Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 291 (5507): 1289-1292

Copyright © 2001 by the American Association for the Advancement of Science

The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains

Huib Caron,12 Barbera van Schaik,13 Merlijn van der Mee,3 Frank Baas,4 Gregory Riggins,6 Peter van Sluis,1 Marie-Christine Hermus,1 Ronald van Asperen,1 Kathy Boon,1 P. A. Voûte,2 Siem Heisterkamp,5 Antoine van Kampen,3 Rogier Versteeg1

The chromosomal position of human genes is rapidly being established. We integrated these mapping data with genome-wide messenger RNA expression profiles as provided by SAGE (serial analysis of gene expression). Over 2.45 million SAGE transcript tags, including 160,000 tags of neuroblastomas, are presently known for 12 tissue types. We developed algorithms to assign these tags to UniGene clusters and their chromosomal position. The resulting Human Transcriptome Map generates gene expression profiles for any chromosomal region in 12 normal and pathologic tissue types. The map reveals a clustering of highly expressed genes to specific chromosomal regions. It provides a tool to search for genes that are overexpressed or silenced in cancer.

1 Department of Human Genetics,
2 Department of Pediatric Oncology, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Post Office Box 22700, 1100 DE Amsterdam, Netherlands.
3 Bioinformatics Laboratory,
4 Neurozintuigen Laboratory,
5 Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
6 Department of Pathology and Department of Genetics, Duke University Medical Center, Durham, NC 27710, USA.

Uncovering the Functional Constraints Underlying the Genomic Organization of the Odorant-Binding Protein Genes.
P. Librado and J. Rozas (2013)
Genome Biol Evol 5, 2096-2108
   Abstract »    Full Text »    PDF »
Regional chromatin decompaction in Cornelia de Lange syndrome associated with NIPBL disruption can be uncoupled from cohesin and CTCF.
L. D. Nolen, S. Boyle, M. Ansari, E. Pritchard, and W. A. Bickmore (2013)
Hum. Mol. Genet. 22, 4180-4193
   Abstract »    Full Text »    PDF »
Isochores and the Regulation of Gene Expression in the Human Genome.
S. Arhondakis, F. Auletta, and G. Bernardi (2013)
Genome Biol Evol 3, 1080-1089
   Abstract »    Full Text »    PDF »
Understanding the regulatory and transcriptional complexity of the genome through structure.
T. R. Mercer and J. S. Mattick (2013)
Genome Res. 23, 1081-1088
   Abstract »    Full Text »    PDF »
A Developmental Transcriptional Network for Maize Defines Coexpression Modules.
G. S. Downs, Y.-M. Bi, J. Colasanti, W. Wu, X. Chen, T. Zhu, S. J. Rothstein, and L. N. Lukens (2013)
Plant Physiology 161, 1830-1843
   Abstract »    Full Text »    PDF »
Uncovering Networks from Genome-Wide Association Studies via Circular Genomic Permutation.
C. P. Cabrera, P. Navarro, J. E. Huffman, A. F. Wright, C. Hayward, H. Campbell, J. F. Wilson, I. Rudan, N. D. Hastie, V. Vitart, et al. (2012)
g3 2, 1067-1075
   Abstract »    Full Text »    PDF »
KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function.
F. R. Santoni de Sio, J. Massacand, I. Barde, S. Offner, A. Corsinotti, A. Kapopoulou, K. Bojkowska, A. Dagklis, M. Fernandez, P. Ghia, et al. (2012)
Blood 119, 4675-4685
   Abstract »    Full Text »    PDF »
Cis-regulatory properties of medaka synexpression groups.
M. Ramialison, R. Reinhardt, T. Henrich, B. Wittbrodt, T. Kellner, C. M. Lowy, and J. Wittbrodt (2012)
Development 139, 917-928
   Abstract »    Full Text »    PDF »
Transcription factories in the context of the nuclear and genome organization.
