Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 289 (5482): 1202-1206

Copyright © 2000 by the American Association for the Advancement of Science

Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3

G. Angus McQuibban,1 Jiang-Hong Gong,2 Eric M. Tam,1 Christopher A. G. McCulloch,4 Ian Clark-Lewis,2 Christopher M. Overall13*

Tissue degradation by the matrix metalloproteinase gelatinase A is pivotal to inflammation and metastases. Recognizing the catalytic importance of substrate-binding exosites outside the catalytic domain, we screened for extracellular substrates using the gelatinase A hemopexin domain as bait in the yeast two-hybrid system. Monocyte chemoattractant protein-3 (MCP-3) was identified as a physiological substrate of gelatinase A. Cleaved MCP-3 binds to CC-chemokine receptors-1, -2, and -3, but no longer induces calcium fluxes or promotes chemotaxis, and instead acts as a general chemokine antagonist that dampens inflammation. This suggests that matrix metalloproteinases are both effectors and regulators of the inflammatory response.

1 Department of Biochemistry and Molecular Biology,
2 Biomedical Research Centre,
3 Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
4 Medical Research Council Group in Periodontal Physiology, University of Toronto, Toronto, ON M5S 3E8, Canada.
*   To whom correspondence should be addressed. E-mail: overall{at}interchange.ubc.ca


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Diverse macrophage populations mediate acute lung inflammation and resolution.
N. R. Aggarwal, L. S. King, and F. R. D'Alessio (2014)
Am J Physiol Lung Cell Mol Physiol 306, L709-L725
   Abstract »    Full Text »    PDF »
Diverse functions of matrix metalloproteinases during fibrosis.
M. Giannandrea and W. C. Parks (2014)
Dis. Model. Mech. 7, 193-203
   Abstract »    Full Text »    PDF »
MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis.
S. A. Gharib, L. K. Johnston, I. Huizar, T. P. Birkland, J. Hanson, Y. Wang, W. C. Parks, and A. M. Manicone (2014)
J. Leukoc. Biol. 95, 9-18
   Abstract »    Full Text »    PDF »
Protein Engineering for Cardiovascular Therapeutics: Untapped Potential for Cardiac Repair.
S. M. Jay and R. T. Lee (2013)
Circ. Res. 113, 933-943
   Abstract »    Full Text »    PDF »
Resolution of inflammation: an integrated view.
A. Ortega-Gomez, M. Perretti, and O. Soehnlein (2013)
EMBO Mol Med. 5, 661-674
   Abstract »    Full Text »    PDF »
Systems-Level Analysis of Proteolytic Events in Increased Vascular Permeability and Complement Activation in Skin Inflammation.
U. auf dem Keller, A. Prudova, U. Eckhard, B. Fingleton, and C. M. Overall (2013)
Science Signaling 6, rs2
   Abstract »    Full Text »    PDF »
In Vivo Processing of CXCL5 (LIX) by Matrix Metalloproteinase (MMP)-2 and MMP-9 Promotes Early Neutrophil Recruitment in IL-1{beta}-Induced Peritonitis.
J. Song, C. Wu, X. Zhang, and L. M. Sorokin (2013)
J. Immunol. 190, 401-410
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinase 9 (MMP-9)-dependent Processing of {beta}ig-h3 Protein Regulates Cell Migration, Invasion, and Adhesion.
Y. H. Kim, H.-J. Kwon, and D.-S. Kim (2012)
J. Biol. Chem. 287, 38957-38969
   Abstract »    Full Text »    PDF »
Control of Allergen-Induced Inflammation and Hyperresponsiveness by the Metalloproteinase ADAMTS-12.
G. Paulissen, M. El Hour, N. Rocks, M. M. Gueders, F. Bureau, J.-M. Foidart, C. Lopez-Otin, A. Noel, and D. D. Cataldo (2012)
J. Immunol. 189, 4135-4143
   Abstract »    Full Text »    PDF »
Matrix metalloproteinases and their inhibitors in pulmonary hypertension.
P. Chelladurai, W. Seeger, and S. S. Pullamsetti (2012)
Eur. Respir. J. 40, 766-782
   Abstract »    Full Text »    PDF »
The porphyrin TmPyP4 unfolds the extremely stable G-quadruplex in MT3-MMP mRNA and alleviates its repressive effect to enhance translation in eukaryotic cells.
