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Science 292 (5514): 110-113

Copyright © 2001 by the American Association for the Advancement of Science

Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

Jun-ichi Nakayama,1 Judd C. Rice,2 Brian D. Strahl,2 C. David Allis,2 Shiv I. S. Grewal1*

The assembly of higher order chromatin structures has been linked to the covalent modifications of histone tails. We provide in vivo evidence that lysine 9 of histone H3 (H3 Lys9) is preferentially methylated by the Clr4 protein at heterochromatin-associated regions in fission yeast. Both the conserved chromo- and SET domains of Clr4 are required for H3 Lys9 methylation in vivo. Localization of Swi6, a homolog of Drosophila HP1, to heterochomatic regions is dependent on H3 Lys9 methylation. Moreover, an H3-specific deacetylase Clr3 and a beta -propeller domain protein Rik1 are required for H3 Lys9 methylation by Clr4 and Swi6 localization. These data define a conserved pathway wherein sequential histone modifications establish a "histone code" essential for the epigenetic inheritance of heterochromatin assembly.

1 Cold Spring Harbor Laboratory, Post Office Box 100, Cold Spring Harbor, NY 11724, USA.
2 Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA.
*   To whom correspondence should be addressed. E-mail: grewal{at}cshl.org

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R. Zaccarini, F. P. Cordelieres, P. Martin, and S. Saule (2007)
Invest. Ophthalmol. Vis. Sci. 48, 5408-5419
   Abstract »    Full Text »    PDF »
USF1 Recruits Histone Modification Complexes and Is Critical for Maintenance of a Chromatin Barrier.
S. Huang, X. Li, T. M. Yusufzai, Y. Qiu, and G. Felsenfeld (2007)
Mol. Cell. Biol. 27, 7991-8002
   Abstract »    Full Text »    PDF »
Polyomavirus Small T Antigen Controls Viral Chromatin Modifications through Effects on Kinetics of Virus Growth and Cell Cycle Progression.
J. Dahl, H. I. Chen, M. George, and T. L. Benjamin (2007)
J. Virol. 81, 10064-10071
   Abstract »    Full Text »    PDF »

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