Loren W. Runnels, Lixia Yue, David E. Clapham^*

We cloned and characterized a protein kinase and ion channel, TRP-PLIK. As part of the long transient receptor potential channel subfamily implicated in control of cell division, it is a protein that is both an ion channel and a protein kinase. TRP-PLIK phosphorylated itself, displayed a wide tissue distribution, and, when expressed in CHO-K1 cells, constituted a nonselective, calcium-permeant, 105-picosiemen, steeply outwardly rectifying conductance. The zinc finger containing -kinase domain was functional. Inactivation of the kinase activity by site-directed mutagenesis and the channel's dependence on intracellular adenosine triphosphate (ATP) demonstrated that the channel's kinase activity is essential for channel function.

Howard Hughes Medical Institute, Department of Cardiology, Department of Neurobiology, Harvard Medical School, 1309 Enders Building, 320 Longwood Avenue, Children's Hospital, Boston, MA 02115, USA.
^*   To whom correspondence should be addressed. E-mail: clapham{at}rascal.med.harvard.edu

Integration of Troponin I Phosphorylation With Cardiac Regulatory Networks.

R. J. Solaro, M. Henze, and T. Kobayashi (2013)
Circ. Res. 112, 355-366
 |  Abstract »  |  Full Text »  |  PDF »

Increase in Serum Ca2+/Mg2+ Ratio Promotes Proliferation of Prostate Cancer Cells by Activating TRPM7 Channels.

Y. Sun, S. Selvaraj, A. Varma, S. Derry, A. E. Sahmoun, and B. B. Singh (2013)
J. Biol. Chem. 288, 255-263
 |  Abstract »  |  Full Text »  |  PDF »

Upregulation of TRPM7 Channels by Angiotensin II Triggers Phenotypic Switching of Vascular Smooth Muscle Cells of Ascending Aorta.

Z. Zhang, M. Wang, X.-H. Fan, J.-H. Chen, Y.-Y. Guan, and Y.-B. Tang (2012)
Circ. Res. 111, 1137-1146
 |  Abstract »  |  Full Text »  |  PDF »

Role of Ion Channels and Transporters in Cell Migration.

A. Schwab, A. Fabian, P. J. Hanley, and C. Stock (2012)
Physiol Rev 92, 1865-1913
 |  Abstract »  |  Full Text »  |  PDF »

Optical Recording Reveals Novel Properties of GSK1016790A-Induced Vanilloid Transient Receptor Potential Channel TRPV4 Activity in Primary Human Endothelial Cells.

M. N. Sullivan, M. Francis, N. L. Pitts, M. S. Taylor, and S. Earley (2012)
Mol. Pharmacol. 82, 464-472
 |  Abstract »  |  Full Text »  |  PDF »

Sensitivity of TRPM7 channels to Mg2+ characterized in cell-free patches of Jurkat T lymphocytes.

R. Chokshi, M. Matsushita, and J. A. Kozak (2012)
Am J Physiol Cell Physiol 302, C1642-C1651
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive expression of a Mg2+-inhibited K+ current and a TRPM7-like current in human erythroleukemia cells.

M. J. Mason, C. Schaffner, R. A. Floto, and Q. A. Teo (2012)
Am J Physiol Cell Physiol 302, C853-C867
 |  Abstract »  |  Full Text »  |  PDF »

The channel kinase, TRPM7, is required for early embryonic development.

J. Jin, L.-J. Wu, J. Jun, X. Cheng, H. Xu, N. C. Andrews, and D. E. Clapham (2012)
PNAS 109, E225-E233
 |  Abstract »  |  Full Text »  |  PDF »

TRPM7 Is Required within Zebrafish Sensory Neurons for the Activation of Touch-Evoked Escape Behaviors.

S. E. Low, K. Amburgey, E. Horstick, J. Linsley, S. M. Sprague, W. W. Cui, W. Zhou, H. Hirata, L. Saint-Amant, R. I. Hume, et al. (2011)
J. Neurosci. 31, 11633-11644
 |  Abstract »  |  Full Text »  |  PDF »

Ion channels and transporters in cancer. 1. Ion channels and cell proliferation in cancer.

