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Science 292 (5525): 2314-2316

Copyright © 2001 by the American Association for the Advancement of Science

Quinones as the Redox Signal for the Arc Two-Component System of Bacteria

Dimitris Georgellis, Ohsuk Kwon, Edmund C. C. Lin*

The Arc two-component signal transduction system mediates adaptive responses of Escherichia coli to changing respiratory conditions of growth. Under anaerobic conditions, the ArcB sensor kinase autophosphorylates and then transphosphorylates ArcA, a global transcriptional regulator that controls the expression of numerous operons involved in respiratory or fermentative metabolism. We show that oxidized forms of quinone electron carriers act as direct negative signals that inhibit autophosphorylation of ArcB during aerobiosis. Thus, the Arc signal transduction system provides a link between the electron transport chain and gene expression.

Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
*   To whom correspondence should be addressed. E-mail: elin{at}hms.harvard.edu


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A novel extracytoplasmic phenol oxidase of Streptomyces: its possible involvement in the onset of morphogenesis.
K. Endo, K. Hosono, T. Beppu, and K. Ueda (2002)
Microbiology 148, 1767-1776
   Abstract »    Full Text »    PDF »
Uptake of Exogenous Coenzyme Q and Transport to Mitochondria Is Required for bc 1 Complex Stability in Yeastcoq Mutants.
C. Santos-Ocana, T. Q. Do, S. Padilla, P. Navas, and C. F. Clarke (2002)
J. Biol. Chem. 277, 10973-10981
   Abstract »    Full Text »    PDF »
The Global Regulator ArcA Controls Resistance to Reactive Nitrogen and Oxygen Intermediates in Salmonella enterica Serovar Enteritidis.
S. Lu, P. B. Killoran, F. C. Fang, and L. W. Riley (2002)
Infect. Immun. 70, 451-461
   Abstract »    Full Text »    PDF »
Bright Lights, Abundant Operons--Fluorescence and Genomic Technologies Advance Studies of Bacterial Locomotion and Signal Transduction: Review of the BLAST Meeting, Cuernavaca, Mexico, 14 to 19 January 2001.
R. B. Bourret, N. W. Charon, A. M. Stock, and A. H. West (2002)
J. Bacteriol. 184, 1-17
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Redox Signal Transduction by the ArcB Sensor Kinase of Haemophilus influenzae Lacking the PAS Domain.
D. Georgellis, O. Kwon, E. C. C. Lin, S. M. Wong, and B. J. Akerley (2001)
J. Bacteriol. 183, 7206-7212
   Abstract »    Full Text »    PDF »
Ubiquinone Is Necessary for Mouse Embryonic Development but Is Not Essential for Mitochondrial Respiration.
F. Levavasseur, H. Miyadera, J. Sirois, M. L. Tremblay, K. Kita, E. Shoubridge, and S. Hekimi (2001)
J. Biol. Chem. 276, 46160-46164
   Abstract »    Full Text »    PDF »
Ubiquinone Is Necessary for Caenorhabditis elegans Development at Mitochondrial and Non-mitochondrial Sites.
A. K. Hihi, Y. Gao, and S. Hekimi (2002)
J. Biol. Chem. 277, 2202-2206
   Abstract »    Full Text »    PDF »

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