S. V. Razin, A. A. Gavrilov, A. Pichugin, M. Lipinski, O. V. Iarovaia, and Y. S. Vassetzky (2011)
Nucleic Acids Res. 39, 9085-9092
   Abstract »    Full Text »    PDF »
Transcriptional Coupling of Neighboring Genes and Gene Expression Noise: Evidence that Gene Orientation and Noncoding Transcripts Are Modulators of Noise.
G.-Z. Wang, M. J. Lercher, and L. D. Hurst (2011)
Genome Biol Evol 3, 320-331
   Abstract »    Full Text »    PDF »
Exploiting prior knowledge and gene distances in the analysis of tumor expression profiles with extended Hidden Markov Models.
M. Seifert, M. Strickert, A. Schliep, and I. Grosse (2011)
Bioinformatics 27, 1645-1652
   Abstract »    Full Text »    PDF »
Clustering with exclusion zones: genomic applications.
M. R. Segal, Y. Xiao, and F. W. Huffer (2011)
Biostat. 12, 234-246
   Abstract »    Full Text »    PDF »
Chromatin Folding: From Linear Chromosomes to the 4D Nucleus.
T. Cheutin, F. Bantignies, B. Leblanc, and G. Cavalli (2011)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
Chromatin folding - from biology to polymer models and back.
M. Tark-Dame, R. van Driel, and D. W. Heermann (2011)
J. Cell Sci. 124, 839-845
   Abstract »    Full Text »    PDF »
Whole-Genome Expression Plasticity across Tropical and Temperate Drosophila melanogaster Populations from Eastern Australia.
M. T. Levine, M. L. Eckert, and D. J. Begun (2011)
Mol. Biol. Evol. 28, 249-256
   Abstract »    Full Text »    PDF »
Meta-analysis of cancer gene expression signatures reveals new cancer genes, SAGE tags and tumor associated regions of co-regulation.
E. Kavak, M. Unlu, M. Nister, and A. Koman (2010)
Nucleic Acids Res. 38, 7008-7021
   Abstract »    Full Text »    PDF »
Alternative Splicing and Polyadenylation Contribute to the Generation of hERG1 C-terminal Isoforms.
Q. Gong, M. R. Stump, A. R. Dunn, V. Deng, and Z. Zhou (2010)
J. Biol. Chem. 285, 32233-32241
   Abstract »    Full Text »    PDF »
Aberrant Silencing of Cancer-Related Genes by CpG Hypermethylation Occurs Independently of Their Spatial Organization in the Nucleus.
H. P. Easwaran, L. Van Neste, L. Cope, S. Sen, H. P. Mohammad, G. J. Pageau, J. B. Lawrence, J. G. Herman, K. E. Schuebel, and S. B. Baylin (2010)
Cancer Res. 70, 8015-8024
   Abstract »    Full Text »    PDF »
Integrating one-dimensional and three-dimensional maps of genomes.
N. Naumova and J. Dekker (2010)
J. Cell Sci. 123, 1979-1988
   Abstract »    Full Text »    PDF »
Proviruses Selected for High and Stable Expression of Transduced Genes Accumulate in Broadly Transcribed Genome Areas.
J. Plachy, J. Kotab, P. Divina, M. Reinisova, F. Senigl, and J. Hejnar (2010)
J. Virol. 84, 4204-4211
   Abstract »    Full Text »    PDF »
DNaseI hypersensitivity at gene-poor, FSH dystrophy-linked 4q35.2.
X. Xu, K. Tsumagari, J. Sowden, R. Tawil, A. P. Boyle, L. Song, T. S. Furey, G. E. Crawford, and M. Ehrlich (2009)
Nucleic Acids Res. 37, 7381-7393
   Abstract »    Full Text »    PDF »
The human insulin gene is part of a large open chromatin domain specific for human islets.
V. Mutskov and G. Felsenfeld (2009)
PNAS 106, 17419-17424
   Abstract »    Full Text »    PDF »
SysPTM: A Systematic Resource for Proteomic Research on Post-translational Modifications.
H. Li, X. Xing, G. Ding, Q. Li, C. Wang, L. Xie, R. Zeng, and Y. Li (2009)
Mol. Cell. Proteomics 8, 1839-1849
   Abstract »    Full Text »    PDF »
Lack of bystander activation shows that localization exterior to chromosome territories is not sufficient to up-regulate gene expression.
