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Science 293 (5533): 1327-1330

Copyright © 2001 by the American Association for the Advancement of Science

Immunocyte Ca2+ Influx System Mediated by LTRPC2

Yorikata Sano,*dagger Kohei Inamura,* Akira Miyake, Shinobu Mochizuki, Hiromichi Yokoi, Hitoshi Matsushime, Kiyoshi Furuichi

We characterized an activation mechanism of the human LTRPC2 protein, a member of the transient receptor potential family of ion channels, and demonstrated that LTRPC2 mediates Ca2+ influx into immunocytes. Intracellular pyrimidine nucleotides, adenosine 5'-diphosphoribose (ADPR), and nicotinamide adenine dinucleotide (NAD), directly activated LTRPC2, which functioned as a Ca2+-permeable nonselective cation channel and enabled Ca2+ influx into cells. This activation was suppressed by intracellular adenosine triphosphate. These results reveal that ADPR and NAD act as intracellular messengers and may have an important role in Ca2+ influx by activating LTRPC2 in immunocytes.

Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: sano.yorikata{at}yamanouchi.co.jp



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