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Science 291 (5506): 1040-1043

Copyright © 2001 by the American Association for the Advancement of Science

An hPer2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome

Kong L. Toh,1* Christopher R. Jones,23* Yan He,4 Erik J. Eide,5 William A. Hinz,5 David M. Virshup,56 Louis J. Ptácek,27dagger Ying-Hui Fu4

Familial advanced sleep phase syndrome (FASPS) is an autosomal dominant circadian rhythm variant; affected individuals are "morning larks" with a 4-hour advance of the sleep, temperature, and melatonin rhythms. Here we report localization of the FASPS gene near the telomere of chromosome 2q. A strong candidate gene (hPer2), a human homolog of the period gene in Drosophila, maps to the same locus. Affected individuals have a serine to glycine mutation within the casein kinase Iepsilon (CKIepsilon ) binding region of hPER2, which causes hypophosphorylation by CKIepsilon in vitro. Thus, a variant in human sleep behavior can be attributed to a missense mutation in a clock component, hPER2, which alters the circadian period.

1 Department of Human Genetics,
2 Department of Neurology,
3 University Hospital Sleep Disorders Center,
4 Department of Neurobiology and Anatomy,
5 Department of Oncological Sciences and the Huntsman Cancer Institute Center for Children,
6 Department of Pediatrics,
7 Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: ptacek{at}

Phosphorylation of the Transcription Activator CLOCK Regulates Progression through a ~24-h Feedback Loop to Influence the Circadian Period in Drosophila.
G. Mahesh, E. Jeong, F. S. Ng, Y. Liu, K. Gunawardhana, J. H. Houl, E. Yildirim, R. Amunugama, R. Jones, D. L. Allen, et al. (2014)
J. Biol. Chem. 289, 19681-19693
   Abstract »    Full Text »    PDF »
The Tau Mutation of Casein Kinase 1{epsilon} Sets the Period of the Mammalian Pacemaker via Regulation of Period1 or Period2 Clock Proteins.
E. S. Maywood, J. E. Chesham, N. J. Smyllie, and M. H. Hastings (2014)
J Biol Rhythms 29, 110-118
   Abstract »    Full Text »    PDF »
Aging of the Suprachiasmatic Clock.
S. Farajnia, T. Deboer, J. H. T. Rohling, J. H. Meijer, and S. Michel (2014)
Neuroscientist 20, 44-55
   Abstract »    Full Text »    PDF »
Glucocorticoid-mediated Period2 induction delays the phase of circadian rhythm.
S. Cheon, N. Park, S. Cho, and K. Kim (2013)
Nucleic Acids Res. 41, 6161-6174
   Abstract »    Full Text »    PDF »
Shift work and cancer research: can chronotype predict susceptibility in night-shift and rotating-shift workers?.
T. C. Erren (2013)
Occup. Environ. Med. 70, 283-284
   Full Text »    PDF »
Per2 Mutation Recapitulates the Vascular Phenotype of Diabetes in the Retina and Bone Marrow.
A. D. Bhatwadekar, Y. Yan, X. Qi, J. S. Thinschmidt, M. B. Neu, S. Li Calzi, L. C. Shaw, J. M. Dominiguez, J. V. Busik, C. Lee, et al. (2013)
Diabetes 62, 273-282
   Abstract »    Full Text »    PDF »
Tissue-Specific Interaction of Per1/2 and Dec2 in the Regulation of Fibroblast Circadian Rhythms.
A. H. Tsang, C. Sanchez-Moreno, B. Bode, M. J. Rossner, M. Garaulet, and H. Oster (2012)
J Biol Rhythms 27, 478-489
   Abstract »    Full Text »    PDF »
Post-translational modifications induce significant yet not extreme changes to protein structure.
F. Xin and P. Radivojac (2012)
Bioinformatics 28, 2905-2913
   Abstract »    Full Text »    PDF »
Human blood metabolite timetable indicates internal body time.
T. Kasukawa, M. Sugimoto, A. Hida, Y. Minami, M. Mori, S. Honma, K.-i. Honma, K. Mishima, T. Soga, and H. R. Ueda (2012)
PNAS 109, 15036-15041
   Abstract »    Full Text »    PDF »
Control of Sleep and Wakefulness.