C. Morey, C. Kress, and W. A. Bickmore (2009)
Genome Res. 19, 1184-1194
   Abstract »    Full Text »    PDF »
Detecting Minimal Residual Disease in Neuroblastoma: The Superiority of a Panel of Real-Time Quantitative PCR Markers.
J. Stutterheim, A. Gerritsen, L. Zappeij-Kannegieter, B. Yalcin, R. Dee, M. M. van Noesel, F. Berthold, R. Versteeg, H. N. Caron, C. E. van der Schoot, et al. (2009)
Clin. Chem. 55, 1316-1326
   Abstract »    Full Text »    PDF »
Dynamic reprogramming of transcription factors to and from the subtelomere.
H. C. Mak, L. Pillus, and T. Ideker (2009)
Genome Res. 19, 1014-1025
   Abstract »    Full Text »    PDF »
Germline Expression Influences Operon Organization in the Caenorhabditis elegans Genome.
V. Reinke and A. D. Cutter (2009)
Genetics 181, 1219-1228
   Abstract »    Full Text »    PDF »
Motif discovery in promoters of genes co-localized and co-expressed during myeloid cells differentiation.
A. Coppe, F. Ferrari, A. Bisognin, G. A. Danieli, S. Ferrari, S. Bicciato, and S. Bortoluzzi (2009)
Nucleic Acids Res. 37, 533-549
   Abstract »    Full Text »    PDF »
A Universal Nonmonotonic Relationship between Gene Compactness and Expression Levels in Multicellular Eukaryotes.
L. Carmel and E. V. Koonin (2009)
Genome Biol Evol 1, 382-390
   Abstract »    Full Text »    PDF »
PHOX2B Is a Novel and Specific Marker for Minimal Residual Disease Testing in Neuroblastoma.
J. Stutterheim, A. Gerritsen, L. Zappeij-Kannegieter, I. Kleijn, R. Dee, L. Hooft, M. M. van Noesel, M. Bierings, F. Berthold, R. Versteeg, et al. (2008)
J. Clin. Oncol. 26, 5443-5449
   Abstract »    Full Text »    PDF »
Gene set enrichment analysis using linear models and diagnostics.
A. P. Oron, Z. Jiang, and R. Gentleman (2008)
Bioinformatics 24, 2586-2591
   Abstract »    Full Text »    PDF »
Association between active genes occurs at nuclear speckles and is modulated by chromatin environment.
J. M. Brown, J. Green, R. P. das Neves, H. A.C. Wallace, A. J.H. Smith, J. Hughes, N. Gray, S. Taylor, W. G. Wood, D. R. Higgs, et al. (2008)
J. Cell Biol. 182, 1083-1097
   Abstract »    Full Text »    PDF »
Coexpression of Linked Genes in Mammalian Genomes Is Generally Disadvantageous.
B.-Y. Liao and J. Zhang (2008)
Mol. Biol. Evol. 25, 1555-1565
   Abstract »    Full Text »    PDF »
Comparative analysis of chicken chromosome 28 provides new clues to the evolutionary fragility of gene-rich vertebrate regions.
L. Gordon, S. Yang, M. Tran-Gyamfi, D. Baggott, M. Christensen, A. Hamilton, R. Crooijmans, M. Groenen, S. Lucas, I. Ovcharenko, et al. (2007)
Genome Res. 17, 1603-1613
   Abstract »    Full Text »    PDF »
Reverse Polarization in Amino acid and Nucleotide Substitution Patterns Between Human Mouse Orthologs of Two Compositional Extrema.
S. K. Bag, S. Paul, S. Ghosh, and C. Dutta (2007)
   Abstract »    Full Text »    PDF »
P-STAT1 mediates higher-order chromatin remodelling of the human MHC in response to IFN{gamma}.
