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Science 289 (5482): 1202-1206

Copyright © 2000 by the American Association for the Advancement of Science

Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3

G. Angus McQuibban,1 Jiang-Hong Gong,2 Eric M. Tam,1 Christopher A. G. McCulloch,4 Ian Clark-Lewis,2 Christopher M. Overall13*

Tissue degradation by the matrix metalloproteinase gelatinase A is pivotal to inflammation and metastases. Recognizing the catalytic importance of substrate-binding exosites outside the catalytic domain, we screened for extracellular substrates using the gelatinase A hemopexin domain as bait in the yeast two-hybrid system. Monocyte chemoattractant protein-3 (MCP-3) was identified as a physiological substrate of gelatinase A. Cleaved MCP-3 binds to CC-chemokine receptors-1, -2, and -3, but no longer induces calcium fluxes or promotes chemotaxis, and instead acts as a general chemokine antagonist that dampens inflammation. This suggests that matrix metalloproteinases are both effectors and regulators of the inflammatory response.

1 Department of Biochemistry and Molecular Biology,
2 Biomedical Research Centre,
3 Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
4 Medical Research Council Group in Periodontal Physiology, University of Toronto, Toronto, ON M5S 3E8, Canada.
*   To whom correspondence should be addressed. E-mail: overall{at}interchange.ubc.ca