R. E. Brown, R. Basheer, J. T. McKenna, R. E. Strecker, and R. W. McCarley (2012)
Physiol Rev 92, 1087-1187
   Abstract »    Full Text »    PDF »
Impairment of heme biosynthesis induces short circadian period in body temperature rhythms in mice.
R. Iwadate, Y. Satoh, Y. Watanabe, H. Kawai, N. Kudo, Y. Kawashima, T. Mashino, and A. Mitsumoto (2012)
Am J Physiol Regulatory Integrative Comp Physiol 303, R8-R18
   Abstract »    Full Text »    PDF »
Assessment of circadian rhythms in humans: comparison of real-time fibroblast reporter imaging with plasma melatonin.
S. Hasan, N. Santhi, A. S. Lazar, A. Slak, J. Lo, M. von Schantz, S. N. Archer, J. D. Johnston, and D.-J. Dijk (2012)
FASEB J 26, 2414-2423
   Abstract »    Full Text »    PDF »
Sleep and circadian rhythm disruption in schizophrenia.
K. Wulff, D.-J. Dijk, B. Middleton, R. G. Foster, and E. M. Joyce (2012)
The British Journal of Psychiatry 200, 308-316
   Abstract »    Full Text »    PDF »
Involvement of Stress Kinase Mitogen-activated Protein Kinase Kinase 7 in Regulation of Mammalian Circadian Clock.
Y. Uchida, T. Osaki, T. Yamasaki, T. Shimomura, S. Hata, K. Horikawa, S. Shibata, T. Todo, J. Hirayama, and H. Nishina (2012)
J. Biol. Chem. 287, 8318-8326
   Abstract »    Full Text »    PDF »
NaV1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms.
S. Han, F. H. Yu, M. D. Schwartz, J. D. Linton, M. M. Bosma, J. B. Hurley, W. A. Catterall, and H. O. de la Iglesia (2012)
PNAS 109, E368-E377
   Abstract »    Full Text »    PDF »
Genetic Interaction of Per1 and Dec1/2 in the Regulation of Circadian Locomotor Activity.
B. Bode, A. Shahmoradi, M. J. Rossner, and H. Oster (2011)
J Biol Rhythms 26, 530-540
   Abstract »    PDF »
Altered sleep and behavioral activity phenotypes in PER3-deficient mice.
S. Hasan, D. R. van der Veen, R. Winsky-Sommerer, D.-J. Dijk, and S. N. Archer (2011)
Am J Physiol Regulatory Integrative Comp Physiol 301, R1821-R1830
   Abstract »    Full Text »    PDF »
The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.
H.-m. Lee, R. Chen, H. Kim, J.-P. Etchegaray, D. R. Weaver, and C. Lee (2011)
PNAS 108, 16451-16456
   Abstract »    Full Text »    PDF »
Casein Kinase 1-dependent Phosphorylation of Familial Advanced Sleep Phase Syndrome-associated Residues Controls PERIOD 2 Stability.
N. P. Shanware, J. A. Hutchinson, S. H. Kim, L. Zhan, M. J. Bowler, and R. S. Tibbetts (2011)
J. Biol. Chem. 286, 12766-12774
   Abstract »    Full Text »    PDF »
miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock.
M. Alvarez-Saavedra, G. Antoun, A. Yanagiya, R. Oliva-Hernandez, D. Cornejo-Palma, C. Perez-Iratxeta, N. Sonenberg, and H.-Y. M. Cheng (2011)
Hum. Mol. Genet. 20, 731-751
   Abstract »    Full Text »    PDF »
Noninvasive method for assessing the human circadian clock using hair follicle cells.
M. Akashi, H. Soma, T. Yamamoto, A. Tsugitomi, S. Yamashita, T. Yamamoto, E. Nishida, A. Yasuda, J. K. Liao, and K. Node (2010)
PNAS 107, 15643-15648
   Abstract »    Full Text »    PDF »
Review: Clock genes at the heart of depression.