A. Becchetti (2011)
Am J Physiol Cell Physiol 301, C255-C265
 |  Abstract »  |  Full Text »  |  PDF »

Calcium-activated K+ channels increase cell proliferation independent of K+ conductance.

J. E. Millership, D. C. Devor, K. L. Hamilton, C. M. Balut, J. I. E. Bruce, and I. M. Fearon (2011)
Am J Physiol Cell Physiol 300, C792-C802
 |  Abstract »  |  Full Text »  |  PDF »

Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer.

N. S. Yee, W. Zhou, and I.-C. Liang (2011)
Dis. Model. Mech. 4, 240-254
 |  Abstract »  |  Full Text »  |  PDF »

Novel Channel Enzyme Fusion Proteins Confer Arsenate Resistance.

B. Wu, J. Song, and E. Beitz (2010)
J. Biol. Chem. 285, 40081-40087
 |  Abstract »  |  Full Text »  |  PDF »

trpm7 Regulation of in Vivo Cation Homeostasis and Kidney Function Involves Stanniocalcin 1 and fgf23.

M. R. Elizondo, E. H. Budi, and D. M. Parichy (2010)
Endocrinology 151, 5700-5709
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Transient Receptor Potential Cation Channels in Ca2+ Signaling.

M. Gees, B. Colsoul, and B. Nilius (2010)
Cold Spring Harb Perspect Biol 2, a003962
 |  Abstract »  |  Full Text »  |  PDF »

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family.

L.-J. Wu, T.-B. Sweet, and D. E. Clapham (2010)
Pharmacol. Rev. 62, 381-404
 |  Abstract »  |  Full Text »  |  PDF »

Methionine Sulfoxide Reductase B1 (MsrB1) Recovers TRPM6 Channel Activity during Oxidative Stress.

G. Cao, K. p. Lee, J. van der Wijst, M. de Graaf, A. van der Kemp, R. J. M. Bindels, and J. G. J. Hoenderop (2010)
J. Biol. Chem. 285, 26081-26087
 |  Abstract »  |  Full Text »  |  PDF »

Development and Optimization of a High-Throughput Bioassay for TRPM7 Ion Channel Inhibitors.

B. Castillo, P. Porzgen, R. Penner, F. D. Horgen, and A. Fleig (2010)
J Biomol Screen 15, 498-507
 |  Abstract »  |  Full Text »  |  PDF »

Renal TRPathies.

A. Dietrich, V. Chubanov, and T. Gudermann (2010)
J. Am. Soc. Nephrol. 21, 736-744
 |  Abstract »  |  Full Text »  |  PDF »

TRPM7-Mediated Ca2+ Signals Confer Fibrogenesis in Human Atrial Fibrillation.

J. Du, J. Xie, Z. Zhang, H. Tsujikawa, D. Fusco, D. Silverman, B. Liang, and L. Yue (2010)
Circ. Res. 106, 992-1003
 |  Abstract »  |  Full Text »  |  PDF »

Zinc-induced Neurotoxicity Mediated by Transient Receptor Potential Melastatin 7 Channels.

K. Inoue, D. Branigan, and Z.-G. Xiong (2010)
J. Biol. Chem. 285, 7430-7439
 |  Abstract »  |  Full Text »  |  PDF »

Molecular identification of ancient and modern mammalian magnesium transporters.

G. A. Quamme (2010)
Am J Physiol Cell Physiol 298, C407-C429
 |  Abstract »  |  Full Text »  |  PDF »

Zn2+ Activates Large Conductance Ca2+-activated K+ Channel via an Intracellular Domain.

S. Hou, L. E. Vigeland, G. Zhang, R. Xu, M. Li, S. H. Heinemann, and T. Hoshi (2010)
J. Biol. Chem. 285, 6434-6442
 |  Abstract »  |  Full Text »  |  PDF »

Mg2+- and MgATP-inhibited and Ca2+/calmodulin-sensitive TRPM7-like current in hepatoma and hepatocytes.

R. Mishra, V. Rao, R. Ta, N. Shobeiri, and C. E. Hill (2009)
Am J Physiol Gastrointest Liver Physiol 297, G687-G694
 |  Abstract »  |  Full Text »  |  PDF »

Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development.