M. J. Morris, K. L. Wingate, J. Silwal, T. C. Leeper, and S. Basu (2012)
Nucleic Acids Res. 40, 4137-4145
   Abstract »    Full Text »    PDF »
Biochemical Characterization and N-terminomics Analysis of Leukolysin, the Membrane-type 6 Matrix Metalloprotease (MMP25): CHEMOKINE AND VIMENTIN CLEAVAGES ENHANCE CELL MIGRATION AND MACROPHAGE PHAGOCYTIC ACTIVITIES.
A. E. Starr, C. L. Bellac, A. Dufour, V. Goebeler, and C. M. Overall (2012)
J. Biol. Chem. 287, 13382-13395
   Abstract »    Full Text »    PDF »
Biochemical Analysis of Matrix Metalloproteinase Activation of Chemokines CCL15 and CCL23 and Increased Glycosaminoglycan Binding of CCL16.
A. E. Starr, A. Dufour, J. Maier, and C. M. Overall (2012)
J. Biol. Chem. 287, 5848-5860
   Abstract »    Full Text »    PDF »
Matrix metalloproteinases in COPD.
A. Churg, S. Zhou, and J. L. Wright (2012)
Eur. Respir. J. 39, 197-209
   Abstract »    Full Text »    PDF »
TopFIND 2.0--linking protein termini with proteolytic processing and modifications altering protein function.
P. F. Lange, P. F. Huesgen, and C. M. Overall (2012)
Nucleic Acids Res. 40, D351-D361
   Abstract »    Full Text »    PDF »
Microarray and Proteomic Analysis of Breast Cancer Cell and Osteoblast Co-cultures: ROLE OF OSTEOBLAST MATRIX METALLOPROTEINASE (MMP)-13 IN BONE METASTASIS.
C. Morrison, S. Mancini, J. Cipollone, R. Kappelhoff, C. Roskelley, and C. Overall (2011)
J. Biol. Chem. 286, 34271-34285
   Abstract »    Full Text »    PDF »
Functional Genomics Reveals the Induction of Inflammatory Response and Metalloproteinase Gene Expression during Lethal Ebola Virus Infection.
C. Cilloniz, H. Ebihara, C. Ni, G. Neumann, M. J. Korth, S. M. Kelly, Y. Kawaoka, H. Feldmann, and M. G. Katze (2011)
J. Virol. 85, 9060-9068
   Abstract »    Full Text »    PDF »
Small-Molecule Anticancer Compounds Selectively Target the Hemopexin Domain of Matrix Metalloproteinase-9.
A. Dufour, N. S. Sampson, J. Li, C. Kuscu, R. C. Rizzo, J. L. DeLeon, J. Zhi, N. Jaber, E. Liu, S. Zucker, et al. (2011)
Cancer Res. 71, 4977-4988
   Abstract »    Full Text »    PDF »
Biological role of matrix metalloproteinases: a critical balance.
S. Loffek, O. Schilling, and C.-W. Franzke (2011)
Eur. Respir. J. 38, 191-208
   Abstract »    Full Text »    PDF »
Changes in Matrix Metalloproteinase Network in a Spontaneous Autoimmune Uveitis Model.
F. Hofmaier, S. M. Hauck, B. Amann, R. L. Degroote, and C. A. Deeg (2011)
Invest. Ophthalmol. Vis. Sci. 52, 2314-2320
   Abstract »    Full Text »    PDF »
A Statistics-based Platform for Quantitative N-terminome Analysis and Identification of Protease Cleavage Products.
U. auf dem Keller, A. Prudova, M. Gioia, G. S. Butler, and C. M. Overall (2010)
Mol. Cell. Proteomics 9, 912-927
   Abstract »    Full Text »    PDF »
Altered lymphocyte trafficking and diminished airway reactivity in transgenic mice expressing human MMP-9 in a mouse model of asthma.
D. Mehra, D. I. Sternberg, Y. Jia, S. Canfield, V. Lemaitre, T. Nkyimbeng, J. Wilder, J. Sonett, and J. D'Armiento (2010)
Am J Physiol Lung Cell Mol Physiol 298, L189-L196
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinase-8 and the Regulation of Blood Pressure, Vascular Inflammation, and Atherosclerotic Lesion Growth.