D. J. Kennaway (2010)
J Psychopharmacol 24, 5-14
   Abstract »    PDF »
No time to lose: workshop on circadian rhythms and metabolic disease.
C. M. Silva, S. Sato, and R. N. Margolis (2010)
Genes & Dev. 24, 1456-1464
   Abstract »    Full Text »    PDF »
Physiology of Circadian Entrainment.
D. A. Golombek and R. E. Rosenstein (2010)
Physiol Rev 90, 1063-1102
   Abstract »    Full Text »    PDF »
Genetic analysis of sleep.
A. Crocker and A. Sehgal (2010)
Genes & Dev. 24, 1220-1235
   Abstract »    Full Text »    PDF »
Probing the Mechanisms of Chronotype Using Quantitative Modeling.
A. J. K. Phillips, P. Y. Chen, and P. A. Robinson (2010)
J Biol Rhythms 25, 217-227
   Abstract »    PDF »
Interaction of MAGED1 with nuclear receptors affects circadian clock function.
X. Wang, J. Tang, L. Xing, G. Shi, H. Ruan, X. Gu, Z. Liu, X. Wu, X. Gao, and Y. Xu (2010)
EMBO J. 29, 1389-1400
   Abstract »    Full Text »    PDF »
DYRK1A and Glycogen Synthase Kinase 3{beta}, a Dual-Kinase Mechanism Directing Proteasomal Degradation of CRY2 for Circadian Timekeeping.
N. Kurabayashi, T. Hirota, M. Sakai, K. Sanada, and Y. Fukada (2010)
Mol. Cell. Biol. 30, 1757-1768
   Abstract »    Full Text »    PDF »
Role of mutation of the circadian clock gene Per2 in cardiovascular circadian rhythms.
A. Vukolic, V. Antic, B. N. Van Vliet, Z. Yang, U. Albrecht, and J.-P. Montani (2010)
Am J Physiol Regulatory Integrative Comp Physiol 298, R627-R634
   Abstract »    Full Text »    PDF »
Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock.
S. Masubuchi, T. Gao, A. O'Neill, K. Eckel-Mahan, A. C. Newton, and P. Sassone-Corsi (2010)
PNAS 107, 1642-1647
   Abstract »    Full Text »    PDF »
Analysis of Cell Type-specific Expression of CK1{varepsilon} in Various Tissues of Young Adult BALB/c Mice and in Mammary Tumors of SV40 T-Ag-transgenic Mice.
A. C. Utz, H. Hirner, A. Blatz, A. Hillenbrand, B. Schmidt, W. Deppert, D. Henne-Bruns, D. Fischer, D. R. Thal, F. Leithauser, et al. (2010)
Journal of Histochemistry & Cytochemistry 58, 1-15
   Abstract »    Full Text »    PDF »
How nuclear receptors tell time.
M. Teboul, A. Grechez-Cassiau, F. Guillaumond, and F. Delaunay (2009)
J Appl Physiol 107, 1965-1971
   Abstract »    Full Text »    PDF »
PERIOD1 is an Anti-apoptotic Factor in Human Pancreatic and Hepatic Cancer Cells.
F. Sato, C. Nagata, Y. Liu, T. Suzuki, J. Kondo, S. Morohashi, T. Imaizumi, Y. Kato, and H. Kijima (2009)
J. Biochem. 146, 833-838
   Abstract »    Full Text »    PDF »
Clock genes and metabolic disease.
B. Marcheva, K. M. Ramsey, A. Affinati, and J. Bass (2009)
J Appl Physiol 107, 1638-1646
   Abstract »    Full Text »    PDF »
CKI{varepsilon}/{delta}-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock.
Y. Isojima, M. Nakajima, H. Ukai, H. Fujishima, R. G. Yamada, K.-h. Masumoto, R. Kiuchi, M. Ishida, M. Ukai-Tadenuma, Y. Minami, et al. (2009)
PNAS 106, 15744-15749
   Abstract »    Full Text »    PDF »
Segregation of expression of mPeriod gene homologs in neurons and glia: possible divergent roles of mPeriod1 and mPeriod2 in the brain.