R. Christova, T. Jones, P.-J. Wu, A. Bolzer, A. P. Costa-Pereira, D. Watling, I. M. Kerr, and D. Sheer (2007)
J. Cell Sci. 120, 3262-3270
   Abstract »    Full Text »    PDF »
Domain-wide regulation of gene expression in the human genome.
H. J. Gierman, M. H.G. Indemans, J. Koster, S. Goetze, J. Seppen, D. Geerts, R. van Driel, and R. Versteeg (2007)
Genome Res. 17, 1286-1295
   Abstract »    Full Text »    PDF »
Human gene organization driven by the coordination of replication and transcription.
M. Huvet, S. Nicolay, M. Touchon, B. Audit, Y. d'Aubenton-Carafa, A. Arneodo, and C. Thermes (2007)
Genome Res. 17, 1278-1285
   Abstract »    Full Text »    PDF »
Identification of aberrant chromosomal regions from gene expression microarray studies applied to human breast cancer.
A. Buness, R. Kuner, M. Ruschhaupt, A. Poustka, H. Sultmann, and A. Tresch (2007)
Bioinformatics 23, 2273-2280
   Abstract »    Full Text »    PDF »
ISACGH: a web-based environment for the analysis of Array CGH and gene expression which includes functional profiling.
L. Conde, D. Montaner, J. Burguet-Castell, J. Tarraga, I. Medina, F. Al-Shahrour, and J. Dopazo (2007)
Nucleic Acids Res. 35, W81-W85
   Abstract »    Full Text »    PDF »
The Three-Dimensional Structure of Human Interphase Chromosomes Is Related to the Transcriptome Map.
S. Goetze, J. Mateos-Langerak, H. J. Gierman, W. de Leeuw, O. Giromus, M. H. G. Indemans, J. Koster, V. Ondrej, R. Versteeg, and R. van Driel (2007)
Mol. Cell. Biol. 27, 4475-4487
   Abstract »    Full Text »    PDF »
Pan-S replication patterns and chromosomal domains defined by genome-tiling arrays of ENCODE genomic areas.
N. Karnani, C. Taylor, A. Malhotra, and A. Dutta (2007)
Genome Res. 17, 865-876
   Abstract »    Full Text »    PDF »
Environmental Effects on Gene Expression Phenotype Have Regional Biases in the Human Genome.
J. K. Choi and S. C. Kim (2007)
Genetics 175, 1607-1613
   Abstract »    Full Text »    PDF »
Evidence of spatially bound gene regulation in Mus musculus: Decreased gene expression proximal to microRNA genomic location.
H. Inaoka, Y. Fukuoka, and I. S. Kohane (2007)
PNAS 104, 5020-5025
   Abstract »    Full Text »    PDF »
Large-scale identification of novel transcripts in the human genome.
B. A. Peters, B. St. Croix, T. Sjoblom, J. M. Cummins, N. Silliman, J. Ptak, S. Saha, K. W. Kinzler, C. Hatzis, and V. E. Velculescu (2007)
Genome Res. 17, 287-292
   Abstract »    Full Text »    PDF »
Integrative genomic analysis reveals distinct transcriptional and genetic features associated with chromosome 13 deletion in multiple myeloma.
L. Agnelli, S. Bicciato, S. Fabris, L. Baldini, F. Morabito, D. Intini, D. Verdelli, A. Callegaro, F. Bertoni, G. Lambertenghi-Deliliers, et al. (2007)
Haematologica 92, 56-65
   Abstract »    Full Text »    PDF »
A locally adaptive statistical procedure (LAP) to identify differentially expressed chromosomal regions.
A. Callegaro, D. Basso, and S. Bicciato (2006)
Bioinformatics 22, 2658-2666
   Abstract »    Full Text »    PDF »
Unraveling the Dynamic Transcriptome.
S. M. Brady, T. A. Long, and P. N. Benfey (2006)
PLANT CELL 18, 2101-2111
   Full Text »    PDF »
Evolutionary Origin and Maintenance of Coexpressed Gene Clusters in Mammals.