Z. Mallat (2009)
Circ. Res. 105, 827-829
   Full Text »    PDF »
Control of Promatrilysin (MMP7) Activation and Substrate-specific Activity by Sulfated Glycosaminoglycans.
H.-J. Ra, S. Harju-Baker, F. Zhang, R. J. Linhardt, C. L. Wilson, and W. C. Parks (2009)
J. Biol. Chem. 284, 27924-27932
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinase (MMP)-9, but Not MMP-2, Is Involved in the Development and Progression of C Protein-Induced Myocarditis and Subsequent Dilated Cardiomyopathy.
Y. Matsumoto, I.-K. Park, and K. Kohyama (2009)
J. Immunol. 183, 4773-4781
   Abstract »    Full Text »    PDF »
Glycogen synthase kinase-3{beta} is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts.
A. D. Kandasamy and R. Schulz (2009)
Cardiovasc Res 83, 698-706
   Abstract »    Full Text »    PDF »
{alpha}9 Integrin and Its Ligands Constitute Critical Joint Microenvironments for Development of Autoimmune Arthritis.
M. Kanayama, D. Kurotaki, J. Morimoto, T. Asano, Y. Matsui, Y. Nakayama, Y. Saito, K. Ito, C. Kimura, N. Iwasaki, et al. (2009)
J. Immunol. 182, 8015-8025
   Abstract »    Full Text »    PDF »
Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Inhibiting CD4 Th17 T Cells in a CC Chemokine Ligand 2-Dependent Manner.
M. Rafei, P. M. Campeau, A. Aguilar-Mahecha, M. Buchanan, P. Williams, E. Birman, S. Yuan, Y. K. Young, M.-N. Boivin, K. Forner, et al. (2009)
J. Immunol. 182, 5994-6002
   Abstract »    Full Text »    PDF »
Epilysin (MMP-28) Restrains Early Macrophage Recruitment in Pseudomonas aeruginosa Pneumonia.
A. M. Manicone, T. P. Birkland, M. Lin, T. Betsuyaku, N. van Rooijen, J. Lohi, J. Keski-Oja, Y. Wang, S. J. Skerrett, and W. C. Parks (2009)
J. Immunol. 182, 3866-3876
   Abstract »    Full Text »    PDF »
Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis.
P. Garg, M. Vijay-Kumar, L. Wang, A. T. Gewirtz, D. Merlin, and S. V. Sitaraman (2009)
Am J Physiol Gastrointest Liver Physiol 296, G175-G184
   Abstract »    Full Text »    PDF »
Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (Activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets.
X.-Y. Du, B. A. Zabel, T. Myles, S. J. Allen, T. M. Handel, P. P. Lee, E. C. Butcher, and L. L. Leung (2009)
J. Biol. Chem. 284, 751-758
   Abstract »    Full Text »    PDF »
Mesenchymal stromal cell-derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction.
M. Rafei, J. Hsieh, S. Fortier, M. Li, S. Yuan, E. Birman, K. Forner, M.-N. Boivin, K. Doody, M. Tremblay, et al. (2008)
Blood 112, 4991-4998
   Abstract »    Full Text »    PDF »
Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx.
R. A. Dean, J. H. Cox, C. L. Bellac, A. Doucet, A. E. Starr, and C. M. Overall (2008)
Blood 112, 3455-3464
   Abstract »    Full Text »    PDF »
Lipopolysaccharide-Induced Expression of Matrix Metalloproteinases in Human Monocytes Is Suppressed by IFN-{gamma} via Superinduction of ATF-3 and Suppression of AP-1.
H. H. Ho, T. T. Antoniv, J.-D. Ji, and L. B. Ivashkiv (2008)
J. Immunol. 181, 5089-5097
   Abstract »    Full Text »    PDF »
Metadegradomics: Toward in Vivo Quantitative Degradomics of Proteolytic Post-translational Modifications of the Cancer Proteome.
A. Doucet, G. S. Butler, D. Rodriguez, A. Prudova, and C. M. Overall (2008)
Mol. Cell. Proteomics 7, 1925-1951
   Abstract »    Full Text »    PDF »
Pharmacoproteomics of a Metalloproteinase Hydroxamate Inhibitor in Breast Cancer Cells: Dynamics of Membrane Type 1 Matrix Metalloproteinase-Mediated Membrane Protein Shedding.