H.-Y. M. Cheng, M. Alvarez-Saavedra, H. Dziema, Y. S. Choi, A. Li, and K. Obrietan (2009)
Hum. Mol. Genet. 18, 3110-3124
   Abstract »    Full Text »    PDF »
The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals.
Y. He, C. R. Jones, N. Fujiki, Y. Xu, B. Guo, J. L. Holder Jr., M. J. Rossner, S. Nishino, and Y.-H. Fu (2009)
Science 325, 866-870
   Abstract »    Full Text »    PDF »
Casein Kinase 1 Delta Regulates the Pace of the Mammalian Circadian Clock.
J.-P. Etchegaray, K. K. Machida, E. Noton, C. M. Constance, R. Dallmann, M. N. Di Napoli, J. P. DeBruyne, C. M. Lambert, E. A. Yu, S. M. Reppert, et al. (2009)
Mol. Cell. Biol. 29, 3853-3866
   Abstract »    Full Text »    PDF »
Roles of CLOCK Phosphorylation in Suppression of E-Box-Dependent Transcription.
H. Yoshitane, T. Takao, Y. Satomi, N.-H. Du, T. Okano, and Y. Fukada (2009)
Mol. Cell. Biol. 29, 3675-3686
   Abstract »    Full Text »    PDF »
Circadian rhythms and memory: not so simple as cogs and gears.
K. L. Eckel-Mahan and D. R. Storm (2009)
EMBO Rep. 10, 584-591
   Abstract »    Full Text »    PDF »
Expression of the Circadian Clock Gene Period2 in the Hippocampus: Possible Implications for Synaptic Plasticity and Learned Behaviour.
L. M.-C. Wang, J. M. Dragich, T. Kudo, I. H. Odom, D. K. Welsh, T. J. O'Dell, and C. S. Colwell (2009)
ASN Neuro 1, AN20090020
   Abstract »    Full Text »    PDF »
Clock Gene Mouse Period2 Overexpression Inhibits Growth of Human Pancreatic Cancer Cells and Has Synergistic Effect with Cisplatin.
Anticancer Res 29, 1201-1209
   Abstract »    Full Text »    PDF »
A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock.
B. Maier, S. Wendt, J. T. Vanselow, T. Wallach, S. Reischl, S. Oehmke, A. Schlosser, and A. Kramer (2009)
Genes & Dev. 23, 708-718
   Abstract »    Full Text »    PDF »
Circadian gene expression is resilient to large fluctuations in overall transcription rates.
C. Dibner, D. Sage, M. Unser, C. Bauer, T. d'Eysmond, F. Naef, and U. Schibler (2009)
EMBO J. 28, 123-134
   Abstract »    Full Text »    PDF »
A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3{beta}.
T. Hirota, W. G. Lewis, A. C. Liu, J. W. Lee, P. G. Schultz, and S. A. Kay (2008)
PNAS 105, 20746-20751
   Abstract »    Full Text »    PDF »
New Developments in Sleep Research: Molecular Genetics, Gene Expression, and Systems Neurobiology.
T. S. Kilduff, E. S. Lein, H. de la Iglesia, T. Sakurai, Y.-h. Fu, and P. Shaw (2008)
J. Neurosci. 28, 11814-11818
   Abstract »    Full Text »    PDF »
A Tribute to Seymour Benzer, 1921-2007.
N. M. Bonini (2008)
Genetics 180, 1265-1273
   Full Text »    PDF »
The Role of {beta}-TrCP1 and {beta}-TrCP2 in Circadian Rhythm Generation by Mediating Degradation of Clock Protein PER2.
K. Ohsaki, K. Oishi, Y. Kozono, K. Nakayama, K. I. Nakayama, and N. Ishida (2008)
J. Biochem. 144, 609-618
   Abstract »    Full Text »    PDF »
Sleep better than medicine? Ethical issues related to "wake enhancement".
A Ravelingien and A Sandberg (2008)
J. Med. Ethics 34, e9
   Abstract »    Full Text »    PDF »
Genetic Differences in Human Circadian Clock Genes among Worldwide Populations.
