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Science 289 (5485): 1751-1754

Copyright © 2000 by the American Association for the Advancement of Science

Subgroup of Reproductive Functions of Progesterone Mediated by Progesterone Receptor-B Isoform

Biserka Mulac-Jericevic, Robert A. Mullinax, Francesco J. DeMayo, John P. Lydon, Orla M. Conneely*

Progesterone regulates reproductive function through two intracellular receptors, progesterone receptor-A (PR-A) and progesterone receptor-B (PR-B), that arise from a single gene and function as transcriptional regulators of progesterone-responsive genes. Although in vitro studies show that PR isoforms can display different transcriptional regulatory activities, their physiological significance is unknown. By selective ablation of PR-A in mice, we show that the PR-B isoform modulates a subset of reproductive functions of progesterone by regulation of a subset of progesterone-responsive target genes. Thus, PR-A and PR-B are functionally distinct mediators of progesterone action in vivo and should provide suitable targets for generation of tissue-selective progestins.

Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
*   To whom correspondence should be addressed. E-mail: orlac{at}bcm.tmc.edu


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   Abstract »    Full Text »    PDF »
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