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Science 291 (5512): 2405-2407

Copyright © 2001 by the American Association for the Advancement of Science

Regulation of Vegetative Phase Change in Arabidopsis thaliana by Cyclophilin 40 

Tanya Z. Berardini, Krista Bollman, Hui Sun, R. Scott Poethig*

During its development, a plant shoot progresses from a juvenile to an adult phase of vegetative growth and from a reproductively incompetent to a reproductively competent state. In Arabidopsis, loss-of-function mutations in SQUINT (SQN) reduced the number of juvenile leaves and had subtle effects on inflorescence morphology but had no effect on flowering time or on reproductive competence. SQN encodes the Arabidopsis homolog of cyclophilin 40 (CyP40), a protein found in association with the Hsp90 chaperone complex in yeast, mammals, and plants. Thus, in Arabidopsis, CyP40 is specifically required for the vegetative but not the reproductive maturation of the shoot.

Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6018, USA.
*   To whom correspondence should be addressed. E-mail: spoethig{at}

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Y. Zhang, B. Li, Y. Xu, H. Li, S. Li, D. Zhang, Z. Mao, S. Guo, C. Yang, Y. Weng, et al. (2013)
PLANT CELL 25, 2504-2521
   Abstract »    Full Text »    PDF »
Cyclophilin 40 facilitates HSP90-mediated RISC assembly in plants.
T. Iki, M. Yoshikawa, T. Meshi, and M. Ishikawa (2012)
EMBO J. 31, 267-278
   Abstract »    Full Text »    PDF »
Binding of the Cyclophilin 40 Ortholog SQUINT to Hsp90 Protein Is Required for SQUINT Function in Arabidopsis.
K. W. Earley and R. S. Poethig (2011)
J. Biol. Chem. 286, 38184-38189
   Abstract »    Full Text »    PDF »
Reproductive competence from an annual and a perennial perspective.
S. Bergonzi and M. C. Albani (2011)
J. Exp. Bot. 62, 4415-4422
   Abstract »    Full Text »    PDF »
The effect of the floral repressor FLC on the timing and progression of vegetative phase change in Arabidopsis.
M. R. Willmann and R. S. Poethig (2011)
Development 138, 677-685
   Abstract »    Full Text »    PDF »
Arabidopsis SBP-Box Genes SPL10, SPL11 and SPL2 Control Morphological Change in Association with Shoot Maturation in the Reproductive Phase.
M. Shikata, T. Koyama, N. Mitsuda, and M. Ohme-Takagi (2009)
Plant Cell Physiol. 50, 2133-2145
   Abstract »    Full Text »    PDF »
Peptidyl-Prolyl Isomerase Activity in Chloroplast Thylakoid Lumen is a Dispensable Function of Immunophilins in Arabidopsis thaliana.
B. Ingelsson, A. Shapiguzov, T. Kieselbach, and A. V. Vener (2009)
Plant Cell Physiol. 50, 1801-1814
   Abstract »    Full Text »    PDF »
Cyclophilin 40 is required for microRNA activity in Arabidopsis.
M. R. Smith, M. R. Willmann, G. Wu, T. Z. Berardini, B. Moller, D. Weijers, and R. S. Poethig (2009)
PNAS 106, 5424-5429
   Abstract »    Full Text »    PDF »
The more and smaller cells mutants of Arabidopsis thaliana identify novel roles for SQUAMOSA PROMOTER BINDING PROTEIN-LIKE genes in the control of heteroblasty.
T. Usami, G. Horiguchi, S. Yano, and H. Tsukaya (2009)
Development 136, 955-964
   Abstract »    Full Text »    PDF »
REBELOTE, SQUINT, and ULTRAPETALA1 Function Redundantly in the Temporal Regulation of Floral Meristem Termination in Arabidopsis thaliana.
N. Prunet, P. Morel, A.-M. Thierry, Y. Eshed, J. L. Bowman, I. Negrutiu, and C. Trehin (2008)
PLANT CELL 20, 901-919
   Abstract »    Full Text »    PDF »
Overexpression of TaVRN1 in Arabidopsis Promotes Early Flowering and Alters Development.
H. Adam, F. Ouellet, N. A. Kane, Z. Agharbaoui, G. Major, Y. Tominaga, and F. Sarhan (2007)
Plant Cell Physiol. 48, 1192-1206
   Abstract »    Full Text »    PDF »
A WD40 Domain Cyclophilin Interacts with Histone H3 and Functions in Gene Repression and Organogenesis in Arabidopsis.
H. Li, Z. He, G. Lu, S. C. Lee, J. Alonso, J. R. Ecker, and S. Luan (2007)
PLANT CELL 19, 2403-2416
   Abstract »    Full Text »    PDF »
Nitric Oxide and cGMP Signaling in Calcium-Dependent Development of Cell Polarity in Ceratopteris richardii.
M. L. Salmi, K. E. Morris, S. J. Roux, and D. M. Porterfield (2007)
Plant Physiology 144, 94-104
   Abstract »    Full Text »    PDF »