C. M. Ciarleglio, K. K. Ryckman, S. V. Servick, A. Hida, S. Robbins, N. Wells, J. Hicks, S. A. Larson, J. P. Wiedermann, K. Carver, et al. (2008)
J Biol Rhythms 23, 330-340
   Abstract »    PDF »
PERspective on PER phosphorylation.
J. Blau (2008)
Genes & Dev. 22, 1737-1740
   Abstract »    Full Text »    PDF »
The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock.
J. C. Chiu, J. T. Vanselow, A. Kramer, and I. Edery (2008)
Genes & Dev. 22, 1758-1772
   Abstract »    Full Text »    PDF »
Probing the Relative Importance of Molecular Oscillations in the Circadian Clock.
X. Zheng and A. Sehgal (2008)
Genetics 178, 1147-1155
   Abstract »    Full Text »    PDF »
Molecular insights into human daily behavior.
S. A. Brown, D. Kunz, A. Dumas, P. O. Westermark, K. Vanselow, A. Tilmann-Wahnschaffe, H. Herzel, and A. Kramer (2008)
PNAS 105, 1602-1607
   Abstract »    Full Text »    PDF »
Protein kinase A and casein kinases mediate sequential phosphorylation events in the circadian negative feedback loop.
G. Huang, S. Chen, S. Li, J. Cha, C. Long, L. Li, Q. He, and Y. Liu (2007)
Genes & Dev. 21, 3283-3295
   Abstract »    Full Text »    PDF »
Circadian clocks: regulators of endocrine and metabolic rhythms.
M. Hastings, J. S O'Neill, and E. S Maywood (2007)
J. Endocrinol. 195, 187-198
   Abstract »    Full Text »    PDF »
{beta}-TrCP1-Mediated Degradation of PERIOD2 Is Essential for Circadian Dynamics.
S. Reischl, K. Vanselow, P. O. Westermark, N. Thierfelder, B. Maier, H. Herzel, and A. Kramer (2007)
J Biol Rhythms 22, 375-386
   Abstract »    PDF »
An Inhibitor of Casein Kinase I{epsilon} Induces Phase Delays in Circadian Rhythms under Free-Running and Entrained Conditions.
L. Badura, T. Swanson, W. Adamowicz, J. Adams, J. Cianfrogna, K. Fisher, J. Holland, R. Kleiman, F. Nelson, L. Reynolds, et al. (2007)
J. Pharmacol. Exp. Ther. 322, 730-738
   Abstract »    Full Text »    PDF »
A DOUBLETIME Kinase Binding Domain on the Drosophila PERIOD Protein Is Essential for Its Hyperphosphorylation, Transcriptional Repression, and Circadian Clock Function.
E. Y. Kim, H. W. Ko, W. Yu, P. E. Hardin, and I. Edery (2007)
Mol. Cell. Biol. 27, 5014-5028
   Abstract »    Full Text »    PDF »
A Small Conserved Domain of Drosophila PERIOD Is Important for Circadian Phosphorylation, Nuclear Localization, and Transcriptional Repressor Activity.
P. Nawathean, D. Stoleru, and M. Rosbash (2007)
Mol. Cell. Biol. 27, 5002-5013
   Abstract »    Full Text »    PDF »
Beyond Intuitive Modeling: Combining Biophysical Models with Innovative Experiments to Move the Circadian Clock Field Forward.
D. Forger, D. Gonze, D. Virshup, and D. K. Welsh (2007)
J Biol Rhythms 22, 200-210
   Abstract »    PDF »
Mutation of the Circadian Clock Gene Per2 Alters Vascular Endothelial Function.
H. Viswambharan, J. M. Carvas, V. Antic, A. Marecic, C. Jud, C. E. Zaugg, X.-F. Ming, J.-P. Montani, U. Albrecht, and Z. Yang (2007)
Circulation 115, 2188-2195
   Abstract »    Full Text »    PDF »
Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation.
B. H. Miller, E. L. McDearmon, S. Panda, K. R. Hayes, J. Zhang, J. L. Andrews, M. P. Antoch, J. R. Walker, K. A. Esser, J. B. Hogenesch, et al. (2007)
PNAS 104, 3342-3347
   Abstract »    Full Text »    PDF »
A novel E4BP4 element drives circadian expression of mPeriod2.
