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Science 291 (5507): 1289-1292

Copyright © 2001 by the American Association for the Advancement of Science

The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains

Huib Caron,12 Barbera van Schaik,13 Merlijn van der Mee,3 Frank Baas,4 Gregory Riggins,6 Peter van Sluis,1 Marie-Christine Hermus,1 Ronald van Asperen,1 Kathy Boon,1 P. A. Voûte,2 Siem Heisterkamp,5 Antoine van Kampen,3 Rogier Versteeg1

The chromosomal position of human genes is rapidly being established. We integrated these mapping data with genome-wide messenger RNA expression profiles as provided by SAGE (serial analysis of gene expression). Over 2.45 million SAGE transcript tags, including 160,000 tags of neuroblastomas, are presently known for 12 tissue types. We developed algorithms to assign these tags to UniGene clusters and their chromosomal position. The resulting Human Transcriptome Map generates gene expression profiles for any chromosomal region in 12 normal and pathologic tissue types. The map reveals a clustering of highly expressed genes to specific chromosomal regions. It provides a tool to search for genes that are overexpressed or silenced in cancer.

1 Department of Human Genetics,
2 Department of Pediatric Oncology, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Post Office Box 22700, 1100 DE Amsterdam, Netherlands.
3 Bioinformatics Laboratory,
4 Neurozintuigen Laboratory,
5 Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
6 Department of Pathology and Department of Genetics, Duke University Medical Center, Durham, NC 27710, USA.


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