defense.

T. Shoji, M. Mishima, and T. Hashimoto (2013)
Plant Physiology 162, 977-990
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The R2R3-MYB-Like Regulatory Factor EOBI, Acting Downstream of EOBII, Regulates Scent Production by Activating ODO1 and Structural Scent-Related Genes in Petunia.

B. Spitzer-Rimon, M. Farhi, B. Albo, A. Cna'ani, M. M. Ben Zvi, T. Masci, O. Edelbaum, Y. Yu, E. Shklarman, M. Ovadis, et al. (2012)
PLANT CELL 24, 5089-5105
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Arabidopsis MYC2 Interacts with DELLA Proteins in Regulating Sesquiterpene Synthase Gene Expression.

G.-J. Hong, X.-Y. Xue, Y.-B. Mao, L.-J. Wang, and X.-Y. Chen (2012)
PLANT CELL 24, 2635-2648
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The Jasmonate-Responsive AP2/ERF Transcription Factors AaERF1 and AaERF2 Positively Regulate Artemisinin Biosynthesis in Artemisia annua L..

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The Transcription Factor CrWRKY1 Positively Regulates the Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus.

N. Suttipanta, S. Pattanaik, M. Kulshrestha, B. Patra, S. K. Singh, and L. Yuan (2011)
Plant Physiology 157, 2081-2093
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Dispersed Benzoxazinone Gene Cluster: Molecular Characterization and Chromosomal Localization of Glucosyltransferase and Glucosidase Genes in Wheat and Rye.

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Plant Physiology 157, 985-997
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Clustered Transcription Factor Genes Regulate Nicotine Biosynthesis in Tobacco.

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The Arabidopsis thaliana STYLISH1 Protein Acts as a Transcriptional Activator Regulating Auxin Biosynthesis.

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SodERF3, a Novel Sugarcane Ethylene Responsive Factor (ERF), Enhances Salt and Drought Tolerance when Overexpressed in Tobacco Plants.

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General Detoxification and Stress Responses Are Mediated by Oxidized Lipids through TGA Transcription Factors in Arabidopsis.

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Molecular Cloning and Characterization of a Vacuolar Class III Peroxidase Involved in the Metabolism of Anticancer Alkaloids in Catharanthus roseus.

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Plant Physiology 146, 403-417
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Identification of a Bipartite Jasmonate-Responsive Promoter Element in the Catharanthus roseus ORCA3 Transcription Factor Gene That Interacts Specifically with AT-Hook DNA-Binding Proteins.

D. Vom Endt, M. Soares e Silva, J. W. Kijne, G. Pasquali, and J. Memelink (2007)
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Identification of a WRKY Protein as a Transcriptional Regulator of Benzylisoquinoline Alkaloid Biosynthesis in Coptis japonica.

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Plant Cell Physiol. 48, 8-18
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Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells.

H. Rischer, M. Oresic, T. Seppanen-Laakso, M. Katajamaa, F. Lammertyn, W. Ardiles-Diaz, M. C. E. Van Montagu, D. Inze, K.-M. Oksman-Caldentey, and A. Goossens (2006)
PNAS 103, 5614-5619
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Genome-Wide Analysis of the ERF Gene Family in Arabidopsis and Rice.

T. Nakano, K. Suzuki, T. Fujimura, and H. Shinshi (2006)
Plant Physiology 140, 411-432
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European plant science: a field of opportunities.

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Functional Analysis of Arabidopsis Ethylene-Responsive Element Binding Protein Conferring Resistance to Bax and Abiotic Stress-Induced Plant Cell Death.

T. Ogawa, L. Pan, M. Kawai-Yamada, L.-H. Yu, S. Yamamura, T. Koyama, S. Kitajima, M. Ohme-Takagi, F. Sato, and H. Uchimiya (2005)
Plant Physiology 138, 1436-1445
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Zinc Finger Proteins Act as Transcriptional Repressors of Alkaloid Biosynthesis Genes in Catharanthus roseus.

B. Pauw, F. A. O. Hilliou, V. S. Martin, G. Chatel, C. J. F. de Wolf, A. Champion, M. Pre, B. van Duijn, J. W. Kijne, L. van der Fits, et al. (2004)
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Conserved MYC transcription factors play a key role in jasmonate signaling both in tomato and Arabidopsis.