G. S. Butler, R. A. Dean, E. M. Tam, and C. M. Overall (2008)
Mol. Cell. Biol. 28, 4896-4914
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinase Processing of CXCL11/I-TAC Results in Loss of Chemoattractant Activity and Altered Glycosaminoglycan Binding.
J. H. Cox, R. A. Dean, C. R. Roberts, and C. M. Overall (2008)
J. Biol. Chem. 283, 19389-19399
   Abstract »    Full Text »    PDF »
Tissue inhibitor of metalloproteinase-1 exacerbated renal interstitial fibrosis through enhancing inflammation.
G. Cai, X. Zhang, Q. Hong, F. Shao, X. Shang, B. Fu, Z. Feng, H. Lin, J. Wang, S. Shi, et al. (2008)
Nephrol. Dial. Transplant. 23, 1861-1875
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinases and Their Tissue Inhibitors (TIMPs) in Plasmodium falciparum Malaria: Serum Levels of TIMP-1 Are Associated with Disease Severity.
A. Dietmann, R. Helbok, P. Lackner, S. Issifou, B. Lell, P.-B. Matsiegui, M. Reindl, E. Schmutzhard, and P. G. Kremsner (2008)
The Journal of Infectious Disease 197, 1614-1620
   Abstract »    Full Text »    PDF »
Increased Activities of Cardiac Matrix Metalloproteinases Matrix Metalloproteinase (MMP)-2 and MMP-9 Are Associated with Mortality during the Acute Phase of Experimental Trypanosoma cruzi Infection.
F. R. S. Gutierrez, M. M. Lalu, F. S. Mariano, C. M. Milanezi, C. Jonathan, R. F. Gerlach, J. E. T. Santos, T.-D. Diego, F. Q. Cunha, S. Richard, et al. (2008)
The Journal of Infectious Disease 197, 1468-1476
   Abstract »    Full Text »    PDF »
Identification of Candidate Angiogenic Inhibitors Processed by Matrix Metalloproteinase 2 (MMP-2) in Cell-Based Proteomic Screens: Disruption of Vascular Endothelial Growth Factor (VEGF)/Heparin Affin Regulatory Peptide (Pleiotrophin) and VEGF/Connective Tissue Growth Factor Angiogenic Inhibitory Complexes by MMP-2 Proteolysis .
R. A. Dean, G. S. Butler, Y. Hamma-Kourbali, J. Delbe, D. R. Brigstock, J. Courty, and C. M. Overall (2007)
Mol. Cell. Biol. 27, 8454-8465
   Abstract »    Full Text »    PDF »
Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation.
P. Van Lint and C. Libert (2007)
J. Leukoc. Biol. 82, 1375-1381
   Abstract »    Full Text »    PDF »
Local Delivery of Protease-Resistant Stromal Cell Derived Factor-1 for Stem Cell Recruitment After Myocardial Infarction.
V. F.M. Segers, T. Tokunou, L. J. Higgins, C. MacGillivray, J. Gannon, and R. T. Lee (2007)
Circulation 116, 1683-1692
   Abstract »    Full Text »    PDF »
Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation.
M. Sariahmetoglu, B. D. Crawford, H. Leon, J. Sawicka, L. Li, B. J. Ballermann, C. Holmes, L. G. Berthiaume, A. Holt, G. Sawicki, et al. (2007)
FASEB J 21, 2486-2495
   Abstract »    Full Text »    PDF »
Kaposi's Sarcoma-Associated Herpesvirus Infection Promotes Invasion of Primary Human Umbilical Vein Endothelial Cells by Inducing Matrix Metalloproteinases.
L.-W. Qian, J. Xie, F. Ye, and S.-J. Gao (2007)
J. Virol. 81, 7001-7010
   Abstract »    Full Text »    PDF »
Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth.
R. A. Mosig, O. Dowling, A. DiFeo, M. C. M. Ramirez, I. C. Parker, E. Abe, J. Diouri, A. A. Aqeel, J. D. Wylie, S. A. Oblander, et al. (2007)
Hum. Mol. Genet. 16, 1113-1123
   Abstract »    Full Text »    PDF »
Proteomics Discovery of Metalloproteinase Substrates in the Cellular Context by iTRAQTM Labeling Reveals a Diverse MMP-2 Substrate Degradome.