H. Zhou and D. E. Clapham (2009)
PNAS 106, 15750-15755
 |  Abstract »  |  Full Text »  |  PDF »

Silencing TRPM7 promotes growth/proliferation and nitric oxide production of vascular endothelial cells via the ERK pathway.

K. Inoue and Z.-G. Xiong (2009)
Cardiovasc Res 83, 547-557
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the Epithelial Mg2+ Channel TRPM6 by Estrogen and the Associated Repressor Protein of Estrogen Receptor Activity (REA).

G. Cao, J. van der Wijst, A. van der Kemp, F. van Zeeland, R. J. Bindels, and J. G. Hoenderop (2009)
J. Biol. Chem. 284, 14788-14795
 |  Abstract »  |  Full Text »  |  PDF »

TRPM1 Forms Ion Channels Associated with Melanin Content in Melanocytes.

E. Oancea, J. Vriens, S. Brauchi, J. Jun, I. Splawski, and D. E. Clapham (2009)
Science Signaling 2, ra21
 |  Abstract »  |  Full Text »  |  PDF »

Divide and Conquer: High Resolution Structural Information on TRP Channel Fragments.

R. Gaudet (2009)
J. Gen. Physiol. 133, 231-237
 |  Full Text »  |  PDF »

gem-1 Encodes an SLC16 Monocarboxylate Transporter-Related Protein That Functions in Parallel to the gon-2 TRPM Channel During Gonad Development in Caenorhabditis elegans.

B. J. Kemp, D. L. Church, J. Hatzold, B. Conradt, and E. J. Lambie (2009)
Genetics 181, 581-591
 |  Abstract »  |  Full Text »  |  PDF »

Evidence that TRPM7 is required for breast cancer cell proliferation.

A. Guilbert, M. Gautier, I. Dhennin-Duthille, N. Haren, H. Sevestre, and H. Ouadid-Ahidouch (2009)
Am J Physiol Cell Physiol 297, C493-C502
 |  Abstract »  |  Full Text »  |  PDF »

Huntingtin-interacting Proteins, HIP14 and HIP14L, Mediate Dual Functions, Palmitoyl Acyltransferase and Mg2+ Transport.

A. Goytain, R. M. Hines, and G. A. Quamme (2008)
J. Biol. Chem. 283, 33365-33374
 |  Abstract »  |  Full Text »  |  PDF »

Deletion of Trpm7 Disrupts Embryonic Development and Thymopoiesis Without Altering Mg2+ Homeostasis.

J. Jin, B. N. Desai, B. Navarro, A. Donovan, N. C. Andrews, and D. E. Clapham (2008)
Science 322, 756-760
 |  Abstract »  |  Full Text »  |  PDF »

TRP channels entering the structural era.

R. Gaudet (2008)
J. Physiol. 586, 3565-3575
 |  Abstract »  |  Full Text »  |  PDF »

Role of the {alpha}-Kinase Domain in Transient Receptor Potential Melastatin 6 Channel and Regulation by Intracellular ATP.

S. Thebault, G. Cao, H. Venselaar, Q. Xi, R. J. M. Bindels, and J. G. J. Hoenderop (2008)
J. Biol. Chem. 283, 19999-20007
 |  Abstract »  |  Full Text »  |  PDF »

TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane.

S. Brauchi, G. Krapivinsky, L. Krapivinsky, and D. E. Clapham (2008)
PNAS 105, 8304-8308
 |  Abstract »  |  Full Text »  |  PDF »

Proton Conductivity through the Human TRPM7 Channel and Its Molecular Determinants.

T. Numata and Y. Okada (2008)
J. Biol. Chem. 283, 15097-15103
 |  Abstract »  |  Full Text »  |  PDF »

Evolutionary determinants of divergent calcium selectivity of TRPM channels.

M. Mederos y Schnitzler, J. Waring, T. Gudermann, and V. Chubanov (2008)
FASEB J 22, 1540-1551
 |  Abstract »  |  Full Text »  |  PDF »

A Constitutive, Transient Receptor Potential-like Ca2+ Influx Pathway in Presynaptic Nerve Endings Independent of Voltage-gated Ca2+ Channels and Na+/Ca2+ Exchange.