M. Semon and L. Duret (2006)
Mol. Biol. Evol. 23, 1715-1723
   Abstract »    Full Text »    PDF »
Viral Determinants of Integration Site Preferences of Simian Immunodeficiency Virus-Based Vectors.
H. Monse, S. Laufs, S. Kuate, W. J. Zeller, S. Fruehauf, and K. Uberla (2006)
J. Virol. 80, 8145-8150
   Abstract »    Full Text »    PDF »
Active Chromatin Hub of the Mouse {alpha}-Globin Locus Forms in a Transcription Factory of Clustered Housekeeping Genes.
G.-L. Zhou, L. Xin, W. Song, L.-J. Di, G. Liu, X.-S. Wu, D.-P. Liu, and C.-C. Liang (2006)
Mol. Cell. Biol. 26, 5096-5105
   Abstract »    Full Text »    PDF »
BABELOMICS: a systems biology perspective in the functional annotation of genome-scale experiments..
F. Al-Shahrour, P. Minguez, J. Tarraga, D. Montaner, E. Alloza, J. M. Vaquerizas, L. Conde, C. Blaschke, J. Vera, and J. Dopazo (2006)
Nucleic Acids Res. 34, W472-W476
   Abstract »    Full Text »    PDF »
Next station in microarray data analysis: GEPAS..
D. Montaner, J. Tarraga, J. Huerta-Cepas, J. Burguet, J. M. Vaquerizas, L. Conde, P. Minguez, J. Vera, S. Mukherjee, J. Valls, et al. (2006)
Nucleic Acids Res. 34, W486-W491
   Abstract »    Full Text »    PDF »
Evidence for variation in abundance of antisense transcripts between multicellular animals but no relationship between antisense transcription and organismic complexity.
M. Sun, L. D. Hurst, G. G. Carmichael, and J. Chen (2006)
Genome Res. 16, 922-933
   Abstract »    Full Text »    PDF »
Strong Regional Biases in Nucleotide Substitution in the Chicken Genome.
M. T. Webster, E. Axelsson, and H. Ellegren (2006)
Mol. Biol. Evol. 23, 1203-1216
   Abstract »    Full Text »    PDF »
Profiling the Epigenome using MSDK (Methylation-Sensitive Digital Karyotyping).
K. Polyak (2006)
Am. Assoc. Cancer Res. Educ. Book 2006, 199-201
   Full Text »    PDF »
Genomic Organization of gypsy Chromatin Insulators in Drosophila melanogaster.
E. Ramos, D. Ghosh, E. Baxter, and V. G. Corces (2006)
Genetics 172, 2337-2349
   Abstract »    Full Text »    PDF »
ChroCoLoc: an application for calculating the probability of co-localization of microarray gene expression.
J. Blake, C. Schwager, M. Kapushesky, and A. Brazma (2006)
Bioinformatics 22, 765-767
   Abstract »    Full Text »    PDF »
Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells.
A. Recchia, C. Bonini, Z. Magnani, F. Urbinati, D. Sartori, S. Muraro, E. Tagliafico, A. Bondanza, M. T. L. Stanghellini, M. Bernardi, et al. (2006)
PNAS 103, 1457-1462
   Abstract »    Full Text »    PDF »
Deregulation of common genes by c-Myc and its direct target, MT-MC1.
K. R. Rogulski, D. E. Cohen, D. L. Corcoran, P. V. Benos, and E. V. Prochownik (2005)
PNAS 102, 18968-18973
   Abstract »    Full Text »    PDF »
Drosophila melanogaster: A case study of a model genomic sequence and its consequences.
M. Ashburner and C. M. Bergman (2005)
Genome Res. 15, 1661-1667
   Abstract »    Full Text »    PDF »
Structure and function of the human genome.
P. F.R. Little (2005)
Genome Res. 15, 1759-1766
   Abstract »    Full Text »    PDF »
Scale-free networks in cell biology.
R. Albert (2005)
J. Cell Sci. 118, 4947-4957
   Abstract »    Full Text »    PDF »
Natural antisense transcripts: sound or silence?.