R. A. Dean and C. M. Overall (2007)
Mol. Cell. Proteomics 6, 611-623
   Abstract »    Full Text »    PDF »
Hemopexin domains as multifunctional liganding modules in matrix metalloproteinases and other proteins.
H. Piccard, P. E. Van den Steen, and G. Opdenakker (2007)
J. Leukoc. Biol. 81, 870-892
   Abstract »    Full Text »    PDF »
Staphylococcus aureus-Derived Staphopain B, a Potent Cysteine Protease Activator of Plasma Chemerin.
P. Kulig, B. A. Zabel, G. Dubin, S. J. Allen, T. Ohyama, J. Potempa, T. M. Handel, E. C. Butcher, and J. Cichy (2007)
J. Immunol. 178, 3713-3720
   Abstract »    Full Text »    PDF »
A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex.
M. Rafei, J. H. Wu, B. Annabi, L. Lejeune, M. Francois, and J. Galipeau (2007)
Blood 109, 2234-2242
   Abstract »    Full Text »    PDF »
Pharmacologic and Genetic Manipulation of MMP-2 and -9 Affects Retinal Neovascularization in Rodent Models of OIR.
J. M. Barnett, G. W. McCollum, J. A. Fowler, J. J.-W. Duan, J. D. Kay, R.-Q. Liu, D. P. Bingaman, and J. S. Penn (2007)
Invest. Ophthalmol. Vis. Sci. 48, 907-915
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinases in Lung: Multiple, Multifarious, and Multifaceted.
K. J. Greenlee, Z. Werb, and F. Kheradmand (2007)
Physiol Rev 87, 69-98
   Abstract »    Full Text »    PDF »
Proteolytic processing of SDF-1{alpha} reveals a change in receptor specificity mediating HIV-associated neurodegeneration.
D. Vergote, G. S. Butler, M. Ooms, J. H. Cox, C. Silva, M. D. Hollenberg, J. H. Jhamandas, C. M. Overall, and C. Power (2006)
PNAS 103, 19182-19187
   Abstract »    Full Text »    PDF »
N-terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4-68 variant.
J. K. Lim, W. Lu, O. Hartley, and A. L. DeVico (2006)
J. Leukoc. Biol. 80, 1395-1404
   Abstract »    Full Text »    PDF »
Proteomic Identification of In Vivo Substrates for Matrix Metalloproteinases 2 and 9 Reveals a Mechanism for Resolution of Inflammation.
K. J. Greenlee, D. B. Corry, D. A. Engler, R. K. Matsunami, P. Tessier, R. G. Cook, Z. Werb, and F. Kheradmand (2006)
J. Immunol. 177, 7312-7321
   Abstract »    Full Text »    PDF »
TIMP-1 Promotes Age-Related Renal Fibrosis Through Upregulating ICAM-1 in Human TIMP-1 Transgenic Mice.
X. Zhang, X. Chen, Q. Hong, H. Lin, H. Zhu, Q. Liu, J. Wang, Y. Xie, X. Shang, S. Shi, et al. (2006)
J Gerontol A Biol Sci Med Sci 61, 1130-1143
   Abstract »    Full Text »    PDF »
Matrix metalloproteinases, their production by monocytes and macrophages and their potential role in HIV-related diseases.
N. L. Webster and S. M. Crowe (2006)
J. Leukoc. Biol. 80, 1052-1066
   Abstract »    Full Text »    PDF »
Novel Differential Neuroproteomics Analysis of Traumatic Brain Injury in Rats.
F. H. Kobeissy, A. K. Ottens, Z. Zhang, M. C. Liu, N. D. Denslow, J. R. Dave, F. C. Tortella, R. L. Hayes, and K. K. W. Wang (2006)
Mol. Cell. Proteomics 5, 1887-1898
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinase-2 Facilitates Wound Healing Events That Promote Functional Recovery after Spinal Cord Injury.