R. A. Nichols, A. F. Dengler, E. M. Nakagawa, M. Bashkin, B. T. Paul, J. Wu, and G. M. Khan (2007)
J. Biol. Chem. 282, 36102-36111
 |  Abstract »  |  Full Text »  |  PDF »

Functional Transient Receptor Potential Melastatin 7 Channels Are Critical for Human Mast Cell Survival.

R. C. E. Wykes, M. Lee, S. M. Duffy, W. Yang, E. P. Seward, and P. Bradding (2007)
J. Immunol. 179, 4045-4052
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Determinants of Mg2+ and Ca2+ Permeability and pH Sensitivity in TRPM6 and TRPM7.

M. Li, J. Du, J. Jiang, W. Ratzan, L.-T. Su, L. W. Runnels, and L. Yue (2007)
J. Biol. Chem. 282, 25817-25830
 |  Abstract »  |  Full Text »  |  PDF »

Neuromodulators, Not Activity, Control Coordinated Expression of Ionic Currents.

O. Khorkova and J. Golowasch (2007)
J. Neurosci. 27, 8709-8718
 |  Abstract »  |  Full Text »  |  PDF »

TRPM7 channel is sensitive to osmotic gradients in human kidney cells.

B. F. Bessac and A. Fleig (2007)
J. Physiol. 582, 1073-1086
 |  Abstract »  |  Full Text »  |  PDF »

Hypomagnesemia with Secondary Hypocalcemia due to a Missense Mutation in the Putative Pore-forming Region of TRPM6.

V. Chubanov, K. P. Schlingmann, J. Waring, J. Heinzinger, S. Kaske, S. Waldegger, M. M. y Schnitzler, and T. Gudermann (2007)
J. Biol. Chem. 282, 7656-7667
 |  Abstract »  |  Full Text »  |  PDF »

Transient Receptor Potential Channels of the Melastatin Family and Ischemic Responses of Central Neurons.

J. F. MacDonald and M. F. Jackson (2007)
Stroke 38, 665-669
 |  Abstract »  |  Full Text »  |  PDF »

Activation of TRPM7 Channels by Phospholipase C-coupled Receptor Agonists.

M. Langeslag, K. Clark, W. H. Moolenaar, F. N. van Leeuwen, and K. Jalink (2007)
J. Biol. Chem. 282, 232-239
 |  Abstract »  |  Full Text »  |  PDF »

Transient Receptor Potential Cation Channels in Disease.

B. Nilius, G. Owsianik, T. Voets, and J. A. Peters (2007)
Physiol Rev 87, 165-217
 |  Abstract »  |  Full Text »  |  PDF »

TRP channels and lipids: from Drosophila to mammalian physiology.

R. C. Hardie (2007)
J. Physiol. 578, 9-24
 |  Abstract »  |  Full Text »  |  PDF »

TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells.

T. Numata, T. Shimizu, and Y. Okada (2007)
Am J Physiol Cell Physiol 292, C460-C467
 |  Abstract »  |  Full Text »  |  PDF »

Calcium-dependent growth regulation of small cell lung cancer cells by neuropeptides.

T. Gudermann and S. Roelle (2006)
Endocr. Relat. Cancer 13, 1069-1084
 |  Abstract »  |  Full Text »  |  PDF »

ATP and PIP2 dependence of the magnesium-inhibited, TRPM7-like cation channel in cardiac myocytes.

A. Gwanyanya, K. R. Sipido, J. Vereecke, and K. Mubagwa (2006)
Am J Physiol Cell Physiol 291, C627-C635
 |  Abstract »  |  Full Text »  |  PDF »

K+-ATP-channel-related protein complexes: potential transducers in the regulation of epithelial tight junction permeability.

T. Jons, D. Wittschieber, A. Beyer, C. Meier, A. Brune, A. Thomzig, G. Ahnert-Hilger, and R. W. Veh (2006)
J. Cell Sci. 119, 3087-3097
 |  Abstract »  |  Full Text »  |  PDF »

Manganese and iron transport across pulmonary epithelium.

E. A. Heilig, K. J. Thompson, R. M. Molina, A. R. Ivanov, J. D. Brain, and M. Wessling-Resnick (2006)
Am J Physiol Lung Cell Mol Physiol 290, L1247-L1259
 |  Abstract »  |  Full Text »  |  PDF »

Functional Characterization of Homo- and Heteromeric Channel Kinases TRPM6 and TRPM7.