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S. Y. Kassim, X. Fu, W. C. Liles, S. D. Shapiro, W. C. Parks, and J. W. Heinecke (2005)
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   Abstract »    Full Text »    PDF »
Multiple pathways of amino terminal processing produce two truncated variants of RANTES/CCL5.
J. K. Lim, J. M. Burns, W. Lu, and A. L. DeVico (2005)
J. Leukoc. Biol. 78, 442-452
   Abstract »    Full Text »    PDF »
Proteolytic Activation of Alternative CCR1 Ligands in Inflammation.
R. D. Berahovich, Z. Miao, Y. Wang, B. Premack, M. C. Howard, and T. J. Schall (2005)
J. Immunol. 174, 7341-7351
   Abstract »    Full Text »    PDF »
Extracellular Proteases in Atherosclerosis and Restenosis.
A. Garcia-Touchard, T. D. Henry, G. Sangiorgi, L. G. Spagnoli, A. Mauriello, C. Conover, and R. S. Schwartz (2005)
Arterioscler Thromb Vasc Biol 25, 1119-1127
   Abstract »    Full Text »    PDF »
Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors.
S. Lee, S. M. Jilani, G. V. Nikolova, D. Carpizo, and M. L. Iruela-Arispe (2005)
J. Cell Biol. 169, 681-691
   Abstract »    Full Text »    PDF »
Increased soluble interleukin-1 receptor type II proteolysis in the endometrium of women with endometriosis.
C. Bellehumeur, T. Collette, R. Maheux, J. Mailloux, M. Villeneuve, and A. Akoum (2005)
Hum. Reprod. 20, 1177-1184
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinase-9 Modulation by Resident Arterial Cells Is Responsible for Injury-Induced Accelerated Atherosclerotic Plaque Development in Apolipoprotein E-Deficient Mice.
E. T. Choi, E. T. Collins, L. A. Marine, M. G. Uberti, H. Uchida, J. E. Leidenfrost, M. F. Khan, K. P. Boc, D. R. Abendschein, and W. C. Parks (2005)
Arterioscler Thromb Vasc Biol 25, 1020-1025
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinase-2 Contributes to Cancer Cell Migration on Collagen.
X. Xu, Y. Wang, Z. Chen, M. D. Sternlicht, M. Hidalgo, and B. Steffensen (2005)
Cancer Res. 65, 130-136
   Abstract »    Full Text »    PDF »
Ischaemia-reperfusion injury activates matrix metalloproteinases in the human heart.
M. M. Lalu, E. Pasini, C. J. Schulze, M. Ferrari-Vivaldi, G. Ferrari-Vivaldi, T. Bachetti, and R. Schulz (2005)
Eur. Heart J. 26, 27-35
   Abstract »    Full Text »    PDF »
MMP-2 null mice exhibit an early onset and severe experimental autoimmune encephalomyelitis due to an increase in MMP-9 expression and activity.
J. ESPARZA, M. KRUSE, J. LEE, M. MICHAUD, and J. A. MADRI (2004)
FASEB J 18, 1682-1691
   Abstract »    Full Text »    PDF »
Cleavage of Lumican by Membrane-Type Matrix Metalloproteinase-1 Abrogates This Proteoglycan-Mediated Suppression of Tumor Cell Colony Formation in Soft Agar.
Y. Li, T. Aoki, Y. Mori, M. Ahmad, H. Miyamori, T. Takino, and H. Sato (2004)
Cancer Res. 64, 7058-7064
   Abstract »    Full Text »    PDF »
Elastase Release by Transmigrating Neutrophils Deactivates Endothelial-bound SDF-1{alpha} and Attenuates Subsequent T Lymphocyte Transendothelial Migration.
R. M. Rao, T. V. Betz, D. J. Lamont, M. B. Kim, S. K. Shaw, R. M. Froio, F. Baleux, F. Arenzana-Seisdedos, R. Alon, and F. W. Luscinskas (2004)
J. Exp. Med. 200, 713-724
   Abstract »    Full Text »    PDF »
Molecular mechanisms governing thymocyte migration: combined role of chemokines and extracellular matrix.
W. Savino, D. A. Mendes-da-Cruz, S. Smaniotto, E. Silva-Monteiro, and D. M. S. Villa-Verde (2004)
J. Leukoc. Biol. 75, 951-961
   Abstract »    Full Text »    PDF »
Membrane associated proteases and their inhibitors in tumour angiogenesis.
A Noel, C Maillard, N Rocks, M Jost, V Chabottaux, N E Sounni, E Maquoi, D Cataldo, and J M Foidart (2004)
J. Clin. Pathol. 57, 577-584
   Abstract »    Full Text »    PDF »
Adenovirus mediated intra-articular expression of collagenase-3 (MMP-13) induces inflammatory arthritis in mice.
K Joronen, R Ala-aho, M-L Majuri, H Alenius, V-M Kahari, and E Vuorio (2004)
Ann Rheum Dis 63, 656-664
   Abstract »    Full Text »
Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates.
E. M. Tam, C. J. Morrison, Y. I. Wu, M. S. Stack, and C. M. Overall (2004)
PNAS 101, 6917-6922
   Abstract »    Full Text »    PDF »
Secreted MMP9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface.
E. Mira, R. A. Lacalle, J. M. Buesa, G. G. de Buitrago, S. Jimenez-Baranda, C. Gomez-Mouton, C. Martinez-A, and S. Manes (2004)
J. Cell Sci. 117, 1847-1857
   Abstract »    Full Text »    PDF »
Matrix Metalloproteinases as Targets for the Immune System during Experimental Arthritis.
J. H. M. van Bilsen, J. P. A. Wagenaar-Hilbers, M. C. J. T. Grosfeld-Stulemeijer, M. J. F. van der Cammen, M. E. A. van Dijk, W. van Eden, and M. H. M. Wauben (2004)
J. Immunol. 172, 5063-5068
   Abstract »    Full Text »    PDF »
The Canonical Methionine 392 of Matrix Metalloproteinase 2 (Gelatinase A) Is Not Required for Catalytic Efficiency or Structural Integrity: PROBING THE ROLE OF THE METHIONINE-TURN IN THE METZINCIN METALLOPROTEASE SUPERFAMILY.
G. S. Butler, E. M. Tam, and C. M. Overall (2004)
J. Biol. Chem. 279, 15615-15620
   Abstract »    Full Text »    PDF »
Furin Is a Chemokine-modifying Enzyme: IN VITRO AND IN VIVO PROCESSING OF CXCL10 GENERATES A C-TERMINALLY TRUNCATED CHEMOKINE RETAINING FULL ACTIVITY.
P. J. Hensbergen, D. Verzijl, C. I. A. Balog, R. Dijkman, R. C. van der Schors, E. M. H. van der Raaij-Helmer, M. J. A. van der Plas, R. Leurs, A. M. Deelder, M. J. Smit, et al. (2004)
J. Biol. Chem. 279, 13402-13411
   Abstract »    Full Text »    PDF »

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