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Science 293 (5531): 872-875

Copyright © 2001 by the American Association for the Advancement of Science

Sorting of Striatal and Cortical Interneurons Regulated by Semaphorin-Neuropilin Interactions

Oscar Marín,1 Avraham Yaron,2 Anil Bagri,2 Marc Tessier-Lavigne,2 John L. R. Rubenstein1*

Most striatal and cortical interneurons arise from the basal telencephalon, later segregating to their respective targets. Here, we show that migrating cortical interneurons avoid entering the striatum because of a chemorepulsive signal composed at least in part of semaphorin 3A and semaphorin 3F. Migrating interneurons expressing neuropilins, receptors for semaphorins, are directed to the cortex; those lacking them go to the striatum. Loss of neuropilin function increases the number of interneurons that migrate into the striatum. These observations reveal a mechanism by which neuropilins mediate sorting of distinct neuronal populations into different brain structures, and provide evidence that, in addition to guiding axons, these receptors also control neuronal migration in the central nervous system.

1 Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, Langley Porter Psychiatric Institute,
2 Department of Anatomy, Howard Hughes Medical Institute (HHMI), and Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA.
*   To whom correspondence should be addressed. E-mail: jlrr{at}cgl.ucsf.edu


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