M. Li, J. Jiang, and L. Yue (2006)
J. Gen. Physiol. 127, 525-537
 |  Abstract »  |  Full Text »  |  PDF »

TRPM7 Regulates Cell Adhesion by Controlling the Calcium-dependent Protease Calpain.

L.-T. Su, M. A. Agapito, M. Li, W. T. N. Simonson, A. Huttenlocher, R. Habas, L. Yue, and L. W. Runnels (2006)
J. Biol. Chem. 281, 11260-11270
 |  Abstract »  |  Full Text »  |  PDF »

TRPM7 Channel Is Regulated by Magnesium Nucleotides via its Kinase Domain.

P. Demeuse, R. Penner, and A. Fleig (2006)
J. Gen. Physiol. 127, 421-434
 |  Abstract »  |  Full Text »  |  PDF »

A voltage-driven switch for ion-independent signaling by ether-a-go-go K+ channels.

A. P. Hegle, D. D. Marble, and G. F. Wilson (2006)
PNAS 103, 2886-2891
 |  Abstract »  |  Full Text »  |  PDF »

Functional TRPM7 Channels Accumulate at the Plasma Membrane in Response to Fluid Flow.

E. Oancea, J. T. Wolfe, and D. E. Clapham (2006)
Circ. Res. 98, 245-253
 |  Abstract »  |  Full Text »  |  PDF »

Differential regulation of transient receptor potential melastatin 6 and 7 cation channels by ANG II in vascular smooth muscle cells from spontaneously hypertensive rats.

R. M. Touyz, Y. He, A. C. I. Montezano, G. Yao, V. Chubanov, T. Gudermann, and G. E. Callera (2006)
Am J Physiol Regulatory Integrative Comp Physiol 290, R73-R78
 |  Abstract »  |  Full Text »  |  PDF »

International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels.

D. E. Clapham, D. Julius, C. Montell, and G. Schultz (2005)
Pharmacol. Rev. 57, 427-450
 |  Full Text »  |  PDF »

Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel.

T. Wang, Y. Jiao, and C. Montell (2005)
J. Cell Biol. 171, 685-694
 |  Abstract »  |  Full Text »  |  PDF »

The Channel Kinases TRPM6 and TRPM7 Are Functionally Nonredundant.

C. Schmitz, M. V. Dorovkov, X. Zhao, B. J. Davenport, A. G. Ryazanov, and A.-L. Perraud (2005)
J. Biol. Chem. 280, 37763-37771
 |  Abstract »  |  Full Text »  |  PDF »

PIP2 Activates TRPV5 and Releases Its Inhibition by Intracellular Mg2+.

J. Lee, S.-K. Cha, T.-J. Sun, and C.-L. Huang (2005)
J. Gen. Physiol. 126, 439-451
 |  Abstract »  |  Full Text »  |  PDF »

Novel TRPM6 Mutations in 21 Families with Primary Hypomagnesemia and Secondary Hypocalcemia.

K. P. Schlingmann, M. C. Sassen, S. Weber, U. Pechmann, K. Kusch, L. Pelken, D. Lotan, M. Syrrou, J. J. Prebble, D. E.C. Cole, et al. (2005)
J. Am. Soc. Nephrol. 16, 3061-3069
 |  Abstract »  |  Full Text »  |  PDF »

A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients.

S. Feske, M. Prakriya, A. Rao, and R. S. Lewis (2005)
J. Exp. Med. 202, 651-662
 |  Abstract »  |  Full Text »  |  PDF »

A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders.

M. C. Hermosura, H. Nayakanti, M. V. Dorovkov, F. R. Calderon, A. G. Ryazanov, D. S. Haymer, and R. M. Garruto (2005)
PNAS 102, 11510-11515
 |  Abstract »  |  Full Text »  |  PDF »

TRP Channels in Disease.

B. Nilius, T. Voets, and J. Peters (2005)
Sci. STKE 2005, re8
 |  Abstract »  |  Full Text »  |  PDF »

Potentiation of TRPM7 Inward Currents by Protons.