T. Ohno, Y. Onishi, and N. Ishida (2007)
Nucleic Acids Res. 35, 648-655
   Abstract »    Full Text »    PDF »
The Multiple Facets of Per2.
U. Albrecht, A. Bordon, I. Schmutz, and J. Ripperger (2007)
Cold Spring Harb Symp Quant Biol 72, 95-104
   Abstract »    PDF »
Structure Function Analysis of Mammalian Cryptochromes.
F. Tamanini, I. Chaves, M. I. Bajek, and G. T. J. van der Horst (2007)
Cold Spring Harb Symp Quant Biol 72, 133-139
   Abstract »    PDF »
Role of Phosphorylation in the Mammalian Circadian Clock.
K. Vanselow and A. Kramer (2007)
Cold Spring Harb Symp Quant Biol 72, 167-176
   Abstract »    PDF »
Posttranslational Control of the Neurospora Circadian Clock.
J. Cha, G. Huang, J. Guo, and Y. Liu (2007)
Cold Spring Harb Symp Quant Biol 72, 185-191
   Abstract »    PDF »
What Is There Left to Learn about the Drosophila Clock?.
J. Blau, F. Blanchard, B. Collins, D. Dahdal, A. Knowles, D. Mizrak, and M. Ruben (2007)
Cold Spring Harb Symp Quant Biol 72, 243-250
   Abstract »    PDF »
The Biology of the Circadian Ck1{epsilon} tau Mutation in Mice and Syrian Hamsters: A Tale of Two Species.
A.S.I. Loudon, Q.J. Meng, E.S. Maywood, D.A. Bechtold, R.P. Boot-Handford, and M.H. Hastings (2007)
Cold Spring Harb Symp Quant Biol 72, 261-271
   Abstract »    PDF »
Novel Insights from Genetic and Molecular Characterization of the Human Clock.
L. J. Ptacek, C. R. Jones, and Y.-H. Fu (2007)
Cold Spring Harb Symp Quant Biol 72, 273-277
   Abstract »    PDF »
Entrainment of the Human Circadian Clock.
T. Roenneberg and M. Merrow (2007)
Cold Spring Harb Symp Quant Biol 72, 293-299
   Abstract »    PDF »
Peripheral Clocks: Keeping Up with the Master Clock.
E. Kowalska and S. A. Brown (2007)
Cold Spring Harb Symp Quant Biol 72, 301-305
   Abstract »    PDF »
Stochastic Phase Oscillators and Circadian Bioluminescence Recordings.
J. Rougemont and F. Naef (2007)
Cold Spring Harb Symp Quant Biol 72, 405-411
   Abstract »    PDF »
Reversible Protein Phosphorylation Regulates Circadian Rhythms.
D. M. Virshup, E. J. Eide, D. B. Forger, M. Gallego, and E. V. Harnish (2007)
Cold Spring Harb Symp Quant Biol 72, 413-420
   Abstract »    PDF »
Molecular Analysis of Sleep: Wake Cycles in Drosophila.
A. Sehgal, W. Joiner, A. Crocker, K. Koh, S. Sathyanarayanan, Y. Fang, M. Wu, J. A. Williams, and X. Zheng (2007)
Cold Spring Harb Symp Quant Biol 72, 557-564
   Abstract »    PDF »
Systems Biology of Circadian Rhythms: An Outlook.
L. De Haro and S. Panda (2006)
J Biol Rhythms 21, 507-518
   Abstract »    PDF »
Improved Tumor Control through Circadian Clock Induction by Seliciclib, a Cyclin-Dependent Kinase Inhibitor..
I. Iurisci, E. Filipski, J. Reinhardt, S. Bach, A. Gianella-Borradori, S. Iacobelli, L. Meijer, and F. Levi (2006)
Cancer Res. 66, 10720-10728
   Abstract »    Full Text »    PDF »
Regulating a Circadian Clock's Period, Phase and Amplitude by Phosphorylation: Insights from Drosophila.
K. Bae and I. Edery (2006)
J. Biochem. 140, 609-617
   Abstract »    Full Text »    PDF »
Molecular components of the mammalian circadian clock.