M. Boter, O. Ruiz-Rivero, A. Abdeen, and S. Prat (2004)
Genes & Dev. 18, 1577-1591
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JASMONATE-INSENSITIVE1 Encodes a MYC Transcription Factor Essential to Discriminate between Different Jasmonate-Regulated Defense Responses in Arabidopsis.

O. Lorenzo, J. M. Chico, J. J. Sanchez-Serrano, and R. Solano (2004)
PLANT CELL 16, 1938-1950
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Jasmonate and ethylene signalling and their interaction are integral parts of the elicitor signalling pathway leading to {beta}-thujaplicin biosynthesis in Cupressus lusitanica cell cultures.

J. Zhao, S.-H. Zheng, K. Fujita, and K. Sakai (2004)
J. Exp. Bot. 55, 1003-1012
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WIN1, a transcriptional activator of epidermal wax accumulation in Arabidopsis.

P. Broun, P. Poindexter, E. Osborne, C.-Z. Jiang, and J. L. Riechmann (2004)
PNAS 101, 4706-4711
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Activation Tagging in Tomato Identifies a Transcriptional Regulator of Anthocyanin Biosynthesis, Modification, and Transport.

H. Mathews, S. K. Clendennen, C. G. Caldwell, X. L. Liu, K. Connors, N. Matheis, D. K. Schuster, D. J. Menasco, W. Wagoner, J. Lightner, et al. (2003)
PLANT CELL 15, 1689-1703
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A functional genomics approach toward the understanding of secondary metabolism in plant cells.

A. Goossens, S. T. Hakkinen, I. Laakso, T. Seppanen-Laakso, S. Biondi, V. De Sutter, F. Lammertyn, A. M. Nuutila, H. Soderlund, M. Zabeau, et al. (2003)
PNAS 100, 8595-8600
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A Role for the GCC-Box in Jasmonate-Mediated Activation of the PDF1.2 Gene of Arabidopsis.

R. L. Brown, K. Kazan, K. C. McGrath, D. J. Maclean, and J. M. Manners (2003)
Plant Physiology 132, 1020-1032
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Camptothecin Biosynthetic Genes in Hairy Roots of Ophiorrhiza pumila: Cloning, Characterization and Differential Expression in Tissues and by Stress Compounds.

Y. Yamazaki, H. Sudo, M. Yamazaki, N. Aimi, and K. Saito (2003)
Plant Cell Physiol. 44, 395-403
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A jasmonate-responsive element within the A. thaliana vsp1 promoter.

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Multiple signalling pathways mediate fungal elicitor-induced {beta}-thujaplicin biosynthesis in Cupressus lusitanica cell cultures.

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J. Exp. Bot. 54, 647-656
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ETHYLENE RESPONSE FACTOR1 Integrates Signals from Ethylene and Jasmonate Pathways in Plant Defense.

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PLANT CELL 15, 165-178
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T-DNA Insertional Mutagenesis for Activation Tagging in Rice.

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Plant Physiology 130, 1636-1644
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Activation Tagging Using the En-I Maize Transposon System in Arabidopsis.

N. Marsch-Martinez, R. Greco, G. Van Arkel, L. Herrera-Estrella, and A. Pereira (2002)
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The Jasmonate Pathway.

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The Jasmonate Signal Pathway.

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PLANT CELL 14, S153-S164
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Plant defense in the absence of jasmonic acid: The role of cyclopentenones.

A. Stintzi, H. Weber, P. Reymond, J. Browse, and E. E. Farmer (2001)
PNAS 98, 12837-12842
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Progress in plant metabolic engineering.

P. Broun and C. Somerville (2001)
PNAS 98, 8925-8927
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Plant Metabolic Engineering.

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Plant Physiology 125, 160-163
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Activation Tagging Identifies a Conserved MYB Regulator of Phenylpropanoid Biosynthesis.

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PLANT CELL 12, 2383-2394
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Plant defense in the absence of jasmonic acid: The role of cyclopentenones.

A. Stintzi, H. Weber, P. Reymond, J. Browse, and E. E. Farmer (2001)
PNAS 98, 12837-12842
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Identification of Arabidopsis Ethylene-Responsive Element Binding Factors with Distinct Induction Kinetics after Pathogen Infection.

L. Onate-Sanchez and K. B. Singh (2002)
Plant Physiology 128, 1313-1322
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