J. Jiang, M. Li, and L. Yue (2005)
J. Gen. Physiol. 126, 137-150
 |  Abstract »  |  Full Text »  |  PDF »

A critical role of TRPM channel-kinase for human magnesium transport.

K. P Schlingmann and T. Gudermann (2005)
J. Physiol. 566, 301-308
 |  Abstract »  |  Full Text »  |  PDF »

Alternative Splicing Switches the Divalent Cation Selectivity of TRPM3 Channels.

J. Oberwinkler, A. Lis, K. M. Giehl, V. Flockerzi, and S. E. Philipp (2005)
J. Biol. Chem. 280, 22540-22548
 |  Abstract »  |  Full Text »  |  PDF »

Channel Function Is Dissociated from the Intrinsic Kinase Activity and Autophosphorylation of TRPM7/ChaK1.

M. Matsushita, J. A. Kozak, Y. Shimizu, D. T. McLachlin, H. Yamaguchi, F.-Y. Wei, K. Tomizawa, H. Matsui, B. T. Chait, M. D. Cahalan, et al. (2005)
J. Biol. Chem. 280, 20793-20803
 |  Abstract »  |  Full Text »  |  PDF »

Store-Operated Calcium Channels.

A. B. Parekh and J. W. Putney Jr. (2005)
Physiol Rev 85, 757-810
 |  Abstract »  |  Full Text »  |  PDF »

The TRP Superfamily of Cation Channels.

C. Montell (2005)
Sci. STKE 2005, re3
 |  Abstract »  |  Full Text »  |  PDF »

Transient Receptor Potential Melastatin 7 Ion Channels Regulate Magnesium Homeostasis in Vascular Smooth Muscle Cells: Role of Angiotensin II.

Y. He, G. Yao, C. Savoia, and R. M. Touyz (2005)
Circ. Res. 96, 207-215
 |  Abstract »  |  Full Text »  |  PDF »

Epithelial Ca2+ and Mg2+ Channels in Health and Disease.

J. G.J. Hoenderop and R. J.M. Bindels (2005)
J. Am. Soc. Nephrol. 16, 15-26
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Annexin I by TRPM7 Channel-Kinase.

M. V. Dorovkov and A. G. Ryazanov (2004)
J. Biol. Chem. 279, 50643-50646
 |  Abstract »  |  Full Text »  |  PDF »

The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis.

F. H. Yu and W. A. Catterall (2004)
Sci. STKE 2004, re15
 |  Abstract »  |  Full Text »  |  PDF »

Magnesium-inhibited, TRPM6/7-like channel in cardiac myocytes: permeation of divalent cations and pH-mediated regulation.

A. Gwanyanya, B. Amuzescu, S. I. Zakharov, R. Macianskiene, K. R. Sipido, V. M. Bolotina, J. Vereecke, and K. Mubagwa (2004)
J. Physiol. 559, 761-776
 |  Abstract »  |  Full Text »  |  PDF »

TRPM7: Channeling the Future of Cellular Magnesium Homeostasis?.

F. I. Wolf (2004)
Sci. STKE 2004, pe23
 |  Abstract »  |  Full Text »  |  PDF »

Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain.

R. Takezawa, C. Schmitz, P. Demeuse, A. M. Scharenberg, R. Penner, and A. Fleig (2004)
PNAS 101, 6009-6014
 |  Abstract »  |  Full Text »  |  PDF »

Insights into the molecular nature of magnesium homeostasis.

M. Konrad, K. P. Schlingmann, and T. Gudermann (2004)
Am J Physiol Renal Physiol 286, F599-F605
 |  Abstract »  |  Full Text »  |  PDF »

Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia.

V. Chubanov, S. Waldegger, M. M. y Schnitzler, H. Vitzthum, M. C. Sassen, H. W. Seyberth, M. Konrad, and T. Gudermann (2004)
PNAS 101, 2894-2899
 |  Abstract »  |  Full Text »  |  PDF »

Downregulation of Ca2+ and Mg2+ Transport Proteins in the Kidney Explains Tacrolimus (FK506)-Induced Hypercalciuria and Hypomagnesemia.

T. Nijenhuis, J. G.J. Hoenderop, and R. J.M. Bindels (2004)
J. Am. Soc. Nephrol. 15, 549-557
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor Activates Store-operated Ca2+ Channels through an Inositol 1,4,5-Trisphosphate-independent Pathway in Human Glomerular Mesangial Cells.