A. Werner and A. Berdal (2005)
Physiol Genomics 23, 125-131
   Abstract »    Full Text »    PDF »
A microarray analysis of the rice transcriptome and its comparison to Arabidopsis.
L. Ma, C. Chen, X. Liu, Y. Jiao, N. Su, L. Li, X. Wang, M. Cao, N. Sun, X. Zhang, et al. (2005)
Genome Res. 15, 1274-1283
   Abstract »    Full Text »    PDF »
Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes.
P. E. Kovanen, L. Young, A. Al-Shami, V. Rovella, C. A. Pise-Masison, M. F. Radonovich, J. Powell, J. Fu, J. N. Brady, P. J. Munson, et al. (2005)
Int. Immunol. 17, 1009-1021
   Abstract »    Full Text »    PDF »
WebGestalt: an integrated system for exploring gene sets in various biological contexts.
B. Zhang, S. Kirov, and J. Snoddy (2005)
Nucleic Acids Res. 33, W741-W748
   Abstract »    Full Text »    PDF »
Profiling of oxygen-modulated gene expression in early human placenta by systematic sequencing of suppressive subtractive hybridization products.
F. Mondon, T.-M. Mignot, R. Rebourcet, H. Jammes, J.-L. Danan, F. Ferre, and D. Vaiman (2005)
Physiol Genomics 22, 99-107
   Abstract »    Full Text »    PDF »
A model-based scan statistic for identifying extreme chromosomal regions of gene expression in human tumors.
A. M. Levin, D. Ghosh, K. R. Cho, and S. L. R. Kardia (2005)
Bioinformatics 21, 2867-2874
   Abstract »    Full Text »    PDF »
Identification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues.
T. Mijalski, A. Harder, T. Halder, M. Kersten, M. Horsch, T. M. Strom, H. V. Liebscher, F. Lottspeich, M. H. de Angelis, and J. Beckers (2005)
PNAS 102, 8621-8626
   Abstract »    Full Text »    PDF »
Male-Driven Biased Gene Conversion Governs the Evolution of Base Composition in Human Alu Repeats.
M. T. Webster, N. G. C. Smith, L. Hultin-Rosenberg, P. F. Arndt, and H. Ellegren (2005)
Mol. Biol. Evol. 22, 1468-1474
   Abstract »    Full Text »    PDF »
Local Coexpression Domains of Two to Four Genes in the Genome of Arabidopsis.
X.-Y. Ren, M. W.E.J. Fiers, W. J. Stiekema, and J.-P. Nap (2005)
Plant Physiology 138, 923-934
   Abstract »    Full Text »    PDF »
Organ-Specific Expression of Arabidopsis Genome during Development.
L. Ma, N. Sun, X. Liu, Y. Jiao, H. Zhao, and X. W. Deng (2005)
Plant Physiology 138, 80-91
   Abstract »    Full Text »    PDF »
Clusters of Co-expressed Genes in Mammalian Genomes Are Conserved by Natural Selection.
G. A. C. Singer, A. T. Lloyd, L. B. Huminiecki, and K. H. Wolfe (2005)
Mol. Biol. Evol. 22, 767-775
   Abstract »    Full Text »    PDF »
Visualizing Chromosomes as Transcriptome Correlation Maps: Evidence of Chromosomal Domains Containing Co-expressed Genes--A Study of 130 Invasive Ductal Breast Carcinomas.
F. Reyal, N. Stransky, I. Bernard-Pierrot, A. Vincent-Salomon, Y. de Rycke, P. Elvin, A. Cassidy, A. Graham, C. Spraggon, Y. Desille, et al. (2005)
Cancer Res. 65, 1376-1383
   Abstract »    Full Text »    PDF »
Relationship between gene expression and GC-content in mammals: statistical significance and biological relevance.
M. Semon, D. Mouchiroud, and L. Duret (2005)
Hum. Mol. Genet. 14, 421-427
   Abstract »    Full Text »    PDF »
Wavelet Transformations of Tumor Expression Profiles Reveals a Pervasive Genome-Wide Imprinting of Aneuploidy on the Cancer Transcriptome.
