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Science 292 (5514): 104-106

Copyright © 2001 by the American Association for the Advancement of Science

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

David J. Clancy,1 David Gems,1* Lawrence G. Harshman,2 Sean Oldham,3 Hugo Stocker,3 Ernst Hafen,3 Sally J. Leevers,45 Linda Partridge1

The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.

1 Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK.
2 School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
3 Zoologisches Institut, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
4 Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK.
5 Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.
*   To whom correspondence should be addressed. E-mail: david.gems{at}ucl.ac.uk

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