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Science 292 (5526): 2501-2504

Copyright © 2001 by the American Association for the Advancement of Science

Conditional Restoration of Hippocampal Synaptic Potentiation in GluR-A-Deficient Mice

Volker Mack,1 Nail Burnashev,2* Katharina M. M. Kaiser,2 Andrei Rozov,2 Vidar Jensen,3 Øvind Hvalby,3 Peter H. Seeburg,1 Bert Sakmann,2 Rolf Sprengel1dagger

Plasticity of mature hippocampal CA1 synapses is dependent on L-alpha -amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In GluR-A-deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)-tagged GluR-A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons. Long-term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR-A-/- mice when GFPGluR-A expression was constitutive or induced in already fully developed pyramidal cells. This shows that GluR-A-independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A-dependent LTP.

Departments of
1 Molecular Neurobiology and
2 Cell Physiology at the Max-Planck-Institute for Medical Research, D-69120 Heidelberg, Germany.
3 Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, 0462 Oslo, Norway.
*   Present address: Department of Neurophysiology, Faculty of Biology, Vrije University, 1081 HV, Amsterdam, Netherlands.

dagger    To whom correspondence should be addressed. E-mail: sprengel{at}mpimf-heidelberg.mpg.de

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