J.-Y. C. Hsu, R. McKeon, S. Goussev, Z. Werb, J.-U. Lee, A. Trivedi, and L. J. Noble-Haeusslein (2006)
J. Neurosci. 26, 9841-9850
   Abstract »    Full Text »    PDF »
Selective Ablation of Matrix Metalloproteinase-2 Exacerbates Experimental Colitis: Contrasting Role of Gelatinases in the Pathogenesis of Colitis.
P. Garg, M. Rojas, A. Ravi, K. Bockbrader, S. Epstein, M. Vijay-Kumar, A. T. Gewirtz, D. Merlin, and S. V. Sitaraman (2006)
J. Immunol. 177, 4103-4112
   Abstract »    Full Text »    PDF »
Cell-surface association between matrix metalloproteinases and integrins: role of the complexes in leukocyte migration and cancer progression.
M. Stefanidakis and E. Koivunen (2006)
Blood 108, 1441-1450
   Abstract »    Full Text »    PDF »
Role of Matrix Metalloproteinases in the Inflammatory Response in Human Airway Cell-Based Assays and in Rodent Models of Airway Disease.
M. A. Birrell, S. Wong, A. Dekkak, J. De Alba, S. Haj-Yahia, and M. G. Belvisi (2006)
J. Pharmacol. Exp. Ther. 318, 741-750
   Abstract »    Full Text »    PDF »
Reduced peribronchial fibrosis in allergen-challenged MMP-9-deficient mice..
D. H. Lim, J. Y. Cho, M. Miller, K. McElwain, S. McElwain, and D. H. Broide (2006)
Am J Physiol Lung Cell Mol Physiol 291, L265-L271
   Abstract »    Full Text »    PDF »
Interaction of HIV Tat and matrix metalloproteinase in HIV neuropathogenesis: a new host defense mechanism.
J. Rumbaugh, J. Turchan-Cholewo, D. Galey, C. St. Hillaire, C. Anderson, K. Conant, and A. Nath (2006)
FASEB J 20, 1736-1738
   Abstract »    Full Text »    PDF »
The Hemopexin and O-Glycosylated Domains Tune Gelatinase B/MMP-9 Bioavailability via Inhibition and Binding to Cargo Receptors.
P. E. Van den Steen, I. Van Aelst, V. Hvidberg, H. Piccard, P. Fiten, C. Jacobsen, S. K. Moestrup, S. Fry, L. Royle, M. R. Wormald, et al. (2006)
J. Biol. Chem. 281, 18626-18637
   Abstract »    Full Text »    PDF »
Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases..
A. M. Houghton, J. L. Grisolano, M. L. Baumann, D. K. Kobayashi, R. D. Hautamaki, L. C. Nehring, L. A. Cornelius, and S. D. Shapiro (2006)
Cancer Res. 66, 6149-6155
   Abstract »    Full Text »    PDF »
Function of Liver Activation-Regulated Chemokine/CC Chemokine Ligand 20 Is Differently Affected by Cathepsin B and Cathepsin D Processing..
L. Hasan, L. Mazzucchelli, M. Liebi, M. Lis, R. E. Hunger, A. Tester, C. M. Overall, and M. Wolf (2006)
J. Immunol. 176, 6512-6522
   Abstract »    Full Text »    PDF »
Earlier onset of tumoral angiogenesis in matrix metalloproteinase-19-deficient mice..
M. Jost, A. R. Folgueras, F. Frerart, A. M. Pendas, S. Blacher, X. Houard, S. Berndt, C. Munaut, D. Cataldo, J. Alvarez, et al. (2006)
Cancer Res. 66, 5234-5241
   Abstract »    Full Text »    PDF »
Costimulation of Chemokine Receptor Signaling by Matrix Metalloproteinase-9 Mediates Enhanced Migration of IFN-{alpha} Dendritic Cells.
Y. Hu and L. B. Ivashkiv (2006)
J. Immunol. 176, 6022-6033
   Abstract »    Full Text »    PDF »
Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis.
S. Agrawal, P. Anderson, M. Durbeej, N. van Rooijen, F. Ivars, G. Opdenakker, and L. M. Sorokin (2006)
J. Exp. Med. 203, 1007-1019
   Abstract »    Full Text »    PDF »
Cleavage of Amyloid-{beta} Precursor Protein (APP) by Membrane-Type Matrix Metalloproteinases..