C. H. Ko and J. S. Takahashi (2006)
Hum. Mol. Genet. 15, R271-R277
   Abstract »    Full Text »    PDF »
The right place at the right time: regulation of daily timing by phosphorylation.
M. Merrow, G. Mazzotta, Z. Chen, and T. Roenneberg (2006)
Genes & Dev. 20, 2629-2633
   Full Text »    PDF »
Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS).
K. Vanselow, J. T. Vanselow, P. O. Westermark, S. Reischl, B. Maier, T. Korte, A. Herrmann, H. Herzel, A. Schlosser, and A. Kramer (2006)
Genes & Dev. 20, 2660-2672
   Abstract »    Full Text »    PDF »
CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loop.
Q. He, J. Cha, Q. He, H.-C. Lee, Y. Yang, and Y. Liu (2006)
Genes & Dev. 20, 2552-2565
   Abstract »    Full Text »    PDF »
A Drosophila model for age-associated changes in sleep:wake cycles.
K. Koh, J. M. Evans, J. C. Hendricks, and A. Sehgal (2006)
PNAS 103, 13843-13847
   Abstract »    Full Text »    PDF »
Circadian rhythms and reproduction..
M. J Boden and D. J Kennaway (2006)
Reproduction 132, 379-392
   Abstract »    Full Text »    PDF »
Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5.
C. L. Partch, K. F. Shields, C. L. Thompson, C. P. Selby, and A. Sancar (2006)
PNAS 103, 10467-10472
   Abstract »    Full Text »    PDF »
Genetic Evidence for a Neurovestibular Influence on the Mammalian Circadian Pacemaker.
P. M. Fuller and C. A. Fuller (2006)
J Biol Rhythms 21, 177-184
   Abstract »    PDF »
Negative Regulation of LRP6 Function by Casein Kinase I {epsilon} Phosphorylation.
W. Swiatek, H. Kang, B. A. Garcia, J. Shabanowitz, G. S. Coombs, D. F. Hunt, and D. M. Virshup (2006)
J. Biol. Chem. 281, 12233-12241
   Abstract »    Full Text »    PDF »
The Epidemiology of Morningness/Eveningness: Influence of Age, Gender, Ethnicity, and Socioeconomic Factors in Adults (30-49 Years).
S.-J. Paine, P. H. Gander, and N. Travier (2006)
J Biol Rhythms 21, 68-76
   Abstract »    PDF »
Molecular Mechanism of Cell-autonomous Circadian Gene Expression of Period2, a Crucial Regulator of the Mammalian Circadian Clock.
M. Akashi, T. Ichise, T. Mamine, and T. Takumi (2006)
Mol. Biol. Cell 17, 555-565
   Abstract »    Full Text »    PDF »
In Vivo Circadian Function of Casein Kinase 2 Phosphorylation Sites in Drosophila PERIOD.
J.-M. Lin, A. Schroeder, and R. Allada (2005)
J. Neurosci. 25, 11175-11183
   Abstract »    Full Text »    PDF »
Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder.
M. Takimoto, A. Hamada, A. Tomoda, S. Ohdo, T. Ohmura, H. Sakato, J. Kawatani, T. Jodoi, H. Nakagawa, H. Terazono, et al. (2005)
Am J Physiol Regulatory Integrative Comp Physiol 289, R1273-R1279
   Abstract »    Full Text »    PDF »
The circadian cycle: daily rhythms from behaviour to genes: First in the Cycles Review Series.
M. Merrow, K. Spoelstra, and T. Roenneberg (2005)
EMBO Rep. 6, 930-935
   Abstract »    Full Text »    PDF »
Transient short free running circadian rhythm in a case of aneurysm near the suprachiasmatic nuclei.
K E Bloch, T Brack, and A Wirz-Justice (2005)
J. Neurol. Neurosurg. Psychiatry 76, 1178-1180
   Abstract »    Full Text »    PDF »
Timing and Consolidation of Human Sleep, Wakefulness, and Performance by a Symphony of Oscillators.
D.-J. Dijk and M. von Schantz (2005)
J Biol Rhythms 20, 279-290
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