A. Aggarwal, S. H. Leong, C. Lee, O. L. Kon, and P. Tan (2005)
Cancer Res. 65, 186-194
   Abstract »    Full Text »    PDF »
Comparison of the chicken and turkey genomes reveals a higher rate of nucleotide divergence on microchromosomes than macrochromosomes.
E. Axelsson, M. T. Webster, N. G.C. Smith, D. W. Burt, and H. Ellegren (2005)
Genome Res. 15, 120-125
   Abstract »    Full Text »    PDF »
Generic Features of Tertiary Chromatin Structure as Detected in Natural Chromosomes.
W. G. Muller, D. Rieder, G. Kreth, C. Cremer, Z. Trajanoski, and J. G. McNally (2004)
Mol. Cell. Biol. 24, 9359-9370
   Abstract »    Full Text »    PDF »
Genome-Wide Analyses of Avian Sarcoma Virus Integration Sites.
A. Narezkina, K. D. Taganov, S. Litwin, R. Stoyanova, J. Hayashi, C. Seeger, A. M. Skalka, and R. A. Katz (2004)
J. Virol. 78, 11656-11663
   Abstract »    Full Text »    PDF »
Gene Order and Dynamic Domains.
S. T. Kosak and M. Groudine (2004)
Science 306, 644-647
   Abstract »    Full Text »    PDF »
A comparative analysis of transcribed genes in the mouse hypothalamus and neocortex reveals chromosomal clustering.
W.-M. Boon, T. Beissbarth, L. Hyde, G. Smyth, J. Gunnersen, D. A. Denton, H. Scott, and S.-S. Tan (2004)
PNAS 101, 14972-14977
   Abstract »    Full Text »    PDF »
Chromosome Transfer Induced Aneuploidy Results in Complex Dysregulation of the Cellular Transcriptome in Immortalized and Cancer Cells.
M. B. Upender, J. K. Habermann, L. M. McShane, E. L. Korn, J. C. Barrett, M. J. Difilippantonio, and T. Ried (2004)
Cancer Res. 64, 6941-6949
   Abstract »    Full Text »    PDF »
Gene Expression, Synteny, and Local Similarity in Human Noncoding Mutation Rates.
M. T. Webster, N. G.C. Smith, M. J. Lercher, and H. Ellegren (2004)
Mol. Biol. Evol. 21, 1820-1830
   Abstract »    Full Text »    PDF »
Over 20% of human transcripts might form sense-antisense pairs.
J. Chen, M. Sun, W. J. Kent, X. Huang, H. Xie, W. Wang, G. Zhou, R. Z. Shi, and J. D. Rowley (2004)
Nucleic Acids Res. 32, 4812-4820
   Abstract »    Full Text »    PDF »
The Use of MPSS for Whole-Genome Transcriptional Analysis in Arabidopsis.
B. C. Meyers, S. S. Tej, T. H. Vu, C. D. Haudenschild, V. Agrawal, S. B. Edberg, H. Ghazal, and S. Decola (2004)
Genome Res. 14, 1641-1653
   Abstract »    Full Text »    PDF »
Increasing the efficiency of SAGE adaptor ligation bydirected ligation chemistry.
A. P. So, R. F. B. Turner, and C. A. Haynes (2004)
Nucleic Acids Res. 32, e96
   Abstract »    Full Text »    PDF »
Comparative Sequence and X-Inactivation Analyses of a Domain of Escape in Human Xp11.2 and the Conserved Segment in Mouse.
K. D. Tsuchiya, J. M. Greally, Y. Yi, K. P. Noel, J.-P. Truong, and C. M. Disteche (2004)
Genome Res. 14, 1275-1284
   Abstract »    Full Text »    PDF »
Form follows function: the genomic organization of cellular differentiation.
S. T. Kosak and M. Groudine (2004)
Genes & Dev. 18, 1371-1384
   Abstract »    Full Text »    PDF »
A naturally occurring C-terminal truncated isoform of the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus does not associate with viral episomal DNA.
M. Canham and S. J. Talbot (2004)
J. Gen. Virol. 85, 1363-1369
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882