M. Ahmad, T. Takino, H. Miyamori, T. Yoshizaki, M. Furukawa, and H. Sato (2006)
J. Biochem. 139, 517-526
   Abstract »    Full Text »    PDF »
Matrix metalloproteinases in destructive pulmonary pathology.
P T G Elkington and J S Friedland (2006)
Thorax 61, 259-266
   Abstract »    Full Text »    PDF »
The Cysteine-rich Domain of the Secreted Proprotein Convertases PC5A and PACE4 Functions as a Cell Surface Anchor and Interacts with Tissue Inhibitors of Metalloproteinases.
N. Nour, G. Mayer, J. S. Mort, A. Salvas, M. Mbikay, C. J. Morrison, C. M. Overall, and N. G. Seidah (2005)
Mol. Biol. Cell 16, 5215-5226
   Abstract »    Full Text »    PDF »
Dissecting the Role of Matrix Metalloproteinases (MMP) and Integrin {alpha}v{beta}3 in Angiogenesis In vitro: Absence of Hemopexin C Domain Bioactivity, but Membrane-Type 1-MMP and {alpha}v{beta}3 Are Critical.
R. E. Nisato, G. Hosseini, C. Sirrenberg, G. S. Butler, T. Crabbe, A. J.P. Docherty, M. Wiesner, G. Murphy, C. M. Overall, S. L. Goodman, et al. (2005)
Cancer Res. 65, 9377-9387
   Abstract »    Full Text »    PDF »
Chemerin Activation by Serine Proteases of the Coagulation, Fibrinolytic, and Inflammatory Cascades.
B. A. Zabel, S. J. Allen, P. Kulig, J. A. Allen, J. Cichy, T. M. Handel, and E. C. Butcher (2005)
J. Biol. Chem. 280, 34661-34666
   Abstract »    Full Text »    PDF »
Expression of Matrix Metalloproteinases Subsequent to Urogenital Chlamydia muridarum Infection of Mice.
K.H. Ramsey, I.M. Sigar, J. H. Schripsema, N. Shaba, and K. P. Cohoon (2005)
Infect. Immun. 73, 6962-6973
   Abstract »    Full Text »    PDF »
NADPH Oxidase Restrains the Matrix Metalloproteinase Activity of Macrophages.
S. Y. Kassim, X. Fu, W. C. Liles, S. D. Shapiro, W. C. Parks, and J. W. Heinecke (2005)
J. Biol. Chem. 280, 30201-30205
   Abstract »    Full Text »    PDF »
Multiple pathways of amino terminal processing produce two truncated variants of RANTES/CCL5.
J. K. Lim, J. M. Burns, W. Lu, and A. L. DeVico (2005)
J. Leukoc. Biol. 78, 442-452
   Abstract »    Full Text »    PDF »
Proteolytic Activation of Alternative CCR1 Ligands in Inflammation.
R. D. Berahovich, Z. Miao, Y. Wang, B. Premack, M. C. Howard, and T. J. Schall (2005)
J. Immunol. 174, 7341-7351
   Abstract »    Full Text »    PDF »
Extracellular Proteases in Atherosclerosis and Restenosis.
A. Garcia-Touchard, T. D. Henry, G. Sangiorgi, L. G. Spagnoli, A. Mauriello, C. Conover, and R. S. Schwartz (2005)
Arterioscler Thromb Vasc Biol 25, 1119-1127
   Abstract »    Full Text »    PDF »
Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors.
S. Lee, S. M. Jilani, G. V. Nikolova, D. Carpizo, and M. L. Iruela-Arispe (2005)
J. Cell Biol. 169, 681-691
   Abstract »    Full Text »    PDF »
Increased soluble interleukin-1 receptor type II proteolysis in the endometrium of women with endometriosis.
C. Bellehumeur, T. Collette, R. Maheux, J. Mailloux, M. Villeneuve, and A. Akoum (2005)
Hum. Reprod. 20, 1177-1184
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinase-9 Modulation by Resident Arterial Cells Is Responsible for Injury-Induced Accelerated Atherosclerotic Plaque Development in Apolipoprotein E-Deficient Mice.
E. T. Choi, E. T. Collins, L. A. Marine, M. G. Uberti, H. Uchida, J. E. Leidenfrost, M. F. Khan, K. P. Boc, D. R. Abendschein, and W. C. Parks (2005)
Arterioscler Thromb Vasc Biol 25, 1020-1025
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinase-2 Contributes to Cancer Cell Migration on Collagen.