W.-P. Li, L. Tsiokas, S. C. Sansom, and R. Ma (2004)
J. Biol. Chem. 279, 4570-4577
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Protein Kinase Activity of TRPM7/ChaK1, a Protein Kinase Fused to the Transient Receptor Potential Ion Channel.

L. V. Ryazanova, M. V. Dorovkov, A. Ansari, and A. G. Ryazanov (2004)
J. Biol. Chem. 279, 3708-3716
 |  Abstract »  |  Full Text »  |  PDF »

TRPM6 Forms the Mg2+ Influx Channel Involved in Intestinal and Renal Mg2+ Absorption.

T. Voets, B. Nilius, S. Hoefs, A. W. C. M. van der Kemp, G. Droogmans, R. J. M. Bindels, and J. G. J. Hoenderop (2004)
J. Biol. Chem. 279, 19-25
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5.

D. Liu and E. R. Liman (2003)
PNAS 100, 15160-15165
 |  Abstract »  |  Full Text »  |  PDF »

International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels: Transient Receptor Potential Channels.

D. E. Clapham, C. Montell, G. Schultz, and D. Julius (2003)
Pharmacol. Rev. 55, 591-596
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Regulation of a TRPM7-like Current in Rat Brain Microglia.

X. Jiang, E. W. Newell, and L. C. Schlichter (2003)
J. Biol. Chem. 278, 42867-42876
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The Promotion of Gonadal Cell Divisions by the Caenorhabditis elegans TRPM Cation Channel GON-2 Is Antagonized by GEM-4 Copine.

D. L. Church and E. J. Lambie (2003)
Genetics 165, 563-574
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Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond.

J.-B. Peng, E. M Brown, and M. A Hediger (2003)
J. Physiol. 551, 729-740
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Voltage Dependence of the Ca2+-activated Cation Channel TRPM4.

B. Nilius, J. Prenen, G. Droogmans, T. Voets, R. Vennekens, M. Freichel, U. Wissenbach, and V. Flockerzi (2003)
J. Biol. Chem. 278, 30813-30820
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Identification of Store-independent and Store-operated Ca2+ Conductances in Caenorhabditis elegans Intestinal Epithelial Cells.

A. Y. Estevez, R. K. Roberts, and K. Strange (2003)
J. Gen. Physiol. 122, 207-223
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The Store-operated Calcium Entry Pathways in Human Carcinoma A431 Cells: Functional Properties and Activation Mechanisms.

K. Gusev, L. Glouchankova, A. Zubov, E. Kaznacheyeva, Z. Wang, I. Bezprozvanny, and G. N. Mozhayeva (2003)
J. Gen. Physiol. 122, 81-94
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Molecular and Functional Characterization of the Melastatin-related Cation Channel TRPM3.

C. Grimm, R. Kraft, S. Sauerbruch, G. Schultz, and C. Harteneck (2003)
J. Biol. Chem. 278, 21493-21501
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2-Aminoethoxydiphenyl Borane Activates a Novel Calcium-Permeable Cation Channel.

F.-J. Braun, O. Aziz, and J. W. Putney Jr. (2003)
Mol. Pharmacol. 63, 1304-1311
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Expression and Characterization of Human Transient Receptor Potential Melastatin 3 (hTRPM3).

N. Lee, J. Chen, L. Sun, S. Wu, K. R. Gray, A. Rich, M. Huang, J.-H. Lin, J. N. Feder, E. B. Janovitz, et al. (2003)
J. Biol. Chem. 278, 20890-20897
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A Novel TRPM2 Isoform Inhibits Calcium Influx and Susceptibility to Cell Death.

W. Zhang, X. Chu, Q. Tong, J. Y. Cheung, K. Conrad, K. Masker, and B. A. Miller (2003)
J. Biol. Chem. 278, 16222-16229
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Mg2+-dependent Gating and Strong Inward Rectification of the Cation Channel TRPV6.

T. Voets, A. Janssens, J. Prenen, G. Droogmans, and B. Nilius (2003)
J. Gen. Physiol. 121, 245-260
 |  Abstract »  |  Full Text »  |  PDF »