Epigenetic regulation of transcription in intermediate heterochromatin.
Y. Habu, O. Mathieu, M. Tariq, A. V. Probst, C. Smathajitt, T. Zhu, and J. Paszkowski (2006)
EMBO Rep. 7, 1279-1284
   Abstract »    Full Text »    PDF »
The C Terminus of the Immunophilin PASTICCINO1 Is Required for Plant Development and for Interaction with a NAC-like Transcription Factor.
C. Smyczynski, F. Roudier, L. Gissot, E. Vaillant, O. Grandjean, H. Morin, T. Masson, Y. Bellec, D. Geelen, and J.-D. Faure (2006)
J. Biol. Chem. 281, 25475-25484
   Abstract »    Full Text »    PDF »
Trans-acting siRNA-mediated repression of ETTIN and ARF4 regulates heteroblasty in Arabidopsis.
C. Hunter, M. R. Willmann, G. Wu, M. Yoshikawa, M. de la Luz Gutierrez-Nava, and S. R. Poethig (2006)
Development 133, 2973-2981
   Abstract »    Full Text »    PDF »
GLABROUS INFLORESCENCE STEMS Modulates the Regulation by Gibberellins of Epidermal Differentiation and Shoot Maturation in Arabidopsis.
Y. Gan, R. Kumimoto, C. Liu, O. Ratcliffe, H. Yu, and P. Broun (2006)
PLANT CELL 18, 1383-1395
   Abstract »    Full Text »    PDF »
The Function of RNAi in Plant Development.
Cold Spring Harb Symp Quant Biol 71, 165-170
   Abstract »    PDF »
Redox regulation in the chloroplast thylakoid lumen: a new frontier in photosynthesis research.
B. B. Buchanan and S. Luan (2005)
J. Exp. Bot. 56, 1439-1447
   Abstract »    Full Text »    PDF »
Heat Stress Phenotypes of Arabidopsis Mutants Implicate Multiple Signaling Pathways in the Acquisition of Thermotolerance.
J. Larkindale, J. D. Hall, M. R. Knight, and E. Vierling (2005)
Plant Physiology 138, 882-897
   Abstract »    Full Text »    PDF »
Tight regulation of expression of two Arabidopsis cytosolic Hsp90 genes during embryo development.
C. Prasinos, K. Krampis, D. Samakovli, and P. Hatzopoulos (2005)
J. Exp. Bot. 56, 633-644
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SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis.
A. Peragine, M. Yoshikawa, G. Wu, H. L. Albrecht, and R. S. Poethig (2004)
Genes & Dev. 18, 2368-2379
   Abstract »    Full Text »    PDF »
Introducing Immunophilins. From Organ Transplantation to Plant Biology.
P. Romano, Z. He, and S. Luan (2004)
Plant Physiology 134, 1241-1243
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Immunophilins and Parvulins. Superfamily of Peptidyl Prolyl Isomerases in Arabidopsis.
Z. He, L. Li, and S. Luan (2004)
Plant Physiology 134, 1248-1267
   Abstract »    Full Text »    PDF »
The Arabidopsis Cyclophilin Gene Family.
P. G.N. Romano, P. Horton, and J. E. Gray (2004)
Plant Physiology 134, 1268-1282
   Abstract »    Full Text »    PDF »
TWISTED DWARF1, a Unique Plasma Membrane-anchored Immunophilin-like Protein, Interacts with Arabidopsis Multidrug Resistance-like Transporters AtPGP1 and AtPGP19.
M. Geisler, H. U. Kolukisaoglu, R. Bouchard, K. Billion, J. Berger, B. Saal, N. Frangne, Z. Koncz-Kalman, C. Koncz, R. Dudler, et al. (2003)
Mol. Biol. Cell 14, 4238-4249
   Abstract »    Full Text »    PDF »
K. Motohashi, F. Koyama, Y. Nakanishi, H. Ueoka-Nakanishi, and T. Hisabori (2003)
J. Biol. Chem. 278, 31848-31852
   Abstract »    Full Text »    PDF »
Phase Change and the Regulation of Developmental Timing in Plants.
R. S. Poethig (2003)
Science 301, 334-336
   Abstract »    Full Text »    PDF »
HASTY, the Arabidopsis ortholog of exportin 5/MSN5, regulates phase change and morphogenesis.
K. M. Bollman, M. J. Aukerman, M.-Y. Park, C. Hunter, T. Z. Berardini, and R. S. Poethig (2003)
Development 130, 1493-1504
   Abstract »    Full Text »    PDF »
Nonlinear partial differential equations and applications: A chloroplast FKBP interacts with and affects the accumulation of Rieske subunit of cytochrome bf complex.
R. Gupta, R. M. Mould, Z. He, and S. Luan (2002)
PNAS 99, 15806-15811
   Abstract »    Full Text »    PDF »
Signalling in Plant Lateral Organ Development.
J. F. Golz and A. Hudson (2002)
PLANT CELL 14, S277-S288
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The early phase change Gene in Maize.
S. H. Vega, M. Sauer, J. A. J. Orkwiszewski, and R. S. Poethig (2002)
PLANT CELL 14, 133-147
   Abstract »    Full Text »    PDF »

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