X. Xu, Y. Wang, Z. Chen, M. D. Sternlicht, M. Hidalgo, and B. Steffensen (2005)
Cancer Res. 65, 130-136
   Abstract »    Full Text »    PDF »
Ischaemia-reperfusion injury activates matrix metalloproteinases in the human heart.
M. M. Lalu, E. Pasini, C. J. Schulze, M. Ferrari-Vivaldi, G. Ferrari-Vivaldi, T. Bachetti, and R. Schulz (2005)
Eur. Heart J. 26, 27-35
   Abstract »    Full Text »    PDF »
MMP-2 null mice exhibit an early onset and severe experimental autoimmune encephalomyelitis due to an increase in MMP-9 expression and activity.
J. ESPARZA, M. KRUSE, J. LEE, M. MICHAUD, and J. A. MADRI (2004)
FASEB J 18, 1682-1691
   Abstract »    Full Text »    PDF »
Cleavage of Lumican by Membrane-Type Matrix Metalloproteinase-1 Abrogates This Proteoglycan-Mediated Suppression of Tumor Cell Colony Formation in Soft Agar.
Y. Li, T. Aoki, Y. Mori, M. Ahmad, H. Miyamori, T. Takino, and H. Sato (2004)
Cancer Res. 64, 7058-7064
   Abstract »    Full Text »    PDF »
Elastase Release by Transmigrating Neutrophils Deactivates Endothelial-bound SDF-1{alpha} and Attenuates Subsequent T Lymphocyte Transendothelial Migration.
R. M. Rao, T. V. Betz, D. J. Lamont, M. B. Kim, S. K. Shaw, R. M. Froio, F. Baleux, F. Arenzana-Seisdedos, R. Alon, and F. W. Luscinskas (2004)
J. Exp. Med. 200, 713-724
   Abstract »    Full Text »    PDF »
Molecular mechanisms governing thymocyte migration: combined role of chemokines and extracellular matrix.
W. Savino, D. A. Mendes-da-Cruz, S. Smaniotto, E. Silva-Monteiro, and D. M. S. Villa-Verde (2004)
J. Leukoc. Biol. 75, 951-961
   Abstract »    Full Text »    PDF »
Membrane associated proteases and their inhibitors in tumour angiogenesis.
A Noel, C Maillard, N Rocks, M Jost, V Chabottaux, N E Sounni, E Maquoi, D Cataldo, and J M Foidart (2004)
J. Clin. Pathol. 57, 577-584
   Abstract »    Full Text »    PDF »
Adenovirus mediated intra-articular expression of collagenase-3 (MMP-13) induces inflammatory arthritis in mice.
K Joronen, R Ala-aho, M-L Majuri, H Alenius, V-M Kahari, and E Vuorio (2004)
Ann Rheum Dis 63, 656-664
   Abstract »    Full Text »
Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates.
E. M. Tam, C. J. Morrison, Y. I. Wu, M. S. Stack, and C. M. Overall (2004)
PNAS 101, 6917-6922
   Abstract »    Full Text »    PDF »
Secreted MMP9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface.
E. Mira, R. A. Lacalle, J. M. Buesa, G. G. de Buitrago, S. Jimenez-Baranda, C. Gomez-Mouton, C. Martinez-A, and S. Manes (2004)
J. Cell Sci. 117, 1847-1857
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinases as Targets for the Immune System during Experimental Arthritis.
J. H. M. van Bilsen, J. P. A. Wagenaar-Hilbers, M. C. J. T. Grosfeld-Stulemeijer, M. J. F. van der Cammen, M. E. A. van Dijk, W. van Eden, and M. H. M. Wauben (2004)
J. Immunol. 172, 5063-5068
   Abstract »    Full Text »    PDF »
The Canonical Methionine 392 of Matrix Metalloproteinase 2 (Gelatinase A) Is Not Required for Catalytic Efficiency or Structural Integrity: PROBING THE ROLE OF THE METHIONINE-TURN IN THE METZINCIN METALLOPROTEASE SUPERFAMILY.
G. S. Butler, E. M. Tam, and C. M. Overall (2004)
J. Biol. Chem. 279, 15615-15620
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882