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Science 292 (5524): 2066-2069

Copyright © 2001 by the American Association for the Advancement of Science

Modulation of Cell Proliferation by Heterotrimeric G Protein in Arabidopsis

Hemayet Ullah,1 Jin-Gui Chen,1 Jeff C. Young,2* Kyung-Hoan Im,1 Michael R. Sussman,2 Alan M. Jones1dagger

The alpha  subunit of a prototypical heterotrimeric GTP-binding protein (G protein), which is encoded by a single gene (GPA1) in Arabidopsis, is a modulator of plant cell proliferation. gpa1 null mutants have reduced cell division in aerial tissues throughout development. Inducible overexpression of GPA1 in Arabidopsis confers inducible ectopic cell division. GPA1 overexpression in synchronized BY-2 cells causes premature advance of the nuclear cycle and the premature appearance of a division wall. Results from loss of function and ectopic expression and activation of GPA1 indicate that this subunit is a positive modulator of cell division in plants.

1 Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
2 Cell and Molecular Biology Program and the Department of Horticulture, University of Wisconsin, 1575 Linden Drive, Madison, WI 53706, USA.
*   Present address: Biology Department, MS-9160, Western Washington University, Bellingham, WA 98225, USA.

dagger    To whom correspondence should be addressed at Department of Biology, CB#3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA. E-mail: alan_jones{at}unc.edu

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