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Science 289 (5480): 768-771

Copyright © 2000 by the American Association for the Advancement of Science

Cloning of the Arabidopsis Clock Gene TOC1, an Autoregulatory Response Regulator Homolog

Carl Strayer,12 Tokitaka Oyama,1 Thomas F. Schultz,1 Ramanujam Raman,1 David E. Somers,1* Paloma Más,1 Satchidananda Panda,1 Joel A. Kreps,1 Steve A. Kay1dagger ddagger

The toc1 mutation causes shortened circadian rhythms in light-grown Arabidopsis plants. Here, we report the same toc1 effect in the absence of light input to the clock. We also show that TOC1 controls photoperiodic flowering response through clock function. The TOC1 gene was isolated and found to encode a nuclear protein containing an atypical response regulator receiver domain and two motifs that suggest a role in transcriptional regulation: a basic motif conserved within the CONSTANS family of transcription factors and an acidic domain. TOC1 is itself circadianly regulated and participates in a feedback loop to control its own expression.

1 Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
2 Department of Biology, University of Virginia, Charlottesville, VA 22903, USA.
*   Present address: Department of Plant Biology, Ohio State University, Columbus, OH 43210, USA.

dagger    Present address: Novartis Agricultural Discovery Institute, San Diego, CA 92121, USA.

ddagger    To whom correspondence should be addressed. E-mail: stevek{at}

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TIME FOR COFFEE Encodes a Nuclear Regulator in the Arabidopsis thaliana Circadian Clock.
Z. Ding, A. J. Millar, A. M. Davis, and S. J. Davis (2007)
PLANT CELL 19, 